Abstract: The present invention relates to a porous particle composite for PCR, wherein the porous particle composite distributes photothermal nano-elements that generate heat by absorbing light in porous particles in which nucleic acid amplification occurs through temperature control so as not to adjust the temperature of the entire sample by using a hot plate or the like but to adjust the temperature inside the particles by irradiating light to the porous particles to allow nucleic acid amplification inside thereof, thereby reducing energy consumption and shortening diagnostic time.

Abstract: Methods herein disclosed include methods of producing a nanoporous membrane by coating a planar substrate (204) with a solution (solution tank 201) containing a reactive metal adatom. The coated planar substrate can then be perforated by initiating a redox reaction between the reactive metal adatom and the planar substrate that causes the reactive metal adatom to remove material, forming nanoscale pores in the planar substrate that result in a nanoporous planar material. This nanoporous planar material can be formed into a nanoporous membrane.

Abstract: The metallic crystal structures inspired edge-to-edge tessellations and a tessellation based lattice structures are disclosed. In accordance with an exemplary embodiment of the invention, basic unit lattice cells are stacked and connected to constitute a three-dimensional tessellations, wherein each of the basic unit lattice cells comprises a multiple flat connecting portions formed on a surface of the basic unit lattice cell and intersecting with a multiple of axes intersecting in a center of the basic unit lattice cell, and the flat connecting portions of one of the basic unit lattice cell is connected to the flat connecting portions of the adjacent basic unit lattice cell to constitute a connection structure of edge-to-edge tessellation. The formed tessellations are periodically tessellated in a design domain to form different tessellated lattice structures. The Functionally Tessellated (FT) lattice structures composed of different tessellations by interlocking into each other are also disclosed.

Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

Abstract: Methods are provided for diagnosing, detecting, or prognosticating a GEP-NEN based on the expression level score of biomarkers exhibiting differential expression in subjects having a GEP-NEN relative to a reference or control sample. The invention also provides compositions and kits comprising these biomarkers and methods of using these biomarkers in subsets or panels thereof to diagnose, classify, and monitor GEP-NEN and types of GEP-NEN. The methods and compositions provided herein may be used to diagnose or classify a subject as having a GEP-NEN, to distinguish between different stages of GEP-NENs, e.g., stable or progressive, to provide a measure of risk of developing a progressive GEP-NEN, and to gauge the completeness of treatments for GEP-NEN including, but not limited to surgery and somatostatin therapy.

Abstract: A fluid delivery system for continuous fluid flow includes a first inlet in fluidic communication with a first pump, a first pressure sensor for detecting a first fluid pressure downstream from the first pump, a second inlet in fluidic communication with a second pump, a second pressure sensor for detecting a second fluid pressure downstream from the second pump, an outlet, a valve including a first position and a second position, wherein the first position fluidically connects the first inlet with the outlet, and the second position fluidically connects the first inlet, the second inlet, and the outlet, and a controller system including a processor and memory.

Abstract: A production method for water for pure water includes adding polyaluminum chloride to raw water to produce first treated water, and filtering the first treated water in two or more stages including filtering with a filtration membrane device in a preceding stage to produce first concentrated water, and filtering the first concentrated water with a filtration membrane device in a subsequent stage. The water for pure water is produced as permeated water produced by the filtering in the two or more stages.

Abstract: A precursor is made of a polymer or the polymer and a high-temperature material. The polymer includes at least one of silicone material, cellulose, hydrogel, and acrylic acid ammonium salt polymer. The silicone material is silicone rubber, and the high-temperature material includes one of ceramics, glass, metal, diamond, and high-temperature composite material.

Abstract: The present disclosure relates to an electrode for a lithium metal battery, the electrode including: a current collector; and a silica layer containing plate-like porous silica, wherein pores of the plate-like porous silica have a cylindrical structure, and a lithium metal battery including the same. The formation of lithium dendrites on a surface of a negative electrode is prevented, such that stability of the battery may be improved and long-term cycle performance and rate capability may be improved.

Abstract: A job ontology generation and maintenance system and method may be used for B2B sales and marketing activity. The job ontology generation and maintenance system and method uses job titles and artificial intelligence to discover and maintain full job ontologies without requiring any information about the person that holds the title (including even basic details such as name).

Abstract: Disclosed is a brain-on-a-chip intelligence complex control system comprising a basic module and an information interaction and training module. The latter integrates a neural signal decoding unit, reward and punishment control unit, task control model, and mapping relationship model. The neural signal decoding unit transforms neural response data into external device-recognizable control instructions. Employed for controlling the external device, the task control model creates a future target control instruction based on task feedback, retrieving the corresponding neural response. The mapping relationship model establishes connections between the brain-on-a-chip's stimulation sequence and neural responses. Calculating task completion, the reward and punishment control unit generates a reward or punishment signal based on task feedback, applying it to the brain-on-a-chip basic module. This innovative brain-on-a-chip intelligence complex enhances control and training capabilities through integrated modules.

Abstract: A system for buoyant-particle-assisted cell therapy includes and/or interfaces with a set of buoyant particles. Additionally or alternatively, the system can include and/or interface with a processing container, a set of processing materials (e.g., buffers, factors, solutions, etc.), and/or any other components. A method for buoyant-particle-assisted cell therapy includes processing the set of cells of interest. Additionally or alternatively, the method can include any or all of: preparing a set of buoyant particles; receiving a sample; and isolating a set of cells of interest from the sample.

Abstract: A method for making a chitosan product from yeast cells is disclosed herein. Yeast cells are cultured to form a biomass of yeast cells. The yeast cells are induced to undergo meiosis causing the yeast cells to form asci containing ascospores wherein each ascospore contains a chitosan protective layer in the ascospore wall. Chitosan is extracted from the ascospores, purified to form purified chitosan, and precipitated and dried to form a chitosan product.

Abstract: A method for quantifying a structural feature forecast error of a meteorological element based on a graphical similarity is based on the concept of graphical similarity to propose a normalized evaluation technique for a forecast error of a scalar meteorological element such as rainfall, radar reflectivity, temperature, visibility, or wind speed. The method can objectively and truly reflect the true capability of forecasting the meteorological element such as precipitation.

Abstract: This application provides a pixel of an image sensor and an image sensor. The pixel may include an optical-to-electrical conversion circuit and a composite measurement circuit. The optical-to-electrical conversion circuit may be configured to generate a first current based on incident light that is incident on the pixel. The composite measurement circuit is coupled to the optical-to-electrical conversion circuit. The pixel may have a first operating mode and a second operating mode. The composite measurement circuit may generate a first pulse signal based on the first current when the pixel operates in the first operating mode, where the first pulse signal represents the intensity information of the incident light. When the pixel operates in the second operating mode, the pixel receives a plurality of sampling signals, and generates a plurality of second pulse signals based on the first current and the plurality of sampling signals.

Abstract: Method for evaluating cardiomyocytes using Raman scattering: a Raman spectrum of cardiomyocytes artificially induced to differentiate from pluripotent stem cells is acquired, an intensity of Raman-scattered light for a protein containing at least one of heme b and heme c as a prosthetic group is acquired from the Raman spectrum, and a state of progress of maturation of the cardiomyocytes is evaluated on the basis of the intensity of the Raman-scattered light. Method for evaluating differentiation into cardiomyocytes using Raman scattering: cells which are pluripotent stem cells are artificially induced to differentiate into cardiomyocytes, a Raman spectrum of the cells induced to differentiate is acquired, an intensity of Raman-scattered light for at least one of heme b and heme c is acquired from the Raman spectrum, and a state of progress of differentiation of the cells into cardiomyocytes is evaluated on the basis of the intensity of the Raman-scattered light.

Abstract: A method of inhibiting phosphorylation of the tau protein and/or a TLR4-mediated immune response is disclosed. The method contemplates administering to cells in recognized need thereof such as cells of the central nervous system an effective amount of a of a compound or a pharmaceutically acceptable salt thereof that binds to a pentapeptide of filamin A (FLNA) of SEQ ID NO: 1, and contains at least four of the six pharmacophores of FIGS. 35-40.

Abstract: Disclosed herein are an amorphous metal oxyhydroxide represented by Chemical Formula 1 below, a negative electrode active material for a secondary battery including the same, and a method for producing the same. MxOy(OH)z??[Chemical Formula 1] In [Chemical Formula 1] above, M is one or more selected from the group consisting of tin, aluminum, titanium, vanadium, chromium, manganese, iron, cobalt, nickel, gallium, zirconium, niobium, molybdenum, indium, and tantalum, and 0.4?x?0.7, 0.1?y?0.4, 1.6?z?1.9, y+z=2, and ?0.1?4x-2y-z?0.1.

Abstract: This application provides a chip, a dynamic vision sensor, and a method for outputting pixel information. The chip includes a pixel array and a processing circuit, and each pixel row in the pixel array includes at least two pixel groups. In the processing circuit, based on a change of a light intensity value of at least one pixel in a first pixel group, a first signal including row location information of the first pixel group in the pixel array is generated, and a second signal including column location information of a pixel row in which the first pixel group is located is generated. The first signal and the second signal are sent to a pixel output circuit, to enable the pixel output circuit to accurately output location information of the first pixel group whose light intensity value changes in the pixel array.

Abstract: A sieving device is described. The sieving device includes an adjustable sieve surface that includes a first sieve surface and a second sieve surface. Openings are formed in each of the first sieve surface and the second sieve surface so as to define a shared pathways extending through the adjustable sieve surface. The shared pathways are defined by a length dimension that is greater than a width dimension. The width dimension can correspond to a cephalothorax width of an insect.