Patents Assigned to Sciences
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Publication number: 20200262873Abstract: Provided are a protein L-derived immunoglobulin binding protein having an increased antibody dissociation rate under acidic conditions, and an affinity support using the same. Disclosed are an immunoglobulin binding protein comprising at least one mutant of an immunoglobulin binding domain, and an affinity support comprising a solid-phase support having the immunoglobulin binding protein bound thereto. A mutant of the immunoglobulin binding domain consists of an amino acid sequence having an identity of at least 85% with the sequence set forth in any one of SEQ ID NO:1 to SEQ ID NO:9 and a predetermined mutation, and the mutant has immunoglobulin ? chain binding activity.Type: ApplicationFiled: September 25, 2018Publication date: August 20, 2020Applicants: JSR CORPORATION, JSR Life Sciences Corporation, JSR Micro Inc., JSR Micro N.V.Inventors: Jun-ichi YASUOKA, Kiichi YOSHIMURA, Tomoaki HAGA
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Publication number: 20200263500Abstract: The invention discloses an anti-rotating device of non-rotating sleeve. The anti-rotating device is connected with the non-rotating sleeve in such way so that the anti-rotating device can transmit circumferential acting force to the non-rotating sleeve, thus the non-rotating sleeve are prevented from rotating, the anti-rotating device comprises an anti-rotating member and a resilient member, the anti-rotating member can move in a generally radial direction of the non-rotating sleeve, and the resilient member acts on the anti-rotating member and provides acting force being substantially radially outward for the anti-rotating member.Type: ApplicationFiled: March 2, 2018Publication date: August 20, 2020Applicant: Institute of Geology and Geophysics, Chinese Academy of SciencesInventors: Qingbo LIU, Qingyun DI, Tsili WANG, Wenxuan CHEN, Jiansheng DU, Yongyou YANG, Xinzhen HE, Linfeng HONG, Qijun XIE
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Publication number: 20200263259Abstract: Provided herein are a kit and method for detecting mutations in CTNNB1, and their use in detection and management of hepatocellular carcinoma (HCC). The kit comprises a first pair of primers, configured to specifically bind sequences flanking the genomic region for amplifying the genomic region in a first PCR reaction; and at least one clamp, each configured to bind to one first allele but not any second allele at an annealing temperature in the first PCR reaction to thereby selectively suppress amplification of the one first allele but still allow amplification of other second allele(s). A method for detecting or monitoring recurrence of HCC is further disclosed, which comprises determining levels of five DNA markers, including CTNNB1 mutations, hTERT mutations, TP53 mutations, RASSF1A methylation, and GSTP1 methylation.Type: ApplicationFiled: March 23, 2020Publication date: August 20, 2020Applicant: JBS Science Inc.Inventors: Wei Song, Surbhi Jain, Jamin Dean Steffen
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Publication number: 20200265976Abstract: Provided are: a novel magnetic material having high magnetic stability, in particular, having an extremely high saturation magnetization; and a method for producing the same, wherein the magnetic material, due to having a higher saturation magnetization than ferrite magnetic materials and a higher electrical resistivity than existing metallic magnetic materials, resolves problems such as eddy current loss. According to the present invention, Co-ferrite nanoparticles obtained by wet synthesis are reduced in hydrogen and subjected to grain growth, and bcc- or fcc-(Fe, Co) phases and Co-enriched phases are nano-dispersed using phase separation via a disproportionation reaction to prepare a magnetic material powder. In addition, the magnetic material powder is sintered into a solid magnetic material.Type: ApplicationFiled: September 20, 2018Publication date: August 20, 2020Applicant: National Institute of Advanced Industrial Science and TechnologyInventors: Shinpei Yamamoto, Nobuyoshi Imaoka, Kimihiro Ozaki
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Publication number: 20200263503Abstract: A hybrid rotary guiding device, includes: rotating shaft, the rotating shaft is used to drive the head of a drill tool to rotate, the rotating shaft includes an upper shaft portion, a lower shaft portion, and a steerable portion, a separation distance exists between the upper shaft portion and the lower shaft portion in the axial direction, the upper shaft portion and the lower shaft portion are steerably connected by the steerable portion; the upper shaft portion is installed with at least three first hydraulic mechanisms, and the lower shaft portion is installed with at least three second hydraulic mechanisms, the second hydraulic mechanism is adapted to drive a pushing member against the wall of the well to guide the head of a drill tool, the first hydraulic mechanism and the second hydraulic mechanism are configured so that the first hydraulic mechanism can drive the second hydraulic mechanism to drive the pushing member.Type: ApplicationFiled: March 2, 2018Publication date: August 20, 2020Applicant: Institute of Geology and Geophysics, Chinese Academy of SciencesInventors: Qingbo LIU, Qingyun DI, Tsili WANG, Wenxuan CHEN, Jiansheng DU, Yongyou YANG, Xinzhen HE, Linfeng HONG, Qijun XIE
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Publication number: 20200261419Abstract: Provided herein are methods of treatment for kidney stones, e.g., for controlling or inhibiting the formation of calcium oxalate kidney stones by inhibiting the production of glyoxylate and/or oxalate, treatment of primary hyperoxaluria, etc. In some embodiments, methods comprise administering to a subject in need thereof, in combination, an inhibitor of hydroxyproline dehydrogenase (HYPDH), an inhibitor of glycolate oxidase (GO), and/or another agent for the treatment of kidney stones. Compositions for such use or the use of active agents in the manufacture of a medicament for the treatment of kidney stones are also provided.Type: ApplicationFiled: December 7, 2016Publication date: August 20, 2020Applicant: Wake Forest University Health SciencesInventors: W. Todd Lowther, Ross P. Holmes, Daniel Yohannes
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Publication number: 20200261828Abstract: A deep cone thickener with an underflow concentration rapid auto-adjustment pertains to the technical field of mining tailing disposal. The thickener includes a shell body, a dilution flocculation system, a shearing dewatering system, an underflow circulatory system, and an auto-control system. The shell body includes a thickener pool wall, a cone body, and a collection cylinder. The dilution flocculation system includes a feed pipe, a flocculant charging pipe, and a central feed well. The shearing dewatering system includes a drive motor, a drive shaft, and a rake. The underflow circulatory system includes discharging valves, underflow pumps, circulatory pipes, and a concentration meter. The auto-control system includes a PLC control system. During the underground paste filling, the dilution flocculation system and shearing dewatering system can form a paste slurry. When there is no need for underground backfill, the underflow circulatory system is used to lower the underflow concentration rapidly.Type: ApplicationFiled: May 30, 2018Publication date: August 20, 2020Applicant: University of Science and Technology BeijingInventors: Aixiang WU, Shaoyong WANG, Zhuen RUAN, Shenghua YIN, Hongjiang WANG, Yiming WANG, Jiandong WANG
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Publication number: 20200260699Abstract: Embodiments of the present disclosure can provide an automated mass rearing system for insect larvae. The automated mass rearing system can facilitate hatching, feeding, monitoring the growth and emergence of insect larvae and pupae. In some embodiments, the automated mass rearing system can include a production unit, a transportation unit, a storage unit, a dispensing unit, and a monitoring unit. In some embodiments, this automated mass rearing system can facilitate mass mosquito growth from egg hatching all the way through to full adults or certain stages in between such as the larvae rearing process (i.e., from larvae to pupae) with little or no human intervention. By automating the rearing and transportation of insect eggs, larvae, and pupae, deaths or developmental issues can be minimized. Various techniques and apparatuses are used in this automation that causes minimal disturbance to the insects during development, and thereby maximizing survival rate and fitness of the insects.Type: ApplicationFiled: April 23, 2020Publication date: August 20, 2020Applicant: Verily Life Sciences LLCInventors: Peter Massaro, Robert Sobecki, Charles Behling, Victor Criswell, Tiantian Zha, Roman Devengenzo
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Process for separating electrode for membrane-electrode assembly of fuel cell and apparatus therefor
Patent number: 10749197Abstract: Disclosed are a process for separating an electrode for membrane-electrode assemblies of fuel cells from the decal transfer film and an apparatus for separating the electrode. In particular, during the electrode separating process, only an electrode is separated from the decal transfer film on which the electrode is coated, without any damage, by a freezing method for freezing the specimen on the deionized water surface, and thus, wasting the expensive MEA is prevented. Thus, mechanical properties of the pristine electrode can be rapidly quantified in advance, and therefore, long term durability evaluation period during developing MEA having excellent durability is substantially reduced.Type: GrantFiled: March 19, 2018Date of Patent: August 18, 2020Assignees: Hyundai Motor Company, Kia Motors Corporation, Korea Advanced Institute of Science and TechnologyInventors: Bo Ki Hong, Byeong-Heon Jeong, Taek-Soo Kim, Jae-Han Kim, Sanwi Kim -
Patent number: 10746708Abstract: The present invention relates to a rotary valve and to a chromatography system comprising such a rotary valve. The rotary valve comprising a stator with an inner stator face, and a rotor with an inner rotor face arranged in sealing contact with the inner stator face, the rotor (1) is rotatably movable to a plurality of rotor positions about a rotational axis (RA) relative to the inner stator face (202), wherein the stator comprises ports and orifices and the rotor comprises two or more rotor interconnection paths for selective fluidic interconnection of said orifices with respect to the rotor position and wherein the rotor interconnection paths are arranged to in a rotary position connect the first orifice (S) to the fourth orifice (LF), the second orifice (W) to the third orifice (LE). And in a rotary position connect the eight orifice (SP) to the seventh orifice (PCFP). And in a rotary position connect the eight orifice (SP) to the fifth orifice (TC), the sixth orifice (FC) to the seventh orifice (PCFP).Type: GrantFiled: March 23, 2016Date of Patent: August 18, 2020Assignee: GE Healthcare Bio-Sciences ABInventor: Bjorn Markus Olovsson
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Patent number: 10748654Abstract: Systems and methods are provided for improving communication by various computing systems in a network. Each computing system can be used to receive and process data. The data can be associated with a process represented by a chain of tasks. The computing systems can determine various parameters associated with the chain of tasks for determining a risk associated with the chain of tasks. The computing system can also determine a risk associated with multiple chains of tasks and aggregate the risks associated with the multiple chains of tasks. Determining the risk associated with each chain of tasks in the multiple chains of tasks can normalize a risk represented by the chains of tasks. Determining the risk associated with each chain of tasks or normalizing the risks represented by the chains can improve communication by the various computing systems in the network.Type: GrantFiled: June 27, 2016Date of Patent: August 18, 2020Assignee: PRA Health Sciences, Inc.Inventors: Piotr J. Chaba, Daniel J. Baker
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Patent number: 10746990Abstract: A multi-focal augmented reality device may include a multi-focal display that provides a plurality of images output from a plurality of image-providing devices and located at different depths and an augmented reality image synthesis device that synthesizes the plurality of images provided by the multi-focal display and an external image.Type: GrantFiled: September 12, 2018Date of Patent: August 18, 2020Assignee: Korea Institute of Science and TechnologyInventors: Soongi Park, Minkoo Kang, Sungkyu Kim
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Patent number: 10746847Abstract: The present invention relates to wireless localization method and apparatus of high accuracy, and measures strength of at least one signal that is transmitted from at least one fixed node, estimates a relative position of a moving node, generates a change pattern of at least one signal strength according to relative changes in positions of the moving node over a plurality of time points from at least one signal strength and the relative position of the moving node, and estimates an absolute position of the moving node, based on a comparison between the change pattern of the at least one signal strength and a map of a distribution pattern shape of signal strength in a region where the moving node is located. Accordingly, it is possible to accurately estimate a position of a moving node using a radio signal which not only accurately estimates the position of the moving node even in a change of wireless environment but also has almost no change in signal strength over a wide region.Type: GrantFiled: December 28, 2017Date of Patent: August 18, 2020Assignee: Korea Institute of Science and TechnologyInventors: Taikjin Lee, Youngmin Jhon, Jaehun Kim, Boseon Yu, Beomju Shin, Jaewon Bang
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Patent number: 10744124Abstract: Human therapeutic treatment compositions comprise at least two of a curcumin component, a harmine component, and an isovanillin component, and preferably all three in combination. The agents are effective for the treatment of human conditions, especially human cancers.Type: GrantFiled: December 23, 2019Date of Patent: August 18, 2020Assignee: Ankh Life Sciences LimitedInventors: Gene H. Zaid, Thomas W. Burgoyne
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Patent number: 10744235Abstract: A degradable, removable, pharmaceutical implant for the sustained release of one or more drugs in a subject, wherein the pharmaceutical implant is composed of a tube comprising an outer wall made of a degradable polymer completely surrounding a cavity, wherein the outer wall has a plurality of openings and wherein the cavity contains one or more sets of micro-particles, which micro-particles contain an active agent or a combination of two or more active agents, and wherein the size of the microparticles is selected such that the majority of the microparticles cannot pass through the openings.Type: GrantFiled: June 10, 2014Date of Patent: August 18, 2020Assignee: Janssen Sciences Ireland Unlimited CompanyInventors: Lieven Elvire Colette Baert, Iksoo Chun, Guenter Kraus, Deborah M. Schachter, Qiang Zhang
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Patent number: 10744001Abstract: An intervertebral implant includes a body formed as an open lattice structure by a plurality of struts. Some of the struts of the plurality of struts intersect at nodes. The nodes can include an enlarged contact member that extends over the node and at least a portion of the width of some of the struts. Enlarged contact members may have an asymmetrical shape with respect to the intersection of struts. The enlarged contact members can provide improved bone contact for the implant. The plurality of struts can have a cross-sectional shape that includes a flattened portion. The flattened portion of the plurality of struts can provide improved bone contact for the implant. An additive manufacturing process can be used to build the implant in a substantially vertical direction.Type: GrantFiled: November 21, 2017Date of Patent: August 18, 2020Assignee: Institute for Musculoskeletal Science and Education, Ltd.Inventor: James A. Sack
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Patent number: 10745037Abstract: A continuous measurement method for a wheel/rail vertical force includes: continuously arranging classic wheel/rail vertical force unit measurement areas in a form of “shear force+support force” on rails, where adjacent unit measurement areas share an end shear force measurement, and each two adjacent unit measurement areas form a unique compound measurement area; obtaining the wheel/rail vertical force when a wheelset passes the unit measurement areas other than the transition area of shear force measurement by using the classic unit measurement areas; obtaining the wheel/rail vertical force when the wheelset passes the transition area of the shared shear force measurement by using the unique compound measurement area; and combining all wheel/rail vertical forces on the unit measurement areas and the compound measurement areas to obtain a long distance fully continuous wheel/rail vertical force of the wheelset.Type: GrantFiled: April 28, 2015Date of Patent: August 18, 2020Assignees: China Academy of Railway Sciences, Locomotive & Car Research Institute of China Academy of Railway Sciences, Railway Engineering Research Institute of China Academy of Railway Sciences, Beijing Zongheng Electro-Mechanical Development Co., CR Technological Development CorporationInventors: Yuqing Zeng, Xuwei Li, Weidong Yu, Xuesong Chai
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Patent number: 10745740Abstract: The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.Type: GrantFiled: May 20, 2013Date of Patent: August 18, 2020Assignee: Qiagen Sciences, LLCInventors: Steven Gordon, Phillip A Veatch
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Patent number: 10746609Abstract: The present invention relates to a patch type thermometer containing a polymer that can be phase changed from a solid phase to a liquid phase. The patch type thermometer provided in an aspect of the present invention demonstrates high precision since it does not include conductive particles which have been a reason of disadvantage of the conventional temperature sensor, and has the effect of no temperature deviation in repeated temperature measurements because it is composed of such a single polymer material that is phase changed in a specific temperature range so that the polymer material can be reversibly changed in the volume and shape.Type: GrantFiled: July 16, 2019Date of Patent: August 18, 2020Assignee: Daegu Gyeongbuk Institute of Science and TechnologyInventors: Sungwon Lee, Wooseong Jeong
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Patent number: D893727Type: GrantFiled: March 6, 2019Date of Patent: August 18, 2020Assignee: Xuzhou Yongkang Electronic Science Technology Co., Ltd.Inventors: Xuecheng Zhao, Zhaohao Qiu, Qingyuan Li