Abstract: According to one embodiment, there is provided a method of producing a gene modification T cell (CAR-T cells) which expresses a chimeric antigen receptor (CAR). This method includes stimulating a cell population containing a T cell with an antibody which activates the T cell, bringing the cell population into contact with a nucleic acid-introducing carrier, wherein the nucleic acid-introducing carrier containing a lipid particle, a first nucleic acid and containing a CAR gene, and a second nucleic acid containing a transposase gene encapsulated in the lipid particle, and culturing the cell population after the contacting.

Abstract: An electrocatalyst including carbon and a nanosheet supported on the carbon. The nanosheet includes a metal ruthenium nanosheet, and a platinum atomic layer formed on an entire surface of the metal ruthenium nanosheet. The metal ruthenium nanosheet is a monoatomic layer, and the platinum atomic layer is a monoatomic layer or a monoatomic layer laminated body.

Abstract: An embolic coil is formed by being spirally wound by an element wire and is filled into an aneurysm. The embolic coil includes: a first coil portion, in which a large-diameter coil portion wound to have a large diameter D1 and a small-diameter coil portion wound to have a diameter D2 smaller than the large-diameter coil portion are arranged in a plurality of coils and alternately in a longitudinal direction Y of the embolic coil. A second coil portion is wound to be continuous with the first coil portion and to have a surface flatter than the first coil portion.

Abstract: Provided are an artificial cornea having sufficient strength and optical properties, in which deviation or infection of the artificial cornea is restrained, and a method for manufacturing the artificial cornea. According to the present invention, the method for manufacturing the artificial cornea includes a nonwoven fabric preparation step of preparing a nonwoven fabric formed therein with a through-hole, and a gel arrangement step of arranging an aqueous polymer gel to cover the through-hole.

Abstract: A method of manufacturing a reverse osmosis composite membrane, including: (i) bringing a mixed liquid containing carbon nanotubes, water, and an amine component into contact with a porous support, the mixed liquid being produced through a step of pressurizing and compressing an aqueous solution containing the carbon nanotubes while flowing the aqueous solution, followed by releasing or reducing a pressure to return a volume of the aqueous solution to an original volume to mix the carbon nanotubes; and then (ii) subjecting the amine component in the mixed liquid adhering to the porous support to a crosslinking reaction.

Abstract: Provided are: a transformation plasmid for transforming anaerobes and enabling highly efficient and stable secretory expression of a target protein; a gene delivery carrier formed from said anaerobes transformed by said plasmid; a pharmaceutical composition including said gene delivery carrier; and a method for diagnosing or treating an ischemic disease utilizing these. Also provided are: a novel secretory signal; a transformation plasmid including said secretory signal; a gene delivery carrier formed from anaerobes transformed by said plasmid; a pharmaceutical composition including said gene delivery carrier; and a method for diagnosing or treating an ischemic disease utilizing these.

Abstract: A core-shell structure nanosheet includes a metal ruthenium nanosheet, and a platinum atomic layer provided on a surface of the metal ruthenium nanosheet. An electrocatalyst includes carbon, and the core shell structure nanosheet supported on the carbon. A method for manufacturing an electrocatalyst includes applying a ruthenium oxide nanosheet colloid which comprises a ruthenium oxide nanosheet, on carbon to obtain a carbon-supported ruthenium oxide nanosheet, in which the ruthenium oxide nanosheet is supported on the carbon. The carbon-supported ruthenium oxide nanosheet is reduced to obtain a carbon-supported ruthenium metal nanosheet, in which a ruthenium metal nanosheet is supported on the carbon. A platinum atomic layer is provided on a surface of the metal ruthenium nanosheet to obtain the electrocatalyst.

Abstract: It is intended to produce a cell expressing a mutant chimeric antigen receptor (CAR) having excellent cytotoxicity to target cells. The present invention provides a genetically modified cell having introduced thereinto a polynucleotide encoding a chimeric antigen receptor (CAR) protein having a target binding domain that specifically binds to a human granulocyte-macrophage colony stimulating factor (GM-CSF) receptor, a transmembrane domain, and an intracellular signaling domain, wherein the tar get binding domain is a mutant having the substitution of glutamic acid at position 21 in the amino acid sequence shown in SEQ ID NO: 1 with another amino acid.

Abstract: A plurality of electrochemical corrosion protection systems (30) for underground buried structure installed geographically dispersed are utilized so as to predict an earthquake. Changes in amounts of current flowing through closed loop electric circuits (W) for electrochemical corrosion protection in the electrochemical corrosion protection systems (30) are detected and an earthquake is predicted based on the detected changes in the amounts of current.

Abstract: A synthetic leather includes: a base cloth; on the base cloth, an adhesion layer, a skin layer, and a flame-retardant layer, in this order, in which the flame-retardant layer includes at least one selected from hydrotalcite or a hydrotalcite-like compound, and is a cured product of a composition that includes a binder and particles having an average particle diameter of from 10 nm to 2500 nm, and is a layer having a thickness of from 1 ?m to 20 ?m.

Abstract: To provide a magnetic sensor element and a magnetic sensor device that can be easily manufactured and can reduce a loss of light to the extent possible. The above-described problem is solved by a magnetic sensor element comprising a planar lightwave circuit (11) provided with a light branching part (12), an input optical fiber (19) and an output optical fiber (20) connected to the planar lightwave circuit (11), a metal magnetic body type light transmitting film (30) that is provided on one end surface of the planar lightwave circuit (11) and transmits light entered from the input optical fiber (19), and a reflecting film (40) that is provided on the metal magnetic body type light transmitting film (30) and reflects the transmitted light. The output optical fiber (20) is a polarization-plane maintaining optical fiber, and the input optical fiber (19) and the output optical fiber (20) are aligned and connected to the planar lightwave circuit (11).

Abstract: A lithium composite negative electrode which allows a hybrid capacitor to operate at room temperature by reducing interfacial resistance in the electrode, a hybrid capacitor comprising the composite negative electrode, and manufacturing methods thereof. The lithium composite negative electrode is a laminar electrode including a lithium ion conductive solid electrolyte, an alginate gel electrolyte, and lithium-doped carbon. Further, a hybrid capacitor includes a positive electrode including a carbon material and/or a metal oxide, the lithium composite negative electrode, and a neutral aqueous electrolyte filled between the positive electrode and the lithium composite negative electrode. The lithium composite negative electrode is configured as a laminar electrode including the lithium ion conductive solid electrolyte, the alginate gel electrolyte, and the lithium-doped carbon.

Abstract: A cathode active material that is able to improve storage characteristics without deteriorating charging and discharging capacity is provided. By mixing lithium nickel containing composite oxide particles comprising a layered rock-salt type crystal structure, a lithium compound, and an alkali metal compound; calcining the mixed powder at a temperature range of 800° C. to 1000° C.; washing and removing alkali metal other than lithium; mixing washed calcined particles with a lithium compound again; calcining the mixture in an oxidizing atmosphere at a temperature range of 600° C. to 800° C., lithium nickel containing composite oxide comprising a layered rock-salt type crystal structure and a peak intensity ratio of (003) plane with respect to (104) plane of 1.2 or more that are obtained by X-ray powder diffraction using Cu-K? ray as an X-ray source is obtained.

Abstract: A method of forming a reverse osmosis membrane 1 of the present invention includes a coating membrane forming step of forming a coating membrane which is soluble in a predetermined solvent on a surface of a porous support substrate 2 that is insoluble in the solvent, a carbon membrane forming step of forming a carbon membrane 3 on the coating membrane by a physical vapor deposition which deposits carbon as a target material under an atmosphere where rare gas and nitrogen gas are contained, and a removing-by-dissolving step of removing the coating membrane by dissolving the same in the solvent after formation of the carbon membrane 3.

Abstract: Endotoxin is detected by electrochemical measurement. A detection device 15 of endotoxin detects endotoxin contained in a fluid to be tested (for example, a dialysate) specifically in the following manner. First, the fluid to be tested is brought into contact with an adsorbent 17 that adsorbs endotoxin to cause the adsorbent 17 to adsorb the endotoxin. Then, a basic solution is brought into contact with the adsorbent 17 to desorb the endotoxin. Electrochemical measurement of the basic solution containing the desorbed endotoxin is performed. The endotoxin can be detected by the electrochemical measurement with high sensitivity at low cost.

Abstract: A soil analyzing device includes: a sensor having an excitation coil and a detection coil; a measurement unit that generates an excitation signal to be input to the excitation coil, and processes a detection signal output from the detection coil; a storage unit that stores data concerning the correlation between a quantitative value of the soil fertility characteristics including CEC of two or more types of the soil having different components and an estimated value of the soil fertility characteristics including CEC found from the processed detection signal measured by the sensor and the measurement unit; and an estimation unit that estimates the soil fertility characteristics based on the detection signal generated by allowing the sensor to apply the alternating magnetic field to the soil to be analyzed and processed by the measurement unit, and by using the data stored in the storage unit.

Abstract: Production of a chimeric antigen receptor (CAR) expressing cell having excellent target cytotoxicity. Provided is a genetically modified cell comprising, introduced thereinto, a polynucleotide encoding a chimeric antigen receptor (CAR) protein having a target binding domain that specifically binds to a human granulocyte-macrophage colony stimulating factor (GM-CSF) receptor, a transmembrane domain and an intracellular signaling domain.

Abstract: The apparatus for producing a gallium oxide crystal relating to the invention contains a vertical Bridgman furnace containing: a base body; a cylindrical furnace body having heat resistance disposed above the base body; a lid member occluding the furnace body; a heater disposed inside the furnace body; a crucible shaft provided vertically movably through the base body; and a crucible disposed on the crucible shaft, heated with the heater, the crucible is a crucible containing a Pt-based alloy, the furnace body has an inner wall that is formed as a heat-resistant wall containing plural ring shaped heat-resistant members each having a prescribed height accumulated on each other, and the ring shaped heat-resistant members each contain plural divided pieces that are joined to each other to the ring shape.

Abstract: The present invention addresses the problem of solving problems of the conventional techniques and producing, by an economically advantageous means, fermented milk having hardness to such an extent that the texture of the fermented milk can be kept during distribution. The present invention relates to a method for producing fermented milk, comprising homogenizing a raw material mix under a high pressure to reduce the average particle diameter of a fat and then fermenting the homogenized product. More specifically, the present invention relates to: a method for producing fermented milk using a material that is sterilized at an ultra-high temperature, said method comprising homogenizing a fat in a raw material mix, which contains a material sterilized at an ultra-high temperature, under a high pressure and then fermenting the resultant product; and fermented milk produced by the method.

Abstract: Provided is a liquid embolic agent composition capable of solving problems of conventional embolic agents, which can be used in a treatment of a vascular disease such as cerebral aneurysm. The problems are solved by a liquid embolic agent composition characterized in containing a hydrogel forming component having a calcium ion entrapping ability, and an anti-biodegradation component. The hydrogel forming component having a calcium ion entrapping ability is at least one kind of acidic polysaccharide selected from the group consisting of alginate, gellan gum, carrageenan, and carboxymethyl cellulose salt; and the anti-biodegradation component is at least one kind selected from the group consisting of hydroxypropyl methylcellulose, methylcellulose, polyvinyl alcohol, polyallylamine, poly-N-vinyl acetamide, and cellulose acetate.