Abstract: Described herein are nucleic acid molecules and complexes useful as i-switch pH reporters that have increased sensitivities as a pH reporter and have alternate pH reporting capacity ranges. Aspects of the disclosure relate to a method for determining pH comprising providing a nucleic acid complex comprising: a first single-stranded nucleic acid molecule comprising the sequence CnXCnYCnZCn (SEQ ID NO.
Type:
Grant
Filed:
September 3, 2021
Date of Patent:
February 13, 2024
Assignees:
The University of Chicago, The National Centre for Biological
Sciences
Abstract: An ophthalmic contact lens configured to treat color vision deficiency is presented herein. The contact lens includes a tinted region containing either or both of a first dye that is configured to absorb at least 50% of incident light in a spectral band between 480 nanometers to 500 nanometers and a second dye that is configured to absorb at least 50% of incident light in a spectral band between 550 nanometers to 580 nanometers. A method of manufacturing such a contact lens and a process of forming an ophthalmic contact lens by an additive manufacturing process is also presented.
Type:
Grant
Filed:
May 4, 2021
Date of Patent:
February 13, 2024
Assignee:
Khalifa University of Science and Technology
Abstract: The present disclosure relates generally to portable energy generation devices and methods. The devices are designed to covert formic acid into released hydrogen, alleviating the need for a hydrogen tank as a hydrogen source for fuel cell power. In particular, an electricity generation device for powering a battery comprising a formic acid reservoir containing a liquid consisting of formic acid; a reaction chamber capable of using a catalyst and heat to convert the formic acid to hydrogen and carbon dioxide; a fuel cell that generates electricity; a delivery system for moving converted hydrogen into the fuel cell; and a battery powered by electricity generated by the fuel cell is provided.
Type:
Grant
Filed:
January 27, 2022
Date of Patent:
February 13, 2024
Assignee:
King Abdullah University of Science and Technology
Abstract: The present invention belongs to the field of energy and environmental protection and particularly relates to an organic solid waste treatment device based on chemical-looping hydrogen production and a method for using the same. The device comprises a pyrolysis reactor and a sleeve-type chemical-looping reactor, the sleeve-type chemical-looping reactor comprises an inner cavity, an outer cavity annularly wrapping the inner cavity, a syngas output device, a hydrogen output device, a pyrolysis gas inlet device, and a water vapor inlet device, and the pyrolysis reactor can generate pyrolysis gas, which then is conveyed to the sleeve-type chemical-looping reactor through the pyrolysis gas inlet device.
Type:
Grant
Filed:
April 25, 2021
Date of Patent:
February 13, 2024
Assignee:
Huazhong University of Science and Technology
Abstract: The present disclosure relates to a seismic imaging free gas structure identification method and system. The method includes: acquiring a seismic imaging dataset, and annotating free gas structures in the seismic imaging sample data set to obtain a training dataset; using a generative adversarial network (GAN) to expand the training dataset for network training, wherein the GAN includes a generative network and a discrimination network; conducting domain conversion on original label data of the free gas training samples to obtain annotating labels; training a Bayesian neural network according to the free gas training datasets and labels, to obtain a free gas structure identification model; acquiring actual seismic imaging data of a target work area; and conducting, according to the actual seismic imaging data, identification by using the free gas structure identification model.
Type:
Grant
Filed:
January 18, 2023
Date of Patent:
February 13, 2024
Assignee:
Institute of Geomechanics, Chinese Academy of Geological Sciences
Inventors:
Hao Zhang, Chongyuan Zhang, Xingqiang Feng, Hui Shi
Abstract: Porous liquid-filtering membranes are provided having a boundary region substantially surrounding the pore region and having greater tear resistance than the pore region.
Type:
Grant
Filed:
December 8, 2020
Date of Patent:
February 13, 2024
Assignee:
Global Life Sciences Solutions Operations UK Limited
Abstract: An image recognition method, electronic device, and storage medium are provided and relate to the fields of artificial intelligence, computer vision, deep learning, image processing, and the like. The method includes: performing joint training on a first sub-network configured for recognition processing and a second sub-network configured for retrieval processing in a classification network by adopting an identical set of training data to obtain a trained target classification network, wherein, the first sub-network and the second sub-network are twin networks that are consistent in network structures and share a set of weights; and inputting image data to be recognized into the target classification network to obtain a recognition result. By adopting the method, the accuracy of the image recognition may be improved.
Type:
Grant
Filed:
June 28, 2021
Date of Patent:
February 13, 2024
Assignee:
Beijing Baidu Netcom Science and Technology Co., Ltd.
Abstract: Provided is a phosphor which emits near-infrared light upon irradiation of visible light or ultraviolet light. A phosphor in an embodiment of the present invention includes an inorganic substance which contains at least an Eu element, an M[3] element (M[3] is at least one selected from the group consisting of Al, Y, La and Gd.), a Si element and nitrogen element, and also contains, if necessary, at least one element selected from the group consisting of M[1] element (M[1] is Li element.), an M[2] element (M[2] is at least one element selected from the group consisting of Mg, Ca, Ba and Sr.) and an oxygen element, while the phosphor has a maximum value of an emission peak at a wavelength in the range of 760 nm or more and 850 nm and less upon irradiation by an excitation source.
Type:
Grant
Filed:
March 16, 2020
Date of Patent:
February 13, 2024
Assignee:
National Institute for Materials Science
Abstract: The present invention provides a disease model animal for tauopathies which reproduces the expression pattern of tau protein isoforms of adult human brain, that is, approximately equal amounts of 3R type tau and 4R type tau being expressed in the adult brain. The method for producing the disease model animal for tauopathies of the present invention comprises the steps of: preparing a tau seeds; and injecting the tau seeds in the brain of an animal carrying a mutation in the tau gene which fails to express the tenth exon. The animal carrying a mutation in the tau gene which fails to express the tenth exon may be produced by using any of the genome editing, gene targeting or base editing technologies.
Type:
Grant
Filed:
February 28, 2020
Date of Patent:
February 13, 2024
Assignee:
Tokyo Metropolitan Institute of Medical Science
Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
Type:
Grant
Filed:
November 9, 2021
Date of Patent:
February 13, 2024
Assignee:
Gilead Sciences, Inc.
Inventors:
Gayatri Balan, Mark J. Bartlett, Jayaraman Chandrasekhar, Julian A. Codelli, John H. Conway, Jennifer L Cosman, Rao V. Kalla, Zachary A. Kasun, Musong Kim, Seung H. Lee, Jennifer R. Lo, Jennifer A. Loyer-Drew, Scott A. Mitchell, Thao D. Perry, Gary B. Phillips, Patrick J. Salvo, Sundaramoorthi Swaminathan, Joshua J. Van Veldhuizen, Suet C Yeung, Jeff Zablocki
Abstract: A system and method for using a mobile device to capture the proper execution of a series of one or more tasks with pre-assigned constraints that are associated with a specific set of assets is disclosed herein. The assets have certain known physical attributes and characteristics and are configured in a known manner. The assets are preferably vehicles such as trucks.
Type:
Grant
Filed:
December 8, 2022
Date of Patent:
February 13, 2024
Assignee:
Platform Science, Inc.
Inventors:
John C. Kennedy, Don Son, Scott Kopchinsky, Emily Stuart, Jacob Fields, Brendan Wood
Abstract: Exemplary embodiments of the present disclosure provide a method and apparatus for managing a knowledge base, a device and a computer readable storage medium. The method for managing a knowledge base includes: forking, in response to receiving a request for modification of a rule for a first namespace, the rule to the first namespace, the rule being used to constrain structured data in a knowledge base; modifying, based on the request for modification of the rule, the rule in the first namespace; and adding the modified rule to a rule base associated with the knowledge base.
Type:
Grant
Filed:
November 7, 2019
Date of Patent:
February 13, 2024
Assignee:
Beijing Baidu Netcom Science and Technology Co., Ltd.
Abstract: A fiber-optic sensor matt detects movements of a person on the matt that cause microbending of a fiber-optic cable that is arranged into a symmetric pair of radial ring groups within the matt. There are no cross-over points or overlapping of the fiber-optic cable within the symmetric pair of radial ring groups that could cause fiber wear and noisy readings. Microbending of the fiber-optic cable pressed into a mesh modulates the light intensity received, which is analyzed to extract both respiration and heart BallistoCardioGram (BCG) waveforms by convolution with Daubechies dB5 wavelet and scaling functions. The reconstructed level-4 detail waveform is output as the extracted BCG, while the reconstructed level-6 approximation waveform is output as the extracted respiration waveform. Respiration and heart rates and variations can be generated from the extracted waveforms. An integrated Fast Wavelet Transform (FWT) using dB5 wavelet thus generates both respiration rate and heart rate.
Type:
Grant
Filed:
October 29, 2020
Date of Patent:
February 13, 2024
Assignee:
Hong Kong Applied Science and Technology Research Institute Company Limited
Inventors:
Qian Cheng Zhao, Tsz Chung Leung, Man Sang Kwok
Abstract: The present disclosure may provide a cooling plant system, a method of operating a cooling plant system and an energy storage and scheduling control system, the cooling plant system comprising one or more cooling towers; one or more thermal energy storage systems coupled to the one or more cooling towers; one or more electrical energy storage systems, the one or more electrical energy storage systems being coupled to the one or more thermal energy storage systems for selectively providing electrical energy to the one or more thermal energy storage systems; and an energy storage and scheduling control system coupled to the one or more thermal energy storage systems and the one or more electrical energy storage systems.
Type:
Grant
Filed:
October 17, 2018
Date of Patent:
February 13, 2024
Assignee:
Agency for Science, Technology and Research Singapore District Cooling Pte Ltd
Inventors:
Wuhua Hu, Chin Choy Chai, Wenxian Yang, Rongshan Yu
Abstract: Embodiments of the present disclosure disclose a flexible printed circuit, a light bar, a backlight module and a liquid crystal display device. The flexible printed circuit includes a substrate and a plurality of groups of LED pads located on the substrate, wherein each group of the LED pads is configured to mount one LED lamp bead, each group of the LED pads includes a first pad, a second pad and a third pad, the firs pad, the second pad and the third pad are arranged sequentially in a first direction, the first pad and the second pad both receive a first voltage signal, the third pad receives a second voltage signal, and the first voltage signal is different from the second voltage signal.
Type:
Grant
Filed:
September 25, 2020
Date of Patent:
February 13, 2024
Assignees:
BOE Optical Science and Technology Co., Ltd., BOE Technology Group Co., Ltd.
Abstract: The present invention belongs to the technical field of medicine, and relates in particular to a crystal form of a fibroblast growth factor receptor inhibitor shown in formula (I), and a preparation method therefor.
Abstract: Provided herein is the identification of insect RNAi target genes (IRTG) involved in gut microbial clearance and containment and examples of a novel biotechnology for devising pesticidal RNAi approaches.
Abstract: The invention relates to antibacterial compositions comprising micrococcin P1 and at least one additional antibacterial agent, which is preferably a bacteriocin or an antibiotic. The compositions may be used as an antibacterial, particularly for preventing or treating a bacterial infection.
Type:
Application
Filed:
September 14, 2021
Publication date:
February 8, 2024
Applicants:
Norwegian University of Life Sciences, Norwegian Institute of Bioeconomy Research
Inventors:
Dzung DIEP, Kirill OVCHINNIKOV, Christian KRANJEC, Tage THORSTENSEN