Patents Assigned to Sandoz Inc.
  • Sustained release tablet formulations
    Patent number: 4012498
    Abstract: This invention provides controlled, e.g., sustained release of drugs from medicament formulations containing a plurality of medicaments, wherein a desirable release pattern is maintained for both low concentration and high concentration drugs of the formulation.
    Type: Grant
    Filed: February 19, 1976
    Date of Patent: March 15, 1977
    Assignee: Sandoz, Inc.
    Inventors: Saul S. Kornblum, Samuel B. Stoopak
  • Hypolipidemic allene carboxylic acids
    Patent number: 4011339
    Abstract: The compounds are 4-aryl substituted buta-2,3-dienoic acids and esters thereof which may also be lower alkyl-substituted at any of the 2- and 4-positions, e.g., 4-(p-methoxyphenyl)-2-methyl-buta-2,3-dienoic acid. The compounds are useful as pharmaceuticals, e.g., as anti-inflammatory agents and hypolipidemic agents.
    Type: Grant
    Filed: August 15, 1975
    Date of Patent: March 8, 1977
    Assignee: Sandoz, Inc.
    Inventors: Eugene E. Galantay, Faizulla G. Kathawala
  • Hypolipidemic bis(pivaloylbenzyl) ureas
    Patent number: 4011340
    Abstract: Pivaloyl benzyl ureas, e.g., 1,1-bis(4-pivaloylbenzyl)-3-methyl urea, are prepared by reacting a corresponding 4", 4'"-iminodimethylene-di-tert. alkylophenones with an alkyl isocyanate, and are useful as hypolipidemic agents.
    Type: Grant
    Filed: October 28, 1975
    Date of Patent: March 8, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Bi-4-[1-(quinazolinyl-4)piperidyls] and bis{4-[1-(quinazolinyl-4)piperidyl]alkanes}
    Patent number: 4011323
    Abstract: Disclosed are bi-4-[1-(quinazolinyl-4)piperidyls] and bis{4-[1-(quinazolinyl-4)piperidyl]alkanes}, e.g. 1,3-bis{4-[1-(6,7-dimethylquinazolinyl-4)piperidyl]propane}, having pharmacological activity in animals and useful for example, as anti-obesity and anti-diabetic agents. Said compounds may be prepared by reacting a 4-haloquinazoline with bi-4-piperidyl or a bis(piperidyl-4)alkane.
    Type: Grant
    Filed: June 18, 1975
    Date of Patent: March 8, 1977
    Assignee: Sandoz, Inc.
    Inventor: William R. J. Simpson
  • Phenoxyphenyl pyridyl compounds
    Patent number: 4011232
    Abstract: Phenoxyphenyl pyridyl carbinols and ketones, e.g., p-[4'-(2,2-dimethylpropyl)-phenoxy]-phenyl-(4-pyridyl)-carbinol, are useful as pharmaceutical agents. The ketones are obtainable by oxidation of corresponding phenoxyphenyl pyridyl carbinols.
    Type: Grant
    Filed: December 18, 1975
    Date of Patent: March 8, 1977
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Iminodimethylene di-tert-alkylophenones and phenols
    Patent number: 4011344
    Abstract: Substituted-iminodimethylene-di-tert-alkylophenones, e.g., 4", 4"'-methyliminodimethylene-dipivalophenone, are prepared by treating a corresponding .alpha.-halo-p-tert-alkanoyl toluene with a substituted amine. The phenylcarbinols are prepared from the corresponding phenones and both the phenones and the phenylcarbinols are useful as hypolipidemic agents.
    Type: Grant
    Filed: June 20, 1975
    Date of Patent: March 8, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Tolyloxypivalophenone derivatives
    Patent number: 4008327
    Abstract: The compounds are cyclic acetals of 4'-(.alpha.-hydroxy-.alpha.-alkyl-p-tolyloxy)pivalophenones, e.g., ethylene glycol acetal of 4'-(.alpha.-hydroxy-.alpha.-heptadecyl-p-tolyloxy)pivalophenone, and are useful as anti-diabetic agents.
    Type: Grant
    Filed: June 16, 1975
    Date of Patent: February 15, 1977
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Substituted .alpha.-methylsulfinyl-o-toluidines
    Patent number: 4006183
    Abstract: The invention discloses optionally substituted .alpha.-methylsulfinyl-o-toluidines having pharmacological activity in animals and useful as CNS depressant agents. The compounds may be prepared by reacting an optionally substituted .alpha.-methylthio-o-toluidine with an oxidizing agent.
    Type: Grant
    Filed: July 8, 1975
    Date of Patent: February 1, 1977
    Assignee: Sandoz, Inc.
    Inventor: Thomas E. Jackson
  • Alkyl-p-pivaloylbenzylaminomethyl-benzophenones
    Patent number: 4006248
    Abstract: Alkyl-p-pivaloylbenzylaminomethyl-benzophenones, e.g., 4-{[methyl(p-pivaloylbenzyl)amino]methyl}benzophenone, are prepared by treating a corresponding 4-benzoyl-N-alkyl-benzylamine with a corresponding .alpha.-halo-p-pivaloyl toluene and are useful as hypolipidemic agents.
    Type: Grant
    Filed: August 21, 1975
    Date of Patent: February 1, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Patient ventilator
    Patent number: 4003377
    Abstract: An improved patient ventilator for providing a mode of operation wherein mandatory breaths are supplied to a patient intermittently, and wherein those mandatory breaths are synchronized with the patient's normal breathing cycle. An adjustable timer provides an output signal for controlling the duration between mandatory breaths, and a delay circuit prevents the output signal from the timer from initiating the mandatory breath for a predetermined delay period to permit the patient to initiate that breath himself. The intermittent mandatory breaths are made "mandatory" by closing off an exhalation valve while a fixed quantity or pressure level of oxygen is supplied to the patient.
    Type: Grant
    Filed: August 21, 1975
    Date of Patent: January 18, 1977
    Assignee: Sandoz, Inc.
    Inventor: William R. Dahl
  • Antihypertensive aryl pyrazolo[4,3-c]pyridazinones
    Patent number: 4004009
    Abstract: The compounds are aryl-pyridazinone derivatives, e.g., 1-methyl-5-(2'-fluoro-5'-trifluoromethylphenyl)-1H-pyrazolo [4,3-c]pyridazin-6(5H)-one. They are useful as antihypertensives and are prepared by treating a hydrazinopyridazinone with a dialkylamino dialkyl-acetal.
    Type: Grant
    Filed: July 31, 1975
    Date of Patent: January 18, 1977
    Assignee: Sandoz, Inc.
    Inventor: Paul L. Anderson
  • 5-Hydrazinopyridazin-3(2H)-ones
    Patent number: 4002751
    Abstract: Substituted 5-hydrazinopyridazin-3(2H)-ones, e.g., 4-chloro-2-(3-trifluoromethylphenyl)-5-(1-methylhydrazino)-pyridazin-3(2H) -one or 4-chloro-2-(2-fluoro-5-trifluoromethylphenyl)-5-(1-methylhydrazino)-pyrida zin-3(2H)-one, are prepared by treating halogenated pyridazin-3-(2H)-ones with hydrazine and substituted hydrazines and are useful as central nervous system depressants and sleep inducers.
    Type: Grant
    Filed: May 2, 1975
    Date of Patent: January 11, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jerome Linder
  • Alkanoyl isoindolinylmethyl alkylphenones
    Patent number: 4000307
    Abstract: Alkanoyl isoindolinylmethyl alkylphenones of the formula, ##STR1## e.g. 4'-(5-pivaloyl-2-isoindolinylmethyl)-pivalophenone, are prepared by reacting a 3',4'-bis(bromomethyl)alkylphenone with a 4'-(aminomethyl)alkylphenone-(2,2-dimethyl-1,3-propanediyl)cyclic ketal and hydrolyzing the ketal formed, and are useful as hypolipidemic agents.
    Type: Grant
    Filed: November 19, 1975
    Date of Patent: December 28, 1976
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Liquid compositions of Bacillus thuringiensis
    Patent number: 4000258
    Abstract: Stable suspensions of Bacillus thuringiensis insecticide in a liquid selected from the group consisting of (a) alcohols having at least about 7 carbon atoms; (b) polyethylene glycols having a molecular weight of at least about 300; (c) polypropylene glycols having a molecular weight of at least about 180; (d) polyethylenepropylene glycols having a molecular weight of at least about 250; (e) ethoxylated alcohols having a molecular weight greater than about 120; and (f) propoxylated alcohols having a molecular weight greater than about 120.
    Type: Grant
    Filed: January 19, 1972
    Date of Patent: December 28, 1976
    Assignee: Sandoz, Inc.
    Inventors: Tsuong R. Shieh, Martin H. Rogoff
  • Substituted-4'-aminoacetyl alkanoylphenones
    Patent number: 3998850
    Abstract: Substituted -4'-aminoacetyl alkanoylphenones, e.g., 4'-(4-methyl-1-piperazinylacetyl)pivalophenone, are prepared by treating corresponding 4'-(haloacetyl)alkanoylphenones with substituted amines, and are useful as hypolipidemic agents.
    Type: Grant
    Filed: January 8, 1975
    Date of Patent: December 21, 1976
    Assignee: Sandoz, Inc.
    Inventors: William J. Houlihan, Jeffrey Nadelson
  • 1-Dioxolanylpropyl-3-indoleacrylic acid esters
    Patent number: 3997670
    Abstract: 1-dioxolanylpropyl-3-indoleacrylic acid esters, e.g., 1-[3-(2-methyl-2-dioxolanyl)propyl]-3-indoleacrylic acid ethyl ester, are prepared by reacting a corresponding 1-dioxolanylpropyl-3-indolecarboxaldehyde with carbalkoxymethylene triphenylphosphorane and are useful as hypolipidemic agents.
    Type: Grant
    Filed: February 6, 1975
    Date of Patent: December 14, 1976
    Assignee: Sandoz, Inc.
    Inventor: Marcel K. Eberle
  • Substituted carbinol derivatives
    Patent number: 3997664
    Abstract: The compounds are steroidal 17-propadienyl carbinols and derivatives thereof. The compounds have estrogenic/progestational activity.
    Type: Grant
    Filed: March 24, 1975
    Date of Patent: December 14, 1976
    Assignee: Sandoz, Inc.
    Inventors: Eugene E. Galantay, Dietmar A. Habeck
  • 4-Phenyl-1-hydroxyalkylpyrazoles
    Patent number: 3997555
    Abstract: CNS depressants of the formula: ##SPC1##Wherein R.sup.o is hydroxyalkyl of 1 to 5 carbon atoms and R is hydrogen, halo, alkyl, alkoxy or trifluoromethyl.
    Type: Grant
    Filed: December 23, 1974
    Date of Patent: December 14, 1976
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • 9-.alpha.-methyl-steroids
    Patent number: 3997574
    Abstract: The compounds are 13-(lower)alkyl-9.alpha.-methyl-17.alpha.-propadienylgona-4-en-17.beta.-ol -3-ones and derivatives thereof, e.g. 9.alpha.-methyl-17.alpha.-propadienylestra-17.beta.-ol-3-one, and are useful as progestational agents.
    Type: Grant
    Filed: September 5, 1974
    Date of Patent: December 14, 1976
    Assignee: Sandoz, Inc.
    Inventors: Robert V. Coombs, Eugene E. Galantay
  • Substituted 2-(4-phenoxyphenyl)-2-tertiary butyl-1,3-dioxalanes
    Patent number: 3997567
    Abstract: Hypolipidemic agents of the formula: ##SPC1##WhereinR is hydrogen, alkyl or halo,R' and R" are hydrogen, halo, alkyl or alkoxy, andn is 1 or 2.
    Type: Grant
    Filed: November 7, 1974
    Date of Patent: December 14, 1976
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala