Abstract: Certain embodiments described herein are directed to chromatography systems that include a microfluidic device and that implement one or more methods to direct sample to a desired fluid flow path. The methods can be used to backflush a sample to a desired fluid flow path to select certain analytes within a sample.

Abstract: The present invention relates compounds of the formula: or pharmaceutically acceptable salts thereof, useful as sodium channel blockers, as well as compositions containing the same, processes for the preparation of the same, and therapeutic methods of use therefore in promoting hydration of mucosal surfaces and the treatment of diseases including cystic fibrosis, chronic obstructive pulmonary disease, asthma, bronchiectasis, acute and chronic bronchitis, emphysema, and pneumonia.

Abstract: A membrane gas-liquid contactor is arranged to define a fluid flow path for contact with a membrane in a manner to improve degassing efficiency. A degassing module housing the membrane is arranged with flow fields for distributing the fluid flow throughout the membrane contact area. The distributed fluid flow may have a uniform membrane contact opportunity.

Abstract: Disclosed is a VR (Virtual Reality) device for diagnosis of nerve disorder, system and method thereof, wherein the device comprises: a display part providing a user with a VR environment in response to an image; and a user response receiver receiving a user response relative to the image, and wherein the image includes an introduction video included with two or more characters, and a question video image provided subsequent to the introduction video to include an inquiry related to the characters, whereby a user's linguistic competence, visual ability and associative ability can be comprehensively evaluated, and more accurately grasp a degree of user's nerve disorder can be accurately grasped without being influenced by a user's academic background and age.

Abstract: In accordance with, the present invention, there is provided an antimicrobial composition comprising an aqueous solution containing copper and/or zinc ions, optionally a hydroxide salt, and phosphorous acid. The composition, is additionally sporicidal and scleroticidal when combined with a salt of nitrous acid such as sodium nitrite. The present invention may also include chemicals containing the phosphite or phosphonaie group (PO/l which can inhibit the formation of scierotia at concentrations that are readily achievable for agricultural applications. Compositions of the present invention, inhibit, scierotia formation by fungi and may therefore be used in the field to prevent the continuation and advancement of pathogenie fungi.

Abstract: A method for manufacturing a diamond substrate, including: a first step of preparing patterned diamond on a foundation surface, a second step of growing diamond from the patterned diamond prepared in the first step to form the diamond in a pattern gap of the patterned diamond prepared in the first step, a third step of removing the patterned diamond prepared in the first step to form a patterned diamond composed of the diamond formed in the second step, and a fourth step of growing diamond from the patterned diamond formed in the third step to form the diamond in a pattern gap of the patterned diamond formed in the third step. There can be provided a method for manufacturing a diamond substrate which can sufficiently suppress dislocation defects, a high-quality diamond substrate, and a freestanding diamond substrate.

Abstract: The disclosed device includes a water storage container, an evaporation cover, a funnel, an indicator rod and a float. The water storage container has an evaporation cover. The evaporation cover is a gas permeable structure. A funnel is connected to the evaporation cover and an indication is provided in the leakage tube of the funnel. A rod. A float is connected to the lower end of the indicator rod and the float drives the indicator rod to indicate the water level in the water storage container. The method is as follows: the water storage container and the evaporation cover are buried in the soil of the plant root, and the water is filled into the water storage container through the funnel. The water in the water container naturally evaporates into the soil through the evaporation hood, which maintains the water in the soil to maintain the survival of the plant.

Abstract: The present disclosure relates to a sensor for indicating food quality comprising a semi-permeable film layer, the semi-permeable film layer comprising at least one integrally formed well having at least one sensing element disposed therein; wherein the well is sealed by a second film layer, the semi-permeable film layer being impermeable to said sensing element but is permeable to at least one analyte detectable by said sensing element.

Abstract: Provided in some embodiments is a method of manufacturing a pipe conformable water-cut sensors system. Provided in some embodiments is method for manufacturing a water-cut sensor system that includes providing a helical T-resonator, a helical ground conductor, and a separator at an exterior of a cylindrical pipe. The helical T-resonator including a feed line, and a helical open shunt stub conductively coupled to the feed line. The helical ground conductor including a helical ground plane opposite the helical open shunt stub and a ground ring conductively coupled to the helical ground plane. The feed line overlapping at least a portion of the ground ring, and the separator disposed between the feed line and the portion of the ground ring overlapped by the feed line to electrically isolate the helical T-resonator from the helical ground conductor.

Abstract: Systems and methods for executing super-resolution microscopy of a specimen with most of the image processing performed in a camera of a fluorescence microscopy instrument are described. In one aspect, the camera includes one or more processors to execute machine-readable instructions that control excitation light output from a multi-channel light source, control capture of intermediate images of the specimen, and perform image processing of the intermediate images to produce a final super-resolution image of the specimen.

Abstract: The present disclosure relates to a method of preventing and/or treating liver disease comprising administering an ASK1 inhibitor in combination with a FXR agonist, to a patient in need thereof.

Abstract: The present invention relates to regulation of ureide levels for optimal plant survival during nutrient remobilization such as occurs during normal growth, dark stress and senescence. Plants can be genetically engineered or selected using a suitable gene marker to have enhanced ureide accumulation. The present invention further provides methods of protecting plants, or extending the shelf life of fresh plant produce by application of exogenous ureides.

Abstract: The present invention discloses a video denoising system based on noise correlation, said system comprises a unit for estimating correlation of noises of adjacent pixels, which receives input of the inter-frame difference and motion probability, and estimates correlation of noises of adjacent pixels according to correlation of inter-frame differences between adjacent pixels in a still region, and outputs a noise correlation coefficient; a maximum filtering weight adjusting unit, which adaptively adjusts the maximum weight for temporal filtering according to the noise correlation coefficient and outputs the maximum weight for temporal filtering; the maximum weight for temporal filtering can control the range of fluctuation of the temporal filtering weight and the difference between the denoising effects for different pixels.

Abstract: Systems and methods for filtering an optical beam are described. In one implementation, a system for filtering an input optical beam includes a first beamsplitter, a first spectral slicing module, a second spectral slicing module, and a second beamsplitter. The first beamsplitter is configured to split the input optical beam into a first optical beam and a second optical beam. The first spectral slicing module has a first passband and is configured to filter the first optical beam. The second spectral slicing module has a second passband and is configured to filter the second optical beam. The second beamsplitter is configured to combine the first optical beam and the second optical beam into an output optical beam. The first and second spectral slicing modules may each comprise a longpass filter and a shortpass filter aligned along its optical axis, and the longpass filter and/or the shortpass filter are rotatable relative to the optical axis.

Abstract: The invention provides a method and system for generating a message authentication code (MAC) for authenticating a message and for verifying the integrity and authenticity of the message. The method for generating the MAC for authenticating the message includes the step of compressing the message to generate a fixed-size residue of the message. The fixed-size residue of the message is computed from the message modulo a divisor. The method, then, multiplies the fixed-size residue of the message by an authentication key. Thereafter, the method computes an authentication tag for the message by encrypting the fixed-size residue of the message utilizing a semantically secure encryption algorithm. The method, then, transmits both the message and the authentication tag of the message from a sender computing device to a receiver computing device where the method verifies the integrity and authenticity of the message using the authentication key.

Abstract: A separation medium consisting of a cyclodextrin metal-organic framework (CD-MOF) for separating aromatic compounds and methods of preparing the same are presented. Bottom-up preparations include the following steps: (a) preparing a first mixture comprising a cyclodextrin, an alkali metal salt, water and an alcohol; (b) performing one of the following two steps: (i) stirring the first mixture; or (ii) adding an amount of a surfactant to the first mixture to form a second mixture; and (c) crystallizing the CD-MOF from the first mixture or the second mixture. Top-down preparations include the following steps: (a) preparing a first mixture comprising the cyclodextrin, an alkali metal salt, water and an alcohol; (b) crystallizing the CD-MOF from the first mixture; and (c) optionally performing particle size reduction of the crystallized CD-MOF. The CD-MOFs are amenable for use in methods for separating alkylaromatic and haloaromatic compounds from a mixture of hydrocarbons.

Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: A method for producing a long length high temperature superconductor wire, includes providing a substrate, having a surface with a length of at least 50 meters and a width. The surface supports a biaxially textured high temperature superconducting layer and the biaxially textured high temperature superconducting layer has a length and a width corresponding to the length and width of the surface of the substrate. The method includes irradiating the biaxially textured high temperature superconductor layer with an ion beam impinging uniformly along the length and across the width of the biaxially textured high temperature superconductor layer to produce a uniform distribution of pinning microstructures in the biaxially textured high temperature superconductor layer.

Abstract: The present invention provides novel anti-HIV antibodies with improved therapeutic properties, related pharmaceutical compositions, and methods of use thereof.

Abstract: A method for manufacturing a large-scale single crystal monolayer of hBN including: preparing a single crystal copper substrate of (111) face in a chemical vapor deposition (CVD) apparatus; removing impurities of the single crystal copper substrate of (111) face; forming a plurality of hBN crystal seeds by depositing a vaporized ammonia borane or a vaporized borazine on the surface of the single crystal copper substrate from which the impurities are removed; and forming a large-scale single crystal monolayer of hBN grown by mutual coherence between the hBN crystal seeds, an apparatus for manufacturing the same, and a substrate for a monolayer UV graphene growth using the same.