Abstract: An object of the present invention is to provide a therapeutic strategy in the solid tumor area and a means useful therefor to further advance the clinical application of CAR therapy. There is prepared a gene-modified lymphocyte which expresses a chimeric antigen receptor having an EphrinB2 extracellular domain at the antigen recognition site.

Abstract: A soil analyzing device includes: a sensor having an excitation coil and a detection coil; a measurement unit that generates an excitation signal to be input to the excitation coil, and processes a detection signal output from the detection coil; a storage unit that stores data concerning the correlation between a quantitative value of the soil fertility characteristics including CEC of two or more types of the soil having different components and an estimated value of the soil fertility characteristics including CEC found from the processed detection signal measured by the sensor and the measurement unit; and an estimation unit that estimates the soil fertility characteristics based on the detection signal generated by allowing the sensor to apply the alternating magnetic field to the soil to be analyzed and processed by the measurement unit, and by using the data stored in the storage unit.

Abstract: It is an object of the present invention to provide signal sequence information capable of secreting an antibody to the outside of cells in generation of the antibody by microorganisms of genus Bifidobacterium, and an antibody expression vector capable of secreting an antibody to the outside of cells by utilizing the signal sequence information. As a means for achieving the aforementioned object, there is prepared Bifidobacterium longum, which is transformed with a vector having inserted thereinto a DNA insert comprising the 5?-terminus of an antibody gene linked to the 3?-terminus of a DNA encoding a signal peptide-linker conjugate having a linker linked to the C-terminus of a signal peptide consisting of an amino acid sequence shown in SEQ ID NO: 1.

Abstract: According to example embodiments, a photoelectric conversion device includes a first electrode including a light-receiving surface, a second electrode spaced apart from the first electrode and facing the first electrode, and an auxiliary layer between the second electrode and an exciton producing layer. The first electrode may be on the second electrode. The exciton producing layer may be between the first electrode and the second electrode. The exciton producing layer may be spaced apart from the second electrode by a distance corresponding to one of a crest and a trough of a standing wave of light to be converted into electricity.

Abstract: Provided are: a transformation plasmid for transforming anaerobes and enabling highly efficient and stable secretory expression of a target protein; a gene delivery carrier formed from said anaerobes transformed by said plasmid; a pharmaceutical composition including said gene delivery carrier; and a method for diagnosing or treating an ischemic disease utilizing these. Also provided are: a novel secretory signal; a transformation plasmid including said secretory signal; a gene delivery carrier formed from anaerobes transformed by said plasmid; a pharmaceutical composition including said gene delivery carrier; and a method for diagnosing or treating an ischemic disease utilizing these.

Abstract: To provide a novel core-shell structure type nanosheet and, when used as an electrocatalyst for a fuel cell, a core-shell structure type nanosheet capable of improving catalytic activity and suppressing a deterioration in catalytic performance. The above-described problem is solved by a core-shell structure type nanosheet (10) comprising a metal nanosheet (1) and a platinum atomic layer (2) provided on a surface of the metal nanosheet (1). In this core-shell structure type nanosheet (10), the platinum atomic layer (2) is preferably provided on the entire surface of the metal nanosheet (1). Further, the core-shell structure type nanosheet (10) can be used as a cathode catalyst or an anode catalyst for a fuel cell or the like. The metal nanosheet (1) is preferably within a range of 0.2 to 0.3 nm in thickness, and within a range of several tens of nm to several ?m, inclusive, in length in an in-plane direction.

Abstract: Provided is a gel actuator having generation force comparable to biological muscle at a low voltage, that can be used in various applications as an actuator element. A gel actuator (10) comprises a unit structure composed of a gel layer (14) containing a dielectric polymer material, and an anode (12) and a cathode (16) which sandwich the gel layer (14) in a thickness direction thereof, and a face of the anode (12) facing the gel layer formed into a concave-convex face, a convex part of the concave-convex face touching the gel layer (14), and a concave part thereof being into a gap.

Abstract: The invention provides a light emitting layer host compound and an electron-blocking compound that have high excited triplet levels, and can completely confine the triplet excitons of phosphorescent material, for use as the material of a high-efficient organic electroluminescent device. The invention also provides a high-efficient, high-luminance organic electroluminescent device with the use of the compounds. The compound of the general formula (1) below has a triphenylsilyl group and a triarylamine structure, and the organic electroluminescent device includes a pair of electrodes and at least one organic layer interposed between the pair of electrodes, wherein the compound of the general formula (1) having a triphenylsilyl group and a triarylamine structure is used as constituent material of the at least one organic layer.

Abstract: The present invention relates to a method for producing useful metabolites such as shikimic acid from filamentous fungus. The useful metabolites can be produced by a production method involving a step of inhibiting the growth of the filamentous fungus, specifically by applying a stimulus of light having a center wavelength shorter than 570 nm to the filamentous fungus, to increase the content of the useful metabolite in a hypha of the filamentous fungus.

Abstract: The present inventors assessed the effect of anti-IL-6 receptor antibodies in suppressing chronic rejection reaction. They assessed the effect of anti-mouse IL-6 receptor antibody (MR16-1) administration in suppressing the chronic rejection reaction using a mouse model for post-heart-transplantation chronic rejection. The result of histopathological analysis of transplanted hearts extirpated 60 days after transplantation revealed that fibrosis of myocardium and vascular stenotic lesions, which are pathological conditions characteristic of the chronic rejection reaction, were significantly suppressed in the MR16-1-treated group as compared to the control group. Thus, MR16-1 administration was demonstrated to have the effect of suppressing chronic rejection reaction. Specifically, the present inventors discovered for the first time that the rejection reaction in the chronic phase after organ transplantation was suppressed by administering an anti-IL-6 receptor antibody.

Abstract: Provided is a fermented food extract that has a blood pressure-lowering action and is useful as a functional health food or pharmaceutical composition. This fermented food extract is obtained by: subjecting a fermented food, preferably a fermented fagopyrum esculentum lyophilisate, to acetone extraction; eluting the fermented fagopyrum esculentum acetone extract using a solid phase extract cartridge filled with a resin to which a phenyl group is bonded, with formic acid-containing water used as an eluent; and fractionating and purifying the eluate using a column (PFP column) filled with a carrier to which a pentafluorophenyl group is bonded, with formic acid/methanol-containing water used as a mobile phase. This functional health food or pharmaceutical composition contains said extract or at least a part thereof as an active ingredient.

Abstract: [Problem] To be able to accurately measure color vision and color-viewing field for different colors. [Solution] The color-viewing function measuring means (1) pertaining to the present invention displays a plurality of chromatically colored targets (A11, . . . ) (for example, Landolt rings) in an achromatic background (B), the brightness of the targets (A11, . . . ) being set so as to be substantially equal to the brightness of the background (B). When vision or the viewing field is measured with this color-viewing function measuring means (1), vision and viewing field can be accurately measured for different colors.

Abstract: The present inventors assessed the effect of anti-IL-6 receptor antibodies in suppressing chronic rejection reaction. They assessed the effect of anti-mouse IL-6 receptor antibody (MR16-1) administration in suppressing the chronic rejection reaction using a mouse model for post-heart-transplantation chronic rejection. The result of histopathological analysis of transplanted hearts extirpated 60 days after transplantation revealed that fibrosis of myocardium and vascular stenotic lesions, which are pathological conditions characteristic of the chronic rejection reaction, were significantly suppressed in the MR16-1-treated group as compared to the control group. Thus, MR16-1 administration was demonstrated to have the effect of suppressing chronic rejection reaction. Specifically, the present inventors discovered for the first time that the rejection reaction in the chronic phase after organ transplantation was suppressed by administering an anti-IL-6 receptor antibody.

Abstract: Provided are a fine-particulate organic semiconductor material, a thin organic semiconductor film and an organic transistor. The fine-particulate organic semiconductor material is in a form of fine particles and is usable as an organic semiconductor material. The fine particles are fine thermotropic liquid crystal particles that undergo a phase transition into a liquid crystal state when heated to a temperature of from 50° C. to 350° C. The fine-particulate organic semiconductor material can easily and uniformly form the thin organic semiconductor film over a large area by a film printing process or a dispersion coating process. The thin organic semiconductor film has high electron mobility and high ON/OFF value.

Abstract: A color perception test has a color matching processor that executes a color matching processing on a color monitor, and an image display controller that displays two or more images for color perception test in order on the color monitor on which the color matching processing was done. When displaying each image for color perception test, a color perception test is done in a state that one of its hue, brightness, saturation and display time is changed and the other elements are fixed. Since the color perception tester has the color matching processor, colors of the image are not changed with passage of time different from color printed one, and correct test can be done thereby. If the test is periodically done on some examinee, a degree of decreasing color perception function by aging can be exactly known.

Abstract: A compound having a benzotriazole ring structure and a formula (1): wherein Ar is a substituted or unsubstituted aromatic hydrocarbon group, aromatic heterocyclic group, or condensed polycyclic aromatic group; A and B are the same as or different from each other and each represent a hydrogen atom or a monovalent group of formula (2), provided that A and B are not simultaneously hydrogen atoms: wherein R1 to R8 are the same as or different and each represent a hydrogen atom, a deuterium atom, a fluorine atom, a chlorine atom, a cyano group, a trifluoromethyl group, a linear or branched alkyl group having 1 to 6 carbon atoms, aromatic hydrocarbon group, a substituted or unsubstituted aromatic heterocyclic group, or condensed polycyclic aromatic group; m is an integer of 0, 1 or 2; X represents a carbon atom or a nitrogen atom; when X is a nitrogen atom, the nitrogen atom does not have substituents or bonding groups of R1, R2, R3 and R4; and when m is 2, a plurality of R1, R2, R3, R4 and X each are the

Abstract: The present invention relates to a metal oxide-platinum compound catalyst comprising 5 to 95 parts by weight of a metal oxide and 95 to 5 parts by weight of platinum as the balance. The platinum has a form to reticulately cover at least a part of a particle of the metal oxide. The wires constituting the platinum mesh have an average wire diameter of 5 nm or smaller.

Abstract: In the case of assaying the level of complex AB in a sample which likely contains the complex AB composed of substance A with another substance B, the complex is assayed by the competitive homogeneous assay method with the use of reagents including a reagent containing partner C specifically binding to substance A, a reagent containing partner D specifically binding to substance B, a reagent containing fine particles carrying substance A or an analog thereof and substance B or an analog thereof, and a reagent containing partner C specifically binding to substance A and partner D specifically binding to substance B. Thus, the complex in the sample can be easily assayed. The above method is applicable to general-purpose biochemical automatic analyzers.

Abstract: The present invention relates to a method for producing useful metabolites such as shikimic acid from filamentous fungus. The useful metabolites can be produced by a production method involving a step of inhibiting the growth of the filamentous fungus, specifically by applying a stimulus of light having a center wavelength shorter than 570 nm to the filamentous fungus, to increase the content of the useful metabolite in a hypha of the filamentous fungus.

Abstract: The present invention has an object of providing the carbon fiber (or the nonwoven fabric configured of the aforementioned carbon fiber) of which the surface area, the graphitization degree, and the fiber diameter are large, high, and small, respectively, and yet of which dispersion is small. The method of producing the carbon fiber nonwoven fabric includes a dispersion liquid preparing step of preparing a dispersion liquid containing resin and pitch, an electrospinning step of producing the nonwoven fabric that is comprised of carbon fiber precursors with electrospinning from the aforementioned dispersion liquid, and a modifying step of modifying the carbon fiber precursors of the nonwoven fabric obtained in the aforementioned electrospinning step into the carbon fiber.