Abstract: A transport device for a container has a base, a vertical member extending up from the base and a complementary handling unit extending from an end of the vertical member spaced from the base. The complementary handling unit is configured for releasably engaging a container, such as a bioreactor container, so that the container can be transported to a holding device.

Abstract: A bioreactor has a stirrer shaft that is driveable by a drive and on which a stirrer element is positioned. The position of the stirrer element is determined by a stirrer installation aid. The stirrer installation aid has a free end with an abutment surface on which the free end of the stirrer element abuts. The stirrer installation aid is designed as a sleeve that comprises a slot extending between the axial ends of the sleeve. The slot is delimited by opposite flanks of a wall, and the sleeve is placed on the stirrer shaft. The stirrer installation aid can be pulled off laterally from the stirrer shaft. A method for installing the stirrer element on the stirrer shaft arranged in the bioreactor also is provided.

Abstract: The invention relates to a device for culturing cells in a bioreactor, the waste-air line of which leading out of the reactor interior comprises a waste-air filter having a sterile-filtration microfilter membrane, wherein at least one prefilter having a hydrophobic filter material is placed upstream of the waste-air filter toward the reactor interior.

Abstract: A filter housing comprising an accommodation space for accommodating a filter is disclosed, wherein the filter housing further comprises at least one connector-like coupling element configured to indirectly or directly mate with at least one mating coupling element of a mating filter housing; and wherein the coupling element is integrally formed on a portion of the filter housing.

Abstract: A method for a measurement or production setup includes providing a visualization system with a processor, an output device and a capturing module for capturing identification data of a working space. The method further provides a first setup component having at least one first marker at the working space and provides a second setup component having at least one second marker at the working space and being connectable to the first setup component through at least one connection. The method captures identification data about the markers and identifies the markers. The processor retrieves digital information for the markers from a database and makes a decision on the connection of the setup components based on the retrieved digital information and the captured identification data. The method then outputs a visual representation of the connection between the first and second setup components according to the decision.

Abstract: The present invention relates to a device for installation into a hose and/or plastic pipe system and mounting of flow measurement sensors which comprises a plastic flow part as a hollow body with a centrally arranged and deformable region with a rectangular cross section. The present invention further relates to the use of the abovementioned device as well as to a method of flow measurement using the device.

Abstract: A single-use container for the prevention of over-pressurization is provided. The single-use container has an enclosure for a fluid and an over-pressurization relief device fluidly connected to the enclosure. The over-pressurization relief device is configured to relieve pressure from the enclosure when a pressure of the fluid within the enclosure exceeds a specified relief pressure. The specified relief pressure is set to be lower than the burst pressure of the enclosure. The over-pressurization relief device is connectable to a controlled pathway for relieving the fluid from the enclosure in a controlled manner.

Abstract: A filter holder for receiving filter cassettes (19) and a method for sterilizing the filter are provided. The filter holder has first and second parallel plates (3, 4). The first plate (3) is fixed and the second plate (4) is movable along at least one rail (2) by a drive (7, 9) so that the filter cassettes (19) can be clamped between the plates (3, 4) with a predefined clamping pressure. The drive (7, 9) is designed to be removable. The at least one rail (2) has at least one tension rod (5) with a spring clamping element (6) so that the first and second plates (3, 4) can be clamped with a pre-definable pressure against the filter cassettes (19).

Abstract: The present invention relates to a microarray device for the screening or the finding of protein inhibitors, to a method for the production thereof, and to a corresponding method for screening or finding protein inhibitors. The microarray device according to the invention comprises a solid supporting element having a support material, at least one protein immobilized thereon for which inhibitors are to be screened or found, and at least one known inhibitor of the at least one protein, the inhibitor being bound to the at least one protein and comprising a detectable label.

Abstract: A tactile button device is provided and is suitable to be sterilized. The tactile button device has at least one receptacle that is adapted to be filled at least partly with a material and further is configured so that the material filled into the receptacle is displaced when subjected to a pressure. At least one duct is connected to the receptacle and allows the pressure exerted to the material to be transmitted. A connector is connected to the at least one duct and is connectable to a detection device so that the pressure on the material is transmitted to the detection device.

Abstract: The present invention relates to a radiation-resistant microporous membrane having a hydrophobicity gradient, to a method for the preparation thereof, and to the use of the membrane in the sterilizing filtration of gaseous fluids or as a liquid barrier in liquid-containing systems to be vented.

Abstract: Disclosed is a filtration device for liquid samples as well as a close and push-through device for said filtration device.

Abstract: A method of determining an internal volume (V) of a filter or bag device includes pressurizing the device to a first pressure (p1) lower than a proof pressure by supplying a test gas, pressurizing the device to proof pressure (pp), and at the same time, measuring the mass flow (m) or the volumetric flow of test gas, determining the gas temperature (T), and determining the internal volume (V) based on the equation for ideal gases, such that: V=m×R×T/(pp?p1) where V is the internal volume, m is the mass flow, R is the gas constant, T is the gas temperature, pp is the proof pressure and p1 is the first pressure. A computer program product and a testing apparatus for performing the above-mentioned method also are provided.

Abstract: A bioreactor vessel has an optical foam sensor (36) with a foam contact surface for contacting the foam to be detected. The foam contact surface is an inner side of a window (38) transparent to light from the visible and ultraviolet spectral range in an outer wall of the bioreactor vessel (10). An outer side of the window (38) is coupled to an illumination and detection unit (52) with at least one first light source (56) of visible light and at least one photodetector (58) to detect light from the first light source (56) that is reflected in the bioreactor vessel (10). The foam contact surface has a titanium dioxide coating (44) superhydrophilizable by photoactivation with ultraviolet light and the illumination and detection unit (52) has at least one second light source (66) of ultraviolet light.

Abstract: A device (1) and a method are provided for treating a porous filtration medium (37) having a receiving unit (2) with of a receiving part (5) and a base part (6). The porous filtration medium (37) can be lifted by the receiving part (5) from a lower part (33) of a filtration device (32), and the receiving part (5) with the porous filtration medium (37) can be mounted on the base part (6). The receiving part (5) is latchable to the base part (6). The base part (6), towards the filtration medium (37) has an incubation chamber (17) connected to a base part (6) outlet (3) that faces away from the receiving part (5), and the outlet (3) has a projection onto which a receiving vessel (4) containing a solvent (28) for dissolving the porous filtration medium (37) can be detachably pushed on.

Abstract: A device and a method for adjusting stirring blades on a stirring blade receptacle of a stirrer, wherein the stirring blades can be fixed with a stirring blade axis in receiving bores, which are arranged transversely to an axis of rotation and are a part of the stirring blade receptacle, at intended predetermined angle of attack relative to a virtual plane that is arranged transversely to the axis of rotation of the stirrer. An associated device body is provided with a receiving element for receiving the stirring blade receptacle with unfixed stirring blades. A stop is arranged on the device body for each lower face, which faces the receiving element and is a part of the stirring blades, outside the respective stirring blade axis. Each respective stirring blade is then brought into abutment against its associated stop, to place it into the predetermined angle of attack.

Abstract: A method and system for creating a design plan to test a product characteristic are described. One or more factors, level corresponding to the factors, and partitions for testing the product characteristic are determined. For each partition, an active matrix is generated. The product characteristic can be tested at each partition using the levels for the factors specified by the corresponding active matrix.

Abstract: The present invention relates to a method for quantitatively determining living and dead cells in a biological sample. The method according to the present invention is based on the determination of the amount of DNA in the sample with the aid of a DNA amplification reaction which does not impair the membrane integrity of living cells.