Abstract: An arrangement includes: a holding device including holding elements; and containers, each of the containers including a container wall which at least partially surrounds a container interior. The container wall has an exterior surface which faces away from the container interior. Each of the containers is detachably held by at least one of the holding elements by contact of the at least one holding element to the exterior surface of the container wall of the respective container. Directly after the arrangement has been subjected to a transport simulation, a number of particles of a particle size of at least 5 ?m on the exterior surfaces of the containers does not exceed 2.7 particles per cm2 of a sum of surface areas of the exterior surfaces of all the containers, the transport simulation consisting of a rotational flat drop test and a random vibration test which are conducted in that order.

Abstract: Apparatuses and methods for inspecting a pharmaceutical cylindrical containers are provided. The apparatus includes a support device, a light emitting unit, and a light receiving unit. The support device supports the pharmaceutical cylindrical container and rotates the cylindrical pharmaceutical container around a longitudinal axis. The light emitting unit has a light source that illuminates the pharmaceutical cylindrical container with a detection beam while the support device rotates the pharmaceutical cylindrical container. The light receiving unit has a camera that acquires polarization information of the detection beam.

Abstract: A transport unit for a packaging structure for a plurality of containers for substances for pharmaceutical, medical or cosmetic uses includes a tray with a plurality of seats for positioning the containers and a planar inlay part for covering the containers positioned in the seats of the tray. The inlay part is configured to cover the containers positioned in the seats and at the same time to be received completely in the tray, without protruding above an upper edge of the tray. A plurality of depressions corresponding to the seats of the tray are formed in the inlay part, in order to position the containers at their two ends lying opposite each other. A gap is formed at least partially between the inlay part, received in the tray, and side walls of the tray.

Abstract: A device is provided that accommodates elongate receptacles and charges. The device includes a superior surface, a first positioning device, a detaining device, and either a pusher or a second positioning device. The first positioning device is adapted and arranged to accommodate a pairing of a charge and a corresponding elongate receptacle. The pusher is moveable along a direction towards the superior surface to introduce the charge into the elongate receptacle. The second positioning device accommodates the pusher with the second positioning device and the pusher being moveable along the direction towards the superior surface to introduce the charge into the elongate receptacle. The detaining device limits the extent of movement of the pusher towards the superior surface.

Abstract: At least one closed container includes a glass container having a total height, being characterized by a center axis and including a shoulder region; and a press-fit cap closing the glass container and including a cylindrical body having an upper end and a lower end. P is any given point at the lower end of the press-fit cap that is located above the shoulder region and that lies on a straight line running parallel to the center axis and hitting an outer surface of the shoulder region at a point Q. Among these points P at the lower end of the press-fit cap point P? is the one that has a smallest distance to its corresponding point Q? and a distance between points P? and Q? on the straight line is in a range from 0.17 to 8.4 mm.

Abstract: A holding structure for holding a plurality of containers for pharmaceutical, medical or cosmetic purposes includes a carrier having openings or receptacles for accommodating the containers. Holding devices for holding the containers are provided at the openings or receptacles. The holding devices can selectively assume two different stable positions, namely a first stable position in which the containers can be inserted without friction into the openings or receptacles and a second stable position in which the containers are held in the respective opening or receptacle by frictional engagement or by positive locking. The containers can be reliably inserted into the openings or receptacles without material abrasion. In the open insertion position of the holding devices, a large number of containers can be inserted concurrently into the openings or receptacles without high forces acting on the holding structure.

Abstract: A separating layer for the transport of pharmaceutical secondary packagings and to a transport system for transporting pharmaceutical secondary packagings which comprises the separating layer are provided. The separating layer is a polymer layer having a planar section extending in an axial direction along a longitudinal axis and an elevation extending normal to the longitudinal axis. The separating layer has in the axial direction a normal spring force that is 0.2 to 5 N.

Abstract: A separating layer for the transport of pharmaceutical secondary packagings and to a transport system for transporting pharmaceutical secondary packagings which comprises the separating layer are provided. The separating layer is a polymer layer having a planar section extending in an axial direction along a longitudinal axis and an elevation extending normal to the longitudinal axis. The separating layer has in the axial direction a normal spring force that is 0.2 to 5 N.

Abstract: A combination includes: a holding structure including receptacles which are arranged in a regular arrangement and are formed by peripherally formed side walls; containers received in the receptacles, the containers having a basic body which, at an upper end, merges into a shoulder portion which is adjoined by a narrowed neck portion with a widened upper edge with an opening; holding projections provided at lower ends of the receptacles and configured to hold the containers in the receptacles, the holding projections at the lower ends protruding radially inwards into the receptacles, the containers being supported directly on the holding projections; and centering elements provided above the holding projections and configured to center the containers in the receptacles. The centering elements have a beveled configuration and protruding into the receptacles in order to reduce a width of the receptacles at the lower ends thereof in a funnel shape.

Abstract: A holding structure for concurrently holding a plurality of containers for substances for pharmaceutical, medical or cosmetic applications includes a plurality of receptacles for receiving the containers therein at least in sections. The receptacles each have an open upper end for inserting the containers into the receptacles and a bottom end having a holding portion for limiting an axial movement of the containers in the receptacles. Guide portions are provided for guiding the containers as they are inserted into the receptacles. The guide portions are formed as guiding ribs extending in the longitudinal direction of the receptacles. Lead-in bevels are formed at upper ends of the guiding ribs which are inclined relative to the guiding ribs.

Abstract: A pharmaceutical container for drug delivery includes a barrel configured to slidably receive a stopper. The container exhibits a ratio of a break loose force (BLF) relative to a glide force (GF) of BLF/GF?2 during a break loose and glide force test and a total glide force variation TGFV=GFmax?GFmin measured when the stopper is moved from a start position to its end position is TGFV<2 N.

Abstract: A method for detecting and classifying defects in high-throughput transparent articles such as syringes, vials, cartridges, ampules, and bottles is provided. The method includes the steps of providing a stream of the articles; capturing a first digital image of each of the articles in the stream; inspecting the first digital image for objects; determining parameters of the objects; performing a first classification step to classify the objects into a first defect class and a second defect class; performing a second classification step to classify the objects into a plurality of defect types using at least two second classification models; comparing at least one object parameter of a classified object with a predetermined defect type dependent threshold; classifying the article as defective or non-defective based on the comparing step; and separating defective articles from non-defective articles.

Abstract: A transport structure for accommodating a plurality of vials for pharmaceutical, medical or cosmetic use under non-sterile conditions is formed by an accommodation member and by a bearing member releasably connected thereto. The accommodation member comprises a plurality of frustro-conical receptacles in a regular arrangement so that the vials can be accommodated upright and while preventing a direct contact between adjacent vials in the receptacles of the accommodation member. The transport structure comprises latching structures for releasable latching of the accommodation member with the bearing member.

Abstract: At least one system for storage of pharmaceutical compositions includes: a container including a neck and a crown that includes an upper crown surface; a stopper including a flange and a plug, the flange including a lower flange surface and a flange height; and a holding element configured to exert a force on the crown and the flange to form a horizontal contact area between the upper crown surface and the lower flange surface. The horizontal contact area has a size of 30 mm2 to 300 mm2 and the flange height is compressed at least partially in the horizontal contact area by 10% to 40%.

Abstract: A method for controlling a rotary drive of a hot forming machine having a plurality of processing stations arranged in a circular manner and a rotary table arranged thereabove, in which glass tubes to be processed are held and moved from one processing station to the next by a stepwise rotary movement, is provided. The rotary table is driven by a step gear by which a movement of a drive shaft is translated into a cyclic step movement, a step cycle of which comprises a movement phase and a subsequent standstill phase. A first value for the angular velocity of the drive shaft is assumed at a first time in the movement phase of the step cycle and a second value different from the first value is assumed at a second time in the standstill phase of the same step cycle.

Abstract: An arrangement includes a holding device for holding primary packaging containers. The holding device includes: a secondary packaging container which is designed and arranged for accommodating the primary packaging containers; holding elements of a first kind arranged in the secondary packaging container, each holding element of the first kind is designed and arranged to detachably hold a primary packaging container by contacting the primary packaging container at a first longitudinal position of the primary packaging container; and holding elements of a further kind arranged in the secondary packaging container. For each holding element of the first kind, a holding element of the further kind is designed and arranged to restrict a movement of the primary packaging container, which is held by the holding element of the first kind, in a lateral direction of the primary packaging container at a further longitudinal position of the primary packaging container.

Abstract: An arrangement includes: a holding device including holding elements; and contain-ers, each of the containers including a container wall which at least partially surrounds a container interior. The container wall has an exterior surface which faces away from the container interior. Each of the containers is detachably held by at least one of the holding elements by contact of the at least one holding element to the exterior surface of the container wall of the respective container. Directly after the arrangement has been subjected to a transport simulation, a number of particles of a particle size of at least 5 ?m on the exterior surfaces of the containers does not exceed 2.7 particles per cm2 of a sum of surface areas of the exterior surfaces of all the containers, the transport simulation consisting of a rotational flat drop test and a random vibration test which are conducted in that order.

Abstract: An arrangement includes a holding device for primary packaging containers including: a first component including first receptacles and spanning a first component plane; and a second component including second receptacles and spanning a second component plane. The first component and the second component superimpose one another such that each primary packaging container can be detachably accommodated in one of the first receptacles and the second receptacles such that the first component and the second component together restrict movement of the primary packaging container in one of the component planes and in a direction which is perpendicular to one of the component planes. For each of the first receptacles, there is one of the second receptacles which has a minimum distance from the first receptacle and, for each of the first receptacles, the minimum distance is predetermined by the second component, a third component of the holding device, or both.

Abstract: The present disclosure relates to a supporting structure for concurrently supporting a plurality of containers for substances for pharmaceutical, medical or cosmetic applications, having a plurality of receptacles for accommodating the containers therein at least partially. Each of the receptacles has an open upper end for inserting the containers into the receptacles and a lower end having a retaining portion for delimiting an axial movement of the containers in the receptacles. Guiding portions are provided for guiding the containers into the receptacles during insertion. The guiding portions can have upper guiding and positioning portions close to the upper ends of the receptacles and lower guiding and positioning portions close to the lower ends of the receptacles, which are formed separately from each other and delimit a radial movement of the containers in the receptacles.

Abstract: A method and device for the continuous heat treatment of pharmaceutical glass containers are provided. The method includes continuously conveying glass containers from an entry region to an exit region via a conveying installation having a separating plate made from an electrically conductive material, the separating plate being positioned above and/or below the conveying installation; heating the glass containers to a maximum temperature in a heating zone after passing the entry region; cooling the glass containers in a first cooling zone after passing the heating zone and before passing the exit region at a first cooling rate, wherein the separating plate separates the glass containers from heating installations in the heating zone and/or temperature changing installations in the first cooling zone; and controlling the heating installations and/or the temperature changing installations to inductively heat the separating plate in the heating zone and/or the first cooling zone.