Abstract: A vapor deposition mask used to manufacture a display device includes a notch portion. The vapor deposition mask is provided with an FMM sheet and a first cover sheet. The first cover sheet includes a trunk portion and a notch forming portion that protrudes from the trunk portion and prevents film formation on the notch portion, and the thickness of at least a part of the notch forming portion is smaller than the thickness of the trunk portion.
Abstract: A license management system subtracts, a number of rights corresponding to a number of users set by a number of users setter from a number of owned rights for each unit period, and uses a first unit period that is an earliest unit period, in which the number of owned rights is expected to be insufficient with respect to a number of rights in a unit period, as a last unit period, in which content can be used by a plurality of users, to set same expiration of a valid period for all of the plurality of users.
Abstract: Systems, devices and methods to improve safety and efficiency in an operating room comprise providing a suture package that holds new suture needles and needle receptacles for storing used needles. The devices can be safely worn for the surgeon to self-dispense new suture needles in the near surgical field and to secure the used needles into a needle trap or a needle retainer located on his extremity, on his operative instruments or on the surgical drapes. The device may provide automated and/or simplified needle counting both during use and after removal from the surgical field. The device may be configured for ergonomic and efficient use so as to minimize the actions and motions of the surgeon to dispense and secure the needle.
Type:
Grant
Filed:
March 25, 2021
Date of Patent:
August 16, 2022
Assignee:
SHARP FLUIDICS, LLC
Inventors:
Josef E. Gorek, Kenneth B. Trauner, Douglas G. Rimer
Abstract: A display device according to the disclosure includes a display unit including a plurality of electro-optical elements as display elements, luminance and transmittance of which are controlled by a current, a luminance measurement unit configured to measure luminance of the display elements of the display unit in a blocked state, and a correction value arithmetic operation unit configured to compensate a data signal provided to each of pixels of the display elements on the basis of a measurement result obtained by the luminance measurement unit. This enables accurate compensation in units of pixels.
Abstract: A light source according to the present invention is for an exposure device of a multifunction peripheral and includes a multi-beam light source. Two laser diodes included in the multi-beam light source are individually driven by a laser driver. Reference signals Vref1 and Vref2 used to control the light emitting power of the laser diodes are individually generated by two reference signal generation circuits. The reference signals Vref1 and Vref2 are each generated by processing including digital calculation, and at least one of the reference signals Vref1 and Vref2 includes a component for correcting the relative output difference of the laser diodes.
Abstract: Each of lead wiring lines that constitutes a TFT layer and is provided to extend parallel to each other in a frame region extends to intersect with a perimeter edge surface of a first organic film that constitutes the TFT layer and is provided on each of the lead wiring lines. A second organic film is provided to cover a lower portion of the perimeter edge surface of the first organic film and each of the lead wiring lines on a side of the perimeter edge surface of the first organic film, the lead wiring lines extending from the perimeter edge surface of the first organic film.
Abstract: A display device includes a TFT substrate including a flattening layer on a surface, a sealing film including a resin film that is an ink-jet resin film, and a first bank that surrounds the flattening layer, is covered with the resin film on an inner side, and has a frame shape. The flattening layer includes, on an entire periphery of a circumferential end portion thereof, a recessed and protruding portion provided with recesses and protrusions having sizes different on a first side and a second side in a plan view.
Abstract: A display device employs a patterned quantum rod layer having pixel elements driven by pixel splitting to generate a privacy viewing mode. The display device includes a patterned quantum rod layer having first pixel elements including first quantum rods wherein the first quantum rods are aligned in a first alignment direction, and second pixel elements including second quantum rods wherein the second quantum rods are aligned in a second alignment direction different from the first alignment direction. An electronic controller is configured to perform pixel splitting whereby the electronic controller drives the first pixel elements and the second pixel elements such that the patterned quantum rod layer has an off-axis luminance different from an on-axis luminance to generate a privacy viewing mode. The first alignment direction may be oriented 90° relative to the second alignment direction.
Abstract: A display device includes an input operation detector that detects an input operation including a gesture operation, a display processor that displays an input operation icon in a first display form when a first gesture operation is detected and displays the input operation icon in a second display form when a second gesture operation is detected, a reception processor that receives a movement operation when the first gesture operation is detected and receives a selection operation when the second gesture operation is detected, and a change processor that, when a third gesture operation is detected, gradually or continuously changes a display form of the input operation icon between the first display form and the second display form.
Abstract: A solids charging containment apparatus and method for mixing a solvent with a dry powder, comprising a dual compartment isolator for safely removing the dry powder from a dry powder container, a mixing vessel, and a negative cascading pressure controller. The dual compartment isolator comprises a staging compartment, a charging compartment and a raw material entry port, which is connected to the staging compartment and configured to isolate the dry powder container from the surrounding atmosphere. The mixing vessel includes a mixing chamber and a solids charging port fluidly connecting the mixing chamber to a containment valve in the charging compartment of the dual compartment isolator. The negative cascading pressure controller generates negative pressure in both the staging compartment and the charging compartment. The containment apparatus and method may be used to produce a slurry or solution mixture of solvent and dry powder during drug processing.
Type:
Application
Filed:
June 15, 2020
Publication date:
August 11, 2022
Applicant:
Merck Sharp & Dohme Corp.
Inventors:
John H. Roosa, Alan S. D'Alessandro, Robert O'Connor, Luke Schenck, Timothy Stanoch
Abstract: The invention provides compositions of anti-PD-1 antibodies or antigen-binding fragments thereof with less than or equal to about 3.0% oxidation of Met105 in the CDRH3 heavy chain region, and methods of obtaining the purified compositions. The invention also provides compositions comprising anti-PD-1 antibody main species and acidic species thereof, wherein the amount of acidic species is about 1.0-12.0%.
Type:
Application
Filed:
January 27, 2022
Publication date:
August 11, 2022
Applicant:
Merck Sharp & Dohme Corp.
Inventors:
Mark A. Brower, Chung-Jr Huang, Brian Wai Kwan, William Nicholas Napoli, Bhumit A. Patel, Nuno J. Dos Santos Pinto, Douglas Dennis Richardson, II, Sen Xu
Abstract: Provided herein are treatments of conditions ameliorated by counteracting tumor mediated immune suppression. More specifically, provided herein are anti-PD-1/LAG-3/TIGIT trispecific antibodies, anti-PD-1/LAG3 bispecific antibodies, anti-LAG3 antibodies and antigen-binding fragments. Also provided here are methods and uses of these antibodies and antigen-binding fragments in the treatment of cancer or infectious disease.
Type:
Application
Filed:
July 28, 2020
Publication date:
August 11, 2022
Applicant:
Merck Sharp & Dohme Corp.
Inventors:
Laurence Fayadat-Dilman, Veronica Juan, Robert A. Kastelein
Abstract: A receiver configured to receive first information on a configuration of a demodulation reference signal via higher layer signaling and receive downlink control information including second information on transmission of the demodulation reference signal via a physical downlink control channel, and a transmitter configured to transmit the demodulation reference signal and uplink data are included. The transmitter transmits the demodulation reference signal and the uplink data by using a same OFDM symbol based on at least the first information and the second information.
Type:
Grant
Filed:
September 25, 2018
Date of Patent:
August 9, 2022
Assignees:
SHARP KABUSHIKI KAISHA, FG Innovation Company Limited
Abstract: An image decoding apparatus is implemented that can suppress a decrease in coding efficiency in a case that a high compression rate is achieved. The image decoding apparatus includes a parameter decoder, and the parameter decoder decodes a skip flag indicating whether a skip mode is applied, and in a case that the skip flag does not indicate the skip mode, decodes a merge flag indicating whether a merge mode is applied, and in a case that the merge flag does not indicate the merge mode, decodes an MMVD flag indicating whether an MMVD mode is applied.
Type:
Grant
Filed:
December 3, 2019
Date of Patent:
August 9, 2022
Assignees:
SHARP KABUSHIKI KAISHA, FG INNOVATION COMPANY LIMITED
Abstract: The present invention relates to methods for the recombinant expression of chlamydia major outer membrane protein (MOMP) comprising transforming a population of E. coli host cells with an expression vector comprising a nucleic acid molecule that encodes chlamydia MOMP and encodes a leader sequence for targeting the MOMP to the outer membrane of the cell, wherein the nucleic acid molecule is operatively linked to a promoter. The method of the invention allows expression of MOMP in the outer membrane of the cell, which leads to protein folding that is more like native MOMP relative to a MOMP protein that is expressed intracellularly. Also provided by the invention are uses of the recombinant MOMP in pharmaceutical compositions and methods for the treatment and/or prophylaxis of chlamydia infection and/or the effects thereof.
Type:
Grant
Filed:
June 8, 2020
Date of Patent:
August 9, 2022
Assignee:
Merck Sharp & Dohme LLC
Inventors:
Lan Zhang, Zhiyun Wen, Craig T. Przysiecki, Ping Qiu
Abstract: The present invention relates to a dimming panel sequentially including a first substrate, a liquid crystal layer, and a second substrate, the first substrate sequentially including an insulating substrate, multiple first electrodes, a first insulating layer, and a second electrode including parallel linear electrodes, each of the first electrodes including a base electrode and multiple island electrodes, the base electrode being provided with multiple apertures, the island electrodes being electrically connected to the base electrode, surrounding the base electrode in a plan view, and being arranged with intervals, at least one of the island electrodes of a selected electrode of the first electrodes being disposed in at least one position selected from the group consisting of a position inside at least one of the apertures of a next electrode and a position between adjacent two of the island electrodes of the next electrode.
Abstract: The instant invention provides for novel lipid nanoparticle (LNP) formulations, containing cationic lipids, for use as vaccine adjuvants and/or as antigen delivery systems. It is an object of the instant invention to provide LNP formulations that demonstrate enhancements in humoral and/or cellular immunogenicity of vaccine antigens, particularly subunit vaccine antigens, when utilized alone or in combination with immunostimulatory agents (e.g. small molecule or oligonucleotide TLR agonists). The instant invention further identifies physical and chemical properties of the LNP formulations that can be manipulated to enhance antigen efficiency and adjuvant tolerability in vivo.
Type:
Grant
Filed:
September 24, 2020
Date of Patent:
August 9, 2022
Assignee:
Merck Sharp & Dohme LLC
Inventors:
Marian Gindy, Danilo R. Casimiro, Andrew Bett, Jan H. Ter Meulen
Abstract: An array board 11b includes a display section AA, a source line 20 connected to the display section AA, a test circuit 40 connected to the source line 20 and configured to test the display section AA, a panel-side image input terminal that is disposed such that the test circuit 40 is between the terminal and the display section AA and to which a signal to be supplied to the source line 20 is input, a terminal connection line 51 connecting the source line 20 to the pane-side image input terminal 35A and the terminal connection line 51 including the terminal connection line 51 at least a part of which overlaps the test circuit 40 and a flattening film (insulation film) 28 at least disposed between an overlapping portion of the test circuit 40 and the terminal connection line 51.
Abstract: Systems, devices and methods to improve safety and efficiency in an operating room comprise providing a suture package that holds new suture needles and needle receptacles for storing used needles. The devices can be safely worn for the surgeon to self-dispense new suture needles in the near surgical field and to secure the used needles into a needle trap or a needle retainer located on his extremity, on his operative instruments or on the surgical drapes. The device may provide automated and/or simplified needle counting both during use and after removal from the surgical field. The device may be configured for ergonomic and efficient use so as to minimize the actions and motions of the surgeon to dispense and secure the needle.
Type:
Application
Filed:
January 20, 2022
Publication date:
August 4, 2022
Applicant:
SHARP FLUIDICS, LLC
Inventors:
Josef E. GOREK, Kenneth B. TRAUNER, Douglas G. RIMER
Abstract: The present invention provides processes for the preparation of 2-fluoroadenine, as well as certain intermediates useful in the preparation of 2?-deoxy-4?-C-ethynyl-2-fluoroadenosine (EFdA): EFdA.
Type:
Application
Filed:
June 18, 2020
Publication date:
August 4, 2022
Applicant:
Merck Sharp & Dohme Corp.
Inventors:
John Y.L. Chung, Cynthia Marilyn Hong, Guy R. Humphrey, Kevin M. Maloney, Yingju Xu, Richard J. Varsolona