Abstract: The present disclosure relates to peptide IL23 receptor antagonists, their pharmaceutical compositions and their medical use, for example in the treatment of inflammatory bowel diseases such as Crohn's disease.

Abstract: VH domain, in which: (i) the amino acid residue at position 112 is one of K or Q; and/or (ii) the amino acid residue at position 89 is T; and/or (iii) the amino acid residue at position 89 is L and the amino acid residue at position 110 is one of K or Q; and (iv) in each of cases (i) to (iii), the amino acid at position 11 is preferably V; and in which said VH domain contains a C-terminal extension (X)n, in which n is 1 to 10, preferably 1 to 5, such as 1, 2, 3, 4 or 5 (and preferably 1 or 2, such as 1); and each X is an (preferably naturally occurring) amino acid residue that is independently chosen, and preferably independently chosen from the group consisting of alanine (A), glycine (G), valine (V), leucine (L) or isoleucine (I).

Abstract: The present invention relates to protein molecules comprising at least one protease-cleavable linker. It also relates to protein molecules obtainable by protease-cleavage of such protein molecules and their use in therapy.

Abstract: A medical device and method for determining a basal dose of insulin and a bolus dose of insulin to be administered for glycemic control is provided. The medical device includes an insulin pump, a control interface including a button configured to select one of a plurality of present bolus insulin doses based on input from a user (e.g., a patient), and a controller configured for executing instructions to determine a basal insulin delivery rate based, at least in part, on a total daily basal insulin dose and to determine the plurality of preset bolus insulin doses based, at least in part, on a total daily bolus insulin dose.

Abstract: The present disclosure relates to an electronic label for a drug delivery device configured for administering a medicament to a patient. The electronic label includes a flexible substrate configured for attachment to a body. The electronic label further includes an electronic display located on the flexible substrate, wherein the electronic display is configured to display a first information content of a first information type, a second information content of a second information type, and a third information content of the first or of the second information type. The electronic label includes a processor connected to the electronic display, which is configured to modify or to control a visual appearance of the electronic display by visualizing at least a portion of the first information content and at least a portion of the third information content separately, simultaneously, sequentially or alternately on the electronic display.

Abstract: The present disclosure relates to a compound of formula (I) wherein R1 represents a hydrogen atom, a —(C1-C6)alkyl group optionally substituted; R2 represents a hydrogen atom, a halogen atom, a —(C1-C6)alkyl group, a —(C3-C7)cycloalkyl group or a —(C2-C6)alkenyl group; R3 represents a hydrogen atom, a halogen atom, a —(C1-C6)alkyl group, a —(C3-C7)cycloalkyl group, or a —(C5-C10)heteroaryl group; X represents a sulfur or oxygen atom; and Ra and Rb represent a hydrogen atom or a —(C1-C6)alkyl group. The present disclosure also relates to a process for their preparation, to novel intermediate compounds, a medicament and a pharmaceutical compostions comprising the compounds of formula (I), as well as their therapeutic uses.

Abstract: The present disclosure relates to an injection device for administering of a dose of a medicament. The injection device includes a housing that configured to accommodates a cartridge filled with the medicament, a first component movable relative to the housing along the longitudinal direction between an initial position and a trigger position for dispensing of the dose of the medicament, a second component rotatable relative to the housing for at least one of setting of the dose or dispensing of the dose, a cavity provided in or formed by at least one of the first component and the second component, the cavity been sized to accommodate an electronic detector, and at least a first gasket fastened to one of the housing, the first component and the second component and configured to seal the cavity against ingress of impurities at least while the first component is in the initial position.

Abstract: The present technology aims at providing a novel type of drug for treating a subject suffering from cancer. Specifically, the technology provides polypeptides comprising at least four immunoglobulin single variable domains (ISVDs), characterized in that one ISVD binds to TCR and at least two ISVDs bind to GPC3. The present technology also provides nucleic acids, vectors and compositions.

Abstract: Provided herein are methods for monitoring treatment for multiple sclerosis in a pregnant subject, and determining the efficacy of a treatment for multiple sclerosis in a pregnant subject. These methods include (a) extracting a drug from a dried blood spot (DBS) sample from a pregnant subject after a treatment for multiple sclerosis has been administered to the pregnant subject; (b) performing mass spectrometry on the extracted DBS sample; (c) determining a peak area ratio of the extracted DBS sample to an internal standard; and (d) identifying the administered treatment as being below the internal standard threshold if the plasma concentration of the treatment is less than 1 as compared to the internal standard ratio. Also provided herein are dried blood spot cards, and kits that include a dried blood spot card pre-treated with at least one internal standard.

Abstract: The present disclosure relates to a rotation sensor for an injection device, the rotation sensor comprising: a rotatable element configured for a mechanical engagement with a ratchet mechanism, the rotatable element comprising an outer rim and a hub is configured for transmission of a torque between the outer rim and the hub, at least one sensor attached to the rotatable element and configured to measure at least one of a mechanical force, a mechanical pressure or a mechanical strain at a portion of the rotatable element during a rotation of the rotatable element, a processor connected to the at least one sensor and configured to calculate an angle of rotation of the rotatable element on the basis of a sensor output of the at least one sensor.