Patents Assigned to Saitama University
  • Patent number: 11867671
    Abstract: The present invention provides a highly versatile method for amino acid analysis, the method enabling separation and analysis of amino acids in a sample with high precision in a shorter time. This method is a method for amino acid analysis, the method including a step of allowing a sample containing a plurality of amino acids to flow together with an eluent 2 through a separation column 4 packed with a cation exchange resin, thereby separating the amino acids, and a step of detecting the separated amino acids, wherein the eluent 2 is an eluent containing a divalent or higher inorganic acid, a cation source, and water, and having a pH of 5.0 or lower, and the sample is allowed to flow through the separation column 4 heated by applying a temperature gradient including a temperature region of 100° C. or higher.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: January 9, 2024
    Assignees: NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITY, HITACHI HIGH-TECH SCIENCE CORPORATION
    Inventor: Masami Shibukawa
  • Publication number: 20240002838
    Abstract: Provided is a linker for both screening assessment of the candidate clones without using enzymes, and to provide an in vitro selection method using thereof. Also, provided is a high-speed photo-crosslinking linker for molecular interaction analysis and in vitro selection comprising a backbone and a side chain. The backbone comprises a solid-phase binding site located at the 5? terminus for forming a bond with a solid-phase; a solid-phase cleavage site for releasing the entire solid-phase at the site; a side chain linking site for linking a side chain; a high-speed photo-crosslinking site for linking the backbone to mRNA having a sequence complementary thereof via photo-crosslinking; and a reverse transcription initiation region located adjacent to the side chain linking site at the 3? terminus of the backbone. The side chain comprises a fluorescent label, a protein binding site located at the free terminus thereof; and a binding site with the backbone.
    Type: Application
    Filed: September 15, 2023
    Publication date: January 4, 2024
    Applicant: Saitama University
    Inventors: Naoto Nemoto, Yuki Mochizuki, Shigefumi Kumachi
  • Publication number: 20230279369
    Abstract: Provided are a mutant cis-prenyltransferase (CPT) family protein and a method for producing a polyisoprenoid, which enable the production of a high molecular weight polyisoprenoid. Included is a mutant cis-prenyltransferase (CPT) family protein obtained by mutating the amino acid sequence of a N-terminal region of a cis-prenyltransferase (CPT) family protein not found on rubber particles to be identical or similar to the amino acid sequence of a N-terminal region of a cis-prenyltransferase (CPT) family protein found on rubber particles.
    Type: Application
    Filed: February 6, 2023
    Publication date: September 7, 2023
    Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., TOHOKU UNIVERSITY, KANAZAWA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITY
    Inventors: Haruhiko YAMAGUCHI, Yukino INOUE, Seiji TAKAHASHI, Toru NAKAYAMA, Satoshi YAMASHITA, Yuzuru TOZAWA
  • Publication number: 20230279371
    Abstract: Provided are a mutant cis-prenyltransferase (CPT) family protein and a method for producing a polyisoprenoid, which enable the production of a high molecular weight polyisoprenoid. Included is a mutant cis-prenyltransferase (CPT) family protein obtained by mutating the amino acid sequence of a C-terminal region of a cis-prenyltransferase (CPT) family protein not found on rubber particles to be identical or similar to the amino acid sequence of a C-terminal region of a cis-prenyltransferase (CPT) family protein found on rubber particles.
    Type: Application
    Filed: February 6, 2023
    Publication date: September 7, 2023
    Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., TOHOKU UNIVERSITY, KANAZAWA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITY
    Inventors: Haruhiko YAMAGUCHI, Yukino INOUE, Seiji TAKAHASHI, Toru NAKAYAMA, Satoshi YAMASHITA, Yuzuru TOZAWA
  • Publication number: 20230279370
    Abstract: Provided are a mutant cis-prenyltransferase (CPT) family protein and a method for producing a polyisoprenoid, which enable the production of a high molecular weight polyisoprenoid. Included is a mutant cis-prenyltransferase (CET) family protein obtained by mutating the amino acid sequence of a N-terminal region of a cis-prenyltransferase (CPT) family protein not found on rubber particles to be identical or similar to the amino acid sequence of a N-terminal region of a cis-prenyltransferase (CPT) family protein found on rubber particles, and mutating the amino acid sequence of a C-terminal region of the cis-prenyltransferase (CPT) family protein not found on rubber particles to be identical or similar to the amino acid sequence of a C-terminal region of a cis-prenyltransferase (CPT) family protein found on rubber particles.
    Type: Application
    Filed: February 6, 2023
    Publication date: September 7, 2023
    Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., TOHOKU UNIVERSITY, KANAZAWA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITY
    Inventors: Haruhiko YAMAGUCHI, Yukino INOUE, Seiji TAKAHASHI, Toru NAKAYAMA, Satoshi YAMASHITA, Yuzuru TOZAWA
  • Patent number: 11646562
    Abstract: A current interrupting device includes a current limiting element on a power supply path from a predetermined power supply to a load device. The current limiting element is configured to exhibit a current limiting action when current flowing in the power supply path exceeds a first current threshold value. The current interrupting device further includes a current diversion path switch, and a controller programmed to control on and off of the current diversion path switch. The controller is programmed to switch a current diversion path switch on from an off state when it is detected that current flowing in the current limiting element is limited to a second current threshold value after the current flowing in the current limiting element has exceeded the first current threshold value, and switch the switch off again after a predetermined switched-on holding time has elapsed since the switch has been switched on.
    Type: Grant
    Filed: September 15, 2020
    Date of Patent: May 9, 2023
    Assignees: National University Corporation Saitama University, Tokyo Institute of Technology, The University of Tokyo
    Inventors: Yuki Inada, Yasushi Yamano, Mitsuaki Maeyama, Shungo Zen, Wataru Ohnishi
  • Publication number: 20230002792
    Abstract: Objects are to provide: a fusion protein capable of binding to lipid droplets while having an enzymatic activity to synthesize a hydrophobic compound; a method for producing a substance including accumulating a hydrophobic compound in lipid droplets using the fusion protein; a vector which can enhance production of a hydrophobic compound when it is introduced into cells using genetic recombination techniques; and a transgenic cell into which the vector or a gene coding for the fusion protein has been introduced. The present disclosure relates to a fusion protein having an amino acid sequence (first amino acid sequence) capable of binding to lipid droplets, and an amino acid sequence (second amino acid sequence) having an enzymatic activity to synthesize a hydrophobic compound, with the enzymatic activity of the second amino acid sequence being maintained.
    Type: Application
    Filed: October 27, 2020
    Publication date: January 5, 2023
    Applicants: Sumitomo Rubber Industries, Ltd., TOHOKU UNIVERSITY, KANAZAWA UNIVERSITY, National University Corporation Saitama University
    Inventors: Haruhiko YAMAGUCHI, Yukino INOUE, Seiji TAKAHASI, Toru NAKAYAMA, Satoshi YAMASHITA, Yuzuru TOZAWA
  • Patent number: 11510987
    Abstract: The present invention addresses the problem of providing an endocytosis enhancer comprising associates formed from a fluorescent protein. The fluorescent protein is preferably any one selected from the group consisting of a white fluorescent protein, a red fluorescent protein, a yellow fluorescent protein, a blue fluorescent protein and a green fluorescent protein. The endocytosis enhancer according to the present invention can enhance the cellular uptake of a drug, which is encapsulated in micelles each formed from a fluorescent-protein-supported carbosilane dendrimer, through endocytosis.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: November 29, 2022
    Assignees: Saitama University, QUARRYMEN & Co. Inc.
    Inventors: Miho Suzuki, Ken Hatano, Shojiro Yoshida, Yasuhiro Yamashita
  • Publication number: 20220360067
    Abstract: A current interrupting device includes: a current limiting element provided on a power supply path from a predetermined power supply to a load device, the current limiting element being configured to exhibit a current limiting action when current flowing the power supply path exceeds a first current threshold value; a current diversion path switch capable of switching on and off of an electric conduction of a current diversion path, the current diversion path switch being connected in parallel with the power supply path; and a controller configured to control on and off of the current diversion path switch, wherein, the controller is configured to: switch the current diversion path switch on from an off state when it is detected that current flowing the current limiting element is limited to a second current threshold value after the current flowing the current limiting element has exceeded the first current threshold value; and switch the current diversion path switch off again after a predetermined switched
    Type: Application
    Filed: September 15, 2020
    Publication date: November 10, 2022
    Applicants: National University Corporation Saitama University, TOKYO INSTITUTE OF TECHNOLOGY, The University of Tokyo
    Inventors: Yuki INADA, Yasushi YAMANO, Mitsuaki MAEYAMA, Shungo ZEN, Wataru OHNISHI
  • Patent number: 11476395
    Abstract: A light source that emits light, wherein, in coordinates in a CIE 1931 chromaticity diagram, the light has a color purity included in a region of 2 to 50 in a region surrounded by a line segment WB and a line segment WG that connect coordinates W (0.33, 0.33) indicating an achromatic color with coordinates B (0.091, 0.133) of 480 nm and coordinates G (0.373, 0.624) of 560 nm on a spectral locus, and the spectral locus, and has an area occupied by a continuous spectral wavelength in a wavelength region of 480 to 540 nm, of 15% or more relative to an area of an overall spectral wavelength of the light source at 380 to 780 nm.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: October 18, 2022
    Assignees: ASAHI RUBBER INC., NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITY
    Inventors: Naoya Mashiko, Takashi Kanahira, Masutsugu Tasaki, Eiji Ishiguro, Keiichi Watanuki, Keiichi Muramatsu, Kazunori Kaede
  • Publication number: 20220283564
    Abstract: A machining state diagnosis apparatus (10) includes a machining state information estimation device (1), a learning information storage (11) storing information on relationship between estimated machining state information and actual machining state information, and a machining state diagnosis unit (12) diagnosing a machining state in actual machining using control information, based on machining state information obtained during the actual machining, machining state information estimated based on corresponding control information by the machining state information estimation device (1), and the relationship information stored in the learning information storage 11.
    Type: Application
    Filed: August 7, 2020
    Publication date: September 8, 2022
    Applicants: DMG MORI CO., LTD., Saitama University, Tokai National Higher Education and Research System, Keio University
    Inventors: Naruhiro IRINO, Yasuhiro IMABEPPU, Junichi KANEKO, Norikazu SUZUKI, Yasuhiro KAKINUMA
  • Publication number: 20220271433
    Abstract: An antenna module includes: a radiating element and a filter device including a plurality of resonators. The plurality of resonators include a first resonator and a second resonator, the second resonator being disposed at a final stage. The first resonator and the second resonator are each electrically coupled to the radiating element. A degree of a coupling of the resonator and the radiating element is weaker than a degree of a coupling of the resonator and the radiating element.
    Type: Application
    Filed: May 11, 2022
    Publication date: August 25, 2022
    Applicants: National University Corporation Saitama University, Murata Manufacturing Co., Ltd.
    Inventors: Masataka OHIRA, Kaoru SUDO, Yoshinori TAGUCHI
  • Patent number: 11396567
    Abstract: It is an object of the present invention to provide a fine fluorescent particle, which does not cause concentration quenching and has low ecotoxicity. Specifically, the present invention relates to a fine fluorescent particle containing an AIE-active compound, the particle consisting of a network polymer, wherein the fine fluorescent particle is characterized in that the AIE-active compound is, for example, a compound represented by the following formula (1): wherein E represents silicon or germanium; R1 and R2, which are the same or different, each represent a hydrocarbon group containing 1 to 6 carbon atoms, or a substituted or unsubstituted phenyl group; and R3, R4, R5 and R6, which are the same or different, each represent a substituted or unsubstituted phenyl group.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: July 26, 2022
    Assignee: NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITY
    Inventors: Ken Hatano, Takahiko Matsushita, Daisuke Fujikawa, Koji Matsuoka
  • Patent number: 11383328
    Abstract: A method for manufacturing a peeled substrate has a laser condensing step for focusing laser light at a prescribed depth from the surface of a substrate and a positioning step for moving and positioning a laser condenser relative to the substrate, the method involving forming a processed layer in the substrate. The laser condensing step includes a laser light adjustment step in which a diffraction optical element is used to branch the laser light into a plurality of branched laser beams, and at least one of the branched laser beams is branched such that the intensity thereof differs from the other branched laser beams. The processed layer is elongated using the branched laser beam having a relatively high intensity among the plurality of branched laser beams to process the substrate, and the elongation of the processed layer is restrained using the branched laser beams having a relatively low intensity.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: July 12, 2022
    Assignees: SHIN-ETSU POLYMER CO., LTD., NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITY
    Inventors: Junichi Ikeno, Yohei Yamada, Hideki Suzuki, Rika Matsuo
  • Publication number: 20220029306
    Abstract: A microstrip antenna corresponds to a rectangular resonator. The resonator has first and second sides being parallel to a first direction and having a length corresponding to 3/2 wavelength, and has a shape notched from each of the first and second sides toward a center of the resonator. The antenna includes: a first portion constituting a periphery of the notched shape; and second and third portions facing each other across the first portion. The notched shape allows the first portion to contribute to a radiation characteristic. The first, second, and third portions each have a length corresponding to ½ wavelength in the first direction. The first portion has a width in the second direction that is narrower because of the notched shape than that of the second and third portions. The second or third portion is provided with a feeding point.
    Type: Application
    Filed: October 5, 2021
    Publication date: January 27, 2022
    Applicants: Space Power Technologies Inc., National University Corporation Saitama University
    Inventors: Minoru FURUKAWA, Zhewang MA
  • Patent number: 11227771
    Abstract: An etching method for etching a substrate using a molten alkali, wherein, while an oxide coating is formed on the surface of the substrate PL to be etched in a high-temperature oxygen-containing environment, the surface to be etched is isotropically etched to remove the oxide coating using a molten alkali AL brought into a prescribed high-temperature range.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: January 18, 2022
    Assignees: SHIN-ETSU POLYMER CO., LTD., NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITY
    Inventors: Junichi Ikeno, Yohei Yamada, Hideki Suzuki
  • Publication number: 20210403604
    Abstract: The purpose of the present invention is to provide a method for producing a peptide that interacts with a lipid bilayer, and a lipid-bilayer-penetrating peptide obtained through the method. Provided is a lipid-bilayer-penetrating peptide constructed from 10 to 100 amino acids, the peptide having an amino acid sequence that penetrates the lipid bilayer at the C-terminal, and having an amino acid sequence with at least six contiguous arginine at the N-terminal. Also provided is a construct for producing a lipid-bilayer-penetrating peptide, the construct including, from the 5? end toward the 3? end, a tag region 1, a region 1 for incorporating a fluorescent protein gene sequence, a fluorescent protein gene region, a region 2 for incorporating a fluorescent protein gene sequence, a random region, and a stop codon region, and the construct being such that the random region has the aforementioned sequences.
    Type: Application
    Filed: May 7, 2021
    Publication date: December 30, 2021
    Applicant: Saitama University
    Inventors: Naoto Nemoto, Yasuhito Utsugi
  • Publication number: 20210381026
    Abstract: The present invention provides an improved immuno-PCR method by using cDNA display comprising the steps of: immobilizing a first antibody having a binding site to a solid phase: contacting a sample fluid to said antibody to bind a target molecule in said sample fluid; contacting said target molecule to a cDNA display being composed of a backbone being composed of a double strand and a side chain having a second antigen binding site to which the second antibody is bound; and conducting polymerase chain reaction to detect said cDNA quantitatively. According to the improved immune-PCR method of the present invention, the target molecule is screened and obtained quantitatively, because it uses cDNA display being composed of one protein/peptide and one DNA.
    Type: Application
    Filed: August 21, 2021
    Publication date: December 9, 2021
    Applicants: EPSILON MOLECULAR ENGINEERING INC., Saitama University
    Inventors: Naoto Nemoto, Hironori Anzai, Takeru Suzuki, Shigefumi Kumachi, Takuya Terai
  • Publication number: 20210367115
    Abstract: A light source that emits light, wherein, in coordinates in a CIE 1931 chromaticity diagram, the light has a color purity included in a region of 2 to 50 in a region surrounded by a line segment WB and a line segment WG that connect coordinates W (0.33, 0.33) indicating an achromatic color with coordinates B (0.091, 0.133) of 480 nm and coordinates G (0.373, 0.624) of 560 nm on a spectral locus, and the spectral locus, and has an area occupied by a continuous spectral wavelength in a wavelength region of 480 to 540 nm, of 15% or more relative to an area of an overall spectral wavelength of the light source at 380 to 780 nm.
    Type: Application
    Filed: July 11, 2019
    Publication date: November 25, 2021
    Applicants: ASAHI RUBBER INC., NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITY
    Inventors: Naoya MASHIKO, Takashi KANAHIRA, Masutsugu TASAKI, Eiji ISHIGURO, Keiichi WATANUKI, Keiichi MURAMATSU, Kazunori KAEDE
  • Patent number: 11160877
    Abstract: The present invention relates to a targeting-type capsule for drug delivery systems. The present invention addresses the problem of providing a capsule for drug delivery systems by utilizing the reactivity of a thiol with an alkyl halide, wherein the capsule comprises a silole-containing carbosilane dendrimer and a labeling protein containing a target recognition site (e.g., green fluorescent protein), can include a biological polymer or another molecule therein, and can deliver the biological polymer or the like selectively into a target cell.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: November 2, 2021
    Assignees: Saitama University, QUARRYMEN & Co. Inc.
    Inventors: Miho Suzuki, Ken Hatano, Shojiro Yoshida, Yasuhiro Yamashita