Patents Assigned to Seikagaku Kogyo Kabushiki Kaisha
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Publication number: 20120197015Abstract: The present invention is directed to providing epoxycarboxamide compounds, azide compounds and amino alcohol compounds which serve as manufacturing intermediates that can lead to useful ?-ketoamide compounds, and the present invention is also is directed to processes for preparing ?-ketoamide compounds using the intermediates. The epoxycarboxamide compounds, azide compounds and amino alcohol compounds are represented by the following formulae: wherein R1, R2, R3, R4 and R5, as well as subvariables for one or more of R1, R2, R3, R4 and R5 are as defined herein.Type: ApplicationFiled: December 14, 2011Publication date: August 2, 2012Applicant: Seikagaku Kogyo Kabushiki Kaisha d/b/a Seikagaku CorporationInventors: Nobuo KOBAYASHI, Tsuneo Koji, Takashi Fujita, Tomofumi Nishimura, Akihiko Hosoda
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Patent number: 8202705Abstract: A sialyltransferase having the following physico-chemical properties: (1) Activity: transfers sialic acid from a sialic acid donor selectively to a 3-hydroxyl group of a galactose residue contained in lactosylceramide as a sialic acid acceptor to produce ganglioside GM3; (2) Optimal Reaction pH: 6.0 to 7.0; and (3) Inhibition and Activation: the activity increases at least 1.5 times with 10 mM of Mn2+ as compared with the case in the absence thereof.Type: GrantFiled: July 22, 2010Date of Patent: June 19, 2012Assignee: Seikagaku Kogyo Kabushiki KaishaInventor: Masaki Saito
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Patent number: 8163943Abstract: The present invention is to provide manufacturing intermediates which can be led to useful ?-ketoamide compounds having protease-inhibiting activity extremely economically and stereoselectively, and to provide epoxycarboxamide compounds, azide compounds and amino alcohol compounds represented by the following formulae: wherein R1 and R2 each represents alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group; R3 represents alkyl group, alkenyl group, aromatic hydrocarbon group, heterocyclic group, R6—O— or R7—N(R8)—; where R6 represents alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group; R7 and R8 each represents hydrogen atom, alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group, and, R4 and R5 represent the same groups as R7 and R8, respectively, and R4 and R5 optionally form a ring together; and X represents —O— or —N(R9)—, where R9 represents hydrogen atom or alkyl group, and X optionally forms a ring together with R4 or R5, andType: GrantFiled: October 31, 2007Date of Patent: April 24, 2012Assignee: Seikagaku Kogyo Kabushiki KaishaInventors: Nobuo Kobayashi, Tsuneo Koji, Takashi Fujita, Tomofumi Nishimura, Akihiko Hosoda
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Publication number: 20090305357Abstract: A chondroitin polymerase having such properties that it transfers GlcUA and GalNAc alternately to a non-reduced terminal of a sugar chain from a GlcUA donor and a GalNAc donor, respectively, and the like; and a process for producing the chondroitin polymerase.Type: ApplicationFiled: August 10, 2009Publication date: December 10, 2009Applicant: Seikagaku Kogyo Kabushiki KaishaInventors: Toshio NINOMIYA, Nobuo Sugiura, Koji Kimata
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Patent number: 7470529Abstract: A human-derived novel chondroitin synthase, which is an enzyme for synthesizing a fundamental backbone of chondroitin and has both glucuronic acid transferring activity and N-acetylgalactosamine transferring activity.Type: GrantFiled: May 14, 2007Date of Patent: December 30, 2008Assignees: Seikagaku Kogyo Kabushiki Kaisha, National Institute of Advanced Industrial Science and TechnologyInventors: Hisashi Narimatsu, Koji Kimata, Toshikazu Yada, Takashi Sato, Masanori Goto
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Publication number: 20080318293Abstract: A galactosamine derivative represented by the following formula (1): wherein R1, R2 and R5 each independently represents SO3? or H, and at least one of them represents SO3?; R3 represents H, acetyl or SO3?; R4 represents H, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted acyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aralkyl group; X represents O, S, NH or CH2; and represents an ? bond or a ? bond, and a sulfotransferase inhibitor comprising the derivative.Type: ApplicationFiled: August 19, 2008Publication date: December 25, 2008Applicant: SEIKAGAKU KOGYO KABUSHIKI KAISHAInventors: Osami HABUCHI, Hirofumi Nakano, Toshihiko Sawada, Sonoko Fujii, Shiori Ohtake
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Patent number: 7354910Abstract: An agent for treating inflammatory bowel diseases and an agent for preventing or improving symptoms accompanied by inflammatory bowel diseases, which each comprises hyaluronic acid or a pharmaceutically acceptable salt thereof as an active ingredient.Type: GrantFiled: October 17, 2002Date of Patent: April 8, 2008Assignee: Seikagaku Kogyo Kabushiki KaishaInventor: Toru Kono
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Publication number: 20080064873Abstract: The present invention is to provide manufacturing intermediates which can be led to useful ?-ketoamide compounds having protease-inhibiting activity extremely economically and stereoselectively, and to provide epoxycarboxamide compounds, azide compounds and amino alcohol compounds represented by the following formulae: wherein R1 and R2 each represents alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group; R3 represents alkyl group, alkenyl group, aromatic hydrocarbon group, heterocyclic group, R6—O— or R7—N(R8)—; where R6 represents alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group; R7 and R8 each represents hydrogen atom, alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group, and, R4 and R5 represent the same groups as R7 and R8, respectively, and R4 and R5 optionally form a ring together; and X represents —O— or —N(R9)—, where R9 represents hydrogen atom or alkyl group, and X optionally forms a ring together with R4 or R5, andType: ApplicationFiled: October 31, 2007Publication date: March 13, 2008Applicant: Seikagaku Kogyo Kabushiki Kaisha d/b/a Seikagaku CorporationInventors: Nobuo Kobayashi, Tsuneo Koji, Takashi Fujita, Tomofumi Nishimura, Akihiko Hosoda
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Publication number: 20080058516Abstract: The present invention is to provide manufacturing intermediates which can be led to useful ?-ketoamide compounds having protease-inhibiting activity extremely economically and stereoselectively, and to provide epoxycarboxamide compounds, azide compounds and amino alcohol compounds represented by the following formulae: wherein R1 and R2 each represents alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group; R3 represents alkyl group, alkenyl group, aromatic hydrocarbon group, heterocyclic group, R6—O— or R7—N(R8)—; where R6 represents alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group; R7 and R8 each represents hydrogen atom, alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group, and, R4 and R5 represent the same groups as R7 and R8, respectively, and R4 and R5 optionally form a ring together; and X represents —O— or —N(R9)—, where R9 represents hydrogen atom or alkyl group, and X optionally forms a ring together with R4 or R5, andType: ApplicationFiled: October 30, 2007Publication date: March 6, 2008Applicant: Seikagaku Kogyo Kabushiki Kaisha d/b/a Seikagaku CorporationInventors: Nobuo Kobayashi, Tsuneo Koji, Takashi Fujita, Tomofumi Nishimura, Akihiko Hosoda
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Patent number: 7335515Abstract: A (1?3)-?-D-glucan binding protein, a fluorescence-labeled (1?3)-?-D-glucan binding domain protein, a (1?3)-?-D-glucan measuring agent comprising the same, a method for measuring (1?3)-?-D-glucan using the same, and a (1?3)-?-D-glucan assay kit comprising the same.Type: GrantFiled: November 17, 2006Date of Patent: February 26, 2008Assignee: Seikagaku Kogyo Kabushiki KaishaInventors: Hiroshi Tamura, Masayuki Tanaka, Tatsushi Muta
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Patent number: 7333847Abstract: Provided are a method for evaluation of tissue adhesion level which comprises relating the detection result of gadolinium from MRI image, on which a cross-section of a “boundary surface between a first tissue and a second tissue” of an animal administered with gadolinium has been imaged, to the adhesion level between the first tissue and the second tissue; and a detecting agent of tissue adhesion level. The detecting method of the present invention and detecting agent of the present invention are markedly useful, because they make it possible to detect the adhesion level, which is otherwise difficult to detect from the outside of the body, conveniently, speedily and precisely.Type: GrantFiled: March 8, 2004Date of Patent: February 19, 2008Assignee: Seikagaku Kogyo Kabushiki KaishaInventors: David Amiel, Richard David Coutts, Robert M. Healey
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Patent number: 7326799Abstract: The present invention is to provide manufacturing intermediates which can be led to useful ?-ketoamide compounds having protease-inhibiting activity extremely economically and stereoselectively, and to provide epoxycarboxamide compounds, azide compounds and amino alcohol compounds represented by the following formulae: wherein R1 and R2 each represents alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group; R3 represents alkyl group, alkenyl group, aromatic hydrocarbon group, heterocyclic group, R6—O— or R7—N(R8)—; where R6 represents alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group; R7 and R8 each represents hydrogen atom, alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group, and, R4 and R5 represent the same groups as R7 and R8, respectively, and R4 and R5 optionally form a ring together; and X represents —O— or —N(R9)—, where R9 represents hydrogen atom or alkyl group, and X optionally forms a ring together with R4 or R5, andType: GrantFiled: December 30, 2002Date of Patent: February 5, 2008Assignee: Seikagaku Kogyo Kabushiki KaishaInventors: Nobuo Kobayashi, Tsuneo Koji, Takashi Fujita, Tomofumi Nishimura, Akihiko Hosoda
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Patent number: 7273729Abstract: A human-derived novel chondroitin synthase, which is an enzyme for synthesizing a fundamental backbone of chondroitin and has both glucuronic acid transferase activity and N-acetylgalactosamine transferase activity.Type: GrantFiled: May 30, 2003Date of Patent: September 25, 2007Assignees: Seikagaku Kogyo Kabushiki Kaisha, National Institute of Advanced Industrial Science and TechnologyInventors: Hisashi Narimatsu, Koji Kimata, Toshikazu Yada, Takashi Sato, Masanori Goto
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Patent number: 7256278Abstract: A sialyltransferase having the following physico-chemical properties; (1) Activity: transfers sialic acid from a sialic acid donor selectively to a 3-hydroxyl group of a galactose residue contained in lactosylceramide as a sialic acid acceptor to produce ganglioside GM3; (2) Optimal reaction pH: 6.0 to 7.0; and (3) Inhibition and activation: the activity increases at least 1.5 times with 10 mm of Mn2+ as compared with the case in the absence thereof.Type: GrantFiled: December 3, 2002Date of Patent: August 14, 2007Assignee: Seikagaku Kogyo Kabushiki KaishaInventor: Masaki Saito
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Patent number: 7232676Abstract: A human-derived novel chondroitin synthase, which is an enzyme for synthesizing a fundamental backbone of chondroitin and has both glucuronic acid transferring activity and N-acetylgalactosamine transferring activity.Type: GrantFiled: May 30, 2003Date of Patent: June 19, 2007Assignees: Seikagaku Kogyo Kabushiki Kaisha, National Institute of Advanced Industrial Science and TechnologyInventors: Hisashi Narimatsu, Koji Kimata, Toshikazu Yada, Takashi Sato, Masanori Goto
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Patent number: 6555371Abstract: A sialyltransferase having the following physico-chemical properties: (1) Activity: transfers sialic acid from a sialic acid donor selectively to a 3-hydroxyl group of a galactose residue contained in lactosylceramide as a sialic acid acceptor to produce ganglioside GM3; (2) Optimal reaction pH: 6.0 to 7.0; and (3) Inhibition and activation: the activity increases at least 1.5 times with 10 mM of Mn2+ as compared with the case in the absence thereof.Type: GrantFiled: October 22, 1999Date of Patent: April 29, 2003Assignee: Seikagaku Kogyo Kabushiki KaishaInventor: Masaki Saito
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Patent number: 6335444Abstract: A process for preparing a 2-acylamino alcohol derivative which comprises (A) reacting an aminopropanol derivative represented by the following formula (1): Y—CH2—C*H (NHP1)—C*H(OH)—R1 (1) with an amine represented by R2H to synthesize an amino alcohol derivative represented by the following formula (2): R2—CH2—C*H(NHP1)—C*H(OH)—R1 (2) (B) leaving P1 from said amino alcohol derivative represented by formula (2) to synthesize an amino alcohol derivative represented by the following formula (3): R2—CH2—C*H(NH2)—C*H(OH)—R1 (3) (C) reacting said amino alcohol derivative represented by formula (3) with a carboxylic acid represented by R11COOH or a reactive derivative thereof to prepare a 2-acylamino alcohol derivative represented by the following formula (4): R2—CH2—C*H(NHCOR11)—C*H(OH)—R1 (4 ) wherein * represents an asymmetric carbon atom, and P1, R1, R2 and RType: GrantFiled: February 23, 1999Date of Patent: January 1, 2002Assignee: Seikagaku Kogyo Kabushiki KaishaInventors: Masayuki Jinbo, Hidekazu Oyamada, Jinichi Inokuchi
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Patent number: 6245897Abstract: A monoclonal antibody which recognizes lipopolysaccharide binding site of macrophage cell surface receptor CD14 and has binding activity to monocyte or macrophage cells. The monoclonal antibody suppresses the production of an inflammatory mediator such as TNF, IL-6 or NO at early stages by recognizing CD14, and competitively inhibiting its binding with LPS. Therefore, it is useful for pathology analysis and the treatment of sepsis.Type: GrantFiled: March 4, 1999Date of Patent: June 12, 2001Assignee: Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation)Inventors: Yoshiyuki Adachi, Naohito Ohno, Toshiro Yadomae
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Patent number: 6228998Abstract: A glycosaminoglycan derivative is disclosed wherein a first amino group of a spacer compound (NH2—Y—NH2) is bonded to an aldehyde formed by reducing and partially oxidizing a reducing end sugar of a glycosaminoglycan, via an aminoalkyl bond, or a lactone formed by oxidizing and cyclodehydrating the reducing end sugar of a glycosaminoglycan, via an acid amide bond, and further a hydrocarbon compound having a allyl group at one end and a functional group at another end which is bonded to the second amino group of the spacer compound. This derivative is useful as a substrate in a process for identifying a glycosaminoglycan-degrading enzyme that gives good reproducibility and sensitivity.Type: GrantFiled: July 20, 1995Date of Patent: May 8, 2001Assignee: Seikagaku Kogyo Kabushiki KaishaInventors: Ryu Miura, Sadako Yamagata, Tatsuya Yamagata
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Patent number: D827814Type: GrantFiled: August 12, 2016Date of Patent: September 4, 2018Assignee: SEIKAGAKU KOGYO KABUSHIKI KAISHAInventors: Atsushi Sekine, Ataru Ide, Tadashi Komuro, Teruyuki Iwama