Patents Assigned to Schering-Plough Corporation
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Publication number: 20040067950Abstract: The present invention relates to the method of treating cough with ORL-1 agonists, alone or in combination with additional agents for treating symptoms of cough, allergy or asthma, pharmaceutical compositions comprising the combinations, and to compounds of the formula 1Type: ApplicationFiled: June 17, 2003Publication date: April 8, 2004Applicant: Schering-Plough CorporationInventors: Deen Tulshian, Ginny D. Ho, Lisa S. Silverman, Julius J. Matasi, Robbie L. McLeod, John A. Hey, Richard W. Chapman, Ana Bercovici, Francis M. Cuss
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Publication number: 20040048848Abstract: This invention discloses novel gamma secretase inhibitors of the formula: 1Type: ApplicationFiled: February 5, 2003Publication date: March 11, 2004Applicant: Schering-Plough Corporation and Pharmacopeia, Inc.Inventors: Dmitri A. Pissarnitski, Hubert B. Josien, Elizabeth M. Smith, John W. Clader, Theodros Asberom, Tao Guo, Douglas W. Hobbs
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Patent number: 6667319Abstract: The present invention discloses compounds which, are novel receptor antagonists for NPY Y5 as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such NPY Y5 receptor antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.Type: GrantFiled: July 24, 2002Date of Patent: December 23, 2003Assignee: Schering-Plough CorporationInventors: Andrew W. Stamford, Ying Huang, Guoqing Li
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Publication number: 20030170216Abstract: Disclosed are aqueous and nonaqueous solution formulations containing agents that are useful for treating cancer.Type: ApplicationFiled: December 20, 2002Publication date: September 11, 2003Applicant: Schering-Plough CorporationInventors: Peter M. Ihnat, Leonore C. Witchey-Lakshmanan, Varda Sandweiss, Sydney O. Ugwu
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Patent number: 6505126Abstract: The invention provides methods for identifying nucleic acids and polypeptides derived from fungi that are useful as antifungal targets for diagnosis and/or treatment of fungal diseases. The invention also provides isolated fungal-specific nucleic acids and polypeptides comprising antifungal targets. Methods for identifying antifungal agents that interact with and/or alter the function the antifungal targets are provided.Type: GrantFiled: March 25, 1999Date of Patent: January 7, 2003Assignees: Schering-Plough Corporation, Genome Therapeutics CorporationInventors: Roberta S. Hare, George H. Miller, Karen J. Shaw, George H. Shimer, Jr.
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Patent number: 5939419Abstract: Antihypertensive and bronchodilating compounds of the formula or a pharmaceutically acceptable salt thereof, and a process for preparing them are disclosed, wherein:R.sub.1, R.sub.2, R.sub.3, R.sup.a, R.sup.b and R.sup.c as defined in the disclosure;pharmaceutical compositions containing said compounds;methods of treatment using said compounds; anda process for preparing polycyclic guanines comprisinga) reducing a nitrosopyrimidine, and treating the reduced nitrosopyrimidine with an acylating reagent to give the amidopyrimidine;b) reacting the amidopyrimidine with a halogenating/cyclizing reagent to give a halopurine;c) reacting, in the presence of a base, the halopurine with an amine to give the substituted aminopurine; andd) closing the ring of the substituted aminopurine with a suitable dehydrating agent.Type: GrantFiled: August 23, 1995Date of Patent: August 17, 1999Assignee: Schering-Plough CorporationInventors: Deen Tulshian, Brian A. McKittrick, Yan Xia, Samuel Chackalamannil
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Patent number: 5874442Abstract: "Novel compounds, such as: ##STR1## are disclosed. Also disclosed are methods for inhibiting the abnormal growth of cells, for inhibiting farnesyl protein transferase and for treating cancers using the novel compounds.Type: GrantFiled: December 12, 1996Date of Patent: February 23, 1999Assignee: Schering-Plough CorporationInventors: Ronald J. Doll, Joseph M. Kelly, Alan K. Mallams, F. George Njoroge, Stacy W. Remiszewski, Arthur G. Taveras
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Patent number: 5767115Abstract: Hydroxy-substituted azetidinone hypocholesterolemic agents of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: Ar.sup.1 and Ar.sup.2 are aryl or R.sup.4 -substituted aryl;Ar.sup.3 is aryl or R.sup.5 -substituted aryl;X, Y and Z are --CH.sub.2 --, --CH(lower alkyl)-- or --C(dilower alkyl)--;R and R.sup.2 are --OR.sup.6, --O(CO)R.sup.6, --O(CO)OR.sup.9 or --O(CO)NR.sup.6 R.sup.7 ;R.sup.1 and R.sup.3 are H or lower alkyl;q is 0 or 1; r is 0 or 1; m, n and p are 0-4; provided that at least one of q and r is 1, and the sum of m, n, p, q and r is 1-6; and provided that when p is O and r is 1, the sum of m, q and n is 1-5;R.sup.4 is selected from lower alkyl, R.sup.5, --CF.sub.3, --CN, --NO.sub.2 and halogen R.sup.5 is selected from --OR.sup.6, --O(CO)R.sup.6, --O(CO)OR.sup.9, --O(CH.sub.2).sub.1-5 OR.sup.6, --O(CO)NR.sup.6 R.sup.7, --NR.sub.6 R.sup.7, --NR.sup.6 (CO)R.sup.7, --NR.sup.6 (CO)OR.sup.9, --NR.sup.6 (CO)NR.sup.7 R.sup.8, --NR.sup.6 SO.sub.2 R.sup.9, --COOR.sup.6, --CONR.sup.Type: GrantFiled: March 18, 1996Date of Patent: June 16, 1998Assignee: Schering-Plough CorporationInventors: Stuart B. Rosenblum, Sundeep Dugar, Duane A. Burnett, John W. Clader, Brian A. McKittrick
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Patent number: 5691362Abstract: Compounds represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein the variables are as defined in the specification; methods of treating asthma, cough, bronchospasm, inflammatory diseases, and gastrointestinal disorders with said compounds, and pharmaceutical compositions comprising said compounds are disclosed.Type: GrantFiled: June 5, 1996Date of Patent: November 25, 1997Assignee: Schering-Plough CorporationInventors: Kevin D. McCormick, Andrew T. Lupo, Jr.
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Patent number: 5686646Abstract: Disclosed are chiral hydrazine derivatives of the formula (Ia), (Ib), (Ic) and (Id) ##STR1## wherein: R.sup.1 and R.sup.2 are independently C.sub.1 -C.sub.10 alkyl;R.sup.3 is H or R.sup.4 wherein R.sup.4 is a hydroxy protecting group; andZ is H, --CHO, --C(O)OC(CH.sub.3).sub.3 or --C(O)OCH.sub.2 C.sub.6 H.sub.5.Also described is a process for preparing chiral hydrazines of the formula (Ia), (Ib), (Ic) and (Id).Type: GrantFiled: May 23, 1995Date of Patent: November 11, 1997Assignee: Schering-Plough CorporationInventors: David R. Andrews, Anantha Sudhakar
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Patent number: 5391706Abstract: A method of purifying granulocyte-macrophage colony-stimulating factor (GM-CSF), particularly recombinant human GM-CSF, in good yield and with retention of biological activity, comprising sequential anion-exchange, dye-ligand affinity, gel filtration and reversed-phase chromatography is disclosed.Type: GrantFiled: September 21, 1993Date of Patent: February 21, 1995Assignee: Schering Plough CorporationInventors: Paul P. Trotta, Gail F. Seelig, Robert A. Kosecki, Paul Reichert
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Patent number: 5382427Abstract: A method of using IL-4, the use of IL-4 for the manufacture of a medicament and pharmaceutical compositions containing IL-4, for treating solid tumor growth by systemically injecting IL-4, such as hIL-4 or recombinant E. coli--derived IL-4, into mammals afflicted with solid tumors is disclosed.Type: GrantFiled: March 4, 1993Date of Patent: January 17, 1995Assignee: Schering-Plough CorporationInventors: Marian L. Plunkett, Joseph J. Catino
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Patent number: 4676650Abstract: A method and apparatus for lighting a container which is to be inspected for particulate contamination comprising a first lighting means consisting of two angularly displaced light beams which create an angular shadow zone, a second lighting means of significantly lower intensity than said first lighting means and positioned intermediate the two light beams and a viewing means positioned in the shadow zone.Type: GrantFiled: November 18, 1983Date of Patent: June 30, 1987Assignee: Schering-Plough CorporationInventors: Paul M. Bjorndal, Julius Z. Knapp, John C. Zeiss
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Patent number: 4672078Abstract: A pharmaceutical preparation containing 1 to 50% urea and 0.05 to 30% of a lactone is disclosed. A preferred lactone is gamma-butyrolactone which is preferably present in an amount of about 0.05 to 0.1 part by weight per 1 part by weight of urea. The lactone stabilizes the urea with respect to various parameters including changes in pH. The pharmaceutical preparation may be any preparation with stabilized urea such as a skin lotion or cream used to moisturize skin, or a post surgical preparation because urea aids in debridement, dissolves coagulum and promotes epithelialization. Alternatively the preparation may be an injectable solution used in the treatment for mobilization of edema fluid, as urea is used for an osmotic diuretic.Type: GrantFiled: July 3, 1985Date of Patent: June 9, 1987Assignee: Schering-Plough CorporationInventors: Kirk Sakai, Timothy W. Quick
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Patent number: 4517200Abstract: Forskolin and its disclosed derivatives are useful as antiallergic agents. Certain of the derivatives are novel.Type: GrantFiled: October 17, 1983Date of Patent: May 14, 1985Assignee: Schering-Plough CorporationInventors: William Kreutner, Michael J. Green, Ho-Jane Shue, Anil K. Saksena
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Patent number: 4011390Abstract: Micromonospora inyoensis strain 1550F-1G NRRL 5742 is incapable of producing antibiotics unless an aminocyclitol is added to the fermentation medium. When such a compound is added, mutamicins are produced, said mutamicins being analogs of known aminoglycoside antibiotics differing therefrom with respect to the aminocyclitol subunit.Type: GrantFiled: June 5, 1974Date of Patent: March 8, 1977Assignee: Schering-Plough CorporationInventors: Marvin J. Weinstein, Peter J. L. Daniels, Gerald H. Wagman, Raymond Testa