Abstract: Methods of treating an age-related disorder in a subject are provided. Aspects of the methods include administering to the subject a nucleic acid vector including a coding sequence for telomerase reverse transcriptase (TERT) and/or telomerase RNA (TR). Gene therapy methods are also provided. Aspects of the invention further include compositions, e.g., nucleic acid vectors and kits, etc., that find use in methods of the invention.

Abstract: A implantable neural electrode assembly is described. The implantable neural electrode assembly includes a plurality of open-ended rings alternatingly connected to a spine. An inner layer of the open-ended rings is formed from a drug-loaded material (e.g., silicone that has been loaded with a steroid) and an outer layer is formed from a drug-free material. One or more electrode assemblies are connected to the inner layer and oriented towards a center of a cylinder defined by the plurality of open-ended rings.

Abstract: An aramid-mica composite insulating nanopaper and a preparation method thereof are disclosed. A mixture of mica and urea is subjected to a solid-phase ball milling, to obtain nano mica modified with amino groups on the surface, which is then assembled with the aramid nanofiber by stepwise suction filtration according to the present disclosure, to form an ordered nanopaper, thereby obtaining an aramid-mica composite insulating nanopaper with ultra-high insulation performances.

Abstract: The present invention includes methods for selecting a therapy for improved cognition as well as prevention of cognitive loss/dysfunction using one or more endophenotypes comprising: obtaining a sample from a subject; measuring biomarkers that differentiate between an inflammatory, a metabolic, a neurotrophic, and a depressive endophenotype; and selecting a course of treatment for the subject based on whether the subject is scored as having a high or a low endophenotype for one or more of the inflammatory, a metabolic, a neurotrophic, and a depressive endophenotypes.

Abstract: A plunger head for a fluid injection device includes a transducer disposed in the plunger head to measure a compressive force when applied to the plunger head. The plunger head also includes a power source and a microcontroller disposed in the plunger head. The microcontroller is coupled to the power source and the transducer, and the microcontroller is coupled to enter a high-power mode in response to sensing application of the compressive force to the plunger head.

Abstract: To better understand the impact of glycemic events, some entities have begun examining the relationship between the blood glucose level and another physiological parameter. However, this relationship can be difficult to understand. Introduced here are computer programs and associated computer-implemented techniques for discovering glycemic events in a series of data values representative of blood glucose measurements and then altering the measurement schedule of a sensor capable of generating measurements in a dimension other than blood glucose based on the glycemic events. By altering the measurement schedule of the sensor, a diabetes management platform can better understand how, if at all, dimensions other than blood glucose are related to the glycemic health state of a subject whose blood glucose level is being monitored.

Abstract: A tidal current energy generating device includes a generator, a connecting shaft, an impeller and an adjustment assembly. The impeller includes an impeller hub and an impeller blade arranged thereon. The impeller hub is connected with the connecting shaft, and the generator is connected with the impeller hub. The impeller blade is driven under the action of a tidal current to drive the impeller hub to rotate synchronously around an axis of the connecting shaft, driving the generator to generate electricity. The adjustment assembly is connected with the impeller blade, and can be driven to swing under the action of the tidal current to drive the impeller blade to rotate around the axis of the impeller blade relative to the impeller hub, thereby adjusting the angle of the impeller blade.

Abstract: An SOI lateral homogenization field high voltage power semiconductor device, and a manufacturing method and application thereof are provided. The device includes a type I conductive semiconductor substrate, a type II conductive drift region, a type I field clamped layer, type I and type II conductive well regions, the first dielectric oxide layer forming a field oxide layer, the second dielectric oxide layer forming a gate oxide layer, a type II conductive buried dielectric layer, a type II conductive source heavily doped region, a type II conductive drain heavily doped region. The first dielectric oxide layer and the floating field plate polysilicon electrodes form a vertical floating field plate distributed throughout the type II conductive drift region to form a vertical floating equipotential field plate array. When the device is in on-state, high doping concentration can be realized by the full-region depletion effect form the vertical field plate arrays.

Abstract: Present disclosure provides a cooling device with safety features and methods for controlling temperature of the cooling device for safe cooling of target surface.

Abstract: A method for operating the 3D printing tool includes positioning a first material distribution barrel within a first barrel orifice, where a first barrel tip is disposed at a first end of the first material distribution barrel. The method further includes positioning a second material distribution barrel within a second barrel orifice, where a second barrel tip is disposed at a first end of the second material distribution barrel. The method further includes dispensing building material from the first material distribution barrel when the first material distribution barrel is substantially vertically oriented and a second material distribution barrel is oriented at an angle from the vertical.

Abstract: The present disclosure provides: a magnetoresistive element having a large magnetoresistance change ratio (MR ratio); and a magnetic sensor, a reproducing head and a magnetic recording and reproducing device.

Abstract: Methods and systems for identifying CNV membranes and vasculature in images obtained using noninvasive imaging techniques are described. An example method includes generating, by a first model based on at least one image of a retina of a subject, a membrane mask indicating a location of a CNV membrane in the retina. The method further includes generating, by a second model based on the membrane mask and the at least one image, a vasculature mask of the retina of the subject, the vasculature mask indicating CNV vascularization in the retina.

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R1, R5, W, X, Y1, Y2, and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: The present disclosure relates to a method for providing information for determining lung tumor through inhalation of a fluorescent contrast agent, more particularly to a method of inhaling a small amount of Indocyanine green. The present disclosure does not have the problem of the existing intravenous injection that the administered fluorescent contrast agent is distributed throughout the body. In addition, when comparing the cancer detection efficiency of inhalation administration and intravenous injection, the inhaled fluorescent contrast agent exhibits remarkably higher cancer detection effect than the intravenously injected fluorescent contrast agent.

Abstract: Systems and methods for tracking unintentional high amplitude muscle movements of a user and stabilizing a handheld tool are described. The method may include detecting motion of a housing of the handheld tool when manipulated by a user while the user is performing a task with a user-assistive device attached to an attachment arm of the handheld tool, and storing the detected motion in a memory of the handheld tool as motion data. Furthermore, the method may include controlling a first motion generating mechanism and a second motion generating mechanism by generating a first motion signal and a second motion signal that respectively drive the first motion generating mechanism in a first degree of freedom and the second motion generating mechanism in a second degree of freedom to stabilize motion of the user-assistive device attached to the attachment arm of the handheld tool.

Abstract: An in-situ steam thermal desorption process for remediating pesticide contaminated sites comprises S1, determining a contaminated layer; S2, primary steam injection; S3, secondary steam injection and regulator injection; wherein the regulator comprises the following components in parts by weight: 0.2-0.8 parts by weight of hyper-thermophilic microbial agent, 0.5-0.9 parts by weight of carbamyl phosphate, 2-3 parts by weight of cyclic 2,3-diphosphoglycerate, 3-4 parts by weight of ethylenediamine tetraacetic acid, 15-17 parts by weight of wort, and 5-6 parts by weight of sodium octadecyl sulfate; S4, tertiary steam injection; S5, conservation.

Abstract: A machine learning-based method for accelerating a generation of automated fraud or abuse detection workflows in a digital threat mitigation platform includes identifying a plurality of distinct digital event features indicative of digital fraud; automatically deriving a plurality of distinct digital event decisioning criteria based on the plurality of distinct digital event features and a digital event data corpus associated with a target subscriber; automatically constructing a probationary automated fraud or abuse detection workflow based on the plurality of distinct digital event decisioning criteria, and deploying the probationary automated fraud or abuse detection workflow to a target digital fraud prevention environment associated with the target subscriber.

Abstract: Provided are a protein L-derived immunoglobulin binding protein having an increased antibody dissociation rate under acidic conditions, and an affinity support using the same. Disclosed are an immunoglobulin binding protein comprising at least one mutant of an immunoglobulin binding domain, and an affinity support comprising a solid-phase support having the immunoglobulin binding protein bound thereto. A mutant of the immunoglobulin binding domain consists of an amino acid sequence having an identity of at least 85% with the sequence set forth in any one of SEQ ID NO:1 to SEQ ID NO:9 and a predetermined mutation, and the mutant has immunoglobulin ? chain binding activity.

Abstract: A laser driving device and a method for enabling a uniform light field, wherein the laser driving device is a high-power laser driving device that enables a uniform light field on the basis of a narrow-band low-spatial-coherence light and is provided for laser fusion. The narrow-band low-spatial-coherence light is configured as a seed of the laser driving device, an amplification and transmission unit amplifies the seed, a frequency conversion unit converts a frequency of the laser, and a focusing component is configured for laser focusing and uniform illumination.

Abstract: An anastomosis protection device, including: a protective sleeve located inside a tubular tissue and positioned correspondingly to an anastomotic stoma; a first fixing assembly provided on an outer wall of the tubular tissue, wherein the first fixing assembly comprises at least one electromagnetic member; a power supply assembly electrically connected to the electromagnetic member, used for supplying power to the electromagnetic member, wherein the electromagnetic member is configured to become magnetic when powered on; and a second fixing assembly provided on an inner surface of the protective sleeve, wherein the second fixing assembly and the electromagnetic member of the first fixing assembly are relatively fixed by means of magnetic attraction. The device provides an extension and retraction space for the tissue.