Patents Assigned to SHANGHAI UNIVERSITY
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Publication number: 20240132492Abstract: The present disclosure provides a class of Pyridopyrimidine compounds having a structure shown in Formula (I) or their pharmaceutically acceptable salts, or stereoisomers or prodrug molecules and applications thereof. The compounds in the present disclosure can efficiently and selectively degrade AKT3 protein in cells without affecting AKT1/2, thereby significantly inhibiting tumor cell proliferation mediated by high expression of AKT3 protein. It can be used to prepare therapeutic drugs for cancer and other diseases related to abnormal expression of AKT3 protein.Type: ApplicationFiled: September 6, 2023Publication date: April 25, 2024Applicants: JINAN UNIVERSITY, SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCESInventors: Ke DING, Xin ZHANG, Fang XU, Xiaomei REN, Xiaoyun LU, Dawei MA, Weixue HUANG
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Publication number: 20240111288Abstract: A method and system for decomposing cross-domain path planning of an amphibious vehicle.Type: ApplicationFiled: January 13, 2023Publication date: April 4, 2024Applicants: CHONGQING UNIVERSITY, SHANGHAI UNIVERSITYInventors: Huayan PU, Lele DING, Xuyang ZHENG, Jun LUO, Jie MA, Jing HUANG, Yongbing CHEN, Hongliang LIU, Anming SHEN, Haonan SUN
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Patent number: 11927235Abstract: Disclosed is an active control Stewart vibration damping platform, including a load-bearing platform, a base, and six telescopic rods. Each telescopic rod includes a driving motor, a rotating shaft, a sleeve, and a moving rod. One end, away from the driving motor, of the rotating shaft is provided with a cylindrical cavity, one end of the moving rod penetrates through the cylindrical cavity, and the sleeve is sleeved outside the rotating shaft. The rotating shaft is in running fit with the sleeve through a first bearing, and the moving rod is in sliding fit with the sleeve through a second bearing. The moving rod and the rotating shaft are respectively provided with a spiral permanent magnet. The spiral permanent magnet on the rotating shaft can drive the moving rod to move in an axial direction of the rotating shaft through the spiral permanent magnet on the moving rod when rotating.Type: GrantFiled: April 14, 2023Date of Patent: March 12, 2024Assignees: Chongqing University, Shanghai UniversityInventors: Huayan Pu, Zhi Sun, Jun Luo, Jinglei Zhao, Jin Yi, Yi Qin, Shujin Yuan
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Patent number: 11925531Abstract: The present disclosure provides a magnetic dressing and a preparation method and use thereof, belonging to the technical field of pharmaceutical preparations. The magnetic dressing includes a magnetic layer, a drug-loading layer, and a protective layer that are stacked in sequence, where the magnetic layer includes polyvinyl alcohol, gluten, and iron particles. In the present disclosure, a swallowed magnetic dressing is controlled by an external magnetic field, and the magnetic dressing is moved to a pathological position by changing a direction of the external magnetic field; after the external magnetic field is removed, the magnetic dressing changes from a ring to a sheet, thereby completing attachment of an entire lesion surface to complete treatment by autonomous drug release.Type: GrantFiled: September 13, 2022Date of Patent: March 12, 2024Assignee: Shanghai UniversityInventors: Na Liu, Ziheng Chen, Huiyu Yuan, Dan Zhang, Kewei Zhang, Tao Yue, Yuanyuan Liu, Yan Peng
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Publication number: 20240078444Abstract: The invention discloses a vehicle fault reasoning method based on a knowledge graph, includes: constructing a knowledge graph of a vehicle fault; obtaining a question statement (QS) from user; performing question classification on the QS by TextCNN to obtain a classification result; marking a training QS by using an NER data marking manner and training an entity extraction model based on a sequence marking result; generating a vehicle fault class by a decision tree model for extracting the QS and searching for an answer in the knowledge graph; and performing question template matching based on the classification result and the answer and substituting the answer into the question template to obtain an answer statement. A question answering system constructed by the method includes word processing, question classification, question template matching, and answer generation, which helps the user judging a fault problem of vehicle, and searching for related knowledge about vehicle fault.Type: ApplicationFiled: November 15, 2022Publication date: March 7, 2024Applicant: SHANGHAI UNIVERSITY of ENGINEERING SCIENCEInventors: Zhijun Fang, Yuanyuan Li, Yongbin Gao, Weibing Wan
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Patent number: 11918253Abstract: An active variable stiffness clamping device for pelvic fracture reduction robot, belonging to the technical field of medical robots. The clamping device includes an affected side adjusting support module and a healthy side fixing module which are in fit with each other. The affected side adjusting support module is provided with a pair of electric pin rod connector modules connected to the affected side adjusting support module. The healthy side fixing module includes a healthy side bed clamp seat, the healthy side bed clamp seat is provided with a healthy side support rod, the healthy side support rod is provided with a healthy side spherical hinge base, and the healthy side spherical hinge base is provided with a pair of healthy side fixers which are in clearance fit with each other.Type: GrantFiled: February 20, 2023Date of Patent: March 5, 2024Assignee: Shanghai UniversityInventors: Jingtao Lei, Xinyi Chen, Shenyang Cai
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Patent number: 11906603Abstract: Disclosed are a system and a method for measuring a magnetorefractive effect of an optical fiber. The system comprises a laser, a coupler A, a sensing optical fiber, a reference optical fiber, a carrier generator, a coupler B, a photoelectric detector and a data acquisition and processing module. The coupler A, the sensing optical fiber, the reference optical fiber and the coupler B form a Mach-Zehnder optical fiber interferometer. An external magnetic field influences the refractive index of the sensing optical fiber, so that the optical path difference between two paths of optical signals in the sensing optical fiber and the reference optical fiber is changed, the intensity of an interference optical signal output by the coupler B is changed, and the refractive index change of the sensing optical fiber under the action of the magnetic field is measured by detecting and processing the interference optical intensity.Type: GrantFiled: June 7, 2022Date of Patent: February 20, 2024Assignee: Shanghai UniversityInventors: Tingyun Wang, Yi Huang, Chuanlu Deng, Chengyong Hu
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Patent number: 11887485Abstract: A control method and system for collaborative interception by multiple unmanned surface vessels are provided. The method includes obtaining task environment information of each unmanned surface vessel in an unmanned surface vessel group at a current moment, estimating interception point information of the intruding target at the current moment by using a Kalman filter according to the task environment information of the unmanned surface vessels at the current moment, determining process state information of each unmanned surface vessel at the current moment, inputting the process state information of each unmanned surface vessel at the current moment into a corresponding intruding target interception policy output model respectively to obtain an execution action of each unmanned surface vessel at a next moment to intercept the intruding target. The application can intercept the intruding target accurately.Type: GrantFiled: September 7, 2021Date of Patent: January 30, 2024Assignees: Shanghai University, Chongqing UniversityInventors: Huayan Pu, Yuan Liu, Jun Luo, Zhijiang Xie, Jiajia Xie, Xiaomao Li, Zhou Su, Yan Peng, Hengyu Li, Shaorong Xie
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Patent number: 11873605Abstract: The present invention relates to a liquid-state temporary reinforcing material, a preparation method therefor and an application thereof. The liquid-state temporary reinforcing material comprises a reinforcing material and a crystallization inhibitor; the reinforcing material is selected from molecules of any two or more of menthol, menthone, menthol ester and menthol ether, and the content of the crystallization inhibitor is less than 50 ppm. For the liquid-state temporary reinforcing material of the present invention, the menthol and the derivatives of the liquid-state temporary reinforcing material are integrally mixed together to form the composite material for temporary reinforcing, the composite material being liquid and volatilization-controllable at room temperature. Thus, the temporary reinforcing requirements for extracting cultural relics at an archaeology excavation site may be met, and the material is convenient to use.Type: GrantFiled: June 15, 2018Date of Patent: January 16, 2024Assignee: SHANGHAI UNIVERSITYInventors: Hongjie Luo, Xiao Huang, Yarong Yu, Xiangna Han, Bo Rong, Qinghua Ren
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Patent number: 11865196Abstract: An engineered radioactive polymeric microsphere, and a preparation and application thereof. The preparation method includes: adding a styrene monomer and a disperser and/or a crosslinker into a medium, followed by feeding of nitrogen or helium and stirring to obtain a first reaction mixture; heating the first reaction mixture, and adding an initiator, followed by reaction under stirring at a constant temperature to obtain a second reaction mixture; subjecting the second reaction mixture to washing with ethanol and water, and vacuum drying to obtain a crude polymeric microsphere; subjecting the crude polymeric microsphere to radiation-induced graft polymerization with a functional monomer to obtain the functionalized polymeric microsphere; and exposing the functionalized polymeric microsphere to a radionuclide to prepare the engineered radioactive polymeric microsphere.Type: GrantFiled: June 21, 2023Date of Patent: January 9, 2024Assignees: Xiamen University, Shanghai UniversityInventors: Gang Liu, Xiao Xu, Hongjuan Ma, Zhenwen Zhao, Hu Chen, Pan He, Chao Liu, Chengchao Chu, Dong Li
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Patent number: 11865503Abstract: A multipurpose solution mixer and a use method thereof are provided. The multipurpose solution mixer includes a main control unit, a solution storage unit and a solution blending unit installed in a case; an operation display unit and a liquid outlet provided on the case; and an atomization humidifying unit connected with the liquid outlet, wherein the main control unit is electrically connected with other units; the operation display unit is a display screen with touch operation functions; the solution storage unit includes sealed bottles and infusion tubes; the solution blending unit includes micropumps infusion tubes and a blending chamber, the blending chamber is connected with the atomization humidifying unit via respective infusion tubes, and the operation display unit sends instructions to the main control unit to control the micropumps to extract solutions from the sealed bottles into the blending chamber, and output a mixed solution via the liquid outlet.Type: GrantFiled: March 26, 2020Date of Patent: January 9, 2024Assignee: SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINEInventors: Jianying Wang, Lei Zhang, Xiaojuan Hu
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Patent number: 11863088Abstract: Disclosed is a vortex-induced vibration-based piezoelectricity and friction nanometer power generation combined energy collector. The energy collector includes a support frame, a piezoelectric plate, a cylinder and a solid-liquid type friction nanometer power generation assembly, wherein the support frame includes a fixed plate, a cantilever plate and a connecting plate which are sequentially connected from top to bottom, the piezoelectric plate is fixed on one side of the cantilever plate, the solid-liquid type friction nanometer power generation assembly has an outer shell, an insulating friction inner shell and a sealing part, the outer shell having two symmetrically arranged induction electrodes, insulating layers are arranged between the butt joint faces of the two induction electrodes, the included angles between the butt joint faces of the two induction electrodes and the plane, provided with the piezoelectric plate, of the cantilever plate are not 90°.Type: GrantFiled: August 24, 2022Date of Patent: January 2, 2024Assignee: SHANGHAI UNIVERSITYInventors: Dan Zhang, Di Zhang, Xiaowei Li, Zhongjie Li, Yan Peng, Shaorong Xie
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Patent number: 11830112Abstract: A method for rapid reconstruction of a woven composite material microstructure based on topological features is provided. First, geometric modeling is performed according to the topological features of fiber bundles and matrix in a woven composite structure, then the topological features are identified on the basis of a ?-computed tomography (CT) sequence image, the change laws of the features are extracted, and finally, a geometric model is reconstructed to complete the modeling of a microstructure. Compared with the structure modeling method based on weaving process parameters, the consistency between the reconstructed model and a real woven structure is improved, facilitating the improvement of the accuracy of the subsequent calculation of the mechanical properties of the material; and compared with the method for structure reconstruction directly on the basis of a ?CT image, a tedious point cloud data process is simplified and calculation costs are greatly reduced.Type: GrantFiled: June 4, 2020Date of Patent: November 28, 2023Assignees: SHAOXING RESEARCH INSTITUTE OF SHANGHAI UNIVERSITY, SHANGHAI UNIVERSITYInventors: Aijun Li, Dan Zhang, Jingchao Yuan, Meihua Shi
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Patent number: 11808319Abstract: A horizontally arranged six-degree-of-freedom constant-stiffness mechanism is provided, and includes an upper platform, a bottom plate, three composite spherical hinges, spherical hinges, support rods, guide rail slider assemblies, and six electromagnetic adjustable stiffness units. Two ends of a shaft on which a permanent magnet is fixed in each electromagnetic adjustable stiffness unit are fixed to the bottom plate via shaft supports. Axially moving housings of electromagnetic adjustable stiffness units are fixed on sliders of the guide rail slider assemblies via slider backing plates respectively. Guide rail slider assembles are fixed on the bottom plate. Tops of the housings are mounted with the spherical hinges respectively. A bottom of the upper platform is uniformly mounted with the composite spherical hinges. One end of each support rod is threadedly connected to a corresponding one of the spherical hinges, and another end is connected with a corresponding one of composite spherical hinges.Type: GrantFiled: July 12, 2021Date of Patent: November 7, 2023Assignees: Chongqing University, Shanghai UniversityInventors: Huayan Pu, Tong Wang, Qimin Li, Jinglei Zhao, Jun Luo, Jie Ma
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Patent number: 11808317Abstract: A squeeze mode giant electrorheological fluid damper is disclosed. The squeeze mode giant electrorheological fluid damper comprises a support, a container and a connecting structure, wherein the support comprises a bottom plate, guide shafts and a top plate, the guide shaft is vertically fixed on the bottom plate, and the top plate is slidably arranged on the guide shaft; the container comprises a container body and two spiral spring pieces coaxially arranged in the container body, the container body is fixed on the bottom plate, the bottoms of the two spiral spring pieces are fixed to the bottom of the container, the two spiral spring pieces are not in contact with each other and are spaced by 180°; the top of the connecting structure is fixedly connected with the top plate, and the bottom of the connecting structure is fixedly connected with the tops of the two spiral spring pieces.Type: GrantFiled: August 23, 2022Date of Patent: November 7, 2023Assignee: Shanghai UniversityInventors: Yi Sun, Ben Lu, Huayan Pu, Min Wang, Jiheng Ding, Wenchuan Jia, Yan Peng, Jun Luo
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Patent number: 11801101Abstract: A spatial series-parallel pelvic fracture reduction robot includes a base support, a mobile platform module, an arc-shaped guide rail platform module, a robot module, and a pelvic external fixator which are connected in sequence. The mobile platform module is fixedly connected on an upper part of the base support and is used for driving the arc-shaped guide rail platform module to linearly translate up and down and left and right; a connecting sliding block of the arc-shaped guide rail platform module is connected to the robot module and used for enabling the robot module to move along an arc-shaped guide rail; the robot module includes a robot and a clamping mechanism, the robot is used for adjusting a spatial pose of the clamping mechanism, and the clamping mechanism is used for fixing bone needles; the pelvic external fixator is used for firmly fixing the pelvis.Type: GrantFiled: November 29, 2022Date of Patent: October 31, 2023Assignees: THE FIRST MEDICAL CENTER OF PLA GENERAL HOSPITAL, SHANGHAI UNIVERSITYInventors: Lihai Zhang, Jingtao Lei, Ziheng Chen, Ye Peng, Hailong Du
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Publication number: 20230341869Abstract: The present disclosure provides a method and system for path planning of an unmanned vehicle in a three-dimensional terrain and relates to the technical field of path planning. The method includes building a random tree with an initial point of a to-be-planned path as a node; generating a random node based on a goal bias strategy and a multi-sampling strategy; determining a node in the random tree and with a minimum two-dimensional distance from the random node as a nearest node; determining a direction from the nearest node to the random node as an extension direction; determining a point corresponding to a preset step length as a to-be-determined node in the extension direction with the nearest node as a starting point; and updating the random tree or determining a path cut-off random tree through elevation detection and path search cut-off detection, so as to determine the to-be-planned path.Type: ApplicationFiled: January 13, 2023Publication date: October 26, 2023Applicants: CHONGQING UNIVERSITY, SHANGHAI UNIVERSITYInventors: Jun LUO, Lele DING, Huayan PU, Jie MA, Xuyang ZHENG, Hongliang LIU, Jing HUANG, Yongbing CHEN, Anming SHEN
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Patent number: 11794471Abstract: The present disclosure relates to the field of display technology, and provides an inkjet assembly, an inkjet printing apparatus and an inkjet printing method. The inkjet assembly includes at least one jet printing member having a first surface on which an inkjet port is formed. The inkjet assembly further includes a deflection member configured to provide a deflection force to a fluid emitted from the inkjet port and a control member configured to control operation of the deflection member.Type: GrantFiled: September 24, 2021Date of Patent: October 24, 2023Assignees: BOE TECHNOLOGY GROUP CO., LTD., Shanghai UniversityInventors: Jinsong Zhang, Jin Cao, Zhiliang Wang, Limin Yan, Xinguo Li, Xiao Wu
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Patent number: 11759124Abstract: Disclosed is a real-time dynamic and quantitative detection device for carbon dioxide in human exhaled air, which comprises: a face mask which comprises an air inlet and an air outlet; an inhalation channel connected with the air inlet of the face mask, a first one-way valve is provided in the inhalation channel; an exhalation channel connected with the air outlet of the face mask, a second one-way valve is provided in the exhalation channel; an air path switching element connected with the exhalation channel to realize the switching between an exhalation air path to be detected and an inflation air path; a detection air chamber connected with the exhalation channel, at least one carbon dioxide sensor connected with an external upper computer is provided in the detection air chamber; before detection, the air path switching element switches to the inflation air path to clean and initialize the detection air chamber; during detection, the air path switching element switches to the exhalation air path to be detType: GrantFiled: January 25, 2021Date of Patent: September 19, 2023Assignee: SHANGHAI UNIVERSITY OF MEDICINE & HEALTH SCIENCESInventors: Gang Huang, Lijun Hao, Jun Zhu
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Patent number: 11752819Abstract: A wheel-legged amphibious mobile robot with a variable attack angle, which belongs to the technical field of robot structure technology. The robot includes three parts: motion unit, body trunk and power unit. As a key structure, the motion unit mainly includes a moving mechanism, a wheel assembly, a telescopic mechanism and a transmission device. The robot drives the telescopic mechanism to reciprocate linearly through a gear and rack set, and pushes “legs” to expand and retract, so as to realize a mutual switching between a wheeled mode and a gait mode. Under transmission of bevel gear set, the blades can rotate at any same angle at the same time, to change the attack angle and realize the steering. The robot provided by the present disclosure can effectively adapt to a complex and harsh amphibious environment, and meet a series of operation requirements such as rapid movement, obstacle climbing, underwater steering.Type: GrantFiled: September 4, 2020Date of Patent: September 12, 2023Assignee: SHANGHAI UNIVERSITYInventors: Yi Sun, Longteng Zhang, Huayan Pu, Min Wang, Yan Peng, Jiheng Ding, Jun Luo, Shaorong Xie