Patents Assigned to Schering-Plough Corporation
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Patent number: 8187630Abstract: A bilayer solid composition comprising (a) an immediate release first layer comprising an anti-allergic effective amount of desloratadine and at least one pharmaceutically acceptable excipient and (b) a sustained release second layer comprising an effective amount of a nasal decongestant, e.g. pseudoephedrine sulfate and a pharmaceutically acceptable sustained release agent wherein the composition contains less than about 2% of desloratadine decomposition products is disclosed. A solid composition comprising an anti-allergic effective amount of desloratadine and at least one, and preferably two pharmaceutically acceptable antioxidants is also disclosed.Type: GrantFiled: October 2, 2009Date of Patent: May 29, 2012Assignee: Schering-Plough CorporationInventor: Wing-Kee Philip Cho
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Publication number: 20120083601Abstract: A process is provided for preparing azetidinones useful as intermediates in the synthesis of penems and as hypocholesterolemic agents, comprising reacting a ?-(substituted-amino)amide, a ?-(substituted-amino)acid ester, or a ?-(substituted-amino)thiolcarbonic acid ester with a silylating agent and a cyclizing agent selected from the group consisting of alkali metal carboxylates, quaternary ammonium carboxylates, quaternary ammonium hydroxides, quaternary ammonium alkoxides, quaternary ammonium aryloxides and hydrates thereof, or the reaction product of: (i) at least one quaternary ammonium halide and at least one alkali metal carboxylate; or (ii) at least one quaternary ammonium chloride, quaternary ammonium bromide, or quaternary ammonium iodide and at least one alkali metal fluoride, wherein a quaternary ammonium moiety of the cyclizing agent is unsubstituted or substituted by one to four groups independently selected from the group consisting of alkyl, arylalkyl and arylalkyl-alkyl.Type: ApplicationFiled: December 12, 2011Publication date: April 5, 2012Applicant: Schering-Plough CorporationInventors: TIRUVETTIPURAM K. THIRUVENGADAM, John S. Chiu, Xiaoyong Fu, Timothy L. McAllister
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Publication number: 20110319434Abstract: The present invention relates to novel Bicyclic Heterocyclic Derivatives, pharmaceutical compositions comprising the Bicyclic Heterocyclic Derivatives and the use of these compounds for treating or preventing treating allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disorder, a cognitive disorder, a metabolic disorder, obesity or an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or impaired fasting glucose.Type: ApplicationFiled: December 18, 2009Publication date: December 29, 2011Applicant: Schering Plough CorporationInventors: Anandan Palani, Ashwin U. Rao, Xiao Chen, Ning Shao, Ying R. Huang, Robert G. Aslanian
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Publication number: 20110244004Abstract: A liquid suspension comprising an antifungally effective amount of the micronized compound represented by the chemical structural formula I: at least one thickening agent, a non-ionic surfactant, and a pharmaceutically acceptable liquid carrier is disclosed.Type: ApplicationFiled: June 15, 2011Publication date: October 6, 2011Applicant: Schering-Plough CorporationInventors: Stefan Sharpe, Joel Sequeira, David Harris, Shashank Mahashabde
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Publication number: 20110245267Abstract: The present invention relates to novel Piperidine and piperazine Derivatives, pharmaceutical compositions comprising the Piperidine and piperazine Derivatives and the use of these compounds of formula (I) for treating or preventing treating allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disorder, a cognitive disorder, a metabolic disorder, obesity or an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or impaired fasting glucose.Type: ApplicationFiled: December 18, 2009Publication date: October 6, 2011Applicant: Schering Plough CorporationInventors: Dong Xiao, Anandan Palani, Robert G. Aslanian
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Publication number: 20110060006Abstract: In its many embodiments, the present invention provides a novel class of heterocyclic derivatives as a2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the a2C adrenergic receptors using such compounds or pharmaceutical compositions.Type: ApplicationFiled: February 19, 2009Publication date: March 10, 2011Applicant: Schering Plough CorporationInventors: Junying Zheng, Jianhua Chao, Kevin D. McCormick, Robert G. Aslanian, Mwangi W. Muthai, Christopher W. Boyce, Walter S. Won
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Publication number: 20110034705Abstract: A process for preparing 3-amino-3-cyclobutylmethyl-2-hydroxypropionamide of the Formula I: or a salt thereof involves providing a compound of the Formula VI described herein in a solution comprising predominately dimethylsulfoxide (DMSO) and converting this compound directly to the compound of the Formula VIII described herein without working up or isolating the intermediate compound of the Formula VII described herein.Type: ApplicationFiled: December 17, 2008Publication date: February 10, 2011Applicant: Schering-Plough CorporationInventors: Shuan Dong, Jeonghan Park, Eugene John Vater
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Patent number: 7884080Abstract: The present invention relates to Azetidinone Derivatives of structural formula 1: and compositions comprising an Azetidinone Derivative and methods for treating or preventing a disorder of lipid metabolism, pain, diabetes, a vascular condition, demyelination or nonalcoholic fatty liver disease, comprising administering to a patient an effective amount of an Azetidinone Derivative.Type: GrantFiled: September 13, 2007Date of Patent: February 8, 2011Assignee: Schering Plough CorporationInventors: Robert G. Aslanian, Chad E. Bennett, Duane A. Burnett, Tin-Yau Chan, Eugenia Y. Kiselgof, Chad E. Knutson, Joel M. Harris, Brian A. McKittrick, Anandan Palani, Elizabeth M. Smith, Henry M. Vaccaro, Dong Xiao, Hyunjin M. Kim
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Patent number: 7846946Abstract: Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt thereof, wherein: M1 and M3 are CH or N; M2 is CH, CF or N; Y is —C(?O)—, —C(?S)—, —(CH2)q—, —C(?NOR7)— or —SO1-2—; Z is a bond or optionally substituted alkylene or alkenylene; R1 is H, or alkyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, all optionally substituted, or a group of the formula: where ring A is a heteroaryl ring; R2 is optionally substituted alkyl, alkenyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; R3 is H, —C(O)NH2, or alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl, all optionally substituted; and the remaining variables are as defined in the specification; compositions and methods of treating allergy-induced airway responses, congestion, obesity, metabolic syndrome, alcoholic fatty liver disease, hepatic steatosis, nonalcoholic steatohepatitis, cirrhosis, hepatacellular carcinoma and cognition deficit disorders using said compounds, alone or in combination with otheType: GrantFiled: July 22, 2009Date of Patent: December 7, 2010Assignee: Schering Plough CorporationInventors: Robert G. Aslanian, Michael Y. Berlin, Christopher W. Boyce, Jianhua Chao, Manuel de Lera Ruiz, Pietro Mangiaracina, Kevin D. McCormick, Mwangi W. Mutahi, Stuart B. Rosenblum, Neng-Yang Shih, Daniel M. Solomon, Wing C. Tom, Henry A. Vaccaro, Junying Zheng, Xiaohong Zhu
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Patent number: 7816118Abstract: The invention relates to a method of excysting and growing protozoal oocysts by in vitro tissue culture resulting in production of a continuous culture of merozoites. The invention also provides an economical and reliable supply of cultured Eimeria sp. for vaccine production, assays and research. Domesticated avians that have been vaccinated using the provied Eimeria sp. are also provided.Type: GrantFiled: May 29, 2007Date of Patent: October 19, 2010Assignees: Schering-Plough Corporation, Pathogenes, Inc.Inventor: Siobhan P. Ellison
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Publication number: 20100256556Abstract: Various aspects of the present invention provide for packages with an outer shell; a first chamber defined at least partially by the outer shell; a second chamber defined at least partially by the outer shell; a fluid-tight rupturable seal separating the first and second chambers; and, a sealed outlet port in communication with the first chamber. With force being applied to the second chamber, the rupturable seal ruptures more readily than the outer shell.Type: ApplicationFiled: March 27, 2008Publication date: October 7, 2010Applicant: Schering Corporation Schering Plough CorporationInventors: Stuart J. Cray, JR., Indradat Jagnandan, David Merle Marxen
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Patent number: 7803828Abstract: In its many embodiments, the present invention provides a novel class of indolines as inhibitors of ?2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the ?2C adrenergic receptors using such compounds or pharmaceutical compositions.Type: GrantFiled: August 23, 2006Date of Patent: September 28, 2010Assignee: Schering-Plough CorporationInventors: Kevin D. McCormick, Christopher W. Boyce, Robert G. Aslanian, Neng-Yang Shih, Salem Fevrier, Pietro Mangiaracina, Chia-Yu Huang, Bo Liang, Rong-Qiang Liu, Huagang Lu
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Patent number: 7728165Abstract: In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.Type: GrantFiled: June 15, 2009Date of Patent: June 1, 2010Assignee: Schering Plough CorporationInventors: Jeonghan Park, Anantha R Sudhakar, George S. K. Wong, Minzhang Chen, Juergen Weber, Xiaojing Yang, Daw-long Kwok, Ingyu Jeon, Ramani R Raghavan, Maria Tamarez, Weidong Tong, Eugene J. Vater
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Publication number: 20100113821Abstract: Disclosed is a process for preparing 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide hydrochloride, an intermediate useful in the preparation of the HCV protease inhibitor (1R,5S)—N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide.Type: ApplicationFiled: December 17, 2007Publication date: May 6, 2010Applicant: Schering-Plough CorporationInventors: Jeonghan Park, Eugene J. Vater, Shuan Dong, Tetsuo Iwama, Ramani R. Raghavan, Hong-Chang Lee, George S.k. Wong
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Patent number: 7652003Abstract: Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, n and X are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer's disease. Also disclosed are methods of treating a cognitive or neurodegenerative disease comprising administering to a patient I need of such treatment a combination of at least one compound of formula I and at least one compound selected from the group consisting of ?-secretase inhibitors other than those of formula I, HMG-CoA reductase inhibitors, gamma-secretase inhibitors, non-steroidal anti-inflammatory agents, N-methyl-D-aspartate receptor antagonists, cholinesterase inhibitors and anti-amyloid antibodies.Type: GrantFiled: July 26, 2005Date of Patent: January 26, 2010Assignee: Schering-Plough CorporationInventors: Andrew W Stamford, Ying Huang, Guoqing Li, Corey O Strickand, Johannes H. Voigt
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Publication number: 20080261289Abstract: A composition is disclosed comprising virus in a formulation comprising a polyhydroxy hydrocarbon buffered to maintain a pH in a range from about 7 to about 8.5 at a temperature in the range from about 2° C. to 27° C. Methods for concentrating and purifying virus preparations are also disclosed.Type: ApplicationFiled: June 26, 2008Publication date: October 23, 2008Applicant: Schering-Plough CorporationInventors: Andreas Frei, Henry K.H. Kwan, Varda E. Sandweiss, Gary J. Vellkamp, Pui-Ho Yuen, Laureano L. Bondoc, Frederick William Porter, John Chu-Tay Tang, Peter Ihnat
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Publication number: 20070224223Abstract: The invention relates to a method of excysting and growing protozoal oocysts by in vitro tissue culture resulting in production of a continuous culture of merozoites. The invention also provides an economical and reliable supply of cultured Eimeria sp. for vaccine production, assays and research. Domesticated avians that have been vaccinated using the provied Eimeria sp. are also provided.Type: ApplicationFiled: May 29, 2007Publication date: September 27, 2007Applicant: SCHERING-PLOUGH CORPORATIONInventor: Siobhan Ellison
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Patent number: 7250286Abstract: The invention relates to a method of excysting and growing protozoal oocysts by in vitro tissue culture resulting in production of a continuous culture of merozoites. The invention also provides an economical and reliable supply of cultured Eimeria sp. for vaccine production, assays and research. Domesticated avians that have been vaccinated using the provied Eimeria sp. are also provided.Type: GrantFiled: May 20, 2003Date of Patent: July 31, 2007Assignees: Schering-Plough Corporation, Pathogenes, Inc.Inventor: Siobhan P. Ellison
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Publication number: 20050176648Abstract: The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.Type: ApplicationFiled: March 24, 2005Publication date: August 11, 2005Applicant: Schering-Plough CorporationInventors: Anil Saksena, Viyyoor Girijavallabhan, Stephane Bogen, Raymond Lovey, Edwin Jao, Frank Bennett, Jinping McCormick, Haiyan Wang, Russell Pike, Yi-Tsung Liu, Tin-Yau Chan, Zhaoning Zhu, Ashok Arasappan, Kevin Chen, Srikanth Venkatraman, Tejal Parekh, Patrick Pinto, Bama Santhanam, F. Njoroge, Ashit Ganguly, Henry Vaccaro, Scott Kemp, Odile Levy, Marguerita Lim-Wilby, Susan Tamura
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Publication number: 20040171614Abstract: This invention discloses novel gamma secretase inhibitors of the formula: 1Type: ApplicationFiled: September 16, 2003Publication date: September 2, 2004Applicants: Schering-Plough Corporation, Pharmacopeia, Inc.Inventors: Dmitri A. Pissarnitski, Hubert B. Josien, Elizabeth M. Smith, John W. Clader, Theodros Asberom, Tao Guo, Douglas W. Hobbs