Patents Assigned to Saitama University
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Patent number: 11867671Abstract: The present invention provides a highly versatile method for amino acid analysis, the method enabling separation and analysis of amino acids in a sample with high precision in a shorter time. This method is a method for amino acid analysis, the method including a step of allowing a sample containing a plurality of amino acids to flow together with an eluent 2 through a separation column 4 packed with a cation exchange resin, thereby separating the amino acids, and a step of detecting the separated amino acids, wherein the eluent 2 is an eluent containing a divalent or higher inorganic acid, a cation source, and water, and having a pH of 5.0 or lower, and the sample is allowed to flow through the separation column 4 heated by applying a temperature gradient including a temperature region of 100° C. or higher.Type: GrantFiled: December 19, 2019Date of Patent: January 9, 2024Assignees: NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITY, HITACHI HIGH-TECH SCIENCE CORPORATIONInventor: Masami Shibukawa
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Publication number: 20240002838Abstract: Provided is a linker for both screening assessment of the candidate clones without using enzymes, and to provide an in vitro selection method using thereof. Also, provided is a high-speed photo-crosslinking linker for molecular interaction analysis and in vitro selection comprising a backbone and a side chain. The backbone comprises a solid-phase binding site located at the 5? terminus for forming a bond with a solid-phase; a solid-phase cleavage site for releasing the entire solid-phase at the site; a side chain linking site for linking a side chain; a high-speed photo-crosslinking site for linking the backbone to mRNA having a sequence complementary thereof via photo-crosslinking; and a reverse transcription initiation region located adjacent to the side chain linking site at the 3? terminus of the backbone. The side chain comprises a fluorescent label, a protein binding site located at the free terminus thereof; and a binding site with the backbone.Type: ApplicationFiled: September 15, 2023Publication date: January 4, 2024Applicant: Saitama UniversityInventors: Naoto Nemoto, Yuki Mochizuki, Shigefumi Kumachi
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Publication number: 20230279369Abstract: Provided are a mutant cis-prenyltransferase (CPT) family protein and a method for producing a polyisoprenoid, which enable the production of a high molecular weight polyisoprenoid. Included is a mutant cis-prenyltransferase (CPT) family protein obtained by mutating the amino acid sequence of a N-terminal region of a cis-prenyltransferase (CPT) family protein not found on rubber particles to be identical or similar to the amino acid sequence of a N-terminal region of a cis-prenyltransferase (CPT) family protein found on rubber particles.Type: ApplicationFiled: February 6, 2023Publication date: September 7, 2023Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., TOHOKU UNIVERSITY, KANAZAWA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITYInventors: Haruhiko YAMAGUCHI, Yukino INOUE, Seiji TAKAHASHI, Toru NAKAYAMA, Satoshi YAMASHITA, Yuzuru TOZAWA
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Publication number: 20230279371Abstract: Provided are a mutant cis-prenyltransferase (CPT) family protein and a method for producing a polyisoprenoid, which enable the production of a high molecular weight polyisoprenoid. Included is a mutant cis-prenyltransferase (CPT) family protein obtained by mutating the amino acid sequence of a C-terminal region of a cis-prenyltransferase (CPT) family protein not found on rubber particles to be identical or similar to the amino acid sequence of a C-terminal region of a cis-prenyltransferase (CPT) family protein found on rubber particles.Type: ApplicationFiled: February 6, 2023Publication date: September 7, 2023Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., TOHOKU UNIVERSITY, KANAZAWA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITYInventors: Haruhiko YAMAGUCHI, Yukino INOUE, Seiji TAKAHASHI, Toru NAKAYAMA, Satoshi YAMASHITA, Yuzuru TOZAWA
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Publication number: 20230279370Abstract: Provided are a mutant cis-prenyltransferase (CPT) family protein and a method for producing a polyisoprenoid, which enable the production of a high molecular weight polyisoprenoid. Included is a mutant cis-prenyltransferase (CET) family protein obtained by mutating the amino acid sequence of a N-terminal region of a cis-prenyltransferase (CPT) family protein not found on rubber particles to be identical or similar to the amino acid sequence of a N-terminal region of a cis-prenyltransferase (CPT) family protein found on rubber particles, and mutating the amino acid sequence of a C-terminal region of the cis-prenyltransferase (CPT) family protein not found on rubber particles to be identical or similar to the amino acid sequence of a C-terminal region of a cis-prenyltransferase (CPT) family protein found on rubber particles.Type: ApplicationFiled: February 6, 2023Publication date: September 7, 2023Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., TOHOKU UNIVERSITY, KANAZAWA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITYInventors: Haruhiko YAMAGUCHI, Yukino INOUE, Seiji TAKAHASHI, Toru NAKAYAMA, Satoshi YAMASHITA, Yuzuru TOZAWA
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Patent number: 11646562Abstract: A current interrupting device includes a current limiting element on a power supply path from a predetermined power supply to a load device. The current limiting element is configured to exhibit a current limiting action when current flowing in the power supply path exceeds a first current threshold value. The current interrupting device further includes a current diversion path switch, and a controller programmed to control on and off of the current diversion path switch. The controller is programmed to switch a current diversion path switch on from an off state when it is detected that current flowing in the current limiting element is limited to a second current threshold value after the current flowing in the current limiting element has exceeded the first current threshold value, and switch the switch off again after a predetermined switched-on holding time has elapsed since the switch has been switched on.Type: GrantFiled: September 15, 2020Date of Patent: May 9, 2023Assignees: National University Corporation Saitama University, Tokyo Institute of Technology, The University of TokyoInventors: Yuki Inada, Yasushi Yamano, Mitsuaki Maeyama, Shungo Zen, Wataru Ohnishi
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Publication number: 20230002792Abstract: Objects are to provide: a fusion protein capable of binding to lipid droplets while having an enzymatic activity to synthesize a hydrophobic compound; a method for producing a substance including accumulating a hydrophobic compound in lipid droplets using the fusion protein; a vector which can enhance production of a hydrophobic compound when it is introduced into cells using genetic recombination techniques; and a transgenic cell into which the vector or a gene coding for the fusion protein has been introduced. The present disclosure relates to a fusion protein having an amino acid sequence (first amino acid sequence) capable of binding to lipid droplets, and an amino acid sequence (second amino acid sequence) having an enzymatic activity to synthesize a hydrophobic compound, with the enzymatic activity of the second amino acid sequence being maintained.Type: ApplicationFiled: October 27, 2020Publication date: January 5, 2023Applicants: Sumitomo Rubber Industries, Ltd., TOHOKU UNIVERSITY, KANAZAWA UNIVERSITY, National University Corporation Saitama UniversityInventors: Haruhiko YAMAGUCHI, Yukino INOUE, Seiji TAKAHASI, Toru NAKAYAMA, Satoshi YAMASHITA, Yuzuru TOZAWA
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Patent number: 11510987Abstract: The present invention addresses the problem of providing an endocytosis enhancer comprising associates formed from a fluorescent protein. The fluorescent protein is preferably any one selected from the group consisting of a white fluorescent protein, a red fluorescent protein, a yellow fluorescent protein, a blue fluorescent protein and a green fluorescent protein. The endocytosis enhancer according to the present invention can enhance the cellular uptake of a drug, which is encapsulated in micelles each formed from a fluorescent-protein-supported carbosilane dendrimer, through endocytosis.Type: GrantFiled: August 7, 2019Date of Patent: November 29, 2022Assignees: Saitama University, QUARRYMEN & Co. Inc.Inventors: Miho Suzuki, Ken Hatano, Shojiro Yoshida, Yasuhiro Yamashita
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Publication number: 20220360067Abstract: A current interrupting device includes: a current limiting element provided on a power supply path from a predetermined power supply to a load device, the current limiting element being configured to exhibit a current limiting action when current flowing the power supply path exceeds a first current threshold value; a current diversion path switch capable of switching on and off of an electric conduction of a current diversion path, the current diversion path switch being connected in parallel with the power supply path; and a controller configured to control on and off of the current diversion path switch, wherein, the controller is configured to: switch the current diversion path switch on from an off state when it is detected that current flowing the current limiting element is limited to a second current threshold value after the current flowing the current limiting element has exceeded the first current threshold value; and switch the current diversion path switch off again after a predetermined switchedType: ApplicationFiled: September 15, 2020Publication date: November 10, 2022Applicants: National University Corporation Saitama University, TOKYO INSTITUTE OF TECHNOLOGY, The University of TokyoInventors: Yuki INADA, Yasushi YAMANO, Mitsuaki MAEYAMA, Shungo ZEN, Wataru OHNISHI
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Patent number: 11476395Abstract: A light source that emits light, wherein, in coordinates in a CIE 1931 chromaticity diagram, the light has a color purity included in a region of 2 to 50 in a region surrounded by a line segment WB and a line segment WG that connect coordinates W (0.33, 0.33) indicating an achromatic color with coordinates B (0.091, 0.133) of 480 nm and coordinates G (0.373, 0.624) of 560 nm on a spectral locus, and the spectral locus, and has an area occupied by a continuous spectral wavelength in a wavelength region of 480 to 540 nm, of 15% or more relative to an area of an overall spectral wavelength of the light source at 380 to 780 nm.Type: GrantFiled: July 11, 2019Date of Patent: October 18, 2022Assignees: ASAHI RUBBER INC., NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITYInventors: Naoya Mashiko, Takashi Kanahira, Masutsugu Tasaki, Eiji Ishiguro, Keiichi Watanuki, Keiichi Muramatsu, Kazunori Kaede
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Publication number: 20220283564Abstract: A machining state diagnosis apparatus (10) includes a machining state information estimation device (1), a learning information storage (11) storing information on relationship between estimated machining state information and actual machining state information, and a machining state diagnosis unit (12) diagnosing a machining state in actual machining using control information, based on machining state information obtained during the actual machining, machining state information estimated based on corresponding control information by the machining state information estimation device (1), and the relationship information stored in the learning information storage 11.Type: ApplicationFiled: August 7, 2020Publication date: September 8, 2022Applicants: DMG MORI CO., LTD., Saitama University, Tokai National Higher Education and Research System, Keio UniversityInventors: Naruhiro IRINO, Yasuhiro IMABEPPU, Junichi KANEKO, Norikazu SUZUKI, Yasuhiro KAKINUMA
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Publication number: 20220271433Abstract: An antenna module includes: a radiating element and a filter device including a plurality of resonators. The plurality of resonators include a first resonator and a second resonator, the second resonator being disposed at a final stage. The first resonator and the second resonator are each electrically coupled to the radiating element. A degree of a coupling of the resonator and the radiating element is weaker than a degree of a coupling of the resonator and the radiating element.Type: ApplicationFiled: May 11, 2022Publication date: August 25, 2022Applicants: National University Corporation Saitama University, Murata Manufacturing Co., Ltd.Inventors: Masataka OHIRA, Kaoru SUDO, Yoshinori TAGUCHI
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Patent number: 11396567Abstract: It is an object of the present invention to provide a fine fluorescent particle, which does not cause concentration quenching and has low ecotoxicity. Specifically, the present invention relates to a fine fluorescent particle containing an AIE-active compound, the particle consisting of a network polymer, wherein the fine fluorescent particle is characterized in that the AIE-active compound is, for example, a compound represented by the following formula (1): wherein E represents silicon or germanium; R1 and R2, which are the same or different, each represent a hydrocarbon group containing 1 to 6 carbon atoms, or a substituted or unsubstituted phenyl group; and R3, R4, R5 and R6, which are the same or different, each represent a substituted or unsubstituted phenyl group.Type: GrantFiled: September 26, 2017Date of Patent: July 26, 2022Assignee: NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITYInventors: Ken Hatano, Takahiko Matsushita, Daisuke Fujikawa, Koji Matsuoka
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Patent number: 11383328Abstract: A method for manufacturing a peeled substrate has a laser condensing step for focusing laser light at a prescribed depth from the surface of a substrate and a positioning step for moving and positioning a laser condenser relative to the substrate, the method involving forming a processed layer in the substrate. The laser condensing step includes a laser light adjustment step in which a diffraction optical element is used to branch the laser light into a plurality of branched laser beams, and at least one of the branched laser beams is branched such that the intensity thereof differs from the other branched laser beams. The processed layer is elongated using the branched laser beam having a relatively high intensity among the plurality of branched laser beams to process the substrate, and the elongation of the processed layer is restrained using the branched laser beams having a relatively low intensity.Type: GrantFiled: October 26, 2017Date of Patent: July 12, 2022Assignees: SHIN-ETSU POLYMER CO., LTD., NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITYInventors: Junichi Ikeno, Yohei Yamada, Hideki Suzuki, Rika Matsuo
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Publication number: 20220029306Abstract: A microstrip antenna corresponds to a rectangular resonator. The resonator has first and second sides being parallel to a first direction and having a length corresponding to 3/2 wavelength, and has a shape notched from each of the first and second sides toward a center of the resonator. The antenna includes: a first portion constituting a periphery of the notched shape; and second and third portions facing each other across the first portion. The notched shape allows the first portion to contribute to a radiation characteristic. The first, second, and third portions each have a length corresponding to ½ wavelength in the first direction. The first portion has a width in the second direction that is narrower because of the notched shape than that of the second and third portions. The second or third portion is provided with a feeding point.Type: ApplicationFiled: October 5, 2021Publication date: January 27, 2022Applicants: Space Power Technologies Inc., National University Corporation Saitama UniversityInventors: Minoru FURUKAWA, Zhewang MA
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Patent number: 11227771Abstract: An etching method for etching a substrate using a molten alkali, wherein, while an oxide coating is formed on the surface of the substrate PL to be etched in a high-temperature oxygen-containing environment, the surface to be etched is isotropically etched to remove the oxide coating using a molten alkali AL brought into a prescribed high-temperature range.Type: GrantFiled: October 26, 2017Date of Patent: January 18, 2022Assignees: SHIN-ETSU POLYMER CO., LTD., NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITYInventors: Junichi Ikeno, Yohei Yamada, Hideki Suzuki
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Publication number: 20210403604Abstract: The purpose of the present invention is to provide a method for producing a peptide that interacts with a lipid bilayer, and a lipid-bilayer-penetrating peptide obtained through the method. Provided is a lipid-bilayer-penetrating peptide constructed from 10 to 100 amino acids, the peptide having an amino acid sequence that penetrates the lipid bilayer at the C-terminal, and having an amino acid sequence with at least six contiguous arginine at the N-terminal. Also provided is a construct for producing a lipid-bilayer-penetrating peptide, the construct including, from the 5? end toward the 3? end, a tag region 1, a region 1 for incorporating a fluorescent protein gene sequence, a fluorescent protein gene region, a region 2 for incorporating a fluorescent protein gene sequence, a random region, and a stop codon region, and the construct being such that the random region has the aforementioned sequences.Type: ApplicationFiled: May 7, 2021Publication date: December 30, 2021Applicant: Saitama UniversityInventors: Naoto Nemoto, Yasuhito Utsugi
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Publication number: 20210381026Abstract: The present invention provides an improved immuno-PCR method by using cDNA display comprising the steps of: immobilizing a first antibody having a binding site to a solid phase: contacting a sample fluid to said antibody to bind a target molecule in said sample fluid; contacting said target molecule to a cDNA display being composed of a backbone being composed of a double strand and a side chain having a second antigen binding site to which the second antibody is bound; and conducting polymerase chain reaction to detect said cDNA quantitatively. According to the improved immune-PCR method of the present invention, the target molecule is screened and obtained quantitatively, because it uses cDNA display being composed of one protein/peptide and one DNA.Type: ApplicationFiled: August 21, 2021Publication date: December 9, 2021Applicants: EPSILON MOLECULAR ENGINEERING INC., Saitama UniversityInventors: Naoto Nemoto, Hironori Anzai, Takeru Suzuki, Shigefumi Kumachi, Takuya Terai
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Publication number: 20210367115Abstract: A light source that emits light, wherein, in coordinates in a CIE 1931 chromaticity diagram, the light has a color purity included in a region of 2 to 50 in a region surrounded by a line segment WB and a line segment WG that connect coordinates W (0.33, 0.33) indicating an achromatic color with coordinates B (0.091, 0.133) of 480 nm and coordinates G (0.373, 0.624) of 560 nm on a spectral locus, and the spectral locus, and has an area occupied by a continuous spectral wavelength in a wavelength region of 480 to 540 nm, of 15% or more relative to an area of an overall spectral wavelength of the light source at 380 to 780 nm.Type: ApplicationFiled: July 11, 2019Publication date: November 25, 2021Applicants: ASAHI RUBBER INC., NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITYInventors: Naoya MASHIKO, Takashi KANAHIRA, Masutsugu TASAKI, Eiji ISHIGURO, Keiichi WATANUKI, Keiichi MURAMATSU, Kazunori KAEDE
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Patent number: 11160877Abstract: The present invention relates to a targeting-type capsule for drug delivery systems. The present invention addresses the problem of providing a capsule for drug delivery systems by utilizing the reactivity of a thiol with an alkyl halide, wherein the capsule comprises a silole-containing carbosilane dendrimer and a labeling protein containing a target recognition site (e.g., green fluorescent protein), can include a biological polymer or another molecule therein, and can deliver the biological polymer or the like selectively into a target cell.Type: GrantFiled: November 27, 2018Date of Patent: November 2, 2021Assignees: Saitama University, QUARRYMEN & Co. Inc.Inventors: Miho Suzuki, Ken Hatano, Shojiro Yoshida, Yasuhiro Yamashita