Abstract: The present invention provides a method for producing customized pluripotent stem cells. Specifically, the present invention comprises following steps: extracting proteins from any of the dedifferentiated stem cells or induced pluripotent stem cells, the said dedifferentiated or pluripotent stem cells being prepared by any known method; introducing the protein extract into the adult somatic cells; and culturing the adult somatic cells to produce pluripotent stem cells having the same pluripotency as that of embryonic stem cells. In addition, pluripotent stem cells produced according to the present method and cell therapeutics comprising the same are provided. The method allows pluripotent stem cells to be produced very easily and at a significantly higher yield, compared to typical methods.

Abstract: The present invention relates to a composition for suppressing the death of stem cells during suspension culturing, a composition for mass culturing of stem cells, and a method for suppressing cell death of stem cells during suspension culturing. The composition of the present invention can be usefully used for effective single suspension culturing of stem cells, particularly, mesenchymal stem cells, or used for mass suspension culturing under the circumstances in which cell aggregation does not occur.

Abstract: The present invention provides, as a novel diagnosis marker for type 1 diabetes mellitus, a type 1 diabetes mellitus diagnostic composition comprising alanyl-tRNA synthetase, glycyl-tRNA synthetase, asparaginyl-tRNA synthetase, or tryptophanyl-tRNA synthetase, a diagnostic kit comprising the same, and a diagnostic method using the same. The composition, the kit, and the method, according to the present invention, may be used for early diagnosis and confirmed diagnosis of type 1 diabetes mellitus because type 1 diabetes mellitus can be easily diagnosed from a patient sample.

Abstract: Provided are a method for preparing a highly active human mesenchymal stem cell, which includes forming a spherical cell aggregate by cultivating human mesenchymal stem cells against gravity; a highly active stem cell prepared thereby; a cell therapeutic agent including the stem cell aggregate; and a method for forming a spherical cell aggregate by cultivating human mesenchymal stem cells, wherein the amount of E-cadherin in the mesenchymal stem cell is increased during the cultivation.

Abstract: The present invention provides, as a novel diagnosis marker for type 1 diabetes mellitus, a type 1 diabetes mellitus diagnostic composition comprising alanyl-tRNA synthetase, glycyl-tRNA synthetase, asparaginyl-tRNA synthetase, or tryptophanyl-tRNA synthetase, a diagnostic kit comprising the same, and a diagnostic method using the same. The composition, the kit, and the method, according to the present invention, may be used for early diagnosis and confirmed diagnosis of type 1 diabetes mellitus because type 1 diabetes mellitus can be easily diagnosed from a patient sample.

Abstract: The present invention provides a method for producing customized pluripotent stem cells. Specifically, the present invention comprises following steps: extracting proteins from any of the dedifferentiated stem cells or induced pluripotent stem cells, the said dedifferentiated or pluripotent stem cells being prepared by any known method; introducing the protein extract into the adult somatic cells; and culturing the adult somatic cells to produce pluripotent stem cells having the same pluripotency as that of embryonic stem cells. In addition, pluripotent stem cells produced according to the present method and cell therapeutics comprising the same are provided. The method allows pluripotent stem cells to be produced very easily and at a significantly higher yield, compared to typical methods.

Abstract: The present invention relates to a method for separating highly active stem cells from human stem cells, the highly active stem cells separated by the method, a cell therapeutic agent containing the stem cells, and a medium for separating the highly active stem cells from stem cells containing a specific cytokine. According to the present invention, the method is useful for separating the highly efficient stem cells from mesenchymal stem cells of various origins. Further, the method is very useful in developing a cell therapeutic agent of high efficiency because the method can be applicable to stem cells of various origins which are cultured under different conditions. Senescent stem cells increased by several passage times in vitro can be effectively sorted out, so the method can be used for reactivating the stem cells.

Abstract: The present invention provides a bipolar radiofrequency ablation catheter comprising a working catheter and a magnetic catheter. The magnetic catheter comprises a first tube; a magnet; a first electrode; and a first electrode connector, and the working catheter comprises a second tube; a metallic element; a second electrode; and a second electrode connector. According to the present invention, it is possible to create transmural lesions more completely and easily at a thick myocardial region such as left ventricle in which a transmural lesion could not be easily created by using conventional radiofrequency ablation catheters and thus it is expected to increase the treatment efficiency for tachycardia such as ventricular tachycardia and atrial fibrillation.

Abstract: Disclosed herein is a system and method for managing information of dormant patients and, more particularly, to such a system and method in which the information of dormant patients is stored and managed in a separate storage server.

Abstract: An object of the present invention is to provide a method for the online management of medical record forms, which can provide web screens through terminals to enable doctors, nurses, pharmacists, or the like to immediately online input and read a variety of information created upon treating and caring for patients in a hospital, and can add, modify, delete or manage various medical record forms provided on the web screens and images inserted into records.

Abstract: Disclosed is an ophthalmic applicator for the treatment of pterygium or or glaucoma using a radioisotope. It comprises a source volume for containing the radioisotope therein; a filter volume for controlling a radiation dose emitted from the radioisotope; and an encapsulation volume for encompassing the source volume and the filter volume, wherein the radioisotope is pure 32P or a combination of 32P and 103Pd. Ensuring the formation of more ideal dose distributions than do the conventional 90Sr ophthalmic applicators, as described hitherto, the ophthalmic applicator for the treatment of pterygium or glaucoma using 32P or a combination of 32P and 103Pd can promise both high therapeutic effects on pterygium or glaucoma and high safety effects on the eye lens. Further, 32P and 103Pd are easier to produce and treat than is 90Sr, thereby allowing the radiotherapy to be useful.

Abstract: Disclosed is a method for managing medical information online, in which documents of various formats created by physicians during or after treatment, nursing notes created by nurses during or after nursing service, and other various notes or reports created by clinical laboratory staff during or after physical examinations performed on the patients are presented through a network and a variety of information input through the network is comprehensively managed to be later given users having access rights to the information, thereby enabling the users to share the variety of information.

Abstract: The present invention relates to an implant inserted into a vocal fold and, more particularly, to a cricoid wedge implant that medializes an arytenoid cartilage of a patient endoscopically to treat vocal fold paralysis. The cricoid wedge implant of the present invention comprises a disc type head portion established on one end thereof, a needle portion, of which a section is inclined, provided on the other end thereof; and a tube type body in which a hole is penetrated from the head portion to the needle portion. The present invention medializes the arytenoid cartilage endoscopically without an invasive operation and thereby has advantages in that it takes a shorter time required for the treatment than the conventional method, in which an invasive arytenoid addition is operated to the patient who cannot be cured only with an injection laryngoplasty, and it will not cause any complications.

Abstract: An artificial heart blood pump including a driving motor which can be contained within the human body and which performs pumping action when supplied from an electric power source from outside of the human body. The pump includes left and right ventricles defined by elastomeric films fixed inside a pump body near each side. Each ventricle has an inlet and an outlet provided with respective check valves. Within the pump body generally between the elastomeric films is a movable body having a cylindrical case with a bidirectional driving motor built in. The movable body rolls from side to side during operation to alternately press against the elastomeric films and discharge blood alternately from the ventricles.