Abstract: A low-resolution imaging apparatus configured to form and transmit a low-resolution image of an object, includes: a low-resolution camera configured to form the low-resolution image of the object; a microcontroller including an analog-to-digital convertor (ADC) that converts the low-resolution image into a digital image; an energy harvesting module configured to provide power to the low-resolution camera and the microcontroller; and a radio frequency identification (RFID) unit configured to transmit the digital-converted low-resolution image. The microcontroller extracts pixel values of pixels at the same position in two consecutive frames of the low-resolution image formed by the low-resolution camera, and calibrates the low-resolution image by adjusting exposure of the pixels in which a difference between the extracted pixel values is greater than a threshold value.

Abstract: Disclosed are a memristor device, a method of fabricating the same, a synaptic device including a memristor device, and a neuromorphic device including a synaptic device. The disclosed memristor device may comprise a first electrode, a second electrode disposed to be spaced apart from the first electrode; and a resistance changing layer including a copolymer between the first electrode and the second electrode. The copolymer may be a copolymer of a first monomer and a second monomer, and the first polymer formed from the first monomer may have a property that diffusion of metal ions is faster than that of the second polymer formed from the second monomer. The second polymer may have a lower diffusivity of metal ions as compared with the first polymer. The first monomer may include vinylimidazole (VI). The second monomer may include 1,3,5-trivinyl-1,3,5-trimethylcyclotrisiloxane (V3D3). The copolymer may include p(V3D3-co-VI).

Abstract: A PTMC-based intestinal anastomosis stent of a bioabsorbable flexible elastomer and a preparation method therefor. The intestinal anastomosis stent that uses PTMC as a base material is prepared by using an electrospinning method, and an appropriate range suitable for being implanted into the body is screened out according to a degradation rate and a mechanical property. The stent is loaded with TCS having a bactericidal effect, so that the stent has a tissue repair adjustment function, enabling a wound to heal more quickly in a severe multi-bacterial intestinal environment, and for adjusting postoperative tissue healing and functional repair. An in-vivo animal intestinal anastomosis experiment is carried out, thus verifying the practical effects and the feasibility of the method.

Abstract: In some aspects, an electronic contact lens for treating dry eye is presented. According to some aspects, the electronic contact lens includes a concave surface configured to conform to an eye of a patient, a sensor configured to generate a signal indicative of an eyelid movement, and at least one capacitor configured to store energy used for stimulating the eye. The electronic contact lens may further include at least two electrodes coupled to the at least one capacitor, wherein the at least two electrodes are exposed to the concave surface and configured to deliver power from the at least one capacitor to stimulate the eye. The electronic contact lens further includes a processor coupled to the sensor and electrodes. The processor may be configured to compute a blink rate from the sensor output, and, based on the blink rate, activate the at least two electrodes to stimulate the eye.

Abstract: Disclosed is an unsupervised deep learning method, which simultaneously performs registration between diffusion weighted magnetic resonance images and quantification of diffusion parameters. The unsupervised deep learning method decreases a registration error caused by a contrast difference by comparing a similarity between images of the same contrast, increases the performance of registration, and increases the accuracy of quantifying magnetic resonance diffusion parameters.

Abstract: Genome-wide data is obtained, and data cleansing, data sparsity processing and bioinformatics feature extraction are performed on the obtained genome-wide data; model construction is performed based on the sparsity-processed genome-wide data and the bioinformatics features to obtain a preliminary hybrid model; model training, regularization, and interpretability enhancement are performed on the preliminary hybrid model to obtain a trained model weight and an interpretability analysis corresponding to the trained model weight; learning and uncertainty estimation are performed based on the trained model weight and to-be-predicted genome-wide data on the hybrid model to obtain an integrated prediction result and uncertainties corresponding to the integrated prediction result; and personalized medical advice and decision assistance are performed based on the integrated prediction result, the interpretability analysis, and the uncertainties corresponding to the integrated prediction result.

Abstract: Provided herein are polypeptides, compositions, and methods for use thereof for genetic and epigenomic engineering, including, genome editing and gene regulation. These polypeptides and compositions include nucleic acid binding domains that bind to a target nucleic acid of interest. The nucleic acid binding domains include repeat units derived from repeat units identified in proteins from animal pathogens such as bacterium of the order Legionellales and the species Legionella and Francisella.

Abstract: Provided is a novel PDGFR kinase inhibitor, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. Further provided are use and a method of the compound of formula (I) for preventing or treating conditions associated with PDGFR kinase activity, particularly use and a method for preventing or treating conditions associated with PDGFR? and/or PDGFR? kinase activity.

Abstract: The disclosure relates to the technical field of experimental detection. A portable experimental device for hazardous chemical and an experimental method thereof are provided. The technical scheme of the disclosure integrates hazardous chemicals information and data of a portable meeting-water air release test device data to construct a perfect hazardous chemicals database, and realizes rapid prediction and response to a fire scene through scene data collection, preprocessing and matching. The scene data of the portable device is received and processed, and is compared with the database information, the random forest model is used to train the chemical reaction prediction model, and the real-time detection data is predicted to obtain the second prediction result. and the test experimental results are shared to each mobile terminal in time to realize the rapid transmission and sharing of information.

Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: A method for automated ICSI includes receiving at least one droplet containing an egg in a dish placed on a stage. The method includes using an artificial intelligence/machine learning system (AI/ML system) and an imaging system to detect a zona pellucida. The imaging system includes a microscopy system, a camera system, and a lighting system. The method includes holding the egg using a robotic microtool and lowering a robotic pipettor into the droplet. The method includes using the AI/ML system and imaging system to determine an area at which to hold the egg and positioning the robotic microtool to that area. The method includes using the AI/ML system and imaging system to instruct the robotic microtool to apply negative pressure to hold the egg to the robotic pipettor. The method includes using the AI/ML system and imaging system to determine a target location where zona ablation should be performed.

Abstract: This patent describes a method and apparatus for harvesting fruits using a snap-off harvesting gripper. The method includes the following steps: identifying the pose of a target fruit according to an image perception; controlling the gripper to grip the target according to the pose; monitoring an acting force of the gripper acted on the fruit to be harvested, determining a connection status between the target's stem and the target fruit according to the acting force, and controlling the gripper to rotate the target fruit according to the connection status. The snap-off harvesting apparatus includes a multi-axis adjusting device, a gripping device, sensor assemblies and a control device. The apparatus features tension sensors for real-time force monitoring and a parallel finger mechanism using pulleys and ropes for adaptive gripping. The apparatus's first joint can rotate the fruit to break the stem without requiring arm movement, enhancing efficiency.

Abstract: Methods and apparatus for additive manufacture of an optical element corresponding with an energy transmissibility image. The optical element may include a contact lens or intraocular lens. The optical element may be formed via intermittent pinning of deposited polymerizable mixture, partial cure, and final cure of the deposited polymerizable mixture. A pattern of multiple defined areas may be manufactured, with each area representing an amount of energy transmissibility associated with each respective area.

Abstract: The present disclosure provides a MEMS micromirror with a high duty cycle, a micromirror array, and a preparation method thereof, wherein a plurality of first movable combs and a plurality of first fixed combs of the MEMS micromirror are located under the silicon layer of the reflector, which improves the duty cycle and effectively reduces the size of the MEMS micromirror while achieving large angle deflection in two directions. The silicon layer of the reflector has a reinforcing rib underneath, which effectively improves surface smoothness of the MEMS micromirror when the latter is still or moving. In addition, the MEMS micromirror has a variety of electrode lead-out forms including a double-sided electrode structure, and the electrode lead-out form during actual implantation can be selected as needed, which is conducive to the commercialization of MEMS micromirrors and micromirror arrays.

Abstract: A hydrogel microneedle patch based on a three-dimensional framework structure is provided and includes a hydrogel microneedle. A raw material of the hydrogel microneedle includes polyvinyl alcohol and aqueous dispersion of acrylic resin. the hydrogel microneedle is obtained by uniformly mixing and molding of the aqueous dispersion of acrylic resin and the polyvinyl alcohol. The hydrogel microneedle patch has good strength, excellent swelling property and puncture property. In addition, a preparation method and an application of the hydrogel microneedle patch are also provided.

Abstract: A method for performing a 3D point cloud object detection is provided. The method includes: receiving an object data comprising a point cloud of a plurality of sensed points; performing a grid-based key-points extraction on raw data points of the point cloud, so as to obtain one or more key-points; performing a hierarchical point-wise convolution on the raw data points of the point cloud according to the key-points, so as to obtain a plurality of target point-wise features; performing a location-aware 3D RoI pooling operation according to the target point-wise features, so as to obtain pooled point-wise features and pooled 3D voxels corresponding to the pooled point-wise features; performing 3D convolution operations on the pooled 3D voxels, so as to obtain represent data points, wherein each of the represent data points includes a represent feature; and inputting the represent data points into multi-layer perceptrons to obtain final predictions.

Abstract: A device positioning an object according to a given direction, including a frame, a holder for holding the object, the holder being movable relative to the frame according to the given direction, a main lever extending between a first point and a second point, said main lever being rotatably mounted to the frame via a first pivot link connecting the main lever and the frame at the first point of the main lever, the main lever being connected to the holder at a third point which is arranged between the first point and the second point, so that a displacement of the second point of the main lever relative to the frame according to the given direction causes displacement of the holder in said given direction.

Abstract: There is provided an apparatus for drawing a fibre, the apparatus comprising, a first outlet for dispensing a volume of a first polyionic polymer solution; and a second outlet for dispensing a volume of a second oppositely charged polyionic polymer solution; said second outlet disposed adjacent to the first outlet such that the polymer solutions dispensed therefrom are capable of contacting each other to form a fused droplet comprising a polyelectrolyte complex interface separating the first polyionic and second polyionic polymer solutions; wherein the fused droplet is arranged to move along a fibre drawing path under gravitational force in an opposing direction from the first and second outlets such that nascent fibre is drawn from the polyelectrolyte complex interface. There is also provided a method of drawing the fibre.

Abstract: Provided are a cell-containing hydrogel body and a method of producing the same, which enable simple and effective control of the size of a boundary surface for an interaction between cells. The method of producing a cell-containing hydrogel body includes: forming, under a gas phase, a first hydrogel droplet on a surface of a substrate, the first hydrogel droplet containing first cells being dispersed therein and a first hydrogel polymer; forming, under a gas phase, a second hydrogel droplet on the surface, the second hydrogel droplet containing second cells being dispersed therein and a second hydrogel polymer, the second hydrogel droplet being combined with the first hydrogel droplet; and forming, under a gas phase, a cell-containing hydrogel body on the surface by gelling a hydrogel droplet-combined body including a first droplet portion derived from the first hydrogel droplet and a second droplet portion derived from the second hydrogel droplet.

Abstract: An apparatus transfers object motion in a source space to a target space. The apparatus defines a mapping function from the source space to the target space based on feature points of the object-positioned source space, and feature points of the object-represented target space; determines a target root position corresponding to a root position of the object based on the mapping function; determines a target direction corresponding to a direction of the object, based on the mapping function; determines a target main joint corresponding to a main joint of the object based on the mapping function; determines a target sub-joint excluding the target main joint in the target space based on unique joint information of the object; and generates data representing the object motion in the target space by modifying a pose of the object in the target space to match the target main joint.