Patents Assigned to Santen Pharmaceutical Co. Ltd.
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Patent number: 5182276Abstract: The present invention relates to a nootropic agent which comprises a derivative of 2-phenyl-3-oxo-2H-1,4-benzothiazine. This nootropic agent is effective for treating diseases accompanied by a lowering of cerebral functions, for instance, cerebral infarction disorders due to ischemia such as transitory cerebral ischemia, brain edema, cerebral disorders due to the after-effect such as cerebral hemorrhage, cerebral disorders due to traumatic injury such as bruise, central nervous degeneration and degenerative diseases such as dementia, mental disorders, neurosis and Alzheimer's diseases.Type: GrantFiled: December 27, 1990Date of Patent: January 26, 1993Assignees: Santen Pharmaceutical Co., Ltd., Daiichi Pharmaceutical Co., Ltd.Inventors: Yasufumi Shirasaki, Shinichiro Ashida
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Patent number: 5153198Abstract: A compound of the formula [II] or pharmaceutically acceptable salt thereof, ##STR1## wherein R.sup.1 is hydrogen or fluorine;R.sup.2 is hydrogen or fluorine;R.sup.3 is hydrogen, lower alkyl, lower alkoxy, halogen or lower alkylenedioxy;A is straight or branched lower alkylene having 1 to 6 carbon atoms; and n is 0 or 1,provided that at least one of R.sup.1 or R.sup.2 is fluorine. Such compound is useful for treatment of disorders of the cerebro-neural transmission system.Type: GrantFiled: October 23, 1991Date of Patent: October 6, 1992Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Takakazu Morita, Tadashi Iso, Hideyasu Yamauchi
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Patent number: 5128467Abstract: This invention relates to cyclic sulfur-containing compounds of the formula [I] and salts thereof which are useful for immunomodulator and treatment of liver diseases.Type: GrantFiled: June 25, 1991Date of Patent: July 7, 1992Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Takakazu Morita, Tadashi Iso, Shiro Mita, Youichi Kawashima
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Patent number: 5087627Abstract: A method for treatment of disorders of the cerebro-neural transmission system which comprises administering a compound of the formula (I) or a pharmaceutically acceptable salt thereof in a therapeutically effective amount, either alone or in admixture with one or more pharmaceutically acceptable excipients, ##STR1## wherein Ar or Ar' is unsubstituted or substituted phenyl or pyridyl; R is hydrogen, lower alkyl, lower alkoxy, halogen or lower alkylenedioxy; A is C.sub.1 -C.sub.6 alkylene; and n is 0 or 1. A compound of the formula (II) or a pharmaceutically acceptable salt thereof, ##STR2## wherein R.sup.1 is hydrogen or fluorine; R.sup.2 is hydrogen or fluorine; R.sup.3 is hydrogen, lower alkyl, lower alkoxy, halogen or lower alkylenedioxy; A is lower C.sub.1 -C.sub.6 alkylene, and n is 0 or 1, provided that at least one of R.sup.1 or R.sup.2 is fluorine.Type: GrantFiled: February 28, 1990Date of Patent: February 11, 1992Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Takakazu Morita, Tadashi Iso, Hideyasu Yamauchi
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Patent number: 5082836Abstract: A pharmaceutical composition for treatment of an autoimmune disease, which comprises (i) a pharmaceutical carrier and (ii) a compound of the formula (I) or pharmaceutically acceptable salts thereof in an amount effective for treatment of an autoimmune disease, ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each is lower alkyl; and R.sup.3 is hydrogen or lower alkyl.Type: GrantFiled: June 25, 1991Date of Patent: January 21, 1992Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Takakazu Morita, Tadashi Iso, Shiro Mita, Youichi Kawashima
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Patent number: 5041435Abstract: Cyclic sulfur-containing compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each is hydrogen or lower alkyl,R.sup.3 is hydrogen or lower alkyl,X is S--S,m is 0 or 1 andn is 1 or 2, with the proviso that when m is 0,n is 2, and pharmaceutically acceptable salts thereof.Such compounds are useful for treating liver disorders and autoimmune diseases.Type: GrantFiled: July 17, 1989Date of Patent: August 20, 1991Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Takakazu Morita, Tadashi Iso, Shiro Mita, Youichi Kawashima
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Patent number: 5034230Abstract: This invention relates to low irritative ophthalmics containing the compound of the formula or salts thereof which are useful for treatment of anti-allergic eye diseases such as allergic conjunctivitis ##STR1##Type: GrantFiled: July 28, 1989Date of Patent: July 23, 1991Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Takakazu Morita, Tadashi Iso, Youichi Kawashima, Mitsushi Hikida
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Patent number: 4786635Abstract: This invention relates to novel benzothizine derivatives of the formula [I], processes for preparing them and therapeutic agents for circulatory diseases containing them as an active ingredient, ##STR1## wherein R.sup.1 is one or more groups selected from those consisting of hydrogen, lower alkyl, halogen, nitro, hydroxy, lower alkoxy, lower alkanoyloxy, amino, lower alkylamino and lower alkoxycarbonyloxy;R.sup.2 is hydrogen, lower alkyl or (C.sub.3 -C.sub.6)cycloalkyl;R.sup.3 is one or more groups selected from those consisting of hydrogen, lower alkyl, hydroxy, lower alkoxy, halogen, nitro, lower alkylenedioxy, lower alkanoyloxy, lower alkanoyl, amino, lower alkylamino, lower alkanoylamino and lower alkoxycarbonyloxy or ##STR2## R.sup.4 is hydrogen or lower alkyl.Type: GrantFiled: March 10, 1987Date of Patent: November 22, 1988Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Jun-ichi Iwao, Tadashi Iso, Masayuki Oya
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Patent number: 4739050Abstract: This invention relates to 2-arylbenzothiazine derivatives of the formula[I] and salts thereof, process of preparation and therapeutic drug comprising them for circulatory diseases, ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are hydrogen, lower alkyl, hydroxy, lower alkoxy, acyloxy, tetrahydropyranyloxy, halogen, nitro, amino, lower alkylamino or ##STR2## and the lower alkoxy group may be substituted by halogen, formyl, lower alkoxy or epoxy;R.sup.3 is hydrogen or lower alkyl;R.sup.4 is hydrogen, lower alkyl, cycloalkyl, hydroxy, lower alkoxy, mercapto, lower alkylthio, arylthio, halogen, cyano, formyl-lower alkyl, lower alkoxy-lower alkyl or ##STR3## R.sup.5,R.sup.6,R.sup.7 and R.sup.Type: GrantFiled: November 4, 1986Date of Patent: April 19, 1988Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Iwao Jun-ichi, Iso Tadashi, Oya Masayuki
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Patent number: 4584300Abstract: This invention relates to benzothiazine derivatives represented by the formula [I] and salts thereof, which are useful for treatment of cardiovascular diseases.Type: GrantFiled: January 17, 1984Date of Patent: April 22, 1986Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Jun-ichi Iwao, Tadashi Iso, Masayuki Oya
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Patent number: 4558125Abstract: The invention relates to benzothiazoline derivatives of the formula [I] and salts thereof, which are useful for (i) treating cardiovascular diseases, and (ii) as the active ingredient of pharmaceutical compositions. Formula [I] follows: ##STR1## wherein R.sup.1 is lower alkanoyl;R.sup.2 is one or more group(s) selected from hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen, nitro, halogenolower alkyl and sulfamoyl;R.sup.3 is --COR.sup.8 ;R.sup.8 is hydroxy, lower alkoxy, ##STR2## Z is straight or branched alkylene containing 1 to 6 carbon atoms; m is 0 or 1; n is 0 or 1; and p is 4 or 5.Type: GrantFiled: May 21, 1984Date of Patent: December 10, 1985Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Jun-ichi Iwao, Tadashi Iso, Masayuki Oya
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Patent number: 4552765Abstract: Aletheine derivatives of the general formula ##STR1## which are useful for treatment of liver damage.Type: GrantFiled: April 25, 1983Date of Patent: November 12, 1985Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Itaru Mita, Jun-ichi Iwao, Tadashi Iso, Masayuki Oya
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Patent number: 4552969Abstract: The invention relates to benzothiazoline derivatives of the formula [I] and salts thereof, which are useful for (i) treating cardiovascular diseases, and (ii) as the active ingredient of pharmaceutical compositions. Formula [I] follows: ##STR1## wherein R.sup.1 is lower alkanoyl;R.sup.2 is one or more group(s) selected from hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen, nitro, halogenolower alkyl and sulfamoyl;R.sup.3 is ##STR2## R.sup.4 and R.sup.5 each is hydrogen, lower alkyl, cyclohexyl or substituted lower alkyl;Z is straight or branched alkylene containing 1 to 6 carbon atoms;m is 0 or 1; n is 0 or 1; and p is 4 or 5.Type: GrantFiled: May 21, 1984Date of Patent: November 12, 1985Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Jun-ichi Iwao, Tadashi Iso, Masayuki Oya
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Patent number: 4547513Abstract: This invention relates to novel benzothiazoline derivatives of the formula [I] and salts thereof, ##STR1## wherein R.sup.1 is formyl or lower alkanoyl;R.sup.2 is hydrogen, lower alkyl, lower alkoxy or nitro;R.sup.3 is hydrogen, lower alkyl, lower alkoxy or halogen;A is lower alkylene;B is --CO--(CH.sub.2).sub.m -- or --CH(OH)--;m is 0 or 1; andwhen m is 0, R.sup.3 is not hydrogen.The compounds of this invention are useful for treatment of cardiovascular diseases.Type: GrantFiled: December 7, 1984Date of Patent: October 15, 1985Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Jun-ichi Iwao, Tadashi Iso, Masayuki Oya
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Patent number: 4517123Abstract: Pharmaceutically active compounds and pharmaceutically acceptable salts thereof having the following formulae ##STR1## wherein A is a straight or branched chain alkylene group containing 1 to 3 carbon atoms; and R.sup.7 and R.sup.8 is each a lower alkyl group. These compounds are useful as the active component of pharmacological preparations.Type: GrantFiled: May 4, 1982Date of Patent: May 14, 1985Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Tadashi Iso, Masayuki Oya
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Patent number: 4499102Abstract: Thiazolidine and pyrrolidine compounds which have the general formula ##STR1## and salts thereof for preventing or relieving diabetic complications and for reducing blood pressure, the processes for their preparation, and the compositions comprising them and pharmaceutically acceptable excipient(s).Type: GrantFiled: December 10, 1981Date of Patent: February 12, 1985Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Masayuki Oya, Tadashi Iso
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Patent number: 4496578Abstract: Novel S-substituted mercapto-lower alkanoyl-4-thiazolidinecarboxylic acids, -2-pyrrolidinecarboxylic acids and their esters represented by the general formula ##STR1## wherein Q is methylene or sulfur;Z is straight or branched alkylene with 1 to 3 carbon atoms, their process for manufacturing, the antihypertensive composition comprising these compounds and the method for reducing blood pressure.Type: GrantFiled: July 6, 1982Date of Patent: January 29, 1985Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Jun-ichi Iwao, Masayuki Oya, Tadashi Iso
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Patent number: 4483861Abstract: Novel S-substituted mercapto-lower alkanoyl-4-thiazolidinecarboxylic acids, -2-pyrrolidinecarboxylic acids and their esters represented by the general formula ##STR1## wherein Q is methylene or sulfur;Z is straight or branched alkylene with 1 to 3 carbon atoms,their process for manufacturing, the antihypertensive composition comprising these compounds and the method for reducing blood pressure.Type: GrantFiled: October 22, 1979Date of Patent: November 20, 1984Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Jun-ichi Iwao, Masayuki Oya, Tadashi Iso
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Patent number: 4482709Abstract: This invention relates to inclusion compounds of cyclodextrin with the compounds of the general formula [I] and salts thereof, which show pharmacological effects (for example antihypertensive effect), ##STR1## wherein A is straight or branched lower alkylene;R.sup.1 is hydrogen or lower alkyl;R.sup.2 is hydrogen, lower alkyl, phenyl, phenyl-lower alkyl, hydroxyphenyl-lower alkyl, hydroxy-lower alkyl, amino-lower alkyl, guanidino-lower alkyl, imidazolyl-lower alkyl, indolyl-lower alkyl, mercapto-lower alkyl or lower alkylthio-lower alkyl;R.sup.1 or R.sup.2 may join to complete pyrrolidine ring or thiazolidine ring, and each ring may be substituted by phenyl or pyridyl, and phenyl may be resubstituted by hydroxy, lower alkoxy, halogen, nitro or sulfamoyl;R.sup.3 is hydrogen or ##STR2## said lower alkyl and lower alkoxy having 1 to 6 carbon atoms.Type: GrantFiled: September 30, 1982Date of Patent: November 13, 1984Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Jun-ichi Iwao, Tadashi Iso, Masayuki Oya
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Patent number: 4479949Abstract: This invention relates to benzothiazoline derivatives of the formula [I] and salts thereof, which are useful for (i) treating cardiovascular diseases, and (ii) as the active ingredient of pharmaceutical compositions. Formula [I] follows: ##STR1## wherein R.sup.1 is lower alkanoyl;R.sup.2 is one or more group(s) selected from hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen, nitro, halogeno-lower alkyl and sulfamoyl;R.sup.3 is ##STR2## R.sup.6 is hydrogen, alkyl, substituted alkyl, alkanoyl, substituted alkanoyl, alkenoyl, substituted alkenoyl or furylcarbonyl;R.sup.7 is hydrogen, hydroxy, phenyl-lower alkyl or banzoyl;Z is strainght or branched alkylene containing 1 to 6 carbon atoms;m is 0 or 1; n is 0 or 1; and p is 5.Type: GrantFiled: April 14, 1983Date of Patent: October 30, 1984Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Jun-ichi Iwao, Tadashi Iso, Masayuki Oya