Abstract: A method of treating colorectal cancer (CRC) is provided. The method comprises administering to a subject in need thereof a therapeutically effective amount of a Mitogen/extracellular signal-regulated kinase (MEK) inhibitor and a SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase (SRC) inhibitor, wherein cancer cells of the subject express an amount of SRC p419 above a predetermined level and do not express a KRAS G12 mutation, thereby treating the CRC.

Abstract: An aerosol-generating device may include a housing having flexible portion along its length. The flexible portion is configured to transition between a relaxed or unloaded configuration and a flexed or deflected configuration. A flexible heating element and mouthpiece may also be disposed in the housing. When the housing is in a relaxed or unloaded configuration, the flexible heating element and the mouthpiece are at least partially longitudinally aligned with the flexible portion of the housing.

Abstract: System and methods for extracting data from and authenticating digital images of documents. The system may receive first digital image data. The system may determine a first image type of the first digital image data. The system may determine a first version identifier based on the first digital image data. The system may determine a first ruleset. The system may determine a first set of pixel coordinate ranges for authenticating digital images. The system may determine a first authentication status for the first digital image. The system may determine a second portion of the first digital image at a second set of pixel coordinate ranges. The system may compare a first portion to the second portion. The system may determine a second ruleset. The system may update the image ruleset database to include the second ruleset.

Abstract: This disclosure provides system and method for auto repairing vulnerable code program fragments of a software. The present disclosure addresses problems of conventional approaches which are dependent on test cases. In the present disclosure, vulnerabilities in an input application are identified and repaired. First, a plurality of vulnerability detection rules is executed against an application in binary form (i.e., input application) and a plurality of vulnerable code fragments are identified. Post identification of the plurality of vulnerable code fragments, a mapping is created from the application in binary form to its source code files. Post mapping, paths capturing different application functionalities are extracted. Subsequently, a plurality of vulnerable source code program fragments is extracted and auto repair rules are applied on entire application functionality.

Abstract: Systems and methods for documenting label versions for machine learning model input datasets are disclosed herein. The system may receive a label modification request for a dataset. The system may determine a dataset identifier and model error indicator. The system may determine a modification timestamp. The system may generate a label record and generate the label record in a label record database.

Abstract: Machine learning systems and methods for validating workflows are provided. The system receives one or more digital images of a work action being performed, and processes the image using a hierarchical modeling process that includes a filter model and a cascaded expert model. The filter model processes the image to ascertain whether the image is suitable for use in validating completion of the work action. If the system determines that the image is suitable, the image is then processed by the expert model to classify whether the image depicts a scene occurring before, during, or after performance of the work action. The hierarchical modeling process can be utilized to validate different workflows based upon a specified workflow type. A plurality of hierarchical modeling processes can be applied in parallel to an input image in the event that a type of workflow to be validated is not specified in advance.

Abstract: The system and methods described herein allow users to give their applicant information to at least one entity when seeking to submit an inquiry associated with an item, and have various lender microservices run in parallel, segregated by entity, in a jailed environment. The result of these microservices may be returned as a response to the inquiry, being determined autonomously for each respective entity based on one or more respective rule sets or executable logic for each respective entity. Payloads for multiple entities may be combined in a single output from the jailed environment due to outputs from the environment being encrypted in a universal format.

Abstract: A train control system minimizes in-train forces in a train with a hybrid consist including a diesel-electric locomotive and a battery electric locomotive. The train control system includes a virtual in-train forces modeling engine configured to simulate in-train forces and train operational characteristics using physics-based equations, kinematic or dynamic modeling of behavior of the train or components of the train when the train is accelerating, and inputs derived from stored historical contextual data characteristic of the train, and a virtual in-train forces model database configured to store in-train forces models. Each of the in-train forces models includes a mapping between combinations of the stored historical contextual data and corresponding simulated in-train forces and train operational characteristics that occur when the consist is changing speed. An energy management system determines an easing function of tractive effort vs.

Abstract: A method of controlling one or more locomotives in a train includes using a machine learning engine and a virtual system modeling engine to model and classify sections of track along which the train is traveling according to the tractive power needs for the train traversing each section of track as a function of an effective weight profile for the train in the section and an effective friction profile for the train in the section of track. The method includes using the results of the effective weight profile, the effective friction profile, and an effective power availability profile to train the virtual system modeling engine using the machine learning engine to model designated areas of the track where the total tractive effort force or dynamic braking force applied by all of the locomotives in the train is less than a tractive effort force or dynamic braking force, respectively, that can be provided by a subset of the available locomotives in the train.

Abstract: A cartridge of an e-vaping device includes a housing extending in a longitudinal direction, a reservoir in the housing, a heater in the housing, and an absorbent material at least partially surrounding the sinusoidal shaped member. The reservoir is configured to store a pre-vapor formulation. The heater has a sinusoidal shaped member translating about an elliptical shape to define a channel there through. The absorbent material is in fluid communication with the reservoir.

Abstract: At least one example embodiment relates to a lid for a container including a base defining an opening and a top configured to engage a portion of the base. The base includes a support wall, a first sidewall, and a second sidewall. The first sidewall and the second sidewall extend from respective ends of the support wall such that the support wall, the first sidewall, and the second sidewall define a gap configured to receive at least a portion of the container. The top includes a cover, a hinge coupled between the cover and the base, and a peripheral wall extending from an interior portion of the cover. The cover is moveable between an open position providing access to the opening and a closed position sealing the opening.

Abstract: Various examples generally directed to unlocking a locked contactless card for use as payment in card-present transactions are provided. The contactless card is a payment card associated with a payment account. An application executing on a mobile device may be operable to enable unlocking the locked contactless card and receive an indication that the contactless card associated with the mobile device is unlocked for use in card-present transactions. The application may present information related to permitted uses of the unlocked contactless card via a graphical user interface. The permitted uses of the unlocked contactless card may be modified via the graphical user interface.

Abstract: A heater and wick assembly for an aerosol generating system includes a capillary body, a heating element on an outer surface of the capillary body, and a pair of spaced apart electrical contacts fixed around the capillary body and coupled with the heating element. The heater and wick assembly also includes a support member extending along at least part of the length of the capillary body.

Abstract: A synthetic turf system is disclosed. The synthetic turf system comprises a synthetic turf system and a poured-in-place (PIP) rubber subsurface. The PIP rubber subsurface is poured with a mixture of rubber buffing and urethane configured to deliver improved safety, playability, and reduced maintenance requirements for the synthetic turf placed on a playing surface. The PIP rubber subsurface is made with rubber buffings combined with a binder such as polyurethane. The system further comprises a layer of compacted gravel disposed underneath the PIP rubber subsurface configured to allow drainage. The system further comprises a plurality of cooling particle infill to avoid dislodging of infill into athlete's shoes, clothes, eyes, or ears. Further, the infill is substantially free of crumb rubber infill and the system is without the use of added shock pads. Further, the system is configured to maintain a consistent concussion resistance throughout the entire playing surface.

Abstract: A section milling system may include an anchor secured to a downhole end of a coiled tubing. The anchor is configured to expand radially outward to set the anchor at a desired downhole position and restrain rotation of the coiled tubing. The section milling system also includes a reamer positioned downhole from the anchor. The reamer having extendable cutting arms configured to extend in response to fluid flowing through the reamer. Additionally, the section milling system includes a motor configured to rotate in response to fluid flowing through the motor, and rotation of the motor is configured to drive rotation of the cutting arms of the reamer to mill wellbore casing positioned adjacent the reamer. The section milling system further includes an actuation feature configured to move the reamer to mill along a wellbore in the uphole direction.

Abstract: Disclosed herein are system, method, and computer program product embodiments for ingesting batch or real-time incoming audio or text interactive communications. The system verifies that the interactive communication excludes security threats, comprises associated metadata, verifies that the interactive communication is linked to an existing or previous customer's interaction within an organization, enriches the associated metadata with additional data from the customer's interaction within an organization, transforms a media file type of the interactive communication to a common media file type, generates a transcript of the interactive communication, registers the enriched associated metadata with a stored copy of the transcript, and instantiates an interface to provide organizational access to the registered enriched associated metadata and stored copy of the transcript.

Abstract: A handheld aerosol-generating device may include an emitter configured to emit light, a sensor configured to receive light, and an aerosol chamber configured to hold an aerosol. The emitter may emit light into the aerosol chamber. The sensor may receive light from the aerosol chamber and measure at least one wavelength of the spectrum of the received light. Direct measurement of parameters, and/or the presence, of the aerosol in the aerosol chamber may be enabled, where the direct measurement of parameters of the aerosol in the aerosol chamber may enable optimal operation of an aerosol-generating system that may be the handheld aerosol-generating device.

Abstract: Methods and apparatus for performing a wellbore operation. A thermal compensator is introduced into a wellbore having a temperature. The thermal compensator comprises an outer layer comprising a first material, an inner layer comprising a second material, and a core disposed between the inner layer and the outer layer; wherein the core comprises a third material. The third material has a higher coefficient of thermal expansion than the first material and the second material. The core contracts when the wellbore temperature is decreasing and the contraction of the core moves the outer layer such that it applies a force to a structure adjacent to the outer layer.

Abstract: A method for estimating a thickness for each of a plurality of nested tubulars may include disposing an electromagnetic (EM) logging tool in a wellbore, transmitting an electromagnetic field from the transmitter into one or more tubulars to energize the one or more tubulars with the electromagnetic field thereby producing an eddy current, and measuring the electromagnetic field generated by the eddy current. Additionally, the method may include defining a prior distribution of at least one pipe thickness log based on the plurality of measurements, processing a first set of measurement depth points to estimate one or more tubulars at one or more depths in the wellbore, computing a posterior distribution of the thickness log based at least in part on the prior distribution and the one or more thicknesses, and determining a second set of measurement depth points to process based on the posterior distribution.

Abstract: Described herein are systems and techniques for improving operation of equipment that identify compounds included in a slurry that exits a wellbore during a drilling operation. Mass flow rates, volumetric data, wellbore equipment data, and other information may be used to identify a total volumetric density of the slurry. Calculations and/or other evaluations may be performed to identify a volumetric density of materials other than a gas included in the slurry. The volumetric density of the other materials may be subtracted from the total volumetric density to identify a volumetric density of the gas included in the slurry. Estimates of percentages of hydrocarbons and molar mass equations may be used to estimate masses of combined sets of hydrocarbons included in the gas. When a volumetric density of a combined set of hydrocarbons matches the gas volumetric density, the gas may be classified as including the set of hydrocarbons.