Abstract: A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.

Abstract: A manufacturing method for an electron source according to the present disclosure includes steps of: (A) cutting out a chip from a block of an electron emission material, (B) fixing a first end portion of the chip to a distal end of a support needle, and (C) sharpening a second end portion of the chip. The step (A) includes forming first and second grooves which constitute first and second surfaces of the chip in the block by irradiating a surface of the block with an ion beam. The first end portion of the chip includes the first surface and the second surface with the surfaces forming an angle ? of 10 to 90°. The step (B) includes forming a joint between the distal end of the support needle and the first end portion of the chip.

Abstract: A system includes a display, and a database including surgical videos, images of organs in a human body obtained from a medical imaging device, and images of disease in a human body obtained from the medical imaging device. A controller including a processor is coupled to memory, the database, and the display, and the memory stores information that when executed by the processor causes the system to perform operations. For example, the processor may determine first organ information from the images of the organs, and first disease information from the images of the disease. The processor my calculate a similarity score between the first organ information and the first disease information and second disease information and second organ information indexed to the surgical videos. The processor selects one or more of the surgical videos based on the similarity score, and displays the surgical videos on the display.

Abstract: A method for rapid reconstruction of a food source habitat of Leucogeranus leucogeranus by using a returned farmland is provided, including following steps: S1, selecting degraded farmland plots; S2, constructing a connected plot network; S3, improving local soil habitat elements; S4, coating water chestnut bulbs; S5, cultivating the water chestnut bulbs; and S6, regulating and controlling and managing a hydrological environment.

Abstract: Systems and methods for 3D printing hollow bodies, such as bodies having an exterior cylindrical shape with a hollow interior, are described. Such systems and methods utilize rotatable hollow print base supports having an interior size and/or shape that matches the desired exterior shape of the final printed structure. The printed bodies, methods, and systems enable printing of the desired hollow printed body from the outside-to-inside. They also allow easy production, customization, and modification of internal structures within the printed hollow body.

Abstract: Devices for detecting an analyte in a sample suspected of containing the analyte, are provided. The devices include bio-functional, nanostructured, isoporous membranes (BNIM) integrated organic electrochemical transistor (OECT), herein BNIM-OECT, for the rapid and sensitive detection of the presence of an analyte of interest, in a sample, for example, a biological sample. The membrane (i.e., BNIM) is physically separated from the OECT channel therefore the electronic device can be used multiple times. The isoporous membrane is functionalized to include a binding partner for the analyte being detected. The BNIM-OECT can be used for disease detection, by functionalizing the BNIM-OECT with a binding partner to an analyte associated with the disease, applying a collected biological sample to the BNIM-OECT. A decrease in channel current as a result of analyte binding to its binding partner on the isoporous membrane indicates the presence of the analyte in the sample.

Abstract: Various embodiments of a laser illumination system are disclosed. In an example, a system includes one or more lasers, a beam combiner (if multiple lasers are used) configured to direct a combined light beam along a path, a focusing optical element to receive the light beam and focus the received light towards a focus point, a MEMS mirror positioned to receive light from the focusing optical element and output a moving light beam, moving in an angular range ar1 and at a frequency f1, a collimating element configured to receive the beam output by the MEMS mirror and output a beam that is more collimated than the light received from the MEMS mirror, and a CLA positioned to receive the light beam from the collimating optical element, alter the received light beam, and output a substantially flat-top distribution of light that propagates through an objective lens to a target plane.

Abstract: A composition of matter is provided comprising hierarchically ordered crystalline microporous material having well-defined long-range mesoporous ordering of hexagonal symmetry. The composition possesses mesopores having walls of crystalline microporous material and a mass of mesostructure between mesopores of crystalline microporous material. Long-range ordering is defined by presence of secondary peaks in an X-ray diffraction (XRD) pattern and/or hexagonal symmetry observable by microscopy.

Abstract: An orthopedic distraction device is provided. The orthopedic distraction device includes a first upper paddle for engaging a first bone of a joint, a lower paddle for engaging a second bone of the joint and a displacement mechanism. The displacement mechanism includes a drive assembly operable to move the upper paddle relative to the lower paddle. The lower paddle is releasably connected to the displacement mechanism.

Abstract: This disclosure relates to a plasma generator including a porous ceramic dielectric. More specifically, this disclosure relates to a plasma generator for air purification capable of effectively generating ozone for removing bacteria, viruses, etc., and minimizing pressure loss while increasing air purification capacity by including a porous ceramic dielectric coated with an antibacterial material.

Abstract: This disclosure describes circuits and techniques for determining inductance on an electrical line. In some examples, a method comprises charging a capacitor in time steps to a voltage level; counting a number of the time steps to the voltage level, wherein the number of the time steps defines a coarse measurement inductance of the electrical line; measuring a charging rate associated with charging the capacitor within a measurement window that is defined at the voltage level, wherein the charging rate associated with charging the capacitor within the measurement window defines a fine measurement of the inductance of the electrical line; and outputting an indication of the number of time steps and an indication of the charging rate associated with charging the capacitor within the measurement window.

Abstract: A method for producing a gas sensor comprising a step of providing a substrate with two coplanar electrodes and a step of forming a ZnO nanowires network on the two electrode. The step of forming a ZnO nanowires network on the two electrodes is performed as follows: synthesizing ZnO nanowires with a liquid phase sequential growth method; dispersing the synthetized nanowires in a solvent; drop casting the solution containing the solvent and the ZnO nanowires on the electrodes; drying the solution at a temperature inferior to 85° C. Also, a gas sensor working at low temperature such as room temperature.

Abstract: Disclosed is a floating platform integrating wave attenuation with marine energy power generation and a working method thereof, the platform includes a breakwater, a tuned damping wave energy converter, and an offshore floating wind turbine. The breakwater includes double-cylindrical-boxes and connecting bulkheads, and a moon pool area is formed in a middle of the breakwater; the offshore floating wind turbine and the tuned damping wave energy converter are both connected to the breakwater through a connecting rod. A circular groove is formed on an inner side of each of the connecting bulkheads of the breakwater. The breakwater provides the floating base and power generation environment for the offshore floating wind turbine and the tuned damping wave energy converter, and a plurality of the tuned damping wave energy converters can be disposed, and are evenly distributed beneath the offshore floating wind turbine.

Abstract: The present invention relates to a compound of formula I or a pharmaceutically acceptable salt, a solvate, an active metabolite, a polymorph, an ester, an optical isomer or a prodrug thereof, a pharmaceutical composition comprising the compound of formula I, and use of the compound, as a Bruton's tyrosine kinase inhibitor with high selectivity for BTK(C481S) mutant, in the manufacture of a medicament for preventing or treating a heteroimmune disease, an autoimmune disease or a cancer.

Abstract: A low-friction long-life ultra-lattice composite coating as well as a preparation method and use thereof are provided. The ultra-lattice composite coating includes a titanium transition layer, a TiNx bearing layer, a TiNx/MoS2 gradient transition layer, a MoS2/Me gradient transition layer and a MoS2/Me ultra-lattice layer which are successively formed on the surface of a matrix; wherein, in a direction gradually far away from the matrix, the content of MoS2 in the TiNx/MoS2 gradient transition layer is increasing, and the content of MoS2 in the MoS2/Me gradient transition layer is decreasing. The ultra-lattice composite coating has excellent mechanical property and tribological performance, with a vacuum friction coefficient being below 0.02 and a friction life exceeding 4×106 revolutions, which can meet the requirements on ultra-low friction and ultra-long service life for aerospace vehicles.

Abstract: The present invention discloses a method for improving cadmium tolerance in rice and reducing cadmium content in rice grains, and belongs to the technical field of microbial applications. In the present invention, an endophytic fungi Falciphora oryzae FO-R20 with a deposit number of CCTCC M 2021505 is subjected to seedling co-raising with rice in a fungal fertilizer form, the endophytic fungi Falciphora oryzae FO-R20 is colonized in the root tissue of rice, and then the rice seedlings are transplanted to a field until harvest. Therefore, the tolerance of rice to cadmium is improved, the content of heavy metal cadmium in the grains of rice is reduced by 12.61%. The FO-R20 has great value by popularization and application in guaranteeing plant health and improving crop quality.

Abstract: Disclosed are a continuous-time delta-sigma analog-to-digital converter and an operation method thereof. More particularly, a continuous-time delta-sigma analog-to-digital converter, including: a linear integrator configured to generate a first output signal corresponding to a preset input voltage based on an operation of a linear Gm circuit that receives the preset input voltage; and a quantizer configured to generate a second output signal corresponding to the first output signal based on an operation of a body-driven VCO that receives the first output signal and to generate a digital output code corresponding to the second output signal based on an operation of a Frequency to Digital Converter (FDC) that receives the second output signal is disclosed.

Abstract: A system and method facilitates transfers of specimen containers (e.g., vials with caps) between storage cassettes and carrier cassettes. The storage cassettes are designed to be stored in cryogenic refrigerators while the carrier cassettes are designed to be temporarily stored in a portable carrier. Identification information is read from wireless transponders carried by the specimen containers. Visual mappings of the positions of the specimen container in the cassettes is provided. Presence and position of the specimen containers in the cassettes is verified, and alerts of inconsistencies provided along with corrective commands. Inventories of specimen container and even specific specimen holders are provided.

Abstract: A method and system for positioning and correcting visual data by seafloor topographic profiles are provided. The method includes: offsetting the water-depth profile of the target survey line equidistantly in a grid layer of a target area to make profiles generated after the offsetting traverse the grid layer of the target area, and obtaining offset data sequences corresponding to the water-depth profile of the target survey line; drawing offset topographic profiles based on offset data of the offset data sequences corresponding to the water-depth profile of the target survey line; calculating a profile similarity between the water-depth profile of the target survey line and each of the offset topographic profiles by using a dynamic time warping (DTW) algorithm; and selecting a geographic location of one of the offset topographic profiles with a largest profile similarity as an actual geographic location of a water-depth profile of a seafloor visual survey line.

Abstract: A molecular marker combination linked to quantitative traits of tea plant (+)-catechin content, including a SNP site 1, a SNP site 2, a SNP site 3, a SNP site 4, a SNP site 5, a SNP site 6, a SNP site 7 and a SNP site 8, which are located in tea genomes Scaffold4239:309117, Scaffold3614: 66549, Scaffold349: 3413816, Scaffold1989: 2316385, Scaffold451: 940283, Scaffold3727:442660, Scaffold115:803980 and Scaffold920:281727, respectively, and genotypes thereof are extremely significantly correlated with the (+)-catechin content is provided. A detection method for detecting each site, and one or more molecular marker site is used to evaluate the tea plant (+)-catechin content.