Abstract: Substituted naphtho [1,2-c] pyrazoles e.g., 4,5-dihydro-5-methyl-3-(4-pyridyl)-2H-naphtho[1,2-c]-pyrazole, are useful as non-estrogenic anti-fertility agents.

Abstract: 1,2,3,12a-tetrahydro-1-(substituted-aminomethyl)-7-methylene-7(12H) pleiadenes, e.g., 1,2,3,12a-tetrahydro-1-(dimethylaminomethyl)-7-methylene-7(12H)-pleiadene, prepared by various methods including acid dehydration of the corresponding 1,2,3,12a-tetrahydro-1-(dimethylaminomethyl)-7-methyl-7(12H) -pleiaden-7-ols, are useful as anti-depressants.

Abstract: Softening agents, especially useful for treatment of synthetic fiber shag carpeting, to impart softening and anti-soiling properties and which do not increase the inherent flammability of the carpeting are provided by reacting a fatty mono- or polyamine with tris-(2,3-dibromopropyl)-phosphate.

Abstract: Apparatus and process for detecting the products of either liquid or gas chromatographic analysis, which products may be either radioactively tagged or not tagged. In one aspect, it provides a moving wire apparatus for conveying a liquid chromatographic sample through a combustion furnace, where the combustion products are conveyed to a catalytic system. Non-radioactive samples are routed through a nickel catalytic converter; and thence, to a flame ionisation detector. Radioactive samples are conveyed from the combustion furnace through either a copper-oxide or an iron catalytic furnace, depending upon whether the sample is tagged with Carbon-14 or tritium. The products of the catalytic furnaces are detected by means of a radioactive detector. Means are also provided for introducing gas chromatographic products into the system for detection.

Abstract: Disclosed are compounds of the class of quinazolines substituted at the 2-position by lower alkyl and at the 4-position by an amino function bearing a hydroxy-alkyl nitrate moiety, e.g., 4-(5-hydroxypentyl) amino-2-methyl-6,7-dimethoxy-quinazoline nitrate. The compounds and their corresponding hydroxy intermediates have various pharmacological activities in animals and are useful, for example, as anti-anginal agents and as agents in the treatment of shock.

Abstract: Citronellyl benzimidazoles, e.g., (.+-.) 1-(3,7-dimethyl-6-octen-1-yl)-2-phenylbenzimidazole, are prepared by reacting an alkali metal salt of a 2-phenylbenzimidazole with citronellyl halide and are useful as hypolipidemic agents.

Abstract: .alpha.-substituted-4-(2,2-dimethyl-1-hydroxypropyl) benzyl alcohols and esters, e.g., .alpha.-methyl-4-(2,2-dimethyl-1-hydroxypropyl) benzyl alcohol, are prepared from the corresponding 1-(4-alkanoylphenyl) alkanols and derivatives and are useful as hypolipidemic agents.

Abstract: N-substituted amino-N-nitroso-aminoacetamides, e.g., .alpha.-(N-morpholino-N-nitrosoamino)acetamide, are prepared by hydrolyzing the corresponding 3-N-substituted amino-sydnonimines and have been found to be useful as hypotensive/anti-hypertensive and anti-anginal agents.

Abstract: 5-hydroxy-5-substituted phenyl-pyrrolidones and piperidinones, 3.g., 5-hydroxy-1-methyl-5-(m-trifluoromethylphenyl)pyrrolidone, are useful as sedative-hypnotic agents and minor tranquilizers.

Abstract: Hypolipidemic agents of the formula: ##SPC1##WhereinR is hydrogen, alkyl or halo,R' and R" are hydrogen, halo, alkyl or alkoxy,R'" is alkyl, andn is 1 or 2.

Abstract: Anti-inflammatory and analgesic agents of the formula I: ##SPC1##whereinn is 2 to 7,R.degree. is lower alkyl,m is 0, 1 or 2,R is lower alkyl, alkenyl, cycloalkyl, cycloalkylalkyl or phenyl,R' is a radical of the formula ##SPC2##In which Y and Y' are the same or different and represent hydrogen, lower alkyl, lower alkoxy, halo of atomic weight of 19 to 36 or one of Y and Y' is trifluoromethyl while the other is hydrogen, or a radical of the formula ##SPC3##In which Y" is hydrogen, fluorine, chlorine or alkyl of 1 to 3 carbon atoms, are prepared by cyclizing a compound of the formula II ##SPC4##in which R, R', R.degree., m and n are as defined above, with, for example, phosgene.

Abstract: Phthalanols disubstituted in the 3-position, e.g. 3-(4-chlorophenyl)-3-(2-dimethylaminomethyl phenyl)-1-methyl-1-phthalanol, prepared by alkylating corresponding phthalides, are useful as anti-inflammatory agents.

Abstract: A synergistic acaricidal composition comprises as a first ingredient the .beta.-exotoxin of Bacillus thuringiensis or a metal salt thereof and has a second ingredient of one or more of the following chemical acaricides:1,1-bis-(p-chlorophenyl) ethanol,Bis-(p-chlorophenyl) sulfide,Bis-(p-chlorophenoxy) methane.The first and second ingredients are used generally in a ratio of about 0.5:1 to 10:1 and may be dispersed in a major portion of an agronomically acceptable carrier.

Abstract: Imidazo isoindoles, e.g. 5-(p-chlorophenyl)-5-hydroxy-2,3-dihydro-5H-imidazo[2,1a]isoindol, may be prepared by treating a corresponding 2-benzoyl benzoic acid with a substituted ethylene diamine, and treating a resulting intermediate first with concentrated acid and then with base. The products are active as anorexic agents.

Abstract: The compounds are 4-naphthyl-4-lower alkyl substituted-2-oxygenated-2-butenes, or butanes; the naphthyl position may be unsubstituted or 6-substituted, e.g., 2-(6-methoxynaphthyl)-2-penten-4-ol, and are useful as pharmaceuticals.

Abstract: Disclosed are compounds of the class of furo[3,2-c]pyridines substituted at the 4-position by an amino function bearing a hydroxy-alkyl nitrate moiety, e.g., 4-[ 4-(2-hydroxyethyl)-1-piperazino]-furo[3,2-c]pyridine nitrate. The compounds have pharmacological activity in animals and are useful, for example, as anti-anginal agents. Also disclosed are the corresponding hydroxy intermediates which are useful in preparation of the nitrates and also as anti-anginal agents or as agents in the treatment of shock.

Abstract: Certain substituted or unsubstituted p-alkanoyl toluenes, e.g., p-alkanoyl toluene, are useful as hypolipidemic agents.

Abstract: Anti-inflammatory agents of the formula I: ##SPC1##whereinR is lower alkyl, cycloalkyl or cycloalkylalkyl,R' is a radical of the formula ##SPC2##in which Y and Y' are hydrogen, lower alkyl, lower alkoxy, halo or trifluoromethyl, or a radical of the formula ##SPC3##in which Y" is hydrogen, halo or alkyl,Are prepared by cyclizing a compound of formula II ##SPC4##in which R and R' are as defined above, with phosgene.

Abstract: 1-isopropyl-7-methyl-4-(p-fluorophenyl)-2(1H)-quinazolinone useful, for example, as a highly active anti-inflammatory agent of extended half line. The compound may be prepared by any of several processes, e.g. by reacting a 2-isopropylamino-4-methylbenzophenone with potassium isocyanate.

Abstract: Disclosed herein is circuitry for producing a signal proportional to the rate of recurrence of a periodic input signal applied to the circuitry. When an input pulse is received a timing circuit is energized to charge a capacitor to a predetermined level. The capacitor is then discharged through a resistance circuit having resistance portions which are electronically switched in and out of the circuit so that the discharge, rate of the capacitor defines the desired rate function. Then, upon commencement of a subsequent pulse a sample and hold circuit is actuated to sample the discharge level of the capacitor to provide an accurate indication of the pulse rate.