Patents Assigned to Sangart, Inc.
  • Methods for preparing PEG-hemoglobin conjugates using reduced reactant ratios
    Patent number: 9493616
    Abstract: The present invention relates generally to methods for preparing polyethylene glycol (“PEG”) conjugated hemoglobin (“Hb”) using reduced reactant ratios. More specifically, the present invention relates to methods for preparing PEG conjugated Hb (“PEG-Hb”) with enhanced yield and purity.
    Type: Grant
    Filed: February 23, 2011
    Date of Patent: November 15, 2016
    Assignee: Sangart, Inc.
    Inventors: Ashok Malavalli, Kim D. Vandegriff
  • Methods for preparing stable deoxygenated PEG-hemoglobin conjugate solutions comprising an antioxidant
    Patent number: 8609815
    Abstract: The present invention is a method for preparing stable HBOC solutions. Specifically, the method comprises the steps of deoxygenating a PEG-Hb conjugate and adding one or more antioxidants during or following the deoxygenating step to form a stabilized PEG-Hb conjugate. The Hb in the PEG-Hb conjugate is not crosslinked and the stabilized PEG-Hb conjugate has a p50 less than that of native SFH from the same animal source when measured under the same conditions. Specifically, the p50 is 6±2 mmHg or less than 10 mmHg.
    Type: Grant
    Filed: September 1, 2011
    Date of Patent: December 17, 2013
    Assignee: Sangart, Inc.
    Inventors: Kim D. Vandegriff, Ashok S. Malavalli
  • METHODS FOR PREPARING PEG-HEMOGLOBIN CONJUGATES USING REDUCED REACTANT RATIOS
    Publication number: 20130217860
    Abstract: The present invention relates generally to methods for preparing polyethylene glycol (“PEG”) conjugated hemoglobin (“Hb”) using reduced reactant ratios. More specifically, the present invention relates to methods for preparing PEG conjugated Hb (“PEG-Hb”) with enhanced yield and purity.
    Type: Application
    Filed: February 23, 2011
    Publication date: August 22, 2013
    Applicant: SANGART, INC.
    Inventors: Ashok Malavalli, Kim D. Vandegriff
  • COMPOSITIONS FOR OXYGEN TRANSPORT COMPRISING A HIGH OXYGEN AFFINITY MODIFIED HEMOGLOBIN
    Publication number: 20130102521
    Abstract: The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to auto oxidation and superior oxygen carrying characteristics.
    Type: Application
    Filed: December 14, 2012
    Publication date: April 25, 2013
    Applicant: SANGART, INC.
    Inventor: Sangart, Inc.
  • Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
    Patent number: 8377868
    Abstract: The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to auto oxidation and superior oxygen carrying characteristics.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: February 19, 2013
    Assignee: Sangart, Inc.
    Inventors: Robert M. Winslow, Kim D. Vandegriff
  • METHODS FOR PREPARING POLYETHYLENE GLYCOL MALEIMIDE USING N-(2-HYDROXYETHYL) MALEIMIDE AS A STARTING MATERIAL
    Publication number: 20130041134
    Abstract: The present invention relates generally to methods for preparing polyethylene glycol maleimide (“PEG-Mal”). More specifically, the present invention relates to methods for synthesizing desired molecular weight PEG-Mal by direct ethoxylation of N-(2-hydroxyethyl)maleimide under specific reaction conditions.
    Type: Application
    Filed: November 2, 2010
    Publication date: February 14, 2013
    Applicant: SANGART ,INC.
    Inventors: John R. Handley, Jonathon B. McKannan
  • METHOD OF DELIVERING OXYGEN USING PEG-HEMOGLOBIN CONJUGATES WITH ENHANCED NITRITE REDUCTASE ACTIVITY
    Publication number: 20120282236
    Abstract: The present invention relates generally to methods for delivering oxygen to tissue and reducing nitrite to nitric oxide in the microvasculature. Specifically, the present invention is directed towards using a deoxygenated pegylated hemoglobin conjugate having enhanced nitrite reductase activity to deliver oxygen to tissues.
    Type: Application
    Filed: May 1, 2012
    Publication date: November 8, 2012
    Applicant: SANGART, INC.
    Inventors: Kim D. Vandegriff, Ashok Malavalli, Scott D. Olsen
  • Method to enhance hemodynamic stability using oxygen carrying compositions
    Patent number: 8278275
    Abstract: The present invention relates to methods for enhancing the hemodynamic stability of an individual undergoing surgery by administering a composition comprising a hemoglobin-based oxygen carrier. In one embodiment, the present invention relates to the use of polyalkylene oxide modified hemoglobins with reduced cooperativity and a high oxygen affinity to enhance oxygen offloading as a preventative measure to avoid hemodynamic stability-related complications during surgery.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: October 2, 2012
    Assignee: Sangart, Inc.
    Inventors: Robert M. Winslow, Kim D. Vandegriff
  • METHODS FOR PRESERVING AN ORGAN FOR TRANSPLANTATION USING A HEMOGLOBIN-CARBON MONOXIDE COMPLEX
    Publication number: 20120196270
    Abstract: The present invention relates generally to methods of preserving an organ for transplantation. Specifically, the present invention is directed towards treating an organ with a hemoglobin-carbon monoxide complex to preserve the organ before transplantation.
    Type: Application
    Filed: February 1, 2012
    Publication date: August 2, 2012
    Applicant: Sangart, Inc.
    Inventors: Mark YOUNG, Kim D. VANDEGRIFF
  • MalPEG-Hb Conjugate-Containing Compositions for Delivering Carbon Monoxide (CO) to Cells
    Publication number: 20120094912
    Abstract: The present invention relates to compositions for delivering carbon monoxide (CO) to cells using heme proteins as carriers. In one embodiment, the present invention relates to the use of MalPEG surface modified hemoglobin to deliver CO to cells.
    Type: Application
    Filed: October 19, 2011
    Publication date: April 19, 2012
    Applicant: Sangart, Inc.
    Inventors: Robert M. WINSLOW, Kim Vandegriff, Nancy Jo Winslow, Ashok Malavalli
  • MalPEG-Hb Conjugate-Containing Compositions for Delivering Nitric Oxide (NO) to Cells
    Publication number: 20120094936
    Abstract: The present invention relates to compositions for delivering nitric oxide (NO) to cells using heme proteins as carriers. In one embodiment, the present invention relates to the use of MalPEG surface modified hemoglobin to deliver NO to cells.
    Type: Application
    Filed: October 19, 2011
    Publication date: April 19, 2012
    Applicant: Sangart, Inc.
    Inventors: Robert M. Winslow, Nancy Jo Winslow, Kim D. Vandegriff
  • METHODS FOR PREPARING STABLE DEOXYGENATED PEG-HEMOGLOBIN CONJUGATE SOLUTIONS COMPRISING AN ANTIOXIDANT
    Publication number: 20120059153
    Abstract: The present invention is a method for preparing stable HBOC solutions. Specifically, the method comprises the steps of deoxygenating a PEG-Hb conjugate and adding one or more antioxidants during or following the deoxygenating step to form a stabilized PEG-Hb conjugate. The Hb in the PEG-Hb conjugate is not crosslinked and the stabilized PEG-Hb conjugate has a p50 less than that of native SFH from the same animal source when measured under the same conditions. Specifically, the p50 is 6±2 mmHg or less than 10 mmHg.
    Type: Application
    Filed: September 1, 2011
    Publication date: March 8, 2012
    Applicant: Sangart, Inc.
    Inventors: Kim D. VANDEGRIFF, Ashok S. Malavalli
  • COMPOSITIONS FOR OXYGEN TRANSPORT COMPRISING A HIGH OXYGEN AFFINITY MODIFIED HEMOGLOBIN
    Publication number: 20120004396
    Abstract: The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to auto oxidation and superior oxygen carrying characteristics.
    Type: Application
    Filed: July 11, 2011
    Publication date: January 5, 2012
    Applicant: Sangart, Inc.
    Inventors: Robert M. WINSLOW, Kim D. Vandegriff
  • Method for making polyalkylene oxide modified hemoglobin
    Patent number: 8021858
    Abstract: The present invention is a method for preparing a hemoglobin based oxygen carrier to deliver oxygen to tissue. The method comprises mixing a deoxygenated hemoglobin with a maleimide-activated polyakylene oxide (PAO) to obtain an oxygen carrying product. This product is characterized as having 2 to about 8 PAO moieties covalently bound to a deoxygenated hemoglobin and a p50 less than native stroma-free hemoglobin from the same animal source when measured under the same conditions.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: September 20, 2011
    Assignee: Sangart, Inc.
    Inventors: Kim D. Vandegriff, Ashok S. Malavalli, Gnel M. Mkrtchyan
  • Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
    Patent number: 7989414
    Abstract: The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to autooxidation and superior oxygen carrying characteristics.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: August 2, 2011
    Assignee: Sangart, Inc.
    Inventors: Robert M. Winslow, Kim D. Vandegriff
  • METHODS FOR MAKING HIGH OXYGEN AFFINITY MODIFIED HEMOGLOBIN FOR OXYGEN TRANSPORT
    Publication number: 20100105606
    Abstract: The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to autooxidation and superior oxygen carrying characteristics.
    Type: Application
    Filed: November 25, 2009
    Publication date: April 29, 2010
    Applicant: Sangart, Inc.
    Inventors: Robert M. WINSLOW, Kim D. Vandegriff
  • METHOD FOR MAKING POLYALKYLENE OXIDE MODIFIED HEMOGLOBIN
    Publication number: 20100075379
    Abstract: The present invention is a method for preparing a hemoglobin based oxygen carrier to deliver oxygen to tissue. The method comprises mixing a deoxygenated hemoglobin with a maleimide-activated polyakylene oxide (PAO) to obtain an oxygen carrying product. This product is characterized as having 2 to about 8 PAO moieties covalently bound to a deoxygenated hemoglobin and a p50 less than native stroma-free hemoglobin from the same animal source when measured under the same conditions.
    Type: Application
    Filed: August 6, 2009
    Publication date: March 25, 2010
    Applicant: Sangart, Inc.
    Inventors: Kim D. Vandegriff, Ashok S. Malavalli, Gnel M. Mkrtchyan
  • Method for making a high oxygen affinity modified hemoglobin for oxygen transport
    Patent number: 7625862
    Abstract: The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to autooxidation and superior oxygen carrying characteristics.
    Type: Grant
    Filed: March 13, 2007
    Date of Patent: December 1, 2009
    Assignee: Sangart, Inc.
    Inventors: Robert M. Winslow, Kim D. Vandegriff
  • Method to enhance hemodynamic stability using oxygen carrying compositions
    Patent number: 7622439
    Abstract: The present invention relates to methods for enhancing the hemodynamic stability of an individual undergoing surgery by administering a composition comprising a hemoglobin-based oxygen carrier. In one embodiment, the present invention relates to the use of polyalkylene oxide modified hemoglobins with reduced cooperativity and a high oxygen affinity to enhance oxygen offloading as a preventative measure to avoid hemodynamic stability-related complications during surgery.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: November 24, 2009
    Assignee: Sangart, Inc.
    Inventors: Robert M. Winslow, Kim D. Vandegriff
  • MalPEG-Hb conjugate- containing compositions for delivering carbon monoxide (CO) to cells
    Publication number: 20090082257
    Abstract: The present invention relates to compositions for delivering carbon monoxide (CO) to cells using heme proteins as carriers. In one embodiment, the present invention relates to the use of MalPEG surface modified hemoglobin to deliver CO to cells.
    Type: Application
    Filed: September 18, 2008
    Publication date: March 26, 2009
    Applicant: Sangart, Inc.
    Inventor: Robert M. Winslow