Abstract: The present disclosure refers to an injection device comprising a housing, a cartridge holder having a first attachment member, a threaded sleeve insert axially and rotationally constrained to the housing, the threaded sleeve insert having a second attachment member for releasable attachment with the first attachment member, and a metering mechanism. The metering mechanism comprises an actuating element, a piston rod, a piston rod sleeve in which the piston rod can be non-rotatably connected in the piston rod sleeve, and a coupling element coupling the actuating element and the piston rod sleeve. The piston rod can be non-rotatably connected to the piston rod sleeve by a coupling sleeve. The cartridge holder is attached to the threaded sleeve insert by axially moving cartridge holder with respect to the threaded sleeve insert and the housing to engage the coupling sleeve with the piston rod sleeve.

Abstract: The present disclosure is generally directed to an attachment mechanism suitable for attaching for example a module to an object that is essentially cylindrical or polygonal in cross-section, e.g. to a portion of a drug delivery device. Further, the disclosure is directed to an electronic system, which is configured to be, e.g. releasably, attached to the drug delivery device as well as an assembly comprising the the electronic system as well as the drug delivery device. The attachment mechanism may comprise a housing, a gripping portion with at least one gripping ring and an actuator for operating the gripping portion between an open condition and a clamping condition.

Abstract: One or more methods of predicting expression levels. At least one of the methods includes preprocessing image data representing at least one biological image of a patient to generate preprocessed image data representing at least one preprocessed biological image of the patient; and applying a trained machine learning model to the preprocessed image data to predict, based at least partially on the at least one preprocessed biological image, an expression level of a biological indicator.

Abstract: Electronics assemblies for an injection device. At least one of the electronics assemblies include: one or more sensors configured to capture injection information of the injection device; one or more processors configured to be communicatively coupled to the one or more sensors; and a memory communicatively coupled to the one or more processors, the memory storing instructions which, when executed by the one or more processors, cause the one or more processors to perform operations. The operations include: receiving the injection information from the one or more sensors; determining, based on the injection information, a dwell time for a user of the injection device; and causing one or more display devices to provide feedback information to the user, the feedback information indicating the determined dwell time.

Abstract: Described is a medicament container carrier adapted to hold a first medicament container having a first predetermined size and capable of containing more than a first volume of a medicament. The container carrier comprises a body, and an adapter coupled to the body. The adapter is adapted to hold a second medicament container having a second predetermined size different from the first predetermined size and capable of containing no more than the first volume of the medicament.

Abstract: The disclosure relates to a fluid dispensing device including: a housing including an orifice and configured to accommodate a portion of a spray delivery device including an outlet, a protective cap configured to accommodate the outlet of the spray delivery device and including a cap portion, wherein the protective cap is configured for fitting to the housing so that the cap portion covers the orifice, a biasing member transferable between a pre-loaded state and an unloaded state and configured to store energy in the pre-loaded state to produce a discharge of the spray delivery device, a releasable interlock configured to retain the biasing member in the pre-loaded state, a trigger engaged with the interlock and configured to release the interlock when actuated, wherein release of the energy stored in the pre-loaded biasing member is prevented as long as the cap portion covers the orifice.

Abstract: A system for designing vaccines includes one or more processors, and computer storage storing executable computer instructions in which, when executed by the one or more processers, cause the one or more processors to perform one or more operations. The one or more operations include applying, to a first temporal sequence data set, a plurality of driver models configured to generate output data representing one or more molecular sequences. The one or more operations include, for each of the plurality of driver models, training the driver model. The one or more operations include selecting, based on one or more trained translational responses, a set of trained driver models of the plurality of driver models. The one or more operations include selecting, based on second translational response data, a subset of trained driver models of the set of trained driver models.

Abstract: According to the invention, an auto-injector for administering a dose of a liquid medicament (M) comprises of a substantially cylindrical housing arranged to contain a pre-filled syringe filled with the medicament (M), a needle shroud slidably arranged with respect to the housing and adapted to rest on the skin of a patient receiving an injection, a releasable drive means arranged within the housing that is capable of, upon release, translating the needle shroud in a proximal direction (P) towards a safe position (PS) and a rotating collar rotatably arranged within the housing. The needle shroud in the safe position (PS) surrounds the injection needle after the injection has been carried out. The rotating collar engages the needle shroud in a manner that forces the rotating collar to rotate within the housing when the needle shroud is translated in the proximal direction (P).

Abstract: A drug delivery device includes a case adapted to hold a medicament container, a plunger disposed within the case and slidable from a proximal position into a distal position for delivering a medicament from the medicament container, at least one feedback mechanism that is in operative connection with the plunger. The feedback mechanism comprises a collar, a control spring biasing the collar in a distal direction, a needle shroud, operatively axially abutting the collar in a first coupled state and prevented from axially decoupling the collar by the plunger in its proximal position The plunger, when approaching the distal position during movement from the proximal position towards the distal position, is adapted to allow axial decoupling of the needle shroud from the collar, allowing for a limited axial movement of the collar relative to the needle shroud until the collar axially abuts the needle shroud in a second coupled state.

Abstract: An injection device includes a cartridge configured to hold a volume of fluid, the cartridge having a proximal end and a distal end through which the fluid is dispensed; a stopper disposed in the cartridge and configured to move from the proximal end toward the distal end to cause the fluid to be dispensed through the distal end of the cartridge; and an electronic device disposed at the distal end of the cartridge, the electronic device including an emitter configured to transmit a signal toward the stopper, a receiver configured to receive reflections of the signal from the stopper, and a controller configured to wirelessly transmit data related to a position of the stopper in the cartridge.

Abstract: A system is provided for providing additional information to a user of an injection device, the system comprising an injection device, a user device and instructions for use of the injection device, the instructions for use comprising at least one tag, wherein the tag is associated with the instructions for use or with a section or a subsection of the instructions for use, wherein the memory of the user device stores instructions which, when executed by the processor, cause the user device to: scan, using a camera and/or a wireless module, the tag; identify the instructions for use or the section of the instructions for use which the tag is associated with; based on the identification, provide the user with additional information on the particular instructions for use or the particular section of the instructions for use.

Abstract: A stopper for use in a cartridge or syringe of a medical device [SL6]is configured to be disposed within a container closure system. The stopper comprises a shell comprising a closed end and an open end with sidewalls extending between the closed end and the open end along a longitudinal axis of the shell. The open end defines a cavity and the sidewalls define an exterior surface sized and shaped to fit inside the container closure system. An insert is configured to be inserted into the cavity, receive a force from a plunger rod, and distribute the force to the shell in order to advance the shell into the container closure system. The closed end of the shell in the cavity defining a convex surface configured to be contacted and deflected by the insert upon insertion into the cavity includes an elastic and/or plastic deformable material.

Abstract: An apparatus is arranged to receive and retain a needle shield for a medicament delivery device, the apparatus comprising a body comprising a wall defining a void and an opening in a proximal end of the body, the opening arranged to allow at least a part of the needle shield to be received into, and at least partially fill, the void, and arms extending from the wall into the void, wherein the arms are configured to engage the needle shield when the needle shield is received in the void and prevent the needle shield from being withdrawn from the void through the opening in the proximal end and wherein at least one of the arms has a first angle with respect to the wall and at least one of the arms has a second angle with respect to the wall that is different to the first angle.

Abstract: According to the invention, an auto-injector for administering a dose of a liquid medicament (M) comprises of a substantially cylindrical housing arranged to contain a pre-filled syringe filled with the medicament (M), a needle shroud slidably arranged with respect to the housing and adapted to rest on the skin of a patient receiving an injection, a releasable drive means arranged within the housing that is capable of, upon release, translating the needle shroud in a proximal direction (P) towards a safe position (PS) and a rotating collar rotatably arranged within the housing. The needle shroud in the safe position (PS) surrounds the injection needle after the injection has been carried out. The rotating collar engages the needle shroud in a manner that forces the rotating collar to rotate within the housing when the needle shroud is translated in the proximal direction (P).

Abstract: According to the invention, an auto-injector for administering a dose of a liquid medicament (M) comprises of a substantially cylindrical housing arranged to contain a pre-filled syringe filled with the medicament (M), a needle shroud slidably arranged with respect to the housing and adapted to rest on the skin of a patient receiving an injection, a releasable drive means arranged within the housing that is capable of, upon release, translating the needle shroud in a proximal direction (P) towards a safe position (PS) and a rotating collar rotatably arranged within the housing. The needle shroud in the safe position (PS) surrounds the injection needle after the injection has been carried out. The rotating collar engages the needle shroud in a manner that forces the rotating collar to rotate within the housing when the needle shroud is translated in the proximal direction (P).

Abstract: Implementations of the present disclosure are directed to an injection device including a medicament reservoir configured to store a medicament to be expelled by the injection device, and an acoustic source configured to generate an acoustic signal including information indicative of an amount of the medicament stored in the medicament reservoir. The acoustic signal is transmitted to an external device configured to process the acoustic signal and to extract injection device data.

Abstract: A medicament delivery device includes a device housing for placing on skin of a patient, the device housing including a needle aperture; a needle for injecting 5 a medicament, the needle arranged to pass through the needle aperture; and sensors configured to provide a signal when the device housing is placed on the skin of the patient. The sensors are arranged around the needle aperture.

Abstract: According to the invention, an auto-injector for administering a dose of a liquid medicament (M) comprises of a substantially cylindrical housing arranged to contain a pre-filled syringe filled with the medicament (M), a needle shroud slidably arranged with respect to the housing and adapted to rest on the skin of a patient receiving an injection, a releasable drive means arranged within the housing that is capable of, upon release, translating the needle shroud in a proximal direction (P) towards a safe position (PS) and a rotating collar rotatably arranged within the housing. The needle shroud in the safe position (PS) surrounds the injection needle after the injection has been carried out. The rotating collar engages the needle shroud in a manner that forces the rotating collar to rotate within the housing when the needle shroud is translated in the proximal direction (P).