Patents Assigned to Sartorius
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Publication number: 20250011829Abstract: A membrane for microbiological analysis, a production method of a membrane for microbiological analysis, and the use of such membranes for microbiological analysis. Examples include a cellulose membrane for microbiological analysis that is impregnated with a non-ionic surfactant in an amount of from 100 ng/cm2 to 1.0 mg/cm2, with the membrane having a nominal pore size of from 0.20 ?m to 0.80 ?m, and a cumulative adsorption pore volume of less than 0.010 cm3/g.Type: ApplicationFiled: November 15, 2022Publication date: January 9, 2025Applicant: Sartorius Stedim Biotech GmbHInventors: Andrea Ernst, Elke Rüngeling, Bastian Gniewosz, Katharina Mazurek-Swidereck, Niels Wagner
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Publication number: 20250011154Abstract: A fluid distribution system includes an input tube, a plurality of vessels, and a distribution hub. The input tube is configured to extend from a supply vessel. Each vessel of the plurality of vessels includes an inflow conduit. The distribution hub includes a single inlet and a plurality of outlets. The single inlet is defined in a bottom of the distribution hub and is in fluid communication with the input tube such that the distribution hub is configured to receive fluid from the input tube through the single inlet. Each outlet of the plurality of outlets is in fluid communication with the single inlet and in fluid communication with a respective inflow conduit such that the distribution hub is configured to provide an equal portion of the fluid received through the single inlet to each of the inflow conduits.Type: ApplicationFiled: September 17, 2024Publication date: January 9, 2025Applicant: Sartorius Stedim North America Inc.Inventors: Michael A. Zumbrum, Kevin M. Perdue, William Kimmick, Jan Neuhaus
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Patent number: 12172140Abstract: A mixing device having a stirring element can include: a container for receiving fluids and/or solids; and at least one rotatable stirring element for mixing the fluids and/or solids; wherein the stirring element comprises a first bearing element and a second bearing element which are arranged at or near opposite ends of the stirring element; wherein the first bearing element is mounted on a first face of the container and the second bearing element is mounted on an opposite second face of the container; wherein the first bearing element comprises at least one non-permanently magnetized element such that it can be moved in rotation by externally induced reluctance forces, and wherein the second bearing element is mounted in a contactless manner by externally induced magnetic forces.Type: GrantFiled: May 17, 2019Date of Patent: December 24, 2024Assignees: Sartorius Stedim Biotech GmbH, Levitronix GmbHInventors: Lars Böttcher, Marco Leupold, Simon Topp-Manske, Thomas Holenstein, Thomas Nussbaumer, Robin Heese
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Publication number: 20240408513Abstract: A separation system for separating and purifying a target component, a method for separating and purifying a target component, and the use of a crossflow diafiltration unit for processing a target phase. The system includes an aqueous-two phase extraction unit for aqueous-two phase extraction of the fluid, a separation unit for separating a target phase, and a crossflow diafiltration unit.Type: ApplicationFiled: October 13, 2022Publication date: December 12, 2024Applicant: Sartorius Stedim Biotech GmbHInventors: Thomas Kruse, Markus Kampmann, Alexander Helling, Martin Leuthold
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Patent number: 12145130Abstract: The present invention relates to a multimodal adsorption medium, in particular a multimodal chromatography medium, a method for its production, as well as use of the adsorption medium according to the invention or an adsorption medium produced according to the invention for the purification of biomolecules.Type: GrantFiled: September 2, 2021Date of Patent: November 19, 2024Assignee: Sartorius Stedim Biotech GmbHInventors: Lukas Kupracz, Florian Taft, Louis Villain, Kornelia Kuper
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Patent number: 12139304Abstract: A composite article includes a lattice and an elastomeric section. The lattice includes a plurality of members that form an open-mesh frame defining a plurality of voids between the adjacent members of the frame. The elastomeric section is formed of an elastomer that is disposed about the lattice and within the voids of the lattice. The composite article may be a circular gasket, a gasket with a grip, a rectangular gasket, a vessel cap, a flask stand, and a handle for a hand tool.Type: GrantFiled: July 23, 2019Date of Patent: November 12, 2024Assignee: Sartorius Stedim North America Inc.Inventors: Michael A. Zumbrum, William Kimmick, Kevin Perdue
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Publication number: 20240351847Abstract: A tube holding apparatus includes a body, a mount, a first guide, and a second guide. The body has a proximal end portion and a distal end portion. The mount is positioned between the proximal end portion and the distal end portion of the body. The mount is configured to secure the body to a valve tower. The first guide is secured about the proximal end portion of the body. The second guide is secured about the distal end portion of the body. The first guide and the second guide each configured to receive a portion of a transfer link that extends between a valve tower and a storage container such that a positive slope container to the valve tower.Type: ApplicationFiled: December 19, 2023Publication date: October 24, 2024Applicant: Sartorius Stedim North America Ins.Inventors: Karine Vizcaino Boissières, Ali Hojeij, Amélie Rethore, Timothy Cardace, Aleksander Shamin, Meghan Keenan
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Publication number: 20240351848Abstract: A tube holding apparatus includes a body, a mount, a first guide, and a second guide. The body has a proximal end portion and a distal end portion. The mount is positioned between the proximal end portion and the distal end portion of the body. The mount is configured to secure the body to a valve tower. The first guide is secured about the proximal end portion of the body. The second guide is secured about the distal end portion of the body. The first guide and the second guide each configured to receive a portion of a transfer link that extends between a valve tower and a storage container such that a positive slope container to the valve tower.Type: ApplicationFiled: March 26, 2024Publication date: October 24, 2024Applicant: Sartorius Stedim North America Inc.Inventors: Karine Vizcaino Boissières, Ali Hojeij, Amélie Rethore, Timothy Cardace, Aleksander Shamin, Meghan Keenan
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Patent number: 12123512Abstract: A housing having a housing body (100) carries on the outside of one of the side walls (110) a bolt (500) aligned parallel to the lid guide grooves (120) and the lid (200) carries a sleeve (222) fixed to a tab (220) projecting over the upper edge of the corresponding side wall (110) of the housing body (100) and aligned coaxially with the bolt (500). The sleeve (222) engages around the bolt (500) to form an axially and rotationally movable sliding bearing.Type: GrantFiled: February 13, 2023Date of Patent: October 22, 2024Assignee: Sartorius Stedim Systems GmbHInventors: Simon Dittmann, Jan-Eike Schubert, Michael Gohs, Yannick Stapel
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Patent number: 12115502Abstract: The present invention relates to a serial arrangement comprising n plies of asymmetric filter media, wherein n is at least two and the pore size of the n plies substantially continuously decreases in the thickness direction of the serial arrangement, to a production method for the serial arrangement, to a filtration unit comprising the serial arrangement, to the use of the serial arrangement, and to a method for characterizing the pores of a filter medium.Type: GrantFiled: June 4, 2019Date of Patent: October 15, 2024Assignee: Sartorius Stedim Biotech GmbHInventors: Volkmar Thom, Jörg Hosch, Benjamin Schneider
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Patent number: 12104716Abstract: A pinch valve having a clamping member (300) mounted between two side walls (110) of a valve housing, the side walls extending parallel to a hose guide axis and to a plunger guide axis. Each of the side walls has a step (112) extending parallel to the hose guide axis and recessing with respect to the advancing direction of the plunger. The clamping jaws (320) of the pinch valve, upon displacement of the clamping member (300), move over the steps (112) with their outer sides, which face away from the hose guide, bearing against the side walls (110).Type: GrantFiled: February 13, 2023Date of Patent: October 1, 2024Assignee: Sartorius Stedim Systems GmbHInventors: Simon Dittmann, Jan-Eike Schubert, Michael Gohs, Swen Weitemeier, Lars Boettcher
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Publication number: 20240319064Abstract: A method for testing integrity of a filter can include pressurizing an upstream side of the filter to a test pressure and performing a check step that includes determining a flow rate of fluid from the upstream side to a downstream side of the filter, comparing the determined flow rate with a flow range including a flow threshold, and setting stop criteria based on the comparison.Type: ApplicationFiled: December 23, 2021Publication date: September 26, 2024Applicant: Sartorius Stedim Biotech GmbHInventor: Kirit Chatterjee
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Publication number: 20240307568Abstract: A method of sterilizing biocontainers including irradiating a biocontainer and measuring a radiation dose received by the biocontainer. The method also includes determining an ageing time of the biocontainer after irradiation based on the radiation dose received by the biocontainer and preventing use of the biocontainer before the ageing time has elapsed.Type: ApplicationFiled: December 21, 2021Publication date: September 19, 2024Applicant: Sartorius Stedim FMT S.A.S.Inventors: Samin Akbari, Magali Barbaroux, Samuel Dorey, David Pollard
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Publication number: 20240310533Abstract: A radiation dose sensor that measures a radiation dose of a biocontainer formed for a first material includes a first electrode, a second electrode, and a film. The first electrode has a plurality of first fingers. And the second electrode has a plurality of second fingers. The fingers of the first electrode extend towards and are interdigitated with the fingers of the second electrode that extend towards the first electrode with gaps formed between the first and second fingers. The film coats the interdigitated fingers and is disposed within the gaps. The film is formed of a second material that is similar to the first material that forms the biocontainer.Type: ApplicationFiled: December 21, 2021Publication date: September 19, 2024Applicant: Sartorius Stedim FMT S.A.S.Inventors: Samin Akbari, Magali Barbaroux, Samuel Dorey, David Pollard
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Publication number: 20240310532Abstract: A method of measuring a radiation dosage during irradiation includes disposing a first sensor in a first package with a first biocontainer and disposing a second sensor in a second package with a second biocontainer. The method further includes placing the first package and the second package in a container and irradiation the container including the first package and the second package. During or after irradiation, a first radiation dosage associated with the first biocontainer is measured with the first sensor and a second radiation dosage associated with the second biocontainer is measured with the second sensor.Type: ApplicationFiled: December 21, 2021Publication date: September 19, 2024Applicant: Sartorius Stedim FMT S.A.S.Inventors: Samin Akbari, Magali Barbaroux, Samuel Dorey, David Pollard
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Patent number: 12092621Abstract: The present invention relates to a method of determining the concentration of at least one compound in a chromatography method, wherein fluctuations of the stationary phase's spatial structure due to variations of the composition of the mobile phase and/or the chromatography temperature are considered by calculating the concentration c(z, t) based on the flow velocity ? and the bulk porosity ?b, which may vary due to the varying composition and/or temperature and which are determined for the varying composition of the mobile phase and/or the varying chromatography temperature.Type: GrantFiled: May 8, 2020Date of Patent: September 17, 2024Assignee: Sartorius Stedim Biotech GmbHInventors: Jan Schwellenbach, Volkmar Thom, Dominik Stein
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Publication number: 20240280487Abstract: Instruments, components thereof, consumables therefor, and associated methods are generally provided. Advantageously, some instruments described herein may be capable of performing and/or configured to perform assays at a rate that is faster and/or requires less input from an operator than assays performed by other methods. Some methods may comprise performing assays at such faster rates and/or involving such reduced input.Type: ApplicationFiled: July 6, 2022Publication date: August 22, 2024Applicant: Sartorius BioAnalytical Instruments Inc.Inventors: Tae Kang, Stewart Holloway, Michael Youngquist
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Publication number: 20240271728Abstract: A union for connecting a first fluid conduit and a second fluid conduit includes a body. The body defines a central passage about a central longitudinal axis of the body with the body having a first side and a second side. The body is configured to define a first adhesive channel between a first fluid conduit and the first side of the body and to define a second adhesive channel between a second fluid conduit and the second side of the body. The body defining an injection port position at a midpoint of the body. The injection port in fluid communication with the first adhesive channel and the second adhesive channel and is configured to deliver adhesive into the first adhesive channel and the second adhesive channel.Type: ApplicationFiled: February 13, 2024Publication date: August 15, 2024Applicant: Sartorius Stedim FMT S.A.S.Inventors: Michael A. Zumbrum, William Kimmick
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Publication number: 20240261786Abstract: The invention relates to a product for providing membrane elements, comprising: a carrier film; and a membrane film, at least comprising: a support layer; and a membrane layer; the membrane film is releasably coupled to the carrier film; and the membrane film has a plurality of substantially discrete membrane elements. The invention also relates to a corresponding manufacturing process.Type: ApplicationFiled: May 23, 2022Publication date: August 8, 2024Applicant: Sartorius Stedim Biotech GmbHInventors: Alfons Kesting, Wei Sun, Marcel Bremerich, Louis Villain
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Patent number: 12048896Abstract: A crossflow filter device for filtering a pressurised feed liquid is provided. The crossflow filter device comprises: a filter membrane; a flow channel for the pressurised feed liquid which extends in a path over a retentate surface of the membrane such that the direction of flow in the channel is tangential to the retentate surface, and a filtrate derived from the feed liquid passes through the membrane leaving retentate liquid in the flow channel; and a collection chamber for the filtrate formed on an opposite, filtrate surface of the membrane. The crossflow filter device further comprises a sealed housing having a retentate side and a filtrate side which enclose therebetween the flow channel, the filter membrane and the collection chamber. The crossflow filter device further comprises, flow channel guide walls provided at an inner surface of the retentate side of the housing.Type: GrantFiled: February 18, 2020Date of Patent: July 30, 2024Assignee: Sartorius Stedim Lab LimitedInventors: Adam Gilbert, Martin Purshouse, Michael Bates, Chris Biddell, Adam Green, Thomas Davidson