Patents Assigned to Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
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Patent number: 9611498Abstract: The present invention provides a method for producing stevioside compounds by microorganism, comprising carrying out heterologous biosynthesis of stevioside compounds from geranyl geranyl pyrophosphate synthase (GGPPS), Copalyl pyrophosphate synthase (CDPS), Kaurene synthase (KS), dual-function kaurene synthase (CPS/KS), kaurene oxidase (KO), a cytochrome P450 redox protein (CPR), kaurenoic acid-13[alpha]-hydroxylase, UGT85C2 glycosyltransferase and UGTB1/IBGT glycosyltransferase (optionally comprising UGT74G1 glycosyltransferase and/or UGT76G1 glycosyltransferase).Type: GrantFiled: September 29, 2013Date of Patent: April 4, 2017Assignee: Shanghai Institutes For Biological Sciences, Chinese Academy of SciencesInventors: Yong Wang, Jianfeng Wang, Zhiqiang Xiong, Shiyuan Li
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Publication number: 20170037425Abstract: Provided is a method for plant improvement with the aim of increasing the light use efficiency of a plant. By expressing a light energy absorption and transduction (LEAT) protein in the plant, and by utilizing light energy absorbed to interact with a related methyl-quinone derivative in the plant body, such as plastoquinone, to catalyze water splitting and to release oxygen, the present invention increases the light use efficiency of the plant. The method effectively extends the utilization of light energy by the plant, thus increasing photosynthesis efficiency and yield.Type: ApplicationFiled: December 31, 2012Publication date: February 9, 2017Applicant: SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCESInventors: Weiming CAI, Weining SUN, Genyun CHEN, Xinguang ZHU, Hualing MI, Haiying CHEN
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Publication number: 20160376247Abstract: Provided is a compound represented by formula I, wherein R9 is a C1-C22 hydrocarbyl group, or a C2-C3 ester-substituted C1-C3 alkyl group, R5, R6, R7, and R8 are alkyl groups or H, and R1, R2, R3, and R4 are H or a lower hydrocarbyl group. Or, R9 is a C2-C22 hydrocarbyl group, or a C2-C3 ester-substituted C1-C3 alkyl group, and R5 is connected to R1, R6 is connected to R2, R7 is connected to R3, R8 is connected to R4 to form six-membered rings. The present compound is temperature-sensitive and can enter into cells. An intracellular temperature distribution image having high spatial and temporal resolution can thus be obtained. The present compound can also perform distribution calibration on a temperature-sensitive fluorescent compound. Also provided is a method for measuring temperature distribution within a living cell, and a corresponding detection kit. The method satisfies the requirements of small size measurement and rapid measurement, thereby achieving high resolution in terms of space and time.Type: ApplicationFiled: December 31, 2014Publication date: December 29, 2016Applicant: SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCESInventors: Jiansheng Kang, Taorong Xie, Chunfeng Liu
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Publication number: 20160230182Abstract: The invention relates to a polypeptide for regulating agronomic characters and yield characters of plants and application thereof. The invention alters agronomic characters and yield characters of plants such as root development, tillering ability, heading period, panicle structure, grains number per panicle, grain morphology, and 1000 grains weight by directional regulating expression level of cytokinin-O-glycosyltransferase 1 in plants, thus achieve the aim of modifying plant type, panicle structure, grain morphology and weight, increasing yield.Type: ApplicationFiled: June 24, 2014Publication date: August 11, 2016Applicant: SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCESInventors: Fangqing GUO, Xiaoling SHANG, Hua TIAN
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Publication number: 20160152996Abstract: The present invention provides a heat-resistance plant gene JAZ5a and use thereof. The inventors of the present invention isolated for the first time a heat resistance gene from the plant of Brassica spp., which can greatly improve the heat-resistance ability of the plant, especially in the bolting stage. The present invention further provides a protein encoded by said gene and its preparation method, vectors and host cells containing said gene, and a method for preparing a transgenic plant containing said gene.Type: ApplicationFiled: February 3, 2016Publication date: June 2, 2016Applicant: Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesInventors: Yu-Ke HE, Chuan-Bao SUN
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Publication number: 20160120908Abstract: The present invention discloses the application of mesenchymal stem cells in the prophylaxis or treatment of stress response-induced weakened immunity. More particularly, the present invention provides the use of mesenchymal stem cells in preparing a pharmaceutical composition for the prophylaxis or treatment of stress response-induced lymphopenia; and/or the use thereof in preparing a pharmaceutical composition for the prophylaxis or treatment of stress response-induced weakened immunity; and/or the use thereof in preparing a pharmaceutical composition for the promotion of interleukin 4 (IL-4) expression and/or enhanced or strengthened activity. The present invention has found that mesenchymal stem cells can, by means of regulating IL-4 and down-stream related signaling pathways, protect against hormonal disorder-induced lymphopenia, thus having the function of activating immune response.Type: ApplicationFiled: April 29, 2014Publication date: May 5, 2016Applicant: Shanghai Institutes For Biological Sciences, Chinese Academy Of SciencesInventors: Yufang Shi, Gang Cao
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Publication number: 20160115515Abstract: Provided are the use of glycosyltransferases gGT25, gGT13, gGT30, gGT25-1, gGT25-3, gGT25-5, gGT29, gGT29-3, gGT29-4, gGT29-5, gGT29-6, gGT29-7, 3GT1, 3GT2, 3GT3, 3GT4 and derived polypeptides therefrom in the catalyzed glycosylation of terpenoid compounds and the synthesis of new saponins, wherein the glycosyltransferases can specifically and efficiently catalyze tetracyclic triterpenoid compound substrates at positions C-20 and/or C-6 and/or C-3 during hydroxyl glycosylation, and/or transfer the glycosyl from a glycosyl donor to the first glycosyl of the tetracyclic triterpenoid compounds at position C-3, so as to extend the sugar chain. The glycosyltransferases can also be used for constructing man-made synthetic rare ginsenosides and a variety of new ginsenosides and derivatives thereof.Type: ApplicationFiled: December 6, 2013Publication date: April 28, 2016Applicant: Shanghai Institutes For Biological Sciences, Chinese Academy of SciencesInventors: Zhihua Zhou, Xing Yan, Yun Fan, Pingping Wang, Yongjun Wei, Wei Wei, Jun Zhang
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Patent number: 9284572Abstract: The present invention provides a heat-resistance plant gene JAZ5a and use thereof. The inventors of the present invention isolated for the first time a heat resistance gene from the plant of Brassica spp., which can greatly improve the heat-resistance ability of the plant, especially in the bolting stage. The present invention further provides a protein encoded by said gene and its preparation method, vectors and host cells containing said gene, and a method for preparing a transgenic plant containing said gene.Type: GrantFiled: July 7, 2011Date of Patent: March 15, 2016Assignee: SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCESInventors: Yu-Ke He, Chuan-Bao Sun
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Publication number: 20160002725Abstract: The invention relates to the use of TRPC6 mRNA levels in peripheral blood cells for the early detection/diagnosis of senile dementia. Specifically, the present invention provides a classic transient receptor potential channel 6 (TRPC6) gene or protein thereof and the use of same in preparing a reagent or test kit for detecting or diagnosing Alzheimer's disease. The present invention further relates to a polypeptide used to prepare a medicament that treats AD, and relates to a composition of said polypeptide.Type: ApplicationFiled: January 24, 2014Publication date: January 7, 2016Applicant: Shanghai Institutes For Biological Sciences, Chinese Academy of SciencesInventors: Yizheng Wang, Junfeng Wang, Rui Lu
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Patent number: 9139840Abstract: Novel crop grain filling genes (GIF1) and the applications thereof are presented in the invention. The GIF1 genes can be applied to control grain filling, enhance crop yield or quality, or improve disease resistance or storage stability of crop grains. A method for improving crops is also presented in the invention. The GIF1 genes shows valuable potentials in controlling crop yield, quality, storage, and resistance to diseases.Type: GrantFiled: December 11, 2012Date of Patent: September 22, 2015Assignee: Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesInventors: Zuhua He, Hongxia Zhang, Bei Li, Hua Liu
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Publication number: 20150190427Abstract: The present invention relates to hepatocyte-like cells. Also disclosed are methods of making the cells and using the cells.Type: ApplicationFiled: February 8, 2014Publication date: July 9, 2015Applicant: SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCESInventors: Lijian Hui, Pengyu Huang, Ludi Zhang, Yimeng Gao
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Patent number: 8968727Abstract: The present invention provides a telomerase activity inhibiting polypeptide. The expression of the polypeptide in tumor cells can inhibit significantly tumor cell telomerase activity, tumor cell growth, and lead to the death of such cells. The present invention further provides a preparation method for the polypeptide and an application thereof in targeted treatments of tumors.Type: GrantFiled: July 4, 2011Date of Patent: March 3, 2015Assignee: Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesInventors: Mujun Zhao, Jian Feng, Guoyuan Chen, Jing Zhao, Guangming Chen, Liang Da, Zaiping Li
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Patent number: 8895805Abstract: A method for improving insect resistance of plants, in which dsRNA of insect's gene is expressed in plants by using transgenic technique, and then the interfering RNAs are formed in the plants. The interfering RNAs then enter into insects' bodies after being ingested by the insect that eats the plant, and conduct RNA interference against the target gene, thereby expression of the target gene is suppressed by RNA interference. A new plant-mediated method for improving insect resistance by suppressing the growth of insects by RNA interference mechanism.Type: GrantFiled: December 4, 2007Date of Patent: November 25, 2014Assignee: Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesInventors: Xiaoya Chen, Yingbo Mao, Zhiping Lin, Lingjian Wang
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Publication number: 20140248254Abstract: This invention provides the use of AChE as nuclease. The use of AChE in regulating the stability of nucleic acid and cell apoptosis, as well as a series of agents based on the use, including the agents for promoting or inhibiting cell apoptosis, the agents for inhibiting tumors, and the agents for protecting nucleic acid from impairing, are provided.Type: ApplicationFiled: August 8, 2012Publication date: September 4, 2014Applicant: SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCESInventors: Xuejun Zhang, Jing Xie, Aiying Du, Kaijie Guo, Jun Wu
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Publication number: 20140100127Abstract: A marker for the detection of liver cancer and application of the marker thereof. The application includes use of cytochrome p450 family 17 subfamily A polypeptide 1 (CYP17A1 protein) in the preparation of diagnostic reagents or kits for the detection of liver cancer kit. Studies have shown that CYP17A1 expression levels are higher in liver cancer tissues than in the adjacent healthy tissues, and the amount of CYP17A1 in sera of liver patients is significantly higher than that of healthy human population. Therefore, CYP17A1 can be used as a marker for the diagnosis of liver cancer (especially serological diagnosis).Type: ApplicationFiled: March 30, 2012Publication date: April 10, 2014Applicant: Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesInventors: Mujun Zhao, Feng Wang, Zhen Xing, Liang Da, Ying Xu, Zaiping Li
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Publication number: 20130330304Abstract: The present invention relates to hepatocyte-like cells. Also disclosed are methods of making the cells and using the cells.Type: ApplicationFiled: November 4, 2011Publication date: December 12, 2013Applicant: Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesInventors: Lijian Hui, Pengyu Huang, Xin Wang
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Patent number: 8557837Abstract: The invention relates to sinomenine derivatives, methods for their synthesis and their applications. The sinomenine derivatives include oxidation derivatives, and C-10 substituted sinomenine derivatives. Based on the readily oxidizable phenol group on sinomenine structure, using oxidation, oxidative dearomatization, or conjugated addition aromatization, one can introduce C-10 substitutions to synthesize the sinomenine derivatives. The sinomenine derivatives of the invention have the following structures: Using in vitro TNF-? inhibition assay, the activities of the synthetic compounds are assessed. Results from these assays shown that most compounds have anti-inflammatory effects, and some compounds have better activities than that of sinomenine. These compounds may be used in treating immune diseases such as rheumatoid arthritis (RA).Type: GrantFiled: February 9, 2011Date of Patent: October 15, 2013Assignees: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesInventors: Zhujun Yao, Bing Sun, Yangtong Lou, Zhenyu Yang, Aizhong Chen, Zhao Ma
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Publication number: 20130247242Abstract: Provided are a crop height regulatory gene from Arabidopsis thaliana, expression regulatory sequences thereof and uses thereof. The crop regulatory gene can be used to regulate the plant height, volume, tiller, yield, flower organ size, or seed size of crops.Type: ApplicationFiled: May 13, 2013Publication date: September 19, 2013Applicant: Shanghai Institutes of Biological Sciences, Chinese Academy of SciencesInventor: Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences
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Publication number: 20130167266Abstract: The present invention provides a heat-resistance plant gene JAZ5a and use thereof. The inventors of the present invention isolated for the first time a heat resistance gene from the plant of Brassica spp., which can greatly improve the heat-resistance ability of the plant, especially in the bolting stage. The present invention further provides a protein encoded by said gene and its preparation method, vectors and host cells containing said gene, and a method for preparing a transgenic plant containing said gene.Type: ApplicationFiled: July 7, 2011Publication date: June 27, 2013Applicant: SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCESInventors: Yu-Ke He, Chuan-Bao Sun
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Publication number: 20130160164Abstract: Novel crop grain filling genes (GIF1) and the applications thereof are presented in the invention. The GIF1 genes can be applied to control grain filling, enhance crop yield or quality, or improve disease resistance or storage stability of crop grains. A method for improving crops is also presented in the invention. The GIF1 genes shows valuable potentials in controlling crop yield, quality, storage, and resistance to diseases.Type: ApplicationFiled: December 11, 2012Publication date: June 20, 2013Applicant: Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesInventor: Shanghai Institutes for Biological Science, Chines