Abstract: The present application includes methods for using IL-8 as a biomarker for, e.g., tumor size, for example, during course of treatment with an anti-cancer agent such as an ERK inhibitor.

Abstract: The present invention is directed to pyridine derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

Abstract: In order to securely ground an exterior shield and reduce burden imposed on a dicing blade and the exterior shield, a method of producing a semiconductor module comprises a hole-forming step of forming a hole 30 extending from a top surface of a sealing resin layer 3 to a ground wiring 111 (112) provided at a collective substrate 100, a film-forming step of forming an electrically conductive film made of an electrically conductive material so as to cover at least the top surface of the sealing resin layer 3, an internal surface of the hole 20, and the ground wiring 111 (112), and a separation step of separating from each other a plurality of individual module sections which the individual module section comprises.

Abstract: A multi-primary-color liquid crystal panel driver (100) according to the present invention includes: a multi-primary-color converter (110) which performs a multi-primary-color conversion to convert the grayscale levels of an input video signal in each of a plurality of vertical scanning periods into grayscale levels of four or more primary colors; and an overdrive circuit (120) which sets, based on the grayscale levels that have been subjected to the multi-primary-color conversion in one vertical scanning period and on the grayscale levels that have been subjected to the multi-primary-color conversion in another vertical scanning period that is earlier than the one vertical scanning period by at least one period, the grayscale levels of the four or more primary colors in that one vertical scanning period. The present invention provides a multi-primary-color liquid crystal panel that can improve the display quality even when the input video signal has varying grayscale levels.

Abstract: The emission efficiency of a light-emitting device including a microcavity structure is improved. The light-emitting device includes a plurality of light-emitting elements. The plurality of light-emitting elements each include a reflective electrode, a transparent electrode, a plurality of light-emitting layers, and a semi-transmissive and semi-reflective electrode stacked in that order. The plurality of light-emitting layers emit light of different colors. A surface roughness of the transparent electrode in the light-emitting element which is among the plurality of light-emitting elements and in which light emitted from the light-emitting layer closest to the reflective electrode is amplified and emitted outside is greater than surface roughnesses of the transparent electrodes in the other light-emitting elements.

Abstract: Compositions and formulations comprising insulin or insulin analogues comprising a carboxy terminal portion (CTP) peptide comprising amino acids 112-188 to 142 of the beta subunit of human chorionic gonadotropin (hCG?) or a partial variant thereof that includes at least one O-glycosylation site of the CTP peptide, wherein the CTP peptide of the CTP peptide-based insulin or insulin analogue is O-glycosylated are described. In particular embodiments, the O-glycosylated insulin analogues are produced in vivo and in further embodiments, the O-glycosylated CTP-based insulin analogues comprise predominantly mannotriose and mannotetrose O-glycans or predominantly mannose O-glycans.

Abstract: Provided is a driving method whereby it is possible to simultaneously compensate for both degradation of a drive transistor and degradation of a light-emitting element without causing special light emission at the time of detecting characteristics in a display device. In a display device which includes a pixel circuit including an electro-optic element and a drive transistor, a driving method includes: a first characteristic detection step for detecting a characteristic of the drive transistor; a second characteristic detection step for detecting a characteristic of the electro-optic element; a correction data storage step for storing characteristic data obtained based on detection results in the first and second characteristic detection steps as correction data; and a video signal correction step for correcting the video signal based on the correction data. The second characteristic detection step is performed in a light emission period.

Abstract: Zero-voltage switching of a switching element (Q2) is achieved by turning off a switching element (Q1) and then turning on switching element (Q2) while the parasitic diode (DQ2) of switching element (Q2) is turned on. Subsequently, switching element (Q2) is turned off when the current flowing through switching element (Q2) changes from negative to positive (in a direction from the drain towards the source) and the current reaches a prescribed threshold value. Then, zero-voltage switching of switching element (Q1) is achieved by turning on switching element (Q1) while the parasitic diode (DQ1) of switching element (Q1) is turned on.

Abstract: This light-diffusing member includes a light-transmissive substrate, a plurality of wavelength-controlling layers formed on one surface of the light-transmissive substrate, and a light-diffusing portion formed on the one surface of the light-transmissive substrate in a region other than a region where the wavelength-controlling layers are formed.

Abstract: The present invention provides a display device which inhibits deterioration in display quality caused by color mixture of luminescent layers. In a case where vapor deposition particles are deposited onto a substrate, P+2Lc?{(Ts×M+0.96×G×Wn)/(Ts?G)}+2Dm and 3 ?m?Dm?5 ?m are satisfied, where “M” is a width of a mask opening, “Wn” is a width of an injection hole, “G” is a distance between the TFT substrate and a vapor deposition mask, “Ts” is a distance between the TFT substrate and a vapor deposition source, “P” is a width of a first pixel opening, and “Lc” is a width of a non-display region.

Abstract: A surface light-emitting unit of the present invention is an LED module (30) for emitting light from an LED chip (6) of a light-emitting element part (1) via a light flux control section (22) of a light flux control part (2), the light flux control section (22) being fixed by a plurality of columnar sections (21) above a fixing surface of a substrate (4) on which fixing surface the light-emitting element part (1) is fixed. This provides an appropriate gap between the light-emitting element part (1) and the light flux control section (22) for heat release.

Abstract: A prediction set determining section selects a prediction set from a prediction set group including a plurality of prediction sets having different combinations of prediction modes corresponding to different prediction directions. Further, a prediction mode determining section selects a prediction mode from the prediction set thus selected. An entropy encoding section encodes the prediction set thus selected, the prediction mode thus selected, and residual data between an input image and a predicted image formed on the basis of the prediction set and the prediction mode. This allows an image encoding device to carry out predictions from more various angles, thereby improving prediction efficiency.

Abstract: A headlamp includes the laser chip which emits excitation light, a light-emitting section which contains a phosphor, and an optical rod. The excitation light emitted from the laser chip is optically guided by the optical rod, and the light output from the optical rod enters the light-emitting section. An edge is present in the light intensity distribution of the light-emitting section.

Abstract: A signal processing system (10) includes a switching circuits (6) which switches between subsystems (5a, 5b), on a basis of a frequency of noise mixed in each of time-series signals, the amount of that noise, and input-output transfer characteristics, to reduce noise present in a result of estimation of the value of a linear element (CX), which estimation is performed by addition- and subtraction-based signal processing.

Abstract: Provided is a method for manufacturing a solar cell with an interconnection sheet, a method for manufacturing a solar cell module, a solar cell with an interconnection sheet, and a solar cell module. Fixing resin is arranged at least on one side of a location between electrodes of solar cell and a location between interconnections of an interconnection sheet. Thereafter, a first cure state of fixing resin is attained. Thereafter, an adjoining member containing conductive material is provided, and a solar cell and interconnection sheet are stacked to soften the fixing resin exhibiting the first cure state and then re-cure the same to attain a second cure state.

Abstract: The present invention relates to stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof. The present invention further provides methods for treating various cancers and chronic infections with stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof.

Abstract: Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compound of Formula I, A3 is a substituted phenyl group or indanyl group. Formula (I).

Abstract: A terminal apparatus that is set to monitor physical downlink control channel candidates in a common search space and a user equipment-specific search space on a downlink component carrier, which are with cyclic redundancy check scrambled by C-RNTI (Cell Radio Network Temporary Identifier), with a same first control channel element index, and with downlink control information of a common payload size and different downlink control information field sets. The terminal apparatus also assumes that, for the physical downlink control channel candidates with the cyclic redundancy check scrambled by the C-RNTI, only either a physical downlink control channel in the common search space or a physical downlink control channel in the user equipment-specific search space is transmitted on the downlink component carrier.

Abstract: This invention relates to aminopyrimidinone compounds of Formula (I) that are inhibitors of Interleukin receptor-associated kinases, in particular IRAK-4, and are useful in the treatment or prevention of inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease.

Abstract: A semiconductor light emitting device that is excellent in radiating heat and that can be molded into a sealing shape having intended optical characteristics by die molding is provided. The semiconductor light emitting device includes: a lead frame including a plate-like semiconductor light emitting element mounting portion having an LED chip mounted on a main surface, and a plate-like metal wire connecting portion extending over a same plane as the semiconductor light emitting element mounting portion; a metal wire electrically connecting the LED chip and the metal wire connecting portion; a thermosetting resin molded by die molding or dam-sheet molding so as to completely cover the LED chip and the metal wire; and a resin portion provided to surround the lead frame and having the thickness not greater than the thickness of the lead frame.