Abstract: Embodiments of this invention generally relate to systems and methods for optical treatment and more particularly to non-invasive refractive treatment method based on sub wavelength particle implantation. In an embodiment, a method for optical treatment identifies an optical aberration of an eye, determines a dopant delivery device configuration in response to the optical aberration of the eye, wherein the determined dopant delivery device is configured to impose a desired correction to the eye to mitigate the identified optical aberration of the eye by applying a doping pattern to the eye so as to locally change a refractive index of the eye.

Abstract: The fiber comprises a core (2) having an index N and diameter of 10 ?m or more, surrounded by a ring (4) having an index N+?n and thickness ?R, and cladding (6) surrounding the ring and comprising for example air gaps (8). According to the invention: ?n?10?3 and ?R=?/(?n)? [1] where: 5×10?4 ?m???5×10?2 ?m and 0.5???1.5. The numbers ? and ? are dependent on the wavelength ? of the light guided by the fiber, the number of missing gaps therein, the diameter d of the gaps, the spacing ? thereof and N. To design the fiber, ?, the number of missing gaps, d/?, the core doping content, ? and ?n are chosen; and ?R is determined using equation [1] so as to obtain a flattened fundamental mode.

Abstract: According to one embodiment of the present invention, a multi-hop network system includes: a transmission node; a reception node; a router node; and a flow control node connected to all nodes within the multi-hop network system. The flow control node periodically receives flow monitoring information from at least one transmission node and evaluates whether the distributed state of the bandwidth of a network is fair. At this time, the flow control node sets a queue length threshold as transmission rate control information for fairly distributing the bandwidth of the network and transmits the set queue length threshold to at least one transmission node when unfairness has been detected. The transmission node sets the queue length threshold as a reference point for adjusting the transmission rate and performs the packet and/or link scheduling.

Abstract: The present invention discloses a cyprinid herpesvirus II-sensitive brain tissue cell line of Carassius auratus gibelio and establishing method and use thereof. The cell line is deposited in China Center for Type Culture Collection under an accession number of CCTCC No: C2013179. The brain tissue cell line of Carassius auratus gibelio is in good growth state and sensitive to CyHV-2 that is presently hardly cultured with ordinary fish cell lines. After six passages of CyHV-2 in GiCB cells, viral nucleic acid can still be detected and a cytopathic effect is stable. When ultrathin microscopic sections are prepared from cells having the cytopathic effect, considerable mature CyHV-2 virions and their replication process can be observed in GiCB cells. The construction method of the brain tissue cell line of Carassius auratus gibelio of the present invention has high repeatability, scientific and reasonable conditions.

Abstract: The disclosure relates to methods for measuring levels of 25(OH)vitamin D (250HD) in a mammalian fluid sample. The disclosure further relates to kits for measuring levels of 25(OH)vitamin D (250HD) in a mammalian fluid, the procedure comprising the step of release of the vitamin D from the serum binding protein (DBP), capturing of the released analyte by a specific antibody and competitive assay of the captured vitamin D against a conjugate between the vitamin D and a tracer. The observed signal is inversely proportional to vitamin D concentration.

Abstract: This invention relates to unsaturated polyol esters that can be used in hydraulic fluid applications, including fire-resistant hydraulic fluid applications, marine hydraulic fluid applications, metalworking fluid applications, food grade fluid applications, and transformer fluid applications, and methods for making the same.

Abstract: The present invention provides oral compositions which contain interferon ? (IFN?) as an active ingredient for preventing and/or treating periodontal disease. The number of causative microorganisms of periodontal disease can be suppressed by administering the compositions into the oral cavity. IFN? of the present invention can produce a sufficient effect even when administered at a very low dose. Furthermore, the compositions of the present invention can also be readily administered to animals such as dogs by formulating them into feed or such.

Abstract: The present invention relates to a mutant microorganism, which is selected from the group consisting of genus Mannheimia, genus Actinobacillus and genus Anaerobiospirillum, producing homo-succinic acid and a method for producing homo-succinic acid using the same, and more particularly to a mutant microorganism producing succinic acid at a high concentration while producing little or no other organic acids in anaerobic conditions, which is obtained by disrupting a gene encoding lactate dehydrogenase (ldhA), a gene encoding phosphotransacetylase (pta), and a gene encoding acetate kinase (ackA), without disrupting a gene encoding pyruvate formate lyase (pfl), as well as a method for producing succinic acid using the same. The inventive mutant microorganism has the property of having a high growth rate and succinic acid productivity while producing little or no organic acids, as compared to the prior strains producing succinic acid.

Abstract: Provided are a compound represented by Formula I, a pharmaceutically acceptable salt thereof, or a solvate thereof; and a pharmaceutical composition for cancer treatment and a pharmaceutical composition for a radiation sensitizer for cancer treatment, each pharmaceutical composition including the compound of Formula I, the pharmaceutically acceptable salt thereof, or the solvate thereof: wherein, in Formula I, —R1 is a C1-C3 alkoxy, ?O, or —OH, and —R2 is a 5- or 6-membered heteroaryl including 1 to 2 hetero atoms selected from nitrogen and oxygen, wherein a carbon of the 5- or 6-memberedheteroaryl is optionally substituted with a C1-C3 alkyl a C1-C3 alkoxy, or hydroxy.

Abstract: Methods of forming a liquid crystal blue phase from composite materials having a chiral nematic liquid crystal host and a bent-shape molecule are described. The stable temperature range of the liquid crystal blue phase may be improved by controlling the thickness of the composite materials. For example, a given composition may have a maximum stable temperature range for the liquid crystal blue phase at about 1 ?m.

Abstract: Methods for rapidly determining earthquake parameters of an earthquake include inputting a seismogram of the earthquake, searching concurrently in pre-established historical seismogram database and theoretical seismogram database by use of an approximate nearest neighbor search method, to find a set of seismograms similar to the input seismogram according to a preset similarity condition, and determining from the set of similar seismograms one or more seismograms matched with the input seismogram, and determining the earthquake parameters from the matched seismograms. With the present invention, it is possible to search in millions of seismograms and determine parameters for an earthquake in a few second, and thus realize rapid and even real-time estimation of earthquake parameters.

Abstract: An apparatus for distinguishing an energy band of a photon in a readout circuit that counts photons in multi-energy radiation incident onto a sensor for each energy band includes an integrator configured to accumulate an electric signal received from the sensor that has undergone photoelectric conversion from the photon; a comparator configured to compare an accumulated electric signal received from the integrator with one of a plurality of threshold values; and a signal processor configured to instruct sequential switching from one of the plurality of threshold values to another one of the plurality of threshold values according to a result of a comparison received from the comparator; and output a digital signal that distinguishes an energy band of the photon based on results received from the comparator of sequential comparisons of the accumulated electric signal with the plurality of threshold values.

Abstract: The disclosure relates to diseases in the peripheral nervous system, particularly hereditary neuropathies, such as Charcot-Marie-Tooth (CMT) disease. It is shown that this disease is associated with decreased acetylated tubulin levels, which can be overcome by inhibition of histone deacetylases (HDACs). Using HDAC inhibitors, it is shown herein that the symptoms of the CMT phenotype can be overcome both in vitro and in vivo. Also provided herein are two different mouse models of CMT disease.

Abstract: Methods, computer program products, and systems are described that include accepting at least one attribute of at least one individual, querying at least one database at least partly based on the at least one attribute, selecting from the at least one database at least one bioactive agent and at least one artificial sensory experience to address the at least one attribute of at least one individual, and/or presenting an indication of the at least one bioactive agent and the at least one artificial sensory experience at least partly based on the selecting from the at least one database at least one bioactive agent and at least one artificial sensory experience to address the at least one attribute of at least one individual.

Abstract: Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more passive cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, wherein at least a portion of the one or more passive cooling elements is configured to be implantable, and wherein the one or more passive cooling elements includes a first portion configured to be in association with the one or more tissues to be cooled, and a second portion configured to be placed in association with one or more tissues adjacent to an external epidermal tissue of the vertebrate subject.

Abstract: A multi-position valve assembly including a valve housing, a stator element and a rotor element rotatably mounted about a rotational axis. The valve assembly further includes a pressure adjustment assembly movable between a release position and a stop position, hard stopped relative to the valve housing. The pressure adjustment assembly includes a pressure adjuster device configured to movably cooperate between the rotor element and the valve housing to adjustably generate an axial compression pressure at the rotor-stator interface at a calibrated operating pressure, PC. When the pressure adjustment assembly is oriented in the release position, the axial compression pressure is substantially removed from the rotor-stator interface. In contrast, when the pressure adjustment assembly is oriented in the stop position, the axial compression pressure is substantially reproduced at the calibrated operating pressure, PC.

Abstract: The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

Abstract: A method cleans a plurality of filters in parallel, each filter having an inlet side and an outlet side separated by a filter barrier. In an operational phase, water is filtered using a plurality of the filters, by passing the water through the filter. In a cleaning phase, at least one of the filters is cleaned while the other filters are filtering water in the operational phase. Each filter is cleaned by supplying sodium hypochlorite to an inlet side of the filter when the filter is off-line. The inlet side of the filter is allowed to soak in the sodium hypochlorite for at least 30 seconds without the sodium hypochlorite being pressurized through the filter barrier during the soaking process. The filters are cycled through the cleaning phase such that each filter is repeatedly cleaned while other filters are filtering in the operational phase.

Abstract: A Direct Sample Analysis (DSA) ion source system operating at essentially atmospheric pressure is configured to facilitate the ionization, or desorption and ionization, of sample species from a wide variety of gaseous, liquid, and/or solid samples, for chemical analysis by mass spectrometry or other gas phase ion detectors. The DSA system includes one or more means of ionizing samples and includes a sealed enclosure which provides protection from high voltages and hazardous vapors, and in which the local background gas environment may be monitored and well-controlled. The DSA system is configured to accommodate single or multiple samples at any one time, and provide external control of individual sample positioning, sample conditioning, sample heating, positional sensing, and temperature measurement.

Abstract: A system and method for use with a voice-capable system, includes but is not limited to receiving a vocal input to the voice-capable system, receiving one or more instructions referential to the first speech output version of the vocal input, and creating a second speech output version of the vocal input representational of the first speech output version of the vocal input manipulated responsive to the one or more instructions.