Patents Assigned to Saitama University
  • Patent number: 12152086
    Abstract: The purpose of the present invention is to provide a method for producing a peptide that interacts with a lipid bilayer, and a lipid-bilayer-penetrating peptide obtained through the method. Provided is a lipid-bilayer-penetrating peptide constructed from 10 to 100 amino acids, the peptide having an amino acid sequence that penetrates the lipid bilayer at the C-terminal, and having an amino acid sequence with at least six contiguous arginine at the N-terminal. Also provided is a construct for producing a lipid-bilayer-penetrating peptide, the construct including, from the 5? end toward the 3? end, a tag region 1, a region 1 for incorporating a fluorescent protein gene sequence, a fluorescent protein gene region, a region 2 for incorporating a fluorescent protein gene sequence, a random region, and a stop codon region, and the construct being such that the random region has the aforementioned sequences.
    Type: Grant
    Filed: May 7, 2021
    Date of Patent: November 26, 2024
    Assignees: Saitama University, Epsilon Molecular Engineering Incorporated
    Inventors: Naoto Nemoto, Yasuhito Utsugi
  • Publication number: 20240200575
    Abstract: Provided is a novel technique that utilizes a vibrator and is applicable to various uses. This rotating apparatus comprises a vibrator having a vibrating surface that is perpendicular to a direction of vibration, and an opposing element that has an opposing surface facing the vibrating surface and rotates about the vibration direction of the vibrator. The vibrating surface and the opposing surface have parallel regions that face each other in parallel, and an impeller region formed in a three-dimensional manner on at least one of the surfaces.
    Type: Application
    Filed: February 28, 2024
    Publication date: June 20, 2024
    Applicant: National University Corporation Saitama University
    Inventors: Masaya TAKASAKI, Yuki NAKASUJI, Hayato SHIBATA, Takehiro ISHIDA
  • Publication number: 20240204412
    Abstract: An antenna module includes a dielectric substrate, a radiating element that is arranged in the dielectric substrate, ground electrodes that are arranged to be opposed to the radiating element, and a resonance circuit. The resonance circuit is arranged between the radiating element and the ground electrode and includes resonators. The radiating element and the resonance circuit constitute a filter device. The resonance circuit includes an input line that receives a radio frequency signal from an RFIC, a resonance portion that is coupled with the input line, and a resonance portion that is coupled with the input line and the radiating element. The ground electrode is arranged between the radiating element and the input line. The resonance portion functions as an extracted pole unit. The input line is arranged between the resonance portion and the resonance portion.
    Type: Application
    Filed: February 29, 2024
    Publication date: June 20, 2024
    Applicants: National University Corporation Saitama University, Murata Manufacturing Co., Ltd.
    Inventors: Masataka OHIRA, Kaoru SUDO, Yoshinori TAGUCHI
  • Publication number: 20240002838
    Abstract: Provided is a linker for both screening assessment of the candidate clones without using enzymes, and to provide an in vitro selection method using thereof. Also, provided is a high-speed photo-crosslinking linker for molecular interaction analysis and in vitro selection comprising a backbone and a side chain. The backbone comprises a solid-phase binding site located at the 5? terminus for forming a bond with a solid-phase; a solid-phase cleavage site for releasing the entire solid-phase at the site; a side chain linking site for linking a side chain; a high-speed photo-crosslinking site for linking the backbone to mRNA having a sequence complementary thereof via photo-crosslinking; and a reverse transcription initiation region located adjacent to the side chain linking site at the 3? terminus of the backbone. The side chain comprises a fluorescent label, a protein binding site located at the free terminus thereof; and a binding site with the backbone.
    Type: Application
    Filed: September 15, 2023
    Publication date: January 4, 2024
    Applicant: Saitama University
    Inventors: Naoto Nemoto, Yuki Mochizuki, Shigefumi Kumachi
  • Patent number: 11646562
    Abstract: A current interrupting device includes a current limiting element on a power supply path from a predetermined power supply to a load device. The current limiting element is configured to exhibit a current limiting action when current flowing in the power supply path exceeds a first current threshold value. The current interrupting device further includes a current diversion path switch, and a controller programmed to control on and off of the current diversion path switch. The controller is programmed to switch a current diversion path switch on from an off state when it is detected that current flowing in the current limiting element is limited to a second current threshold value after the current flowing in the current limiting element has exceeded the first current threshold value, and switch the switch off again after a predetermined switched-on holding time has elapsed since the switch has been switched on.
    Type: Grant
    Filed: September 15, 2020
    Date of Patent: May 9, 2023
    Assignees: National University Corporation Saitama University, Tokyo Institute of Technology, The University of Tokyo
    Inventors: Yuki Inada, Yasushi Yamano, Mitsuaki Maeyama, Shungo Zen, Wataru Ohnishi
  • Publication number: 20230002792
    Abstract: Objects are to provide: a fusion protein capable of binding to lipid droplets while having an enzymatic activity to synthesize a hydrophobic compound; a method for producing a substance including accumulating a hydrophobic compound in lipid droplets using the fusion protein; a vector which can enhance production of a hydrophobic compound when it is introduced into cells using genetic recombination techniques; and a transgenic cell into which the vector or a gene coding for the fusion protein has been introduced. The present disclosure relates to a fusion protein having an amino acid sequence (first amino acid sequence) capable of binding to lipid droplets, and an amino acid sequence (second amino acid sequence) having an enzymatic activity to synthesize a hydrophobic compound, with the enzymatic activity of the second amino acid sequence being maintained.
    Type: Application
    Filed: October 27, 2020
    Publication date: January 5, 2023
    Applicants: Sumitomo Rubber Industries, Ltd., TOHOKU UNIVERSITY, KANAZAWA UNIVERSITY, National University Corporation Saitama University
    Inventors: Haruhiko YAMAGUCHI, Yukino INOUE, Seiji TAKAHASI, Toru NAKAYAMA, Satoshi YAMASHITA, Yuzuru TOZAWA
  • Patent number: 11510987
    Abstract: The present invention addresses the problem of providing an endocytosis enhancer comprising associates formed from a fluorescent protein. The fluorescent protein is preferably any one selected from the group consisting of a white fluorescent protein, a red fluorescent protein, a yellow fluorescent protein, a blue fluorescent protein and a green fluorescent protein. The endocytosis enhancer according to the present invention can enhance the cellular uptake of a drug, which is encapsulated in micelles each formed from a fluorescent-protein-supported carbosilane dendrimer, through endocytosis.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: November 29, 2022
    Assignees: Saitama University, QUARRYMEN & Co. Inc.
    Inventors: Miho Suzuki, Ken Hatano, Shojiro Yoshida, Yasuhiro Yamashita
  • Publication number: 20220360067
    Abstract: A current interrupting device includes: a current limiting element provided on a power supply path from a predetermined power supply to a load device, the current limiting element being configured to exhibit a current limiting action when current flowing the power supply path exceeds a first current threshold value; a current diversion path switch capable of switching on and off of an electric conduction of a current diversion path, the current diversion path switch being connected in parallel with the power supply path; and a controller configured to control on and off of the current diversion path switch, wherein, the controller is configured to: switch the current diversion path switch on from an off state when it is detected that current flowing the current limiting element is limited to a second current threshold value after the current flowing the current limiting element has exceeded the first current threshold value; and switch the current diversion path switch off again after a predetermined switched
    Type: Application
    Filed: September 15, 2020
    Publication date: November 10, 2022
    Applicants: National University Corporation Saitama University, TOKYO INSTITUTE OF TECHNOLOGY, The University of Tokyo
    Inventors: Yuki INADA, Yasushi YAMANO, Mitsuaki MAEYAMA, Shungo ZEN, Wataru OHNISHI
  • Publication number: 20220283564
    Abstract: A machining state diagnosis apparatus (10) includes a machining state information estimation device (1), a learning information storage (11) storing information on relationship between estimated machining state information and actual machining state information, and a machining state diagnosis unit (12) diagnosing a machining state in actual machining using control information, based on machining state information obtained during the actual machining, machining state information estimated based on corresponding control information by the machining state information estimation device (1), and the relationship information stored in the learning information storage 11.
    Type: Application
    Filed: August 7, 2020
    Publication date: September 8, 2022
    Applicants: DMG MORI CO., LTD., Saitama University, Tokai National Higher Education and Research System, Keio University
    Inventors: Naruhiro IRINO, Yasuhiro IMABEPPU, Junichi KANEKO, Norikazu SUZUKI, Yasuhiro KAKINUMA
  • Publication number: 20220271433
    Abstract: An antenna module includes: a radiating element and a filter device including a plurality of resonators. The plurality of resonators include a first resonator and a second resonator, the second resonator being disposed at a final stage. The first resonator and the second resonator are each electrically coupled to the radiating element. A degree of a coupling of the resonator and the radiating element is weaker than a degree of a coupling of the resonator and the radiating element.
    Type: Application
    Filed: May 11, 2022
    Publication date: August 25, 2022
    Applicants: National University Corporation Saitama University, Murata Manufacturing Co., Ltd.
    Inventors: Masataka OHIRA, Kaoru SUDO, Yoshinori TAGUCHI
  • Publication number: 20220029306
    Abstract: A microstrip antenna corresponds to a rectangular resonator. The resonator has first and second sides being parallel to a first direction and having a length corresponding to 3/2 wavelength, and has a shape notched from each of the first and second sides toward a center of the resonator. The antenna includes: a first portion constituting a periphery of the notched shape; and second and third portions facing each other across the first portion. The notched shape allows the first portion to contribute to a radiation characteristic. The first, second, and third portions each have a length corresponding to ½ wavelength in the first direction. The first portion has a width in the second direction that is narrower because of the notched shape than that of the second and third portions. The second or third portion is provided with a feeding point.
    Type: Application
    Filed: October 5, 2021
    Publication date: January 27, 2022
    Applicants: Space Power Technologies Inc., National University Corporation Saitama University
    Inventors: Minoru FURUKAWA, Zhewang MA
  • Publication number: 20210403604
    Abstract: The purpose of the present invention is to provide a method for producing a peptide that interacts with a lipid bilayer, and a lipid-bilayer-penetrating peptide obtained through the method. Provided is a lipid-bilayer-penetrating peptide constructed from 10 to 100 amino acids, the peptide having an amino acid sequence that penetrates the lipid bilayer at the C-terminal, and having an amino acid sequence with at least six contiguous arginine at the N-terminal. Also provided is a construct for producing a lipid-bilayer-penetrating peptide, the construct including, from the 5? end toward the 3? end, a tag region 1, a region 1 for incorporating a fluorescent protein gene sequence, a fluorescent protein gene region, a region 2 for incorporating a fluorescent protein gene sequence, a random region, and a stop codon region, and the construct being such that the random region has the aforementioned sequences.
    Type: Application
    Filed: May 7, 2021
    Publication date: December 30, 2021
    Applicant: Saitama University
    Inventors: Naoto Nemoto, Yasuhito Utsugi
  • Publication number: 20210381026
    Abstract: The present invention provides an improved immuno-PCR method by using cDNA display comprising the steps of: immobilizing a first antibody having a binding site to a solid phase: contacting a sample fluid to said antibody to bind a target molecule in said sample fluid; contacting said target molecule to a cDNA display being composed of a backbone being composed of a double strand and a side chain having a second antigen binding site to which the second antibody is bound; and conducting polymerase chain reaction to detect said cDNA quantitatively. According to the improved immune-PCR method of the present invention, the target molecule is screened and obtained quantitatively, because it uses cDNA display being composed of one protein/peptide and one DNA.
    Type: Application
    Filed: August 21, 2021
    Publication date: December 9, 2021
    Applicants: EPSILON MOLECULAR ENGINEERING INC., Saitama University
    Inventors: Naoto Nemoto, Hironori Anzai, Takeru Suzuki, Shigefumi Kumachi, Takuya Terai
  • Patent number: 11160877
    Abstract: The present invention relates to a targeting-type capsule for drug delivery systems. The present invention addresses the problem of providing a capsule for drug delivery systems by utilizing the reactivity of a thiol with an alkyl halide, wherein the capsule comprises a silole-containing carbosilane dendrimer and a labeling protein containing a target recognition site (e.g., green fluorescent protein), can include a biological polymer or another molecule therein, and can deliver the biological polymer or the like selectively into a target cell.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: November 2, 2021
    Assignees: Saitama University, QUARRYMEN & Co. Inc.
    Inventors: Miho Suzuki, Ken Hatano, Shojiro Yoshida, Yasuhiro Yamashita
  • Patent number: 10918726
    Abstract: The object of the present invention is to provide an aggregatable carrier material for drug delivery system and a micelle formed thereof. The present invention provides an aggregatable carrier material for drug delivery system, which is formed by utilizing the reaction between thiol group and alkyl halide. It is formed by using carbosilane dendrimers containing silole and labeled proteins such as green fluorescent protein in aqueous solvent or in mixed solvent of the aqueous solvent and organic solvent. The micelle composed of the material may incorporate compounds having a variety of molecular weight and biopolymers in the aqueous solvent.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: February 16, 2021
    Assignees: QUARRYMEN & Co. Inc., Saitama University
    Inventors: Miho Suzuki, Ken Hatano, Shojiro Yoshida, Yasuhiro Yamashita
  • Patent number: 10772973
    Abstract: The present invention is related to a targeted type shell for drug delivery system. The object of the present invention is to provide the targeted type shell for DDS, which comprises a carbosilane dendrimer containing a silole produced by which is formed by utilizing the reaction between thiol group and alkyl halide, and a targeted protein containing a labeled proteins such as green fluorescent protein with a target recognition site. The shell may incorporate compounds having a variety of molecular weight and biopolymers, and selectively deliver them into targeted cells.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: September 15, 2020
    Assignees: QUARRYMEN & Co. Inc., Saitama University
    Inventors: Miho Suzuki, Ken Hatano, Shojiro Yoshida, Yasuhiro Yamashita
  • Publication number: 20200002249
    Abstract: A method for producing an unsaturated hydrocarbon, comprising: a step of contacting a raw material gas containing an alkane with a dehydrogenation catalyst to obtain a product gas containing at least one unsaturated hydrocarbon selected from a group consisting of olefins and conjugated dienes, wherein the dehydrogenation catalyst contains at least one additive element selected from the group consisting of Na, K, and Ca, Al, Mg, a group 14 metal element, and Pt, and a content of the additive element is 0.05% by mass or more and 0.70% by mass or less based on a total mass of the dehydrogenation catalyst.
    Type: Application
    Filed: December 27, 2017
    Publication date: January 2, 2020
    Applicants: JXTG Nippon Oil & Energy Corporation, National University Corporation Saitama University
    Inventors: Hideki KUROKAWA, Tatsuya ICHIJO, Nobuhiro KIMURA
  • Patent number: 10287612
    Abstract: Provided is a cyanobacterium improved in fatty acid productivity. A method for producing a modified cyanobacterium, comprising causing loss of function of a LexA transcriptional regulator and acyl-ACP synthetase in a cyanobacterium.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: May 14, 2019
    Assignees: Kao Corporation, Saitama University
    Inventors: Akihito Kawahara, Yukako Sonoike, Ayumi Kizawa
  • Patent number: 10006066
    Abstract: Provided is a cyanobacterium with improved productivity of fatty acid. A method for producing a modified cyanobacterium, comprising causing loss of functions of an AbrB-like transcriptional regulator and acyl-ACP synthetase in a cyanobacterium.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: June 26, 2018
    Assignees: Kao Corporation, Saitama University
    Inventors: Akihito Kawahara, Yukako Sonoike
  • Publication number: 20180163237
    Abstract: Provided is a cyanobacterium improved in fatty acid productivity. A method for producing a modified cyanobacterium, comprising causing loss of function of a LexA transcriptional regulator and acyl-ACP synthetase in a cyanobacterium.
    Type: Application
    Filed: December 21, 2015
    Publication date: June 14, 2018
    Applicants: Kao Corporation, Saitama University
    Inventors: Akihito KAWAHARA, Yukako SONOIKE, Ayumi KIZAWA