Abstract: The present disclosure provides novel semi-targeted polycistronic transposon-based expression constructs and methods of producing recombinant antibodies therefrom.

Abstract: An arrangement for a drug delivery device is provided, the arrangement comprising: a housing having a proximal end and a distal end, a dose setting member which is rotatable relative to the housing for a dose setting operation in order to set a dose of drug to be delivered, a tracking member, and a guide track. Wherein the tracking member is operatively coupled or coupleable to the dose setting member, or wherein b) the dose setting member is a tracking member. The guide track is configured to form a guiding interface to guide and/or drive movement of the tracking member. The tracking member can be displaced towards an axial tracking member end position during the dose setting operation, wherein the distance by which the tracking member is displaced towards the axial tracking member end position depends on the size of the set dose.

Abstract: A wireless data communication accessory is disclosed, which is configured for attachment to a drug delivery device and comprises an interface for data exchange between the accessory and the drug delivery device, wireless communication means configured to communicate with an external device paired with the wireless communication means via wireless communication, and a controller coupled to the interface and the wireless communication means and being configured to control operation of the interface and the wireless communication means such that data received from the drug delivery device via the interface are processed for transmission to the external device via the wireless communication.

Abstract: A mechanism unit for a drug delivery device, comprising a housing, a piston rod, and a dose setting and drive mechanism that comprises a first drive member, a second drive member, and a clutch mechanism, which has at least two different states: a setting state and a delivery state. In the setting state, the second drive member is rotationally secured with respect to the housing at least against rotation in a delivery direction, and, in the delivery state, the second drive member is rotatable relative to the housing in the delivery direction. In the setting state, the first drive member is rotatable relative to the second drive member at least in the delivery direction. In the delivery state, the second drive member is rotationally locked to the first drive member at least against rotation of the second drive member relative to the first drive member in the delivery direction.

Abstract: A wireless data communication circuitry for a drug delivery device is disclosed, wherein the circuitry comprises a wireless communication processor for handling wireless data communication, a battery connector having a positive and a negative terminal, the positive terminal and the negative terminal being connected to respective terminals of the wireless communication processor for supplying the wireless communication processor with electrical energy from a battery connectable to the battery connector, and an arrangement of one or more capacitors, each one of the capacitors being connected in parallel to the positive terminal and the negative terminal of the battery connector and provided for backing up the supplying of the wireless communication processor with electrical energy from the battery connectable to the battery connector.

Abstract: A dose counting system of an injection device or of a module configured to be used with or applied to an injection device, the dose counting system comprising: a sensor arrangement comprising a first sensor configured to output a first signal and a second sensor configured to output a second signal, wherein the first sensor and the second sensor have an angular offset relative to each other and wherein the sensor arrangement is configured to detect movement of a rotary encoder system relative to the sensor arrangement during dosing of a medicament; and a processor configured to: compute numerical derivatives of the first signal and the second signal; detect a peak in the derivative values of the first signal and a peak in the derivative values of the second signal when the first and second derivative signal values exceed a predefined threshold; determine that a unit of medicament has been administered when the peaks in the derivative values of the first signal and the derivative values of the second signal ar

Abstract: An electronic system for a drug delivery device including a dose setting and drive mechanism, a communication unit, an electronic control unit, and an electrical use detection. The dose setting and drive mechanism includes a first member and a second member that move relative to each other at least in the dose delivery operation and/or in the dose setting operation of the drug delivery device. The electronic system has a first state in which the communication unit is not activated and a second state in which the communication unit is activated. The electrical use detection unit is configured to generate a first signal indicative that the user has commenced or finished the relative movement between the first member and the second member. The electronic control unit is configured to switch the electronic system from the first state into the second state in response to the first signal.

Abstract: Disclosed herein are compositions, kits, and methods comprising interleukin (IL) conjugates (e.g., IL-2 conjugates) useful for the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).

Abstract: An electronic system for a drug delivery device is provided. The electronic system comprises a dose setting and drive mechanism comprising a first member and a second member, wherein in the dose delivery operation and/or in the dose setting operation, the first member moves, e.g. rotates, relative to the second member; an electronic control unit; an electrical use detection unit operatively connected to the electronic control unit, and configured to generate a use signal in response to the relative movement, e.g. a relative rotational movement, between the first member and the second member, preferably during the dose delivery operation. The electronic system is configured such that it is switched from a first state into a second state by the electronic control unit in response to the use signal, wherein the electronic system has an increased electrical power consumption in the second state as compared to the first state.

Abstract: The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.

Abstract: The present disclosure relates to a wearable electronic device. The wearable electronic device includes a housing, a processor arranged inside the housing, and at least a first sensor that is connected to the processor and configured to detect at least one of a mechanical vibration or an acoustic noise caused or generated by a click noise generator of a handheld injection device.

Abstract: The present disclosure provides a method for identifying modulators of protein secretion. Also provided are modulators of protein secretion and use thereof.

Abstract: A wearable medical device includes: a spatial sensor configured to determine distance to objects in an environment in front of the spatial sensor; an acoustic signal generator operable to generate an acoustic signal; a processor; and a memory configured to store instructions which, when executed the processor, cause the wearable medical device to: detect, using the spatial sensor, objects in the environment, calculate the distance to objects detected in the environment, and when the distance to an object is less than a predetermined value, control the acoustic signal generator to generate a first alert.

Abstract: The disclosure relates to a cartridge assembly for a drug delivery device, the cartridge assembly comprising a cartridge containing a drug; a cartridge holder, the cartridge holder defining an interior cartridge holding section, where the cartridge is arranged within the cartridge holding section, wherein the cartridge holder comprises a distal region with a needle connector arranged at a distal end of the distal region and a main body region; a fixing feature which is arranged at the distal region; and a region with reduced mechanical stiffness compared to the stiffness of the main body region, the region with reduced mechanical stiffness being integrated into the distal region and arranged between the needle connector and the fixing feature, such that when the cartridge is moved in a proximal direction, an emerging load is transferred from the cartridge to the fixing feature and to the main body region in the proximal direction.

Abstract: The present invention provides compounds for use in the treatment of pulmonary diseases, in particular asthma, wherein said compounds bind the cytokines IL-13 and TSLP. The treatments according to the present invention can lower the level of fractional exhaled nitric oxide (FeNO) by at least 18 ppb compared to placebo. The treatments of the present invention can also reduce eosinophil count, increase FEV1 and/or reduce airway inflammation.

Abstract: The present technology aims at providing a novel type of drug for treating a subject suffering from acute myeloid leukemia (AML). Specifically, the present technology provides polypeptides comprising at least three immunoglobulin single variable domains (ISVDs), characterized in that at least one ISVDs binds to T cell receptor ?? (TCR??), at least ISVD binds to CD33, and at least one ISVD binds to CD123. The present technology also provides nucleic acids, vectors and compositions.

Abstract: Disclosed is a modular system for a drug delivery device with electronic, comprising a mechanical module that comprises a distal end and a proximal end, and a mechanism that is configured to set and/or to deliver a dose of the drug out of the distal end (D) of the mechanical module, an electronic module that comprises a detector unit, and an electronic unit that is operatively coupled to the detector unit, wherein the electronic module is removably mechanically coupled or coupleable to the mechanical module in a proximal end region of the mechanical module.

Abstract: The present invention relates to compounds that are IL-17A modulators. The compounds have the structural Formula I as shown below, wherein X1, X2, X3, X4, Y, R1, R2, R3, and R4 are as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with modulation of IL-17A activity.

Abstract: The present disclosure refers to a switch assembly for an electronic system of a drug delivery device. The switch assembly includes a chassis supporting a PCBA including at least a first electrical contact, a second electrical contact, a third electrical contact and a fourth electrical contact and a ring with a ratchet profile. The chassis moves axially relative to the ring from a first axial position to a second axial position during a first switch operation mode. The chassis and the ring are configured such that the ring rotates relative to the chassis during a second switch operation mode. The first electrical contact and the second electrical contact are arranged such that upon axial movement of the chassis towards the ring during the first switch operation mode, an electrical connection between the first electrical contact and the second electrical contact is closed.