Abstract: Ammonium salts of aromatic sulpho group-containing condensation products of at least one sulpho group-containing aromatic compound and at least one dihydroxydiphenylsulphone with formaldehyde or a formaldehyde-yielding compound or of defined starting mono- or oligosulphones which are partially metallized and compositions containing them, optionally together with UV-absorbers, are suitable as assistants in the treatment of various substrates and act in particular as improvers of the light-fastness of synthetic polyamide fibres and their dyeings, as assistants in the dyeing or tanning of leather and in the production of paper and as wood-preserving agents.
Abstract: A process for applying a reactive dye to a cellulosic substrate comprising:(a) adding one or more dyeing assistants selected from the condensation product of sulphonated diphenyl ethers, condensation product of sulphonated ditolyl ethers, condensation products of polydiphenylsulphones with formaldehyde and condensation products of polyditolyl sulphones with formaldehyde (and salts thereof) into an aqueous liquor, optionally together with a salt (hereinafter defined as Process Step a);(b) introducing the substrate into the dyebath and adding one or more reactive dyes, (hereinafter defined as Process Step b) ; and(c) fixing the dyestuff onto the substrate (hereinafter defined as Process Step c).
Abstract: The invention relates to the stabilization of alkaline solutions of peroxide bleaching compounds using, as stabilizing agent, a water-soluble poly-.alpha.-hydroxyacrylic acid salt which in the sodium salt form has an average molecular weight Mw from 2000 to 10,000 and to the preparation of such a salt.
Abstract: A method for manufacturing a cementitious composition comprisinga) uniformally fluidising in a container, particles of a substantially dry powdered cementitious composition by creating aerial motion of the particles by rotational motion perpendicular to the fall of the particles,b) at the same time uniformally spraying the particles with 0.1 to 10 parts by weight (per 100 parts of cementitious composition) of water, optionally containing a cement admixture, andc) mixing the particles and the water intensively by shearing forces.
Abstract: The invention provides immunostimulatory compositions comprising an aggregate immunostimulatory amount ofa) a compound associated with the synthesis of polyamines,b) a nucleobase source,c) omega-3 polyunsaturated fatty acids, andd) omega-6 polyunsaturated fatty acidsthe use of such compositions and their manufacture.
Type:
Grant
Filed:
February 19, 1992
Date of Patent:
July 27, 1993
Assignee:
Sandoz Ltd.
Inventors:
J. Wesley Alexander, Vigen K. Babayan, George L. Blackburn, Frank B. Cerra, John Daly, Mitchell T. Gersovitz, John E. Kinsella, Jerome J. LiCari, Frederick Rudolph, Charles T. Van Buren
Abstract: A process for preparing the (R) stereoisomer of 2,2-bis(hydroxmethyl)-tetrahydrofuran monobutyrate comprising subjecting the dibutyric ester of the 2,2-bis(hydroxymethyl)-tetrahydrofuran to enzymatic hydrolysis. The invention also relates to the novel (R) stereoisomer prepared by the instant process and to its more stable forms. In addition, the invention relates to the use of the (R) stereoisomer in preparing stereoisomers of pharmacologically active compounds and to certain specific stereoisomers produced thereby.
Type:
Grant
Filed:
April 26, 1991
Date of Patent:
July 20, 1993
Assignee:
Sandoz Ltd.
Inventors:
Heinrich Estermann, Prasad K. Kapa, Russell L. Underwood, William J. Houlihan
Abstract: Compounds of the formula ##STR1## and salts thereof, wherein R.sub.1 is hydrogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy,R.sub.2 is hydrogen, halo, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, (C.sub.1-4 alkyl)carbonylamino or --NHCONH.sub.2, andW is -NR.sub.3 -B.sub.1 -NR.sub.3 -, ##STR2## wherein B.sub.1 is linear or branched C.sub.2-6 alkylene, linear or branched C.sub.2-6 alkylene interrupted by --O-- or --NR.sub.3 -- or linear or branched C.sub.3-6 alkylene monosubstituted or disubstituted by hydroxy, with the proviso that the hydroxy groups of any linear or branched C.sub.3-6 alkylene disubstituted by hydroxy are bound to different carbon atoms, andR.sub.4 is linear or branched C.sub.2-4 alkylene,whereineach R.sub.3 is independently hydrogen, C.sub.1-4 alkyl or C.sub.1-4 alkyl substituted by hydroxy, halo, cyano, sulfo, sulfato or carboxy,with the provisos that the --N.dbd.
Abstract: Compounds of the formula ##STR1## in which either and salts thereof R.sub.1 is hydrogen or hydroxy-C.sub.2-3 alkyl, andR.sub.2 is hydroxy-C.sub.2-3 alkyl, orR.sub.1 is hydrogen or 2-cyanoethyl, andR.sub.2 is --CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OH,and mixtures of such compounds, which compounds are in free acid or salt form, are useful for dyeing or printing hydroxy group- or nitrogen-containing organic substrates, particularly leather and textiles containing or consisting of natural or synthetic polyamides or of natural or regenerated cellulose, especially textile material containing or consisting of cotton.
Abstract: Metal-free compounds of the formula ##STR1## a 1:1 or 1:2 metal complex of a metallizable compound of said formula or a salt of a metal-free compound of said formula or of a 1:1 or 1:2 metal complex thereof each cation of which is independently a non-chromophoric cation, or a mixture, thereof, whereinF.sub.c is the radical of a water-soluble azo, formazan, phthalocyanine, azomethine, oxazine, thiazine, phenazine or triphenylmethane dye,each W is independently --NR.sub.1 --B.sub.1 --NR.sub.1 --, ##STR2## wherein B.sub.1 is linear or branched C.sub.2-6 alkylene; linear or branched C.sub.2-6 alkylene interrupted by --O-- or --NR.sub.1 --; linear or branched C.sub.3-6 alkylene monosubstituted by hydroxy or carboxy or disubstituted by hydroxy, ##STR3## wherein R.sub.2 is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, carboxy or sulfo, andn is 0, 1, 2, 3 or 4, andm is 0 or 1,each X is independently a direct bond, --CO-- or --SO.sub.
Type:
Grant
Filed:
July 26, 1991
Date of Patent:
July 13, 1993
Assignee:
Sandoz Ltd.
Inventors:
Gunther Auerbach, Kurt Brenneisen, Markus Doerr, Paul Doswald, Markus Gisler, Werner Koch, Helmut A. Moser, Roland Wald
Abstract: Arylaminocarbonyl compounds of the formula (I) ##STR1## wherein R.sub.2-6, X.sub.1, A and m are as defined in the disclosure, intermediates therefore, synthesis thereof, and the use of said compounds for the control of weeds are described.
Type:
Grant
Filed:
August 17, 1992
Date of Patent:
June 22, 1993
Assignee:
Sandoz Ltd.
Inventors:
Karl Seckinger, Karlheinz Milzner, Fred Kuhnen, Sasank S. Mohanty
Abstract: The saccharides of formula I, ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 independently are optionally substituted acyl, are novel. They possess interesting pharmacological, especially immunostimulant, antiinflammatory and antitumor properties. They may be obtained by deprotection of a corresponding compound in protected form.
Abstract: The invention provides compounds of formula I wherein R, R.sub.1 and Az are as defined in the description, the fungicidal use of such compounds, compositions for facilitating such use and the preparation of compounds of formula I.
Abstract: Compounds of the formula ##STR1## and salts thereof, and their use as as reactive dyes for the dyeing and printing of hydroxy group- and nitrogen- containing organic substrates, e.g., leather, natural and synthetic polyamides and natural and regenerated cellulose.
Abstract: This invention relates to a hard gelatin capsule containing no more than 5 to 10 milligrams of crystalline temazepam and its use in the treatment of transient insomnia.
Abstract: The 3-O-[N-acetylmuramyl-D-isoglutaminyl]-1,2-di-O-palmitoyl-sn-glycerol derivative of formula I ##STR1## wherein the carbon atom marked with an asterisk * has the R or, respectively, the S configuration, possesses interesting pharmacological, in particular immunomodulating properties. It is particularly useful as an immunomodulant, as an adjuvant in vaccines and as a suppressing agent for IgE formation in e.g. type I allergies and atopical dermatitises.It is obtained by deprotection of a corresponding compound having one or more hydroxy group(s) in protected form.
Type:
Grant
Filed:
June 27, 1990
Date of Patent:
May 11, 1993
Assignee:
Sandoz Ltd.
Inventors:
Louis Chedid, Peter Dukor, Pierre Lefrancier, Peter Stutz
Abstract: Compounds and mixtures of compounds obtainable by condensation of sulphonation products of defined alkyl-substituted naphthalenes and sulphonation products of optionally alkyl-substituted diphenylethers with formaldehye and optionally treated with further components, are valuable interface-active compounds suitable as assistants in various application fields, in particular as dispersing or levelling agents in the dyeing with disperse dyes or as tanning-assistants or dyeing-assistants for leather.
Abstract: An improved process for preparing the R- and S-isomers of 2-hydroxymethyl-2-octadecyloxymethyl-tetrahydrofuran, a critical step of which involves the preparation of the R- and S-isomers of 2-[3-(1-methoxy-1-methylethoxy)]propyl-oxiranemethanol employing metal-catalyzed Sharpless epoxidation. In addition, the invention relates to the use of the R- and S-isomers of 2-hydroxymethyl-2-octadecyloxymethyl-tetrahydrofuran in preparing stereoisomers of pharmacologically active compounds, and to the R- and S-isomers of 2-[3-(1-methoxy-1-methylethoxy)]-propyl-oxiranemethanol as novel compounds.
Type:
Grant
Filed:
April 2, 1992
Date of Patent:
May 4, 1993
Assignee:
Sandoz Ltd.
Inventors:
Chung-Pin Chen, Prasad K. Kapa, William J. Houlihan
Abstract: The compounds of formula I ##STR1## wherein the substituents have various significances, possess pharmacological, particularly antiinflammatory and immunosuppressant activity.They can be prepared by one or more of the following process variants: reduction, deprotection, acylation, reaction with N,N'-carbonyl- or N,N'-thiocarbonyldiimidazole, halogenation, splitting off of hydrogen halide, reaction with a hydrogen carbonate, radical deoxygenation, dehydration or reaction with diazomethane of -ethane, optionally under transient protection of reactive groups which it is not desired to react.
Type:
Grant
Filed:
June 13, 1991
Date of Patent:
April 6, 1993
Assignee:
Sandoz, Ltd.
Inventors:
Andrew J. F. Edmunds, Maximilian Grassberger