Abstract: This invention relates to methods and compositions for the attenuation of HIV-1 replication in human cells, and especially in human macrophages. The invention particularly concerns the use of inhibitors of P21 (CDKNIA) expression to attenuate such replication. The invention particularly concerns the use of antisense P21 oligonucleotides, siRNA and/or 2-cyano-3,12-dioxooleana-1,9-dien28-oic (CDDO) to attenuate such replication.

Abstract: An automated malware analysis method is disclosed which can perform receiving a first universal resource locator identifying a first intermediate network node, accessing the first intermediate network node to retrieve a first malware artifact file, storing the malware artifact file in a data storage device, analyzing the malware artifact file to identify a second universal resource locator within the malware artifact file, and accessing a second intermediate network node to retrieve a second malware artifact file.

Abstract: A preforming device and method of use thereof, the device including a rack, a pinion, belt, belt tensioning feature, and mechanism for supporting a variably appliable enhanced pressure, such as may be applied using a bladder or bladders having one or more valves, the device capable of engaging a mandrel to form at least one ply and a binder against the exterior of the mandrel.

Abstract: A detonator assembly is provided. The detonator assembly comprises a deflagration to detonation transition body, a first thermally stable secondary explosive contained by the body, and a bulkhead coupled to the deflagration to detonation transition body. The bulkhead contains pressure within the body associated with firing the detonator assembly at least until a transition from a deflagration operation mode of the detonator assembly to a detonation operation mode of the detonator assembly has occurred. A second thermally stable secondary explosive may alternatively be included in the deflagration to detonation transition body, either separated from the first thermally stable secondary explosive or mixed with the first thermally stable secondary explosive. The detonator assembly comprises effectively no primary explosive.

Abstract: To deposit a negotiable instrument electronically, a digital image may be used. Systems and methods are described herein that facilitate the use of a digital camera to provide the digital image. A user may capture an image of a negotiable instrument to create a digital image. The digital image may be compressed and saved as a digital image file. The user may then transmit the digital image file to a financial institution, such as a bank, to deposit funds drawn from the account of the negotiable instrument into the user's account. A financial institution may receive digital image files created by a digital camera from account holders and process a deposit request using the digital image file.

Abstract: A system for predicting healthcare financial risk including the process of accessing patient data associated with one or more patents, accessing geographic and healthcare system data, filtering the patient data, geographic data, and healthcare system data into clean data, and applying a predictive risk model to the clean data to generate patient profile data and to identify a portion of the patients associated with a level of predicted financial risk.

Abstract: A temperature sensor array comprises an optical fiber (16) on which are a plurality of Bragg gratings (18) on respective spaced apart portions of the fiber. Each portion is in a housing (14) which freely houses the said portion substantially without axial strain on the fiber within the housing and which also isolates the grating from strain imposed on the fiber outside the housing. Thus substantially only changes in temperature affect the Bragg grating of that portion. The array may be used to detect and control the temperature of a tool (12) for forming a composite component amongst other uses.

Abstract: A method of communicating individual packets i of K bits includes permutation mapping of the packets, with each permuted packet being denoted by ?n(i), wherein ?n is a permutation on K letters that is unique for each packet transmission. Each permuted packet ?n(i) is modulated to provide a complex vector x(?n(i)) for each packet. The packets are transmitted over a AWGN channel so each individual packet i is received as a variable of the vector x(?n(i)) in a complex vector yn=x(?n(i))+vn, wherein n represents the sequential number of the transmission attempt for a particular packet and vn represents noise. This method enables the packets to be transmitted while using an improved ARQ routine that includes soft-combining decisions and a constant constellation with a constellation complexity greater than two bits/symbol to thereby significantly improve ARQ-routine performance over the current state of the art.

Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating inflammatory arthropathies by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.

Abstract: The present invention concerns enhancements in the cooling effects of certain physiological coolant-containing compositions such as topically applied cosmetic, toiletry or pharmaceutical products, wherein the cooling effect of the physiological coolants is enhanced by the addition of a substance according to formula (I) or dermatologically acceptable salts thereof: R1—CR2(OR3)—CO—NR4—CR5R6—X—OR7??(I) It was found that substances represented by formula (I) are capable of bringing about greater cooling effects from reduced concentrations of physiological coolants without behaving as physiological coolants themselves, thereby enabling the preparation of compositions that do not necessarily have the characteristic minty odor of menthol-containing products and/or to allow greater freedom in creating perfumed products.

Abstract: A method of maintaining a desired downhole pressure during a drilling operation can include measuring a parameter with a sensor, communicating actual parameter values from the sensor to a predictive device, training the predictive device to output predicted parameter values in response to input of the actual parameter values, and outputting the predicted parameter values from the predictive device when the predictive device ceases receiving the actual parameter values. A well drilling system can include a predictive device which outputs predicted parameter values in response to input of actual parameter values to the predictive device. The predictive device continues to output the predicted parameter values, even when the predictive device fails to receive valid actual parameter values. Another well drilling system includes a data validator which communicates valid actual parameter values to the predictive device, but does not communicate invalid actual parameter values to the predictive device.

Abstract: Systems and methods for processing bill payments. A consumer may send a bill payment request online to a payment processing network, such as through an online bill payment interface. The payment processing network can coordinate with a non-bank acquirer to settle the bill payment with the biller. The liability for the transaction may fall on the issuer, who may be responsible for all parties fulfilling the transaction. The non-bank acquirer may coordinate among the various parties, but may not have liability for fulfillment of the transaction. The non-bank acquirer can deposit funds for the bill payment in a biller bank, and accounts receivable data can be sent to the biller for reconciliation of the bill.

Abstract: A system, method and computer program product for processing utility data of a power grid is provided. In one embodiment, the system includes a datamart comprised of a plurality of physical databases storing utility data, a plurality of applications comprising an automated meter application configured to process power usage data from a plurality of automated meters, a power outage application configured to identify a location of a power outage, and a power restoration application configured to identify a location of a power restoration. The system may include an analysis engine comprising a plurality of analysis objects with each analysis object configured to process data to provide a specific analysis, wherein said analysis engine is accessible via one or more of the plurality of applications, and the system may include a report module configured to receive an output from the analysis engine and to output a report.

Abstract: Methods, systems, and machine-readable media are disclosed for identification of an individual and evaluation of risk from doing business with that individual. In one embodiment a method of evaluating a risk from conducting business with an individual comprises receiving identity information related to the individual. The identity information includes information from an identity credential presented by the individual. The identity credential is validated based on the information from the identity credential and one or more positive databases. An identity of the individual is verified based on the identity information and the one or more positive databases. The identity information is screened against one or more negative databases indicating past losses to one or more entities. Results of the screening are reported based on one or more criteria of an entity considering doing business with the individual.

Abstract: The present invention provides a vehicle-mounted device, a method for activating the vehicle-mounted device, and a vehicle-mounted system. The vehicle-mounted system includes a vehicle-mounted device, a data center, and a service platform. The vehicle-mounted device not only can be locally activated according to an activating information corresponding to an identity information of the vehicle-mounted device which indicates an unique identity of the vehicle-mounted device, but also can be remotely activated through wireless communication. Moreover, the vehicle-mounted system further includes application sub-modules which can provide extended/added functions. Therefore, by the method for activating a vehicle-mounted device provided by the present invention, the vehicle-mounted device can be activated in time, so that the information resources can be more easily and conveniently obtained by the user.

Abstract: Compositions and methods are provided for the treatment or prevention of RSV disease by modulating RSV infection and immunity. In particular, amino acid sequences in the RSV G glycoprotein, containing the chemokine motif defined as C-X-X-X-C (or CX3C), are identified that are essential in causing RSV infection and disease. The chemokine motif is biologically active and participates in virus binding to and infection of susceptible cells. The prevention or treatment of RSV infection is achieved by interfering with the motif, such as by administering a vaccine in which the motif is altered or by administration or induction of blocking molecules that inhibit the biological activity of the motif.

Abstract: A slip for use in the anchoring of a downhole tool in a well casing is provided. The slip's outer diameter is about equal to the inner diameter of the well casing. The slip is positioned about a mandrel and radially expands upon the application of force. The wickers on the slip deformably engage the casing in response to a force.

Abstract: Various optical fiber-based seismic monitoring system embodiments include a light source that drives an optical fiber positioned within a borehole. At least one light sensor analyzes Rayleigh backscattered light to obtain an acoustic signal for each of multiple points along the borehole. One or more processors operate to determine microseismic event direction, distance, and/or intensity based at least in part on phase information of said acoustic signals. The acoustic signal cross-correlations, semblances, or phase-sensitive similarity measures can be determined as a function of scanning direction to accurately determine the relevant microseismic event information. The optical fiber may be positioned in the cemented annulus of a cased borehole having a shape that extends along more than one dimension (e.g., an L-shaped borehole).

Abstract: Recombinant immunotoxins are fusion proteins composed of the Fv domains of antibodies fused to bacterial or plant toxins. RFB4 (Fv)-PE38 is an immunotoxin that targets CD22 expressed on B cells and B cell malignancies. The present invention provides antibodies and antibody fragments that have improved ability to bind the CD22 antigen of B cells and B cell malignancies compared to RFB4. Immunotoxins made with the antibodies and antibody fragments of the invention have improved cytotoxicity to CD22-expressing cancer cells. Compositions that incorporate these antibodies into chimeric immunotoxin molecules that can be used in medicaments and methods for inhibiting the growth and proliferation of leukemia and lymphoma cells.

Abstract: Ester based drilling fluids with enhanced stability at high temperatures for drilling, running casing in, and/or cementing a borehole in a subterranean formation. The drilling fluids comprise a monomeric or polymeric carbodiimide hydrolysis inhibitor.