Abstract: Disclosed are the ERK inhibitors of formula (I) and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (I). This invention also provides a pharmaceutical composition comprising an effective amount of at least one compound of formula (I) and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition comprising an effective amount of at least one compound of formula (I) and an effective amount of at least one other pharmaceutically active ingredient (such as, for example, a chemotherapeutic agent), and a pharmaceutically acceptable carrier. This invention also provides a method of inhibiting ERK (i.e., inhibiting the activity of ERK2) in a patient in need of such treatment comprising administering to said patient an effective amount of at least one compound of formula (I).

Abstract: The present invention is directed to halo and trifluoromethyl substituted compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

Abstract: The present invention relates to methods for identifying and using modulators of FDF03 biological activity in vitro and in vivo that are useful in the treatment of cancer.

Abstract: A liquid crystal display device is provided with: a light-emitting diode LED; a liquid crystal panel; a light guide plate having an end surface that is disposed in such a manner as to face the LED, and having edge portions that are disposed further to the outside than the ends of the liquid crystal panel; holding members comprising a frame and a chassis that hold the liquid crystal panel and the light guide plate in a form in which the liquid crystal panel and the light guide plate are sandwiched between a display surface and the opposite side thereof, and accommodating the LED therebetween; panel pressing sections provided to the frame; second screw attachment sections provided to the frame; second screw members that are attached to the second screw attachment sections, and secure the frame and chassis in an assembled state by sandwiching at least the chassis between the second screw attachment sections; and hole-like sections that are provided to the edge portions of the light guide plate, and through which

Abstract: The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

Abstract: This invention provides for certain bridged and fused compounds of the formula G-L-A??I or a pharmaceutically acceptable salt, ester of solvate thereof wherein: A is and the other variables are defined herein; the inventive compounds are agonists of the G-protein coupled receptor 40 (GPR40, also known as free fatty acid receptor FFAR). This invention further relates to pharmaceutical compositions containing these compounds, and the use of these compounds to regulate insulin levels in a mammal. The compounds may be used, for example in the prevention and treatment of Type 2 diabetes mellitus and in the prevention and treatment of conditions related to Type 2 diabetes mellitus, such as insulin resistance, obesity and lipid disorders.

Abstract: A method of manufacturing a first phosphor of which emission spectrum shape well matches with a color filter of three primary colors of light, a light-emitting device including the first phosphor, and an image display apparatus including the light-emitting device are provided. The light-emitting device includes a semiconductor light-emitting element emitting excitation light and the first phosphor absorbing the excitation light and emitting green light. The first phosphor contains a solid solution of aluminum element and a metal element M selected from the group consisting of Mn, Ce and Eu in crystals of an oxynitride having a ?-type Si3N4 crystal structure, an amount of oxygen in the crystals being not higher than 0.8 mass %.

Abstract: Provided is a highly reliable configuration of a one glass solution touch panel, in which a sensor electrode and a wiring line can be reliably connected to each other. A touch panel (1) is provided with: an insulating substrate (10) having a sensing area (V) and a non-sensing area (P); sensor electrodes (11, 12), which are formed in the sensing area (P); terminals (13), which are formed in the non-sensing area (P); wiring lines (14), which electrically connect the sensor electrodes (11, 12) and the terminals (13); a light-shielding layer (171), which is formed to cover the non-sensing area (P); and a planarizing film (172), which is formed to cover the light-shielding layer (171). The planarizing film (172) is formed only in the non-sensing area (P).

Abstract: A dual band color filter includes a periodic arrangement of metallic dots in a middle transparent medium, having an index of refraction, interposed between a first and a second transparent medium, each having an index of refraction greater than the middle transparent medium index of refraction. The filter accepts visible spectrum light. In response to the periodic arrangement of metallic dots, a surface plasmon mode is generated. In response to a diameter common to all the metallic dots, a local mode is generated, and in response to the combination of the middle, first, and second transparent medium indices of refraction, a waveguide mode is generated. As a result, two distinct wavelength bands of visible spectrum light are transmitted through the bottom surface of the dual band color filter, while attenuating one wavelength band of visible spectrum light.

Abstract: A shift register includes series-connection circuits to transmit a shift pulse. The series-connection circuits include a continuous stage group with continuous stages. Each stage of the continuous stage group includes a first output transistor, a first capacitor, an input gate, a first switching element, a second switching element, a third switching element, and a fourth switching element.

Abstract: For simplification of a structure and a manufacturing process of an element, and reduction of manufacturing cost, the present disclosure provides a light-receiving device including: a photoelectric conversion element; and an active element, wherein the active element includes at least one of a reset element configured to reset the photoelectric conversion element, an amplifier element configured to amplify a detection signal based on the photoelectric conversion element, or a selection element configured to selectively output the detection signal based on the photoelectric conversion element, and the photoelectric conversion element and at least part of the active element are formed by using an identical organic semiconductor material or an identical high molecular functional material.

Abstract: A driving device is used in an image reading apparatus, and reciprocates a scanning unit for reading an image on an original. The driving device comprises a pull member, a driving pulley which transmits driving force to the pull member, a following pulley which applies tension to the pull member and a pulley holder having a pulley axis which holds the following pulley rotatably. Then, the pulley axis has a lock pawl capable of locking an upper end portion of the following pulley and canceling engagement with the following pulley by being tilted toward a side of an axial center by elastic deformation. Furthermore, the lock pawl is arranged at a side of a tension acting direction from the pull member to the following pulley except the farthest position from the driving pulley among positions in a circumferential direction of the pulley axis. It is possible to attach and detach the following pulley easily at a time of maintenance or the like.

Abstract: An image forming apparatus includes an image reading unit, an image forming unit, a discharge unit, and a discharge tray. The image reading unit is configured to read a document placed on a document placement table by moving and scanning of a scanning body in a sub-scanning direction. The image forming unit is configured to form an image read by the image reading unit on a paper sheet. The discharge unit is configured to discharge the paper sheet on which an image is formed by the image forming unit to a direction perpendicular to the sub-scanning direction. The discharge tray is on which the paper sheet from the discharge unit is to be placed with a space portion at a lower side of the image reading unit. A bottom surface of a housing of the image reading unit facing the discharge tray is constituted of a first surface and a second surface. The first surface is a surface at a front side of the discharge unit in a discharging direction and high with respect to the discharge tray.

Abstract: A wireless reception device is notified of whether a multi-user MIMO signal transmitted from a wireless transmission device has undergone linear precoding or non-linear precoding without increasing the amount of control information. A wireless transmission device having a plurality of transmit antennas 303, for transmitting spatially multiplexed signals to a plurality of wireless reception devices includes a group construction unit 307 configured to classify the wireless reception devices into a plurality of groups and to determine a precoding scheme for each of the groups, a selection unit 315 configured to select one group from among the groups, and a precoding unit 323 configured to precode transmit data addressed to each of wireless reception devices belonging to the selected group, using a precoding scheme determined for the selected group.

Abstract: To prevent a collision from occurring at the time of random access in cases such as handover, response to paging and the like where a mobile station apparatus performs random access in response to directions from a base station apparatus. In a mobile communication system in which a mobile station apparatus 200 uses a signature of a beforehand determined signature group at the time of random access with a base station apparatus 100, the signature group is comprised of a signature group managed by the base station apparatus 100 and another signature group managed by the mobile station apparatus 200. The signature group managed by the base station apparatus 100 includes signatures associated with particular random access reasons to be selected by the base station apparatus 100.

Abstract: An image forming apparatus includes a first wireless communication unit that receives data from a mobile phone, and a reader-writer that transmits an address of the first wireless communication unit to the mobile phone. The mobile phone includes a contact/non-contact IC card that receives the address, and a second wireless communication unit that transmits image data to the first wireless communication unit utilizing the address. When communication is made between the mobile phone and the image forming apparatus, the address of the first wireless communication unit is transmitted to the contact/non-contact IC card through the reader-writer, and the second wireless communication unit transmits data to the first wireless communication unit utilizing the address.

Abstract: The present invention provides quinoline carboxamide and quinoline carbonitrile compounds of formula (I) wherein ring A, RQ, -L-, R1, n, R2, and R3 are as defined herein. The compounds of the invention are useful as non-competitive mGluR2 antagonists, or mGluR2 negative allosteric modulators (NAMs), and in methods of treating a patient (preferably a human) for diseases or disorders in which the mGluR2-NAM receptor is involved, such as Alzheimer's disease, cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders, by administering to the patient a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof.

Abstract: A viewing angle extending film (a light diffusing member) includes a base material with optical transparency, a plurality of light-shielding layers dotted on one surface of the base material, and a transparent resin layer (optically transparent material layer) provided on the one surface of the base material. At least a light-shielding layer, which is part of the plurality of light-shielding layers, has a planar shape surrounded by a first figure and a second figure contained in the first figure or a planar shape surrounded by at least part of the first figure and at least part of the second figure overlaid with the first figure. Hollow portions are provided in a formation region of the light-shielding layers, each hollow portion being shaped so that a cross-sectional area obtained by cutting along a plane parallel to the one surface of the base material is large on the light-shielding layer side and is gradually decreased as being away from the light-shielding layer.

Abstract: A display device that adopts a field sequential method and that is capable of achieving desired luminance while suppressing mixing of colors is provided. With respect to display of each color by a liquid crystal display device adopting a field sequential method, a period is provided for which light sources of each color remain turned on until a turning-off delay time has elapsed since an end timing of a subframe period. The turning-off delay time relating to LEDs for which an off state begins in a preceding subframe period is configured in such a way as to be shorter than a turning-on delay time relating to LEDs for which an on state begins in a succeeding subframe period. As a result, an all-off period, in which LEDs of all colors are in the off state, is provided between on periods of two colors.

Abstract: Provided are: a color filter substrate that can improve the uniformity of thickness of color filters, and a method of manufacturing the color filter substrate. The method of manufacturing a color filter substrate includes: forming a plurality of photoresist films in layers on a transparent substrate; exposing said plurality of photoresist films via a photomask; forming a pattern having an opening by developing the plurality of photoresist films after exposure; and discharging ink into the opening. The photosensitivities of the plurality of photoresist films differ from each other.