Patents Assigned to Sanofi
  • Patent number: 11911591
    Abstract: A disposable cartridge for a drug delivery device includes a flexible bag to accommodate a liquid medicament and having an opening adjacent to a sidewall, a socket having a fluid channel in fluid communication with a cartridge fluid coupling, and a housing covering at least a portion of the flexible bag and having a receptacle to receive the socket with the flexible bag. The socket extends into the opening of the flexible bag. The flexible bag's sidewall is fixed between the socket and the receptacle.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: February 27, 2024
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Michael Schabbach, Meinolf Werner, Olaf Zeckai
  • Patent number: 11911452
    Abstract: Provided are mixed carrier, multivalent pneumococcal conjugate compositions comprising 21 different pneumococcal capsular polysaccharide-protein conjugates, wherein each of the conjugates includes a capsular polysaccharide from a different serotype of Streptococcus pneumoniae conjugated to either tetanus toxoid (TT) or CRM197, wherein the Streptococcus pneumoniae serotypes are selected from 1, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11 A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F, where the capsular polysaccharides of two of serotypes 1, 3, and 5 and one or both of serotypes 15B and 22F are conjugated to TT and the remaining capsular polysaccharides are conjugated to CRM197. Also provided are methods of producing the mixed carrier, multivalent pneumococcal conjugate compositions and methods of using the same for prophylaxis against Streptococcus pneumoniae infection or disease in a subject.
    Type: Grant
    Filed: September 10, 2021
    Date of Patent: February 27, 2024
    Assignees: SANOFI PASTEUR INC., SK BIOSCIENCE CO., LTD.
    Inventors: Kyungjun An, Dongsoo Ham, Hun Kim, Sunghyun Kim, Jinhwan Shin, Robert Hopfer, Richard D. Kensinger, Moe Kyaw, Philippe Talaga
  • Patent number: 11912721
    Abstract: A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6, 7-dihydro-7, 14-methanobenzimidazo[1, 2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: February 27, 2024
    Assignees: UCB Biopharma SRL, Sanofi
    Inventors: Teresa De Haro Garcia, Michael Deligny, Jag Paul Heer, Joanna Rachel Quincey, Mengyang Xuan, Zhaoning Zhu, Daniel Christopher Brookings, Mark Daniel Calmiano, Yves Evrard, Martin Clive Hutchings, James Andrew Johnson, Sophie Jadot, Jean Keyaerts, Malcolm MacCoss, Matthew Duncan Selby, Michael Alan Shaw, Dominique Louis Leon Swinnen, Laurent Schio, Yann Foricher, Bruno Filoche-Romme
  • Patent number: 11904153
    Abstract: Described is a medicament delivery device comprising a case adapted to hold a container with a medicament and having a needle, a needle sleeve telescopically coupled to the case and having a first extended position relative to the case in which the needle is covered, a retracted position relative to the case in which the needle is exposed, and a second extended position relative to the case in which the needle is covered, a first indicia disposed on the needle sleeve which is visible in the first extended position and the second extended position, and a second indicia disposed on the needle sleeve and not visible in the first extended position and visible the second extended position.
    Type: Grant
    Filed: August 24, 2020
    Date of Patent: February 20, 2024
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Stephan Riedel, Steffen Raab, Kerstine Hemmann, Michael Caspers, Katja Hoerhold, Daniel Kerkow
  • Patent number: 11904141
    Abstract: A coding system for a drug reservoir, where the drug reservoir is intended for use with a reservoir holder of a drug delivery device. The coding system includes a collar fitted around the drug reservoir. The collar includes a coding feature that is configured to pass through a corresponding coding feature provided by the reservoir holder of the drug delivery device.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: February 20, 2024
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Richard James Vincent Avery, Joseph Butler
  • Patent number: 11904151
    Abstract: The present disclosure relates to a cap for an injection device. The injection device comprises a body for holding a syringe having a needle extending from an end thereof. The cap is removably attachable to the body. The cap comprises an actuator and a needle shield to cover said needle. The cap further comprises a coupling between the actuator and the needle shield. The coupling is configured such that when the cap is attached to the body of the injection device axial movement of the actuator away from the body causes rotation of the needle shield relative to the body.
    Type: Grant
    Filed: June 14, 2021
    Date of Patent: February 20, 2024
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Stefan Wendland, Michael Harms
  • Patent number: 11904009
    Abstract: Ferritin proteins comprising a mutation replacing a surface-exposed amino acid with a cysteine, an N- or C-terminal linker comprising a cysteine, and/or one or more immune-stimulatory moieties linked to the ferritin protein via a surface-exposed amino acid are disclosed. The ferritin proteins can further comprise a non-ferritin polypeptide and be antigenic, e.g., for use in eliciting antibodies against the non-ferritin polypeptide.
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: February 20, 2024
    Assignee: SANOFI
    Inventors: Gary J. Nabel, Chih-Jen Wei, Kurt Swanson
  • Patent number: 11904012
    Abstract: The present invention provides, among other things, modified recombinant HA polypeptides with broadened immunogenic profile that extends coverage to antigenically distinct influenza strains and methods of making and using the same.
    Type: Grant
    Filed: August 12, 2021
    Date of Patent: February 20, 2024
    Assignee: SANOFI PASTEUR INC.
    Inventors: Tod Strugnell, Eliud Oloo, Raymond Oomen
  • Patent number: 11904132
    Abstract: The present disclosure relates to a packaging for a medicament container, wherein the medicament container comprises at least one distal container abutment section and at least one proximal container abutment section, the packaging comprising: a bottom and a sidewall structure connected to the bottom, the bottom and the sidewall structure confining a storage space configured to accommodate at least one medicament container, at least one distal packaging abutment section, and at least one proximal packaging abutment section, wherein the at least one distal packaging abutment section is integrated into or arranged at one of the sidewall structure and the bottom and configured to abut with the at least one distal container abutment section, wherein the at least one proximal packaging abutment section is integrated into or arranged at the sidewall structure and configured to abut with the at least one proximal container abutment section.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: February 20, 2024
    Assignee: Sanofi
    Inventors: Martin Otten, Sebastian Thiel, Daniel Wagner
  • Publication number: 20240050518
    Abstract: This disclosure relates to antigenic EBV polypeptides and their use in eliciting antibodies against EBV. Also disclosed are antigenic polypeptides comprising an EBV polypeptide and a ferritin protein.
    Type: Application
    Filed: June 15, 2023
    Publication date: February 15, 2024
    Applicant: SANOFI
    Inventors: Gary J. Nabel, Chih-Jen Wei, Laura Nguyen, Kurt Swanson, Te-Hui Chou, Stefan Koester
  • Patent number: 11897951
    Abstract: The present disclosure provides a novel type of drug for treating a subject suffering from an inflammatory and/or autoimmune disease, and specifically rheumatoid arthritis. Specifically, the disclosure provides polypeptides comprising at least three immunoglobulin single variable domains (ISVDs), characterized in that at least one ISVD binds to TNF-? and at least two ISVDs bind to IL-6. The present disclosure also provides nucleic acids, vectors and compositions.
    Type: Grant
    Filed: December 17, 2021
    Date of Patent: February 13, 2024
    Assignees: Ablynx N.V., Sanofi
    Inventors: Heidi Rommelaere, Christian Asbrand, Nadine Biesemann, Ann Brigé, Sigrid Cornelis, Karen Heyninck, Eric Lorent, Shanna Van Zwam
  • Patent number: 11897911
    Abstract: The present disclosure relates to novel nucleotide precursors and nucleotide analogs that can be incorporated into oligonucleotides, including double-stranded oligonucleotides such as siRNAs. Oligonucleotides containing these analogs have superior biological activity, for example, increased in vitro stability and improved in vivo potency especially duration of action. The improved oligonucleotides are useful for silencing (e.g., reducing or eradicating) the expression of a target gene. In particular embodiments, this invention encompasses specific nucleotide analogs to be included in double-stranded RNAs (dsRNAs), and especially in siRNAs, that can hybridize to messenger RNAs (mRNAs) of interest, so as to reduce or block the expression of target genes of interest. The present compounds have general formula (I), wherein each of Ra, Rb, Rc and Rd is independently, H or a (C1-C6) alkyl group and B is a heterocyclic nucleobase.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: February 13, 2024
    Assignee: Sanofi
    Inventors: Armin Hofmeister, Kerstin Jahn-Hofmann
  • Publication number: 20240043878
    Abstract: The present invention concerns a cell line comprising an endogenous dihydroorotate dehydrogenase (DHODH) and glutamine synthetase (GS) genes which are partially or fully inactivated, and its use for producing recombinant proteins.
    Type: Application
    Filed: September 21, 2021
    Publication date: February 8, 2024
    Applicant: SANOFI
    Inventors: Bruno Louis DUMAS, Mohammed Nabil LOUNIS
  • Patent number: 11890454
    Abstract: Apparatus for recording information concerning the use of an injection device, the apparatus comprising: one or more sensors for providing information indicative of how the injection device is used; a processor configured to analyse said information detected by the one or more sensors to determine use information, said use information corresponding to how the injection device is used; and a memory for storing said use information in an image format such that said use information can be retrieved from the memory and displayed in an image.
    Type: Grant
    Filed: March 14, 2022
    Date of Patent: February 6, 2024
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: George Cave
  • Patent number: 11887711
    Abstract: Described is a system comprising an input module receiving a first data set indicative of at least one patient condition for each of a plurality of patients obtained during a predetermined time period, a comparison module comparing each of the at least one patient condition to at least one filter criteria, a filter module selecting a patient to include in a second data set if the at least one patient condition of the patient satisfies the at least one filter criteria, a report module generating a report based on the second data set, wherein the report includes at least one patient identifier for each patient in the second data set and at least one descriptor of the at least one patient condition for each patient in the second data set, and a classification module storing at least one classification value for the at least one patient condition.
    Type: Grant
    Filed: May 6, 2022
    Date of Patent: January 30, 2024
    Assignee: Sanofi
    Inventors: Ronald Draghi, Michael Hauser, Brian Stancampiano
  • Publication number: 20240024453
    Abstract: The present invention is directed to an artificial nucleic acid and to polypeptides suitable for use in treatment or prophylaxis of an infection with Zika virus or a disorder related to such an infection. In particular, the present invention concerns a Zika virus vaccine. The present invention is directed to an artificial nucleic acid, polypeptides, compositions and vaccines comprising the artificial nucleic acid or the polypeptides. The invention further concerns a method of treating or preventing a disorder or a disease, first and second medical uses of the artificial nucleic acid, polypeptides, compositions and vaccines. Further, the invention is directed to a kit, particularly to a kit of parts, comprising the artificial nucleic acid, polypeptides, compositions and vaccines.
    Type: Application
    Filed: June 21, 2023
    Publication date: January 25, 2024
    Applicants: CureVac SE, Sanofi Pasteur
    Inventors: Benjamin PETSCH, Edith JASNY, Yves GIRERD-CHAMBAZ
  • Patent number: 11878150
    Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: January 23, 2024
    Assignee: Sanofi
    Inventors: Michael Schabbach, Anthony Paul Morris, Ronald Antony Smith, Brian Charles Molyneux, Paul Richard Draper, Craig Ashley Mason, Oliver Charles Gazeley, Daniel Edward Clark, David Aubrey Plumptre, Aidan Michael O'Hare, Richard James Thomas, Felix Kramer, Beat Wyss, Philipp Muller
  • Patent number: 11878146
    Abstract: The present disclosure relates to a measurement probe for measuring a mechanical load. The measurement probe includes: an elongated body comprising a tubular portion configured for insertion into a cartridge holder of an injection device, a sensor tab arranged on or integrated into the elongated body, wherein the sensor tab comprises an outside surface portion, an inside surface portion and an outer abutment section, wherein the outer abutment section is configured to abut with an inside of a sidewall of the cartridge holder and wherein the sensor tab is deformable in a radial direction, a sensor element mechanically connected to the at least one sensor tab and configured to measure a deformation of the at least one sensor tab.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: January 23, 2024
    Assignee: Sanofi
    Inventors: Torsten Kraft, Alex Meier
  • Patent number: 11878152
    Abstract: An electronic device comprising: a housing for attachment to an injection device; a first sensor assembly comprising a first coil and two magnets of opposite polarity, wherein the first coil is configured to provide a first voltage pulse as a first Wiegand wire of the injection device moves from a first position proximate to one of the magnets of the first sensor assembly to a second position proximate to the other magnet of the first sensor assembly; and one or more processors configured to enter an enabled state from a sleep state after receiving the first voltage pulse from the first coil.
    Type: Grant
    Filed: December 8, 2022
    Date of Patent: January 23, 2024
    Assignee: Sanofi
    Inventor: Michael Helmer
  • Publication number: 20240016918
    Abstract: Provided are novel vaccines for prophylactic treatment of SARS-CoV-2 infections and COVID-19 and methods of making the vaccines.
    Type: Application
    Filed: August 23, 2021
    Publication date: January 18, 2024
    Applicant: SANOFI PASTEUR INC.
    Inventors: Natalie ANOSOVA, Salvador Fernando AUSAR, Catherine BERRY, Florence BOUDET, Danilo CASIMIRO, Roman M. CHICZ, Gustavo DAYAN, Guy DE BRUYN, Carlos DIAZGRANADOS, Tong-Ming FU, Marie GARINOT, Lorry GRADY, Sanjay GURUNATHAN, Kirill KALNIN, Nikolai KHRAMTSOV, Valérie LECOUTURIER, Nausheen RAHMAN, Sophie RUIZ, Stephen SAVARINO, Saranya SRIDHAR, Indresh K. SRIVASTAVA, James TARTAGLIA, Timothy TIBBITTS