Abstract: A medical device may include an insertion portion longitudinally extending between a proximal end and a distal end. The insertion portion may define a channel extending therethrough. The medical device may further include a handle coupled to the proximal end of the insertion portion. The handle may further include an irrigation port in fluid communication with the channel and coupled to a source of irrigation fluid. Additionally, the handle may include an actuator and a pressurizer. Manipulation of the actuator may be configured to actuate the pressurizer to urge irrigation fluid distally through the channel.

Abstract: Intravascular imaging catheters and methods for making and using intravascular imaging catheters are disclosed. An example intravascular imaging catheter may include an elongate catheter shaft having a distal end region and a proximal region. A guidewire lumen may be defined in the elongate catheter shaft. The distal end region may include an imaging window defined by an open gap in the elongate catheter shaft. An imaging core may be disposed within the elongate catheter shaft. The imaging core may include an imaging device configured to be axially aligned with the imaging window.

Abstract: A biopsy cap may be operatively connected to a port of a medical device. The biopsy cap seals a working channel that is configured to allow the passing of different diameter devices. During endoscopy procedures, the tip of many devices, such as guidewires and catheters, may be wetted before use to avoid excessive dragging forces when inserting such devices through the working channel of the endoscope. A cap system comprising a cap for a port of a first medical device; and a wetting device configured to couple to a portion of the cap and wet a second medical device passing through the cap system.

Abstract: Various embodiments are generally directed to devices, systems, and methods for controlling the flow of fluids in endoscopic systems, such as endoscopic ultrasound (EUS) enabled endoscopes. Some embodiments are particularly directed to valve sets and/or valve interface mechanisms for controlling air, water, and/or suction flow through a valve well for an endoscopic system. Several embodiments are directed to user interface mechanisms and techniques for enabling an operator to interact with and control endoscope valves. Many embodiments are directed to mechanisms and techniques for translating interface input motion into valve control motions. In one or more embodiments, the valve sets and/or valve interface mechanisms may be disposable.

Abstract: Delivery devices for an occlusive implant and method for making and using delivery devices are disclosed. An example delivery device may include a delivery sheath having a proximal region and a distal tip region. A reinforcing member may extend along the proximal region. The distal tip region may include a grooved distal section. The grooved distal section may be configured to shift between a delivery configuration and an expanded configuration. A core member may be slidably disposed within the delivery sheath. An occlusive implant may be releasably coupled to the core member.

Abstract: Devices and methods for the treatment of chronic total occlusions are provided. One disclosed embodiment comprises a method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein. The method includes providing an intravascular device having a distal portion, inserting the device into the vascular lumen, positioning the distal portion in the vascular wall to at least partially surround the occlusion, and removing at least a portion of the surrounded occlusion from the lumen.

Abstract: In various aspects, the present disclosure pertains to methods of forming an iodinated peptide compound that comprises: (a) forming a multifunctional precursor compound comprising (i) a residue of an amine-protected peptide that comprises two or more amino acid residues with primary-amine-containing side groups and (ii) a multifunctional moiety linked to the amine-protected peptide residue through an amide group or an ester group; (b) reacting the multifunctional precursor compound in an amide coupling reaction or an esterification coupling reaction with an iodinated compound to form an iodinated, amine-protected peptide compound comprising n iodinated moieties that are covalently attached to the amine-protected peptide residue through a residue of the multifunctional moiety; and (c) deprotecting the iodinated, amine-protected peptide compound to form the iodinated peptide compound.

Abstract: Example aspiration catheters and systems including aspiration catheters are disclosed. An example aspiration catheter includes a catheter body having a proximal end region, a distal end region and a lumen extending therein. The aspiration catheter also includes a fluid supply tube extending within the lumen of the catheter body, the fluid supply tube having a distal end region and a distal facing surface. The aspiration catheter also includes a funnel having a proximal end and a distal end, wherein the proximal end is coupled to the distal end region of the catheter body, and wherein the funnel is configured to shift between a collapsed configuration and an expanded configuration.

Abstract: A biopsy device may include a first jaw having a first distal tip configured to pierce tissue, and a second jaw movable relative to the first jaw between a closed configuration where the first jaw and the second jaw are axially aligned, and an open configuration where the first jaw and the second jaw are offset from one another, the second jaw having a second distal tip proximal to the first distal tip in the closed configuration.

Abstract: In some aspects, the present disclosure pertains to multi-arm polymers that comprise a core, a plurality of polymer segments having a first end that is covalently attached to the core and a second end comprising a moiety that comprises a reactive group, wherein the polymer segments comprise one or more free-radical-polymerizable monomers. In some aspects, systems are provided that comprise a first composition comprising such a multi-arm polymer and a second composition comprising a multifunctional compound that comprises functional groups that are reactive with the reactive groups of the multi-arm polymer. In some aspects, systems are provided that comprise crosslinked reaction products of such a multi-arm polymer and such a multifunctional compound.

Abstract: Delivery devices for an occlusive implant and method for making and using delivery devices are disclosed. An example delivery device may include a delivery sheath having a proximal region and a laser cut distal tip region. A reinforcing member may extend along the proximal region. The laser cut distal tip region may have one or more laser cuts formed therein that form a patterned distal section. The patterned distal section may be configured to shift between a delivery configuration and an expanded configuration. A core member may be slidably disposed within the delivery sheath. An occlusive implant may be releasably coupled to the core member.

Abstract: Thrombectomy systems including a console having a radiofrequency identification (RFID) reader, a fluid inflow pump, the fluid inflow pump driven by the console, a thrombectomy catheter, the fluid inflow pump configured to provide fluid inflow through the thrombectomy catheter, and an RFID tag coupled to a body portion of the fluid inflow pump. When the fluid inflow pump is positioned within the drive unit, the RFID reader may be configured to receive one or more operating parameters from the RFID tag.

Abstract: An apparatus for treating a total occlusion in a blood vessel may include a self-orienting device including an elongate shaft and an inflatable orienting element. The shaft includes an inflation lumen having a first noncircular shape and a working lumen having a second noncircular shape. The inflatable orienting element includes first and second inflatable members extending laterally from the shaft. An outer diameter of the shaft is 0.045 inches or less, a cross-sectional area of the first noncircular cross-sectional shape is at least 0.00013 square inches, and a cross-sectional area of the second noncircular cross-sectional shape is at least 0.00056 square inches. The shaft may include a distal tail extending distally from the inflatable orienting element, the distal tail being at least 15 millimeters long. The shaft may include a plurality of first apertures communicating with the working lumen and disposed in the distal tail.

Abstract: An endoscopic device includes a flexible shaft extending distally from a handle which, during use remains outside a living body, the shaft comprising a pull wire extending therethrough from the handle and a distal tip rotatably coupled to a distal end of the shaft, the distal tip comprising an imager directed distally from a distal face of the distal tip, the imager including a chip and a lens, a distal end of the pull wire being coupled to the distal tip in combination with an actuation mechanism coupled to a proximal end of the pull wire so that, actuation of the actuation mechanism, pulls the pull wire proximally through the shaft rotating the distal tip relative to the shaft to alter a field of view of the imager.

Abstract: A cryoballoon deflation assembly for an intravascular catheter system for use during a cryoablation procedure includes a first deflation initiator and a first deflation initiator inhibitor. The first deflation initiator is configured to automatically activate a vacuum pump to deflate a cryoballoon upon completion of a stage of the cryoablation procedure. The first deflation initiator inhibitor is manually changeable to between an activated and deactivated state. When in the activated state, the first deflation initiator inhibitor is configured to inactivate the first deflation initiator. The cryoballoon deflation assembly can further include a second deflation initiator. The second deflation initiator is manually changeable between an activated and deactivated state. When in the activated state, the second deflation initiator is triggered to activate the vacuum pump to deflate the cryoballoon.

Abstract: A device for treating tissue includes a catheter including an elongated body extending from a proximal end to a distal end and including a lumen extending therethrough, a distal tip connected to the distal end of the elongated body and including a first electrode and a second electrode extending thereabout, the first electrode extending to a distal opening of the lumen and a first needle extending longitudinally from a proximal end to a distal end, the first needle slidably received within the lumen of the catheter to be moved between a retracted bipolar configuration, in which the distal end of the needle is proximal the distal opening of the catheter, and an extended monopolar configuration, in which the distal end of the first needle extends distally past the distal opening of the catheter so that the first needle contacts the first electrode and is configured to cut tissue.

Abstract: A scope system includes a processor and a scope device. The scope device includes a handle configured to remain outside of the body and an elongated shaft extending from the handle to a distal tip and including a working channel extending therethrough. The working channel is open at the distal tip of the shaft. The shaft is inserted through a bodily lumen to a target surgical site. The shaft includes at least one sensor transmitting to the processor sensor data relating to the target surgical site.

Abstract: A method for evaluating a gastrointestinal tract may include characterizing one or more disease parameters using objective measures obtained from imaging data of a gastrointestinal tract. The one or more disease parameters reflect a measure of at least one of lesions, ulcers, bleeding, stenosis, and vasculature. The method may also include using the one or more characterized disease parameters to classify a disease state.

Abstract: A device for fluidizing and delivering a powdered agent, including a canister extending longitudinally from a first to a second end and defining a space within which a powdered agent is received, an inlet coupleable to a gas source for supplying gas to the space to fluidize the powdered agent to create a fluidized mixture, an outlet via which the gas mixture is delivered to a target area, a tube extending from the outlet into the interior space, the tube including a slot extending through a wall thereof so that gas mixture is passable from the interior space through the outlet via the second end and the slot, and a door movably coupled to the tube so that the door is movable over the slot to control a size of the slot open to the interior space of the canister.

Abstract: Various embodiments are generally directed to devices, systems, and methods for controlling the flow of fluids in endoscopic systems, such as endoscopic ultrasound (EUS) enabled endoscopes. Some embodiments are particularly directed to valve sets and/or valve interface mechanisms for controlling air, water, and/or suction flow through a valve well for an endoscopic system. Several embodiments are directed to user interface mechanisms and techniques for enabling an operator to interact with and control endoscope valves. Many embodiments are directed to mechanisms and techniques for translating interface input motion into valve control motions. In one or more embodiments, the valve sets and/or valve interface mechanisms may be disposable.