Abstract: The present invention provides a number of process improvements related to the conjugation of capsular polysaccharides from Streptococcus pneumoniae to a carrier protein. These process are serotype specific and include acid hydrolysis, addition of sodium chloride to the reductive amination reaction, and addition of sucrose to dissolve polysaccharides. Polysaccharide-protein conjugates prepared using the processes of the invention can be included in multivalent pneumococcal conjugate vaccines.

Abstract: A meeting system includes an identification information acquirer that acquires a card ID, based on a user's operation of touching a reader with an ID card 5 for identifying the user, an authentication process operator that determines whether or not to grant an authentication of the user, based on the card ID acquired by the identification information acquirer, and a command process operator that issues a command for commanding an operation corresponding to a desired operation of the user, where the command is associated with the card ID corresponding to the user, if the authentication of the user is granted by the authentication process operator.

Abstract: The present invention is directed to processes for preparing a diazepane compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is further directed to crystalline forms of this diazepane compound and pharmaceutical compositions thereof.

Abstract: A moving image decoder (1) includes an intermediate estimated prediction mode deriving section (124) for transforming a prediction mode of each neighbor partition into an intermediate prediction mode included in an intermediate prediction set which is a sum of prediction sets (PS); and an estimated prediction mode deriving section (125) for deriving an estimated prediction mode by estimating a prediction mode of a target partition based on the intermediate prediction mode of each neighbor partition which is obtained by the transform.

Abstract: The present invention avoids waste caused by performing both a Secondary Transform and an Adaptive Multiple Core Transform. Provided is a device including: a core transform unit (1521) that can perform an Adaptive Multiple Core Transform on a Coding Tree Unit; and a Secondary Transform unit (1522) that can perform, before the Adaptive Multiple Core Transform, a Secondary Transform on at least any one of sub-blocks included in the Coding Tree Unit. The device omits any of the Adaptive Multiple Core Transform and the Secondary Transform in accordance with at least any of a flag associated with the Adaptive Multiple Core Transform and a flag associated with the Secondary Transform, or in accordance with a size of the Coding Tree Unit.

Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

Abstract: Disclosed are a process and an automated facility for manufacturing a purified protein of interest. The protein of interest can be a recombinant or naturally occurring protein and/or a therapeutic or other medically useful protein. For example, the disclosed process and automated facility are useful for manufacturing a purified protein drug substance.

Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XI activation inhibitors.

Abstract: Disclosed are a process and an automated facility for manufacturing a purified protein of interest. The protein of interest can be a recombinant or naturally occurring protein and/or a therapeutic or other medically useful protein. For example, the disclosed process and automated facility are useful for manufacturing a purified protein drug substance.

Abstract: Disclosed are dihydroisoxazole compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, E, and R1 are as defined herein. Also disclosed are compositions which comprise at least one of these dihydroisoxazole compounds, methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis comprising administering a therapeutically effective amount of these dihydroisoxazole compounds and/or a pharmaceutically acceptable salt thereof, or a composition comprising such compound and/or salt.

Abstract: The present invention provides a process improvement related to the conjugation of capsular polysaccharides from Streptococcus pneumoniae (S. pneumoniae) serotype 35B to a carrier protein. The serotype 35B polysaccharide-protein conjugate, prepared by the disclosed process, is, among other things, more immunogenic than similar conjugates made by prior art methods. S. pneumoniae serotype 35B polysaccharide-protein conjugates prepared using the processes of the invention can be included in multivalent pneumococcal conjugate vaccine compositions.

Abstract: Glucose-responsive insulin conjugates that contain one or more linear oligomer sugar cluster are provided. Such insulin conjugates that may display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose, even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule.

Abstract: The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these N serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Steptococcus pneumoniae serotypes.

Abstract: A display device includes a non-transmissive display section and a transmissive display section. The non-transmissive display section includes a base member including a first polyimide. The transmissive display section includes a base member including a second polyimide that has higher transparency than the first polyimide. The base member of the non-transmissive display section and the base member of the transmissive display section are connected in a connecting section. A bending portion is provided in the base member of the non-transmissive display section or the base member of the transmissive display section. The connecting section and the bending portion do not overlap each other.

Abstract: In a display device, a drive circuit drives LEDs arranged in n rows (n is an integer equal to or greater than two) so as to correspond to a plurality of areas of a backlight, row by row through division into n time slots or every k rows (k is an n's divisor equal to or greater than two and is smaller than n) through division into n/k time slots in accordance with the status of use of the display device.

Abstract: The information processing device includes a display panel, a touch panel, a controller, and a storage. The display panel includes a first area and a second area. When a drawing operation on the first area is received, the controller displays an image based on the drawing operation in the first area. The controller performs second processing and third processing. The second processing corresponds to processing of storing a reproduction target image displayed in the first area and a reduced image of the reproduction target image in the storage, when a specific type of operation excluding the drawing operation is received on the touch panel, and displaying the reduced image in the second area. The third processing corresponds to processing of displaying, when an operation of selecting the reduced image is received on the touch panel, the reproduction target image corresponding to the selected reduced image in the first area.

Abstract: A light detection devices includes a SPAD bias control block that adjusts a reverse bias voltage in accordance with a pulse number of a pulse signal which is output by a SPAD array upon incidence of first light.

Abstract: A light-emitting device includes: an anode electrode; a cathode electrode; a plurality of light-emitting layers sandwiched between the anode electrode and the cathode electrode; and a light absorption layer disposed between the plurality of light-emitting layers and a light extraction surface, wherein the plurality of light-emitting layers include InP based quantum dots and are configured to emit at least green color of light and red color of light, and the light absorption layer selectively absorbs light at 570 to 610 nm.

Abstract: In a step of forming a plurality of control lines composed of a first metal layer a first metal layer branch line is formed. In a step of forming a plurality of power source lines composed of a second metal layer a second metal layer connecting portion is formed that connects each power source line with the first metal layer branch line via an opening of a first insulating film. In a step of forming a plurality of data signal lines composed of a third metal layer that is formed on a second insulating film the first metal layer branch line formed in the opening of the first insulating and the second metal layer connecting portion formed in an opening of the second insulating film are etched.

Abstract: In a memory liquid crystal display including a liquid crystal panel with a built-in touch panel, a black voltage or a white voltage is provided to a pixel electrode in accordance with a value of binary data stored in a memory circuit, and a display voltage generation circuit changes voltage values of the black voltage and the white voltage in synchronization with a continuous pulse voltage for touch detection in a touch detection period so that an absolute value of a voltage between the pixel electrode and a common electrode is maintained at a constant magnitude in each pixel circuit throughout a period from a point in time immediately before the start of the touch detection period to a point in time immediately after the end of the touch detection period.