Abstract: Alloy compositions suitable for fabricating medical devices, such as stents, are disclosed. In certain embodiments, the compositions have small amounts of nickel, e.g., the compositions can be substantially free of nickel.

Abstract: A medical device, and related method, for manipulating material, such as calculi, within a patient's body includes a handle, a sheath, a retrieval basket, and a retainer coupled to the distal end of the retrieval basket. The retrieval basket includes a plurality of legs, each of which includes an intermediate portion located at the distal end of the retrieval basket. The retainer secures at least the intermediate portion of one of the plurality of legs to the intermediate portion of another of the plurality of legs.

Abstract: The suturing instrument includes an elongate member having an articulating distal portion biased offset from the elongate member, and a sheath slideably disposed about the elongate member. The user positions the sheath in contact with the articulating distal portion to actuate the distal portion relative to the elongate member. The articulating distal portion is pivotally coupled to the elongate member for improved maneuverability within the body of a patient during surgical procedures.

Abstract: The invention provides a system which comprises a medical device that delivers a combination of therapies. These therapies include the administration of radiation, biologically active materials, cryotherapy, and thermotherapy. The present invention is also directed to a method of treating body lumen surfaces using the system of the invention. A system is provided for delivering a biologically active material to a surface of a body lumen being exposed to a radioactive source. In one aspect, the system comprises an implantable medical device which has two opposing ends, each having a surface, and a middle portion. The two opposing ends comprise a biologically active material and the middle portion of the medical device is substantially free of any biologically active material. In another aspect, the system delivers a genetic material to a surface of a body lumen which is exposed to a radioactive source.

Abstract: Various methods and devices for treating a patient who has lost, or is at risk of losing cardiac function by cardiac ischemia are disclosed. Treatment includes first imaging a patient's heart, or a portion thereof, to identify underperfused regions of cardiac muscle, and a source of oxygenated blood that is proximate to the underperfused region. Between the underperfused regions and the oxygenated blood source, a target area is selected where thermal or mechanical injury is introduced, and optionally reintroduced, to convert initial capillary blush, resulting from the injury.

Abstract: A stent for treatment of a body lumen through which a flow is effected on either side of a sphincter, said stent comprising one or more windings and having an inner core substantially covered by an outer core and including a first segment, a second segment, and a connecting member disposed between the segments. When the stent is positioned within a patient's urinary system, the first segment and second segments are located on either side of the external sphincter to inhibit migration of the stent while not interfering with the normal functioning of the sphincter. The outer coating comprises an absorbable material that provides temporary structural support to the stent. After absorption of substantially all the outer coating of the stent, the remaining relatively compliant inner core facilitates easy removal by the patient by pulling a portion of the stent that extends outside the patient's body for this purpose.

Abstract: A stent for treatment of a body lumen through which a flow is effected on either side of a sphincter, said stent comprising one or more windings and having an inner core substantially covered by an outer core and including a first segment, a second segment, and a connecting member disposed between the segments. When the stent is positioned within a patient's urinary system, the first segment and second segments are located on either side of the external sphincter to inhibit migration of the stent while not interfering with the normal functioning of the sphincter. The outer coating comprises an absorbable material that provides temporary structural support to the stent. After absorption of substantially all the outer coating of the stent, the remaining relatively compliant inner core facilitates easy removal by the patient by pulling a portion of the stent that extends outside the patient's body for this purpose.

Abstract: A stent for treatment of a body lumen through which a flow is effected on either side of a sphincter, said stent comprising one or more windings and having an inner core substantially covered by an outer core and including a first segment, a second segment, and a connecting member disposed between the segments. When the stent is positioned within a patient's urinary system, the first segment and second segments are located on either side of the external sphincter to inhibit migration of the stent while not interfering with the normal functioning of the sphincter. The outer coating comprises an absorbable material that provides temporary structural support to the stent. After absorption of substantially all the outer coating of the stent, the remaining relatively compliant inner core facilitates easy removal by the patient by pulling a portion of the stent that extends outside the patient's body for this purpose.

Abstract: A bifurcated stent comprises a first stent section and a second stent section. Each stent section is expandable from a predeployed state to a deployed state independently from one another. The second stent section having an end engaged to a receiving region of the first stent section. In the deployed state the first stent section defines a primary flow path and the second stent section defines a secondary flow path in fluid communication with the first flow path. At least a portion of one or both the first stent section and second stent section is constructed from a wire member.

Abstract: Described herein are embolic assemblies that can be reinforced in situ. In particular, assemblies are described comprising (i) an implantable device designed to allow injection of a liquid agent through the lumen of the device or a lumen defined by the device and (ii) an implantable device and a liquid agent, wherein the liquid agent is capable of solvating polymeric material of the device. Methods of making and using these assemblies are also provided.

Abstract: An instrument for collecting body tissue includes a tubular cutting member having an exterior surface, a proximal end, and a distal end capable of penetrating body tissue; and a flexible cutting extension coaxially and slidably disposed around the exterior surface of the cutting member, the flexible cutting extensions having a proximal end and distal end capable of cutting tissue located at the distal end of the cutting member and covering the distal end of the cutting member so that tissue that has entered the cutting member is retained in the cutting member. A first tubular member may be connected to the cutting member, and a second tubular member maybe connected to the cutting extension, the second tubular member being coaxially disposed on the first tubular member.

Abstract: A self-expanding tubular stent comprises a plurality of stent segments. Each stent segment is formed of an elongate ribbon having portions cut therefrom to form a wave-like undulating pattern, opposed edges of which are attached to one another so as to form a generally cylindrical configuration. A disclosed method effects formation of such an expandable tubular stent by first providing an elongate flat ribbon of biocompatible stent material and selectively removing portions of such material to form an undulating wave-like pattern along the length of the ribbon. The ribbon is then coiled into a generally cylindrical configuration and opposed ends of the ribbon are secured to one another to form a generally cylindrical and expandable spiral stent section. After forming a plurality of such stent sections, the stent sections are arranged in longitudinal succession and interconnected so as to form an elongated stent configuration.

Abstract: Baskets with atraumatic distal tips allow the capture of material from difficult-to-reach areas of the body, while reducing the risk of tissue damage.

Abstract: A medical retrieval device includes a basket formed of two or more loops. The basket may be used to retrieve material (e.g., a urinary stone) from a body. The basket opens and closes for end-encapsulation of a stone and is strengthened by support members that interconnect the basket loops. A captured stone may be released from the basket with the basket still in the body by opening the loops.

Abstract: Medical devices may be made of shape-memory materials portions of which have been heat treated to exhibit spatial variations in the stiffness of the material. Devices including stents, vena cava filters and guidewires may be constructed from such materials. Devices may also be made from shape-memory materials which have been locally heat treated such that the superelasticity of the treated portion is destroyed while the remainder of the shape-memory material can transition between the martensitic and austenitic states.

Abstract: An endoscopic catheter distal end position control that enables precise control of distal catheter sheath ends relative to each other while accommodating the long length and flexibility of typical catheters and proximal, remote hand-operable control mechanisms. In a catheter assembly employing this control, an elongated flexible tubular sheath is provided having a distal end and a proximal end. A distal end member is internal to the sheath; this end member is reciprocally axially moveable relative to the sheath distal end between a retracted position that is proximal of the sheath distal end and an extended position in which the end member protrudes beyond the sheath distal end. An elongated end member interconnector is provided, with a distal end of the interconnector being connected to the end member and a proximal end of the interconnector being connected to a position actuator for axially reciprocating the end member relative to the distal end of the sheath.

Abstract: A high pressure dilation medical device delivery catheter having a proximal and distal end comprising two tubes mounted generally concentrically about an inner tube. The balloons being characterized as a relatively short inner tube which is inflated with high pressure and a longer outer tube which is inflated with low pressure. The balloons have independent inflation lumens which extend toward the proximal end of the inner tube. A medical device mounting region is disposed about at least a portion of the outer balloon and may have a stent or other medical device mounted thereupon. A retractable outer sheath is further disposed about the medical device mounting region and is operatively connected near the proximal end of the catheter.

Abstract: The present invention is directed to a scanning system that uses uniform rotary motion of an optical reflector to create reciprocal linear scanning. The system converts uniform rotation into uniform longitudinal scanning. The system thereby creates mechanical reciprocal linear scanning free of reciprocally moving mechanical parts common in conventional scanning systems. In a preferred embodiment of the invention, the scanning system is incorporated within an imaging catheter for medical scanning. The optical reflector is rotatable and includes a spiral reflecting portion. The spiral reflecting portion may be a single uniform reflecting surface or may include several reflection surfaces arranged in a spiral configuration.

Abstract: An endoscopic instrument having an end effector assembly at a distal end, a flexible member connected to and extending from the end effector assembly and a handle assembly connected to the flexible member. The handle assembly includes a handle member, a nose member and a biasing element. The handle member has an inner bore. The hollow nose member has a shank configured for insertion into the inner bore. The biasing element is located within the inner bore and biases the flexible member relative to the handle member. The handle member may have a keyway or a projection configured for insertion into a keyway, and the nose member may have the other of the keyway or the projection. The flexible member has a retaining element affixed to its proximal end. The flexible member is inserted through the nose member with the retaining element located proximate the proximal end of the nose member and thereby retained between the handle member and the nose member.

Abstract: Disclosed are bio-active coating compositions for polymeric substrates. In particular, a bio-active coating is described which is the reaction product formed by providing a polymer backbone with at least one free isocyanate group, wherein the isocyanate group is pendant from the polymer backbone. There is further provided a hydrophilic, amine-terminated spacer which has at least one amine group at its first and second ends. One of the amine groups of the spacer is reacted with one or more of the isocyanate groups on the polymer backbone in the presence of an optional catalyst agent. A bio-active agent is then covalently bonded onto an unreacted end of the spacer in the presence of a catalyst. Also disclosed are coating compositions for a substrate and methods of preparing same.