Abstract: Described herein are compounds, including pharmaceutically acceptable salts, solvates, metabolites, prodrugs thereof, methods of making such compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat non-alcoholic steatohepatitis and other diseases characterized by dysfunctional tissue healing and fibrosis.

Abstract: A spring assembly having at least two canted coil spring lengths nested together are disclosed. Two sections of coils of a canted coil spring length can each be positioned between two adjacent coils of another canted coil spring. Each section of the coils of the canted coil spring length includes at least one coil and up to several coils or a plurality of coils. The canted coil spring lengths are nested together to increase the deflection force of the overall spring assembly. The spring assembly having two or more nested spring lengths can be used in connector applications.

Abstract: Controlled-release therapeutic compositions including melatonin combined with sedative and/or analgesic ingredients are described. The compositions have a solid core including melatonin in an acidified polymeric matrix. A sedative ingredient such as GABA receptor agonist may also be in the acidified polymeric matrix. The composition may include an expedited release portion providing a burst release of active ingredients and a sustained release portion providing a sustained release of active ingredients.

Abstract: The rotary face seal with magnet loading replaces known spring mechanisms with magnetic technology that provides a consistent load with minimal variation, which is not affected by natural frequency and material fatigue due to cyclic loading. This improves seal performance and service life. The tubular magnetic ring is advantageous because it replaces existing seals within stationary cartridge with a puller type magnetic assembly design that results with the stationary cartridges being an exact exchange. The use of magnetic technology attached to the seal case, which is attached to the shaft, does not produce eddy currents because it is of a single pole configuration. The single pole magnetic assembly design is achieved by either axial or radial magnet orientation, such as in the form of a tubular magnetic band located in a circumferential notch in the seal case.

Abstract: A valve stem assembly for a tire includes a removable grommet of a plurality of grommets having different shapes and sizes. The removable grommets allow the valve stem assembly to be used on a variety of rims. Each grommet fits into distinct holes within the rims. The valve stem assembly also includes a valve stem body that receives the removable grommets and an attachment end that encloses a valve core within the valve stem body. A cap may cover the valve core and attachment end.

Abstract: The present invention relates to a container sleeving method for arranging sleeves around a plurality of containers, the method includes: transporting an array of containers past a sleeve discharge unit; arranging a sleeve of heat shrinkable foil around a container passing by the sleeve discharge unit by shooting the sleeve from the sleeve discharge unit towards the container; detecting whether the sleeve has been correctly arranged around the container; and, if the sleeve has not been arranged correctly around the container, continue transporting one or more containers along the sleeve discharge unit and discontinue shooting one or more sleeves towards the containers.

Abstract: The invention relates to container sleeving system and method. Sleeves of heat shrinkable foil are arranged around the container. The sleeves are supplied by ejecting the sleeve from the sleeve supply. Containers are supplied form a container supply. The sleeve supply arranges the sleeve around the container by moving the sleeve upwardly around the container. A heat shrink oven is arranged for fixing the sleeve to the container. A conveyor transports containers.

Abstract: An axle seal is provided and includes a seal element having a seal element top, a seal element bottom, a seal element mounting lip which extends downwardly from the seal element bottom, and a seal element sleeve, wherein the seal element sleeve is securely and sealingly associated with the seal element mounting lip, and wherein the seal element includes, a first surface having a first edge, and a second surface having a second edge, wherein the first surface and second surface extend circumferentially away from the seal element, and wherein the first surface and second surface are separated from each other to form an edge channel which extends circumferentially around the seal element.

Abstract: Device, system, and method are described directed to seal assemblies with support to reduce seal extrusion under high to very high pressure changes due to repeated piston reciprocating movement. In some examples, concave features are incorporated on the inner and outer edges of support and backup ring elements to support and hug the preceding element and constrain extrusion, as well as utilizing multiple contact points on certain elements in order to reduce friction against the dynamic surface. The seal assemblies described herein can also incorporate bearing surfaces to reduce damage to seal ID due to off-axis floating rod, such as incorporating one or more multi-point contacts to reduce friction.

Abstract: Seal assemblies with a seal body having an inside flange and an outside flange that are biased outwardly away from one another by a spring energizer, such as a canted coil spring or a V-spring. The seal assemblies further include EMI shielding by incorporating at least one spring energizer that provides at least part of a conductive path between a housing and a pin. The conductive path can alternatively be provided by two different spring energizers and optionally with a conductive strip or trace or via a conductive contact ring element. The present seal assemblies are usable in applications having the needle for both sealing and EMI shielding.

Abstract: A multi-layer fire safety tape comprising a flexible closed-cell polymer foam layer adjoined to a flexible intumescent material layer is disclosed, including methods of making and using the same. The multi-layer fire safety tape is preferably composed of, in series, a flexible backing/release layer; a flexible closed-cell polymer foam thermal barrier layer; a first adhesive interface layer between the backing/release layer and the closed-cell polymer foam thermal barrier layer; a flexible intumescent material layer; a second adhesive interface layer between the intumescent material layer and the closed-cell polymer foam thermal barrier layer; and a flexible outer protective layer. In further embodiments, the multi-layer fire safety tape of the present invention further comprises a second closed-cell polymer foam layer adjacent to the intumescent material layer and/or the outer protective layer.

Abstract: An oral controlled-release multiparticulate dosage form comprises a plurality of individually enteric coated particulates containing an L-carnitine that independently disperse in a patient's stomach after oral ingestion and travel through the stomach and past the pyloric sphincter without substantially releasing the L-carnitine in the stomach. The individual particulates contain (a) a solid core containing the L-carnitine, (b) a subcoating containing a cellulosic water soluble polymer over the core, and (c) an enteric coating over the subcoating. The dosage form may be used to treat conditions associated with a reduction of the amount of L-carnitine in the body.

Abstract: A connector assembly having a housing and pin and a spring contact located therebetween to take up a set gap between the pin and the housing. The spring contact can be a canted coil spring and the spring contact can be made to have a large range of deflection to take up the gap with a large range of variation, such as when the pin diameter varies for a given groove bore diameter or when the groove bore diameter varies for a given pin diameter.

Abstract: A spreading unit for a container sleeving device, configured to spread open flattened tubular foil material to form a sleeve, to bring the sleeve in a target tubular shape and to discharge the sleeve towards the container, the spreading unit including a mandrel including: an upstream mandrel element for spreading open the flattened tubular foil material having a substantially constant cross-section in axial direction; a downstream mandrel element having a non-constant cross-section in axial direction; an intermediate mandrel element positioned between the upstream and downstream mandrel elements; wherein the downstream mandrel element comprises flaring sides and tapering sides and the intermediate mandrel element is recessed relative to the upstream mandrel element to allow the upstream part of a sleeve to move radially inward when the downstream part of the sleeve moves along the flaring sides of the downstream mandrel element.

Abstract: In the present invention, a pouch container is provided with a first wall surface sheet and a second wall surface sheet disposed facing the first wall surface sheet and has a sealed section in which the back surfaces of the respective wall surface sheets are bonded to each other. The first wall surface sheet and the second wall surface sheet each have a base film, a sealant layer provided on the back surface of the base film, and a platelessly printed layer formed between the base film and the sealant layer. Moreover, the edges of the platelessly printed layer are provided at positions that are at a distance from the container end faces.

Abstract: A bearing with an integral diverted lantern ring for installation into the seal cavity of a rotary mechanical device to provide a bearing surface and allow for flush fluid to engage the shaft closer to the motor end is provided. The bearing eliminates whip in a rotating shaft and is split to allow easy installation over an installed shaft. The bearing is substantially cylindrical with an inner bore closely approximating the outer diameter of the shaft. The diverted lantern ring includes an outer groove at the impeller end on the outer surface at a flush port and a groove on the inner surface at a location closer to the motor end. Flush fluid channels are provided between the outer groove and inner groove of the bearing. The purpose is to redirect the external flush from the impeller end on the OD to the motor end on the ID, thus repositioning the flush deposit on the sleeve, under the bearing. This allows the throttling characteristic of the close clearance bearing surface to increase.

Abstract: Provided is a pouch container aligned structure, wherein: each pouch container has a folded body part that is the top end of one of a pair of body sheets folded into a substantial V shape, with one end of a top sheet also forming the folded body part by being joined to the top end of the body sheet and the other end of the top sheet forming the distal end portion of the container by being joined to the top end of the other of the pair of body sheets; and the pouch containers are aligned in a state in which the distal end portion of one pouch container is inserted into the folded body part of another pouch container.

Abstract: A hole former for use in casting a gasket within an opening of a structure of the type used in underground water systems, such as a manhole. The hole former includes a body defining a central axis and an outer peripheral surface, with at least one gasket retention element projecting radially outwardly from the outer peripheral surface to interface with a corresponding locating feature of the gasket. In this manner, axial shifting or movement of the gasket with respect to the hole former is restricted, thereby positively locating and retaining the gasket on the hole former before and during the casting process. The hole former may have a compound curvature, with the gasket retained around the periphery of the hole former in a compound curved configuration.

Abstract: A manhole base assembly and a method for making the same, in which a non-cylindrical, low-volume concrete base is fully lined to protect the concrete against chemical and physical attack while in service. This lined concrete manhole base assembly may be readily produced using a modular manhole form assembly which can be configured for a wide variety of geometrical configurations compatible with, e.g., varying pipe angles, elevations and sizes. The form assembly is configurable to provide any desired angle and elevation for the pipe apertures using existing, standard sets of form assembly materials, and may also be used in conjunction with industry-standard cylindrical casting jackets for compatibility with existing casting operations. The resulting system provides for flexible construction of a wide variety of lined manhole base assemblies at minimal cost, reduced concrete consumption and reduced operational complexity.

Abstract: An endoscope comprising a lens, and an anti-fog film, wherein an optically clear adhesive bonds the anti-fog film to the lens or lens section.