Patents Assigned to Sciences
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Publication number: 20230419694Abstract: A machine learning predictor model is trained to generate a prediction of the appearance of a tissue sample stained with a special stain such as an IHC stain from an input image that is either unstained or stained with H&E. Training data takes the form of thousands of pairs of precisely aligned images, one of which is an image of a tissue specimen stained with H&E or unstained, and the other of which is an image of the tissue specimen stained with the special stain. The model can be trained to predict special stain images for a multitude of different tissue types and special stain types, in use, an input image, e.g., an H&E image of a given tissue specimen at a particular magnification level is provided to the model and the model generates a prediction of the appearance of the tissue specimen as if it were stained with the special stain. The predicted image is provided to a user and displayed, e.g., on a pathology workstation.Type: ApplicationFiled: September 7, 2023Publication date: December 28, 2023Applicant: Verily Life Sciences LLCInventors: Martin Stumpe, Philip Nelson, Lily Peng
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Publication number: 20230417770Abstract: Methods for medical diagnosis of heat-related health conditions including heatstroke, compositions comprising RNA or protein biomarkers for heatstroke and heat-associated conditions, probes and primers and antibodies to such biomarkers.Type: ApplicationFiled: May 31, 2023Publication date: December 28, 2023Applicants: National Guard Health Affairs, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research CenterInventor: Abderrezak BOUCHAMA
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Publication number: 20230420703Abstract: The invention relates to a device and to a method for transferring a functional layer, in particular a catalyst-coated membrane (2) and/or a gas diffusion layer for a membrane electrode assembly, onto a first material web, wherein: precuts (20) of a functional layer are transferred onto a moving counter surface with a first spacing (x1); the precuts (20) are supplied by means of a second material web (3) with a second spacing; the first spacing (x1) is greater than the second spacing (x2); the second material web (5), at least in a handover portion for carrying over a precut (20) moves synchronously with a conveying speed of the counter surface and is braked relative to the conveying speed to change the spacing; and the dispensing edge (6) in the first transport direction (1) relative to the second material web (5) is adjusted in order to create a braking and acceleration section for the precuts (20) moving discontinuously with the second material web (5).Type: ApplicationFiled: October 8, 2021Publication date: December 28, 2023Applicant: OPTIMA life science GmbHInventors: Norbert Dylla, Johannes Jansen, Rolf Grotehusmann, Jürgen Gronemann, Philipp Winterer, Karl-Heinz Halder
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Publication number: 20230422319Abstract: A system (100) and method (250) for a temporary secure connection between a vehicle device (135) for a vehicle (1000) and wireless authorized network (60) is disclosed herein. The system (100) comprises a vehicle (1000) comprising a vehicle device (135) and a known service provider comprising a physical location (58), a server (56) and a wireless authorized network (60). The vehicle device (135) is configured to initiate an authorized transaction (65), authorized by an assigning authority (1105), for a service (66) over the wireless authorized network (60) with the known service provider (55).Type: ApplicationFiled: September 6, 2023Publication date: December 28, 2023Applicant: Platform Science, Inc.Inventors: John C. Kennedy, Don Son, Scott Kopchinsky, Matthew Garofalo
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Publication number: 20230414534Abstract: Topical compositions and methods for using topical compositions comprising tapinarof to treat mild to moderate atopic dermatitis or plaque psoriasis are described herein. Also described are clinical endpoints for treatment of subjects diagnosed with mild to moderate atopic dermatitis, wherein about 5% to about 35% of body surface area was affected, and Investigator Global Assessment (IGA) score was greater than or equal to 3. Also described are clinical endpoints for treatment of subjects diagnosed with chronic mild to moderate plaque psoriasis for greater than or equal to 6 months, wherein about 3% to about 20% of body surface area was affected, and Physician Global Assessment (PGA) score was greater than or equal to 2.Type: ApplicationFiled: September 1, 2023Publication date: December 28, 2023Applicant: Dermavant Sciences GmbHInventors: John E. KRAUS, James LEE
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Patent number: 11855453Abstract: A method for calculating a gross primary productivity of an ecosystem is provided. The application belongs to a technical field of gross primary productivity calculation, and includes: acquiring key parameters of the ecosystem and screening out standard parameters, where the key parameters include a gross primary productivity, a solar altitude angle and an atmospheric column material content; calculating factor parameter terms based on the standard parameters and ground water vapor pressure parameters; where the factor parameter terms include a photochemical term, a scattering term and a gross primary productivity term; and based on the factor parameter terms, acquiring a calculation model of a gross primary productivity through an energy balance principle of a photosynthetically active radiation; through the calculation model, acquiring a calculated value of the gross primary productivity of the ecosystem.Type: GrantFiled: June 27, 2023Date of Patent: December 26, 2023Assignee: Institute of Atmospheric Physics, Chinese Academy of SciencesInventor: Jianhui Bai
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Patent number: 11854283Abstract: The present disclosure provides a method for visual question answering, which relates to fields of computer vision and natural language processing. The method includes: acquiring an input image and an input question; detecting visual information and position information of each of at least one text region in the input image; determining semantic information and attribute information of each of the at least one text region based on the visual information and the position information; determining a global feature of the input image based on the visual information, the position information, the semantic information, and the attribute information; determining a question feature based on the input question; and generating a predicted answer for the input image and the input question based on the global feature and the question feature. The present disclosure further provides a device for visual question answering, a computer device and a medium.Type: GrantFiled: February 5, 2021Date of Patent: December 26, 2023Assignee: Beijing Baidu Netcom Science Technology Co., Ltd.Inventors: Pengyuan Lv, Xiaoqiang Zhang, Shanshan Liu, Chengquan Zhang, Qiming Peng, Sijin Wu, Hua Lu, Yongfeng Chen
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Patent number: 11850118Abstract: Techniques are disclosed for detecting a presence of a biological substance through an article such as a diaper. For example, a detection system causes a light source to transmit light through the article. The light includes a peak wavelength that corresponds to an excitation wavelength of a biological substance that may be present in the article. The detection system detects a measurement of light intensity within a range of emission wavelengths of the biological substance. By comparing the measurement of light intensity to a threshold, the detection system identifies a presence of the biological substance on the article.Type: GrantFiled: June 17, 2022Date of Patent: December 26, 2023Assignee: Verily Life Sciences LLCInventor: Brian Schiffer
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Patent number: 11849792Abstract: A head-mounted device capable of more highly accurately measuring the physical conditions of a wearer as a worker that are necessary for estimating the possibility of heat stroke is provided. A head-mounted device includes an outer shell; a first channel as a gap between a head of a wearer and the outer shell; a second channel provided in the outer shell and connected to the first channel; a fan configured to send air from one of the first channel and the second channel to the other; a salinity sensor configured to measure salt concentration of sweat of the wearer; a first humidity sensor configured to measure an absolute humidity of intake air entering one of the first channel and the second channel; and a second humidity sensor configured to measure an absolute humidity of exhaust air exiting from the other of the first channel and the second channel.Type: GrantFiled: March 12, 2020Date of Patent: December 26, 2023Assignees: Public University Corporation Suwa University of Science Foundation, Fujita CorporationInventors: Nobuaki Hashimoto, Yoshinori Kumita, Toshihito Kondo
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Patent number: 11850398Abstract: A therapeutic agent delivery system includes a catheter, a vascular occluder, a pressure sensor system, and a pump system. The vascular occluder is provided at a distal end of the catheter. The pressure sensor system is provided to sense pressure at a distal end of a catheter lumen, and provides feedback to the pump system. The pump system is adapted to control a rate of infusion of a therapeutic agent through the catheter lumen based on the pressure sensed by the pressure sensor system. A method includes deploying the vascular occluder in a vessel, and then sensing a pressure in the vessel. The therapeutic agent is infused into the vessel at a flow rate based on the sensed pressure in the vessel.Type: GrantFiled: May 9, 2019Date of Patent: December 26, 2023Assignee: TriSalus Life Sciences, Inc.Inventors: James E. Chomas, Aravind Arepally, David Benjamin Jaroch, Mike Bojanowski
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Patent number: 11852625Abstract: Described herein are systems and methods of collecting, processing, and analyzing breath exhaled from a subject. Specifically, described herein are systems and methods for minimizing the amount of breath needed for analysis. Further disclosed herein are systems and methods to analyze compounds contained in a subject's breath that are indicative of certain ailments and/or present in a low concentration in the subject's breath. The systems can include a reaction chamber, a breath inlet, a reactant inlet, a fluid atomizer, and a receiving substrate for analyzing the process subject's breath. The methods can include reacting a subject's breath with a reactant to analyze the contents of the subject's breath.Type: GrantFiled: April 15, 2020Date of Patent: December 26, 2023Assignee: Verily Life Sciences LLCInventors: Benjamin Krasnow, Eric Peeters
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Patent number: 11854745Abstract: A modified Ni—Ti—Ta dielectric material for multi-layer ceramic capacitor (MLCC) and a low-temperature preparation method thereof are provided. By using characteristics that radii of the Cu2+ ion and (Al1/2Nb1/2)4+ ion are close to those of Ni and Ti elements, respectively, Cu2+, Al3+ and Nb5+ ions are introduced into a Ni0.5Ti0.5TaO4 matrix for partial substitution, a negative temperature coefficient of dielectric constant of ?220±30 ppm/° C. is provided while a sintering temperature is significantly reduced, and deterioration factors of loss caused by sintering aids is reduced, so that the dielectric material applied to radio frequency MLCC with low loss, low cost and good process stability is prepared.Type: GrantFiled: April 27, 2023Date of Patent: December 26, 2023Assignee: Yangtze Delta Region Institute (Huzhou), University of Electronic Science and Technology of ChinaInventors: YuanYuan Yang, XiaoZhen Li, MengJiang Xing, YanLing Luo, HongYu Yang, QingYang Fan, Hao Li, YunSheng Zhao
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Patent number: 11850645Abstract: A method for preparing a multilayer metal composite pipe includes steps of: internally and externally grinding blank pipes; cleaning oil stains; assembling a multilayer metal pipe; drawing to reduce a diameter; performing high-speed friction welding at the pipe ends; performing heat treatment; performing four-roller cross-rolling; straightening; performing two-roller cold-rolling; performing cold-drawing to reduce the diameter; performing cold-expansion to reduce the diameter; performing precise cold-rolling; degreasing; brightening; performing surface grinding; cleaning dust; detecting multilayer metal interface bonding; detecting flaws; testing metal structure performance; and sizing and packaging.Type: GrantFiled: October 24, 2021Date of Patent: December 26, 2023Assignee: Taiyuan University of Science and TechnologyInventors: Zhibing Chu, Chun Xue, Duo Zhang, Dong Wei, Qianhua Yang, Cuirong Liu, Yugui Li
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Patent number: 11851696Abstract: The present invention relates to a recombinant microorganism which exhibits i) a conversion activity from D-ribulose-5-phosphate into D-arabinose-5-phosphate, increased in comparison with the same, non-modified microorganism; ii) a cleavage catalysis activity from D-arabinose-5-phosphate into D-glyceraldehyde-3-phosphate and glycolaldehyde, increased in comparison with the same, non-modified microorganism; iii) an oxidation activity from glycolaldehyde into glycolate, increased in comparison with the same, non-modified microorganism; and iv) an oxidation activity from glyceraldehyde-3-phosphate into 1,3-bisphosphoglycerate, decreased in comparison with the same, non-modified microorganism. The present invention also relates to a process for preparing glycolic acid from pentoses and/or hexoses, using such a recombinant microorganism.Type: GrantFiled: July 12, 2019Date of Patent: December 26, 2023Assignees: Institut National Des Sciences Appliquées De Toulouse, Centre National De La Recherche Scientifique, Institut National Recherche Pour L'Agriculture, L'Alimentation Et L'EnvironementInventors: Cléa Lachaux, Thomas Walther, Jean-Marie Francois
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Patent number: 11850449Abstract: An irradiation method and system for irradiating a target volume, the method comprising: providing thermal neutron absorbing nuclides (such as in the form of a high neutron cross-section agent) at the target volume; and producing neutrons by irradiating nuclei in or adjacent to the target volume with a beam of particles consisting of any one or more of protons, deuterons, tritons and heavy ions, thereby prompting production of the neutrons through non-elastic collisions between the atoms in the path of the beam (including the target) and the particles. The neutron absorbing nuclides absorb neutrons produced in the non-elastic collisions, thereby producing capture products or fragments that irradiate the target volume.Type: GrantFiled: September 14, 2018Date of Patent: December 26, 2023Assignees: Australian Nuclear Science and Technology Organisation, University of WollongongInventors: Mitra Safavi-Naeini, Andrew Stephen Chacon
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Patent number: 11855203Abstract: A power semiconductor device includes a P-type substrate, an N-type well region, a P-type body region, a gate oxide layer, a polysilicon gate, a first oxide layer, a first N+ contact region, a first P+ contact region, drain metal, a first-type doped region, and a gate oxide layer. An end of the P-type body region is flush with or exceeds an end of the polysilicon gate, wherein Cgd of the power semiconductor device is reduced and a switching frequency of the power semiconductor device is increased. A polysilicon field plate connected with a source is introduced over a drift region that is not only shield an influence of the polysilicon gate on the drift region, thereby eliminating Cgd caused by overlapping of traditional polysilicon gate and drift region, but also enable the power semiconductor device to have strong robustness against an hot carrier effect.Type: GrantFiled: July 5, 2021Date of Patent: December 26, 2023Assignee: University of Electronic Science and Technology of ChinaInventors: Ming Qiao, Liu Yuan, Zhao Wang, Wenliang Liu, Bo Zhang
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Patent number: 11851438Abstract: 1?-Cyano nucleoside analogs of Formula I and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.Type: GrantFiled: March 6, 2023Date of Patent: December 26, 2023Assignee: Gilead Sciences, Inc.Inventors: Mark J. Bartlett, Daniel H. Byun, Yifan Deng, Jennifer L. Cosman Ellis, Rao V. Kalla, Richard L. Mackman, Dustin S. Siegel, Xianhuang Zeng
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Patent number: 11850313Abstract: A tissue oxygenation composition comprising (a) an oxygenated solution or a solution containing an oxygen carrier and (b) hydrogen sulfide (H2S). The disclosure also relates to methods of preserving, reperfusing and/or transfusing tissue with a tissue oxygenation composition according to the present disclosure.Type: GrantFiled: December 18, 2020Date of Patent: December 26, 2023Assignee: The London Health Sciences Centre Research Inc.Inventors: Alp Sener, Smriti Juriasingani
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Patent number: 11851419Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.Type: GrantFiled: November 18, 2021Date of Patent: December 26, 2023Assignee: Gilead Sciences, Inc.Inventors: Gediminas J. Brizgys, James S. Cassidy, Chienhung Chou, Jeromy J. Cottell, Chao-I Hung, Kavoos Kolahdouzan, James G. Taylor, Nathan E. Wright, Zheng-Yu Yang
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Patent number: 11851568Abstract: This application relates to ink compositions, in particular ink compositions for use in continuous inkjet printing. The ink compositions are suitable for producing printed images for example with reduced printer error and good adhesion to low surface energy substrates, in particular, low energy substrates such as polypropylene, LDPE and HDPE. The ink composition contains a liquid carrier and carbon black. The ink composition has a surface resistance of at least 2 M?/sq after washing the printed deposit with the liquid carrier and an adhesion of 50% or more after applying an adhesive tape to the printed deposit and removing the adhesive tape.Type: GrantFiled: March 28, 2019Date of Patent: December 26, 2023Assignee: Domino Printing Sciences PLCInventors: Emanuela Morgan Beltrame, Mary Thomson