Patents Assigned to Sciences
  • Process for producing particles of a metal compound
    Patent number: 6919060
    Abstract: The object of the present invention is to provide a process for producing particles of a metal compound having a spherical particle shape and an average particle diameter larger than 0.3 ?m without employing high-pressure conditions. This object is achieved by a process for producing particle of a metal compound comprising a step of adjusting pH of an aqueous solution containing urea and at least one metal element to from 4 to 8, a step of heating the aqueous solution under normal pressure, a step of separating a solid from the solution, and a step of drying the solid.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: July 19, 2005
    Assignees: Sumitomo Chemical Company, Limited, National Institute of Advance Industrial Science and Technology
    Inventors: Keiji Ono, Susumu Miyazaki, Takayoshi Ezuhara, Yoshihiro Nishisu, Mikio Kobayashi
  • Antibodies to protein HPMBQ91
    Patent number: 6919433
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: July 19, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Yi Li, Zhizhen Zeng, Hla Kyaw, Carrie L. Fischer, Haodong Li, Daniel R. Soppet, Reiner L. Gentz, Ying-Fei Wei, Paul A. Moore, Paul E. Young, John M. Greene, Ann M. Ferrie, Gregg A. Hastings
  • Conjugates of agents and transglutaminase substrate linking molecules
    Patent number: 6919076
    Abstract: Methods, products, compositions and kits are provided for attaching agents to tissue with a linking molecule in the presence of transglutaminase. The linking molecule and/or agent is a substrate of transglutaminase. The agent can be a nonprotein or an enzyme such as cholinesterase or phosphodiesterase. The transglutaminase may be exogenously added or be endogenous in tissue. In specific embodiments, the agent is not a transglutaminase substrate and the linking molecule is a substrate for transglutaminase containing at least two contiguous linked glutamines or at least three contiguous linked lysines, and may be a polymer. A conjugate of the agent and the linking molecule may be applied to tissue, and in the presence of transglutaminase covalently bonded to the tissue via the linking molecule.
    Type: Grant
    Filed: July 22, 1999
    Date of Patent: July 19, 2005
    Assignee: Pericor Science, Inc.
    Inventors: Howard Green, Bruce Compton, George Corey, Philippe Djian
  • Antibodies to human tumor necrosis factor receptor TR9
    Patent number: 6919078
    Abstract: The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are antibodies, vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.
    Type: Grant
    Filed: January 10, 2002
    Date of Patent: July 19, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Guo-Liang Yu, Ping Fan, Reiner L. Gentz
  • Method for isolating satellite sequences
    Patent number: 6919443
    Abstract: A highly homogeneous library can be obtained by cleaving a genomic DNA by a sequence-independent cleavage method, such as sonication. By selecting satellite sequences from such a library, efficiency of isolation is improved. Thus, an efficient method of isolating microsatellite sequences, which are useful as DNA markers, is provided.
    Type: Grant
    Filed: July 1, 1999
    Date of Patent: July 19, 2005
    Assignee: National Institute of Agrobiological Sciences
    Inventors: Hideaki Takahashi, Masashi Sekino
  • Titanium dioxide cobalt magnetic film and its manufacturing method
    Patent number: 6919138
    Abstract: A mixture of TiO2 and Co is placed in a vacuum chamber under selected oxygen pressure and irradiated in the vacuum chamber with a selected laser light to cause TiO2 and Co to evaporate from the target and a layer of TiO2-Co to epitaxially grow on a heated single crystal substrate. The titanium dioxide-cobalt magnetic film for use in a photocatalyst, a semiconductor material having optical, electrical and magnetic functions, and a transparent magnet. The film is expressed by Ti1-xCoxO2 where 0<x?0.3, and wherein a Ti atom at its lattice position is replaced with a Co atom. The film has anatase or rutile crystalline structure, has its band gap energy varying in a range between 3.13 eV and 3.33 eV, retains its magnetization even at a temperature higher than a room temperature, and is transparent to visible light.
    Type: Grant
    Filed: August 17, 2001
    Date of Patent: July 19, 2005
    Assignee: Japan Science and Technology Corporation
    Inventors: Hideomi Koinuma, Yuji Matsumoto
  • Methods for disease detection
    Patent number: 6919174
    Abstract: The present invention provides methods for detecting disease by analysis of a patient sample to determine the integrity of nucleic acids in the sample.
    Type: Grant
    Filed: February 28, 2000
    Date of Patent: July 19, 2005
    Assignee: Exact Sciences Corporation
    Inventor: Anthony P. Shuber
  • Modified shine-dalgarno sequences and methods of use thereof
    Publication number: 20050153339
    Abstract: Novel Shine-Dalgarno (ribosome binding site) sequences, vectors containing such sequences, and host cells transformed with these vectors are provided. Methods of use of such sequences, vectors, and host cells for the efficient production of proteins and fragments thereof in prokaryotic systems are also provided. In particular embodiments of the invention, compounds and methods for high efficiency production of soluble protein in prokaryotic systems are provided.
    Type: Application
    Filed: December 7, 2004
    Publication date: July 14, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventor: Michael Laird
  • Human glycosylation enzymes
    Publication number: 20050153331
    Abstract: The present invention relates to novel human glycosylation enzyme polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human glycosylation enzyme polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human glycosylation enzyme polypeptides.
    Type: Application
    Filed: December 1, 2004
    Publication date: July 14, 2005
    Applicants: Human Genome Sciences, Inc., Johns Hopkins University
    Inventors: Timothy Coleman, Michael Betenbaugh
  • Regeneration and genetic transformation of acacia mangium
    Publication number: 20050155116
    Abstract: The present invention is directed to a method of Acacia mangium regeneration through organogenesis and a method of genetic transformation of Acacia mangium. The method of regeneration comprises inducing callus from different parts of seedlings and vegetatively micropropagated plantlets as explants; adventitious bud induction followed by pinnate leaf and bud elongation and eventually, elongated shoots were induced to root. Based on the regeneration system, a marker gene GUS under cauliflower mosaic virus promoter was introduced to Acacia mangium via Agrobacterium infection. GUS staining in the regenerated plants and Southern blot hybridization prove the incorporation of the foreign gene into the host genome and expression of the foreign gene.
    Type: Application
    Filed: December 9, 2004
    Publication date: July 14, 2005
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Deyu Xie, Yan Hong
  • Copolymer of propylene with a conjugated diene and a process of preparing the same
    Publication number: 20050154139
    Abstract: The present invention provides a new copolymer of propylene and a conjugated diene having a carbon-carbon double bond in a side chain, wherein a molar ratio of a total of 1,2-adducts and 3,4-adducts to 1,4-adducts, derived from the conjugated diene, is 100:0. The copolymer is prepared in a process, characterized in that propylene and the conjugated diene are copolymerized in the presence of hydrogen, an organometallic compound comprising a transition metal selected from the group 4 of the periodic table, and at least one Lewis acid.
    Type: Application
    Filed: September 17, 2004
    Publication date: July 14, 2005
    Applicants: Tonen Chemical Corporation, National Institute of Advanced Industrial Science and Technology
    Inventors: Takeshi Ishihara, Ban Hoang, Hideaki Hagihara, Kenji Tsuchihara, Takeshi Shiono
  • Biochip kit comprising biochip based on antigen-antibody reactions, and its usage
    Publication number: 20050153382
    Abstract: This invention concerns a biochip kit, comprising at least one biochip with at least one reactor, in which probe antibody and probe antigen are immobilized non-randomly in the form of probes array or/and probes pattern. This invention also concerns a method for testing a biological sample by using the kit. This kit can be used to analyze different target molecules corresponding to said probe antibody and probe antigen. By using this kit, the reactor number and the detection time needed for the analysis are reduced while the detection comparability is increased. So this kit has the advantage of being economical, timesaving and more efficient.
    Type: Application
    Filed: December 2, 2004
    Publication date: July 14, 2005
    Applicants: Chengdu Kuachang Science and Technology Co., Ltd., Human Plasma Product Services Asia Ltd.
    Inventors: Fanglin Zou, Chunsheng Chen, Jianxia Wang
  • Two-way broadcasting system allowing a viewer to produce and send a program
    Publication number: 20050151834
    Abstract: A program broadcasting system is provided with: a material server; a plurality of communication terminal apparatuses; and an information management server connected through a communication network. The material server comprises a material DB which accumulates material composing a program. The communication terminal apparatus comprises a program progress table and a HDD which accumulates the material. The information management server comprises a material index list DB which stores contents of the material corresponding to the material server or the communication terminal apparatus, and a program DB which stores the program progress table corresponding to the communication terminal apparatus. In accordance with the program progress table, the information management server instructs the material server to send the material, and the communication terminal apparatus to send or receive the material.
    Type: Application
    Filed: December 7, 2004
    Publication date: July 14, 2005
    Applicants: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, BROTHER KOGYO KABUSHIKI KAISHA, XING INC., UTAGOE, LTD.
    Inventors: Yuichi Yasutomo, Kazuhiro Omura, Kazuyuki Shudo, Tomonari Sonoda
  • Method for forming optical waveguide
    Publication number: 20050152657
    Abstract: The present invention provides a method for forming an optical waveguide characterized by applying a paste containing a copper compound to a glass substrate containing an alkali metal as a glass component over the whole surface thereof or in a patterned form, and performing heat treatment at a temperature lower than the softening temperature of the glass substrate. The method of the invention can produce an optical waveguide without the need for a high vacuum as in the thin film deposition method and without the use of a molten salt, and is capable of dispersing Cu+ ions selectively in a glass substrate with excellent controllability.
    Type: Application
    Filed: December 9, 2002
    Publication date: July 14, 2005
    Applicants: ISUZU GLASS CO., LTD, NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE
    Inventors: Tatsuya Suetsugu, Kohei Kadono, Norimasa Kominami, Takeshi Yokoi, Minoru Takada, Takashi Tarumi, Takashi Tarumi, Toshihiko Einishi, Tetsuo Yazawa
  • Colostrinin, and uses thereof
    Publication number: 20050152985
    Abstract: The use of Colostrinin as a medicament, particularly in the treatment of chronic disorders of the central nervous system and the immune system.
    Type: Application
    Filed: December 3, 2004
    Publication date: July 14, 2005
    Applicants: experimental Therapy, Polish Academy of Sciences, Georgiades Biotech Limited
    Inventors: Marin Janusz, Jozef Lisowski, Anna Dubowska-Inglot, Mieczyslaw Inglot
  • Dilutions in high throughput systems with a single vacuum source
    Publication number: 20050153459
    Abstract: Flow rates in a microfluidic device are modulated after performing serial dilutions by flow reduction channels that draw fluid from the main channel, thus reducing the flow rate. The reduction in flow rate and/or use of smaller dimension channels allow reduced reagent consumption. In addition, multiple flow reduction channels are used for multiple concentration measurements and for performing multiple assays simultaneously on a single sample. Also included are microfluidic devices and integrated systems for performing assays using serial dilutions, single pressure sources, multiple concentration measurements, and reduced reagent consumption. Devices comprising flow reduction channels are also used to suppress pressure perturbations from spontaneous injection.
    Type: Application
    Filed: December 6, 2004
    Publication date: July 14, 2005
    Applicant: Caliper Life Sciences, Inc.
    Inventors: Anne Kopf-Sill, Steven Sundberg, Andrea Chow, Claudia Poglitsch
  • Photodetector
    Publication number: 20050151061
    Abstract: Quantum wire is formed on the bottom of a V-shaped groove in a V-grooved substrate as a channel between source and drain electrodes or as at least part of the channel. A photocarrier accumulation region is provided within the quantum wire or at a position connected to or adjacent to the quantum wire for accumulating charges generated when light shines onto a photosensitive region that comprises at least a clad layer that covers the quantum wire. A recess is provided in the upper clad layer to localize the photocarrier accumulation region. As a result, it is possible to provide a photodetector that exhibits high sensitivity, high speed and low power consumption in an expanded wavelength region. It is also possible to provide a photodetector capable of constructing core portions thereof by one-time selective growth.
    Type: Application
    Filed: July 13, 2004
    Publication date: July 14, 2005
    Applicant: NAT. INST. OF ADVANCED INDUSTR. SCIENCE AND TECH.
    Inventors: Mutsuo Ogura, Yasushi Nagamune, Takeyoshi Sugaya
  • 44 human secreted proteins
    Publication number: 20050153335
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: December 3, 2004
    Publication date: July 14, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: David LaFleur, Steven Ruben, Craig Rosen, Paul Moore, Yanggu Shi, Hla Kyaw, Ying-Fei Wei
  • Bricklaying structure, bricklaying method, and brick manufacturing method
    Patent number: 6915614
    Abstract: A bricklaying structure, a bricklaying method and a brick manufacturing method that is adaptable to a variety of architectural details. Each brick is provided with a bolt hole and through-holes. The bolt hole has a diameter which allows a bolt to extend therethrough and the through-hole has a diameter for containing a nut. The bolt hole and through-holes are arranged on a longitudinal center line of the brick, and a center of the bolt hole, centers of the through-holes and respective end faces of the brick are spaced apart an equal distance from each other in a longitudinal direction of the brick. The bricks and metallic plates are vertically stacked and the bricks are integrally connected under pre-stress with each other by tightening the bolts extending through the vertical bolt holes.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: July 12, 2005
    Assignee: Japan Science and Technology Agency
    Inventor: Yasunori Matsufuji
  • Tissue factor pathway inhibitor-3
    Patent number: 6916629
    Abstract: The present invention relates to a novel TFPI-3 protein which is a member of the tissue factor protease inhibitor family. In particular, isolated nucleic acid molecules are provided encoding human TFPI-3 proteins. TFPI-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TFPI-3 activity. Also provided are diagnostic methods for detecting hemostasis system-related disorders and therapeutic methods for treating hemostatis system-related disorders.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: July 12, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Reiner L. Gentz, Tsu-An Hsu, Craig A. Rosen, Jian Ni