Abstract: Methods, systems, devices, and computer program products include positioning single-use radiation sensor patches that have adhesive onto the skin of a patient to evaluate the radiation dose delivered during a medical procedure or treatment session. The sensor patches are configured to be relatively unobtrusive and operate during radiation without the use of externally extending power cords or lead wires.
Type:
Grant
Filed:
June 10, 2004
Date of Patent:
June 21, 2011
Assignee:
Sicel Technologies, Inc.
Inventors:
Robert D. Black, Steven R. Widener, John Carroll, Gregory Glenwood Mann, Phillip M. Lehman
Abstract: Methods, systems, devices, and computer program products include positioning single-use radiation sensor patches that have adhesive means onto the skin of a patient to evaluate the radiation dose delivered during a treatment session. The sensor patches are configured to be minimally obtrusive and operate without the use of externally extending power cords or lead wires.
Type:
Grant
Filed:
May 29, 2009
Date of Patent:
April 12, 2011
Assignee:
Sicel Technologies, Inc.
Inventors:
Robert D. Black, Gregory Glenwood Mann, Steven R. Widener, Phillip M. Lehman
Abstract: Methods, systems, devices, and computer program products include positioning single-use radiation internal dosimeters with MOSFETs into a patient to evaluate the radiation dose delivered during a medical procedure or treatment session. The MOSFETs can be unpowered during irradiation.
Type:
Grant
Filed:
January 15, 2009
Date of Patent:
March 1, 2011
Assignee:
Sicel Technologies, Inc.
Inventors:
Robert D. Black, Steven R. Widener, John Carroll, Gregory Glenwood Mann, Phillip M. Lehman
Abstract: Biocompatible sensors configured for implantation include a first body in communication with a plurality of remote sensor bodies to detect physiological parameters in vivo.
Type:
Application
Filed:
June 25, 2010
Publication date:
October 14, 2010
Applicants:
SICEL Technologies, Inc., North Carolina State University
Inventors:
Charles W. Scarantino, H. Troy Nagle, Lester C. Hall, Jeffrey Mueller, Bahram Ghaffarzadeh Kermani
Abstract: Methods and systems for evaluating external beam radiation therapy delivered to a subject include: (a) placing at least one wireless implantable sensor in a first subject at a target location; (b) administering a first dose of radiation therapy into the first subject; (c) obtaining radiation data from the at least one wireless implantable sensor; and (d) calculating a radiation dose amount received by the first subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to the first administered dose of radiation to determine and/or verify a dose amount of radiation delivered to the target location.
Type:
Grant
Filed:
July 20, 2005
Date of Patent:
August 31, 2010
Assignees:
North Carolina State University, Sicel Technologies, Inc.
Inventors:
Charles W. Scarantino, H. Troy Nagle, Lester C. Hall, Jeffrey Mueller, Bahram G. Kermani
Abstract: Methods and systems for evaluating external beam radiation therapy delivered to a subject include: (a) placing at least one wireless implantable sensor in a first subject at a target location; (b) administering a first dose of radiation therapy into the first subject; (c) obtaining radiation data from the at least one wireless implantable sensor; and (d) calculating a radiation dose amount received by the first subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to the first administered dose of radiation to determine and/or verify a dose amount of radiation delivered to the target location.
Type:
Grant
Filed:
May 2, 2006
Date of Patent:
August 17, 2010
Assignees:
North Carolina State University, Sicel Technologies, Inc.
Inventors:
Charles W. Scarantino, H. Troy Nagle, Lester C. Hall, Jeffrey Mueller, Bahram G. Kermani
Abstract: Methods, systems, devices and computer program product include: (i) administering a fluorescent analyte to a subject; (ii) repetitively emitting excitation light from an implanted sensor over a desired monitoring period; (iii) detecting fluorescence intensity in response to the excitation light using the implanted sensor that outputs the excitation light; and (iv) using data associated with the detected fluorescence intensity to perform at least one of: (a) calculate the concentration or dose of the analyte received proximate to the implanted sensor site; (b) evaluate the pharmacodynamic or pharmacokinetic activity of the fluorescent analyte; (c) confirm Ab attachment to a tumor site; (d) monitor a non-target site to confirm it is not unduly affected by a therapy; (e) monitor for changes in cellular properties; (f) use the calculated dose or concentration data to adjust or customize a therapeutic amount of the analyte administered to the subject; (g) confirm micelle concentration at a target site and then sti
Abstract: Methods and systems for evaluating external beam radiation therapy delivered to a subject include: (a) placing at least one wireless implantable sensor in a first subject at a target location; (b) administering a first dose of radiation therapy into tile first subject; (c) obtaining radiation data from the at least one wireless implantable sensor; and (d) calculating a radiation dose amount received by the first subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to the first administered dose of radiation to determine and/or verify a dose amount of radiation delivered to the target location.
Type:
Grant
Filed:
May 2, 2006
Date of Patent:
August 3, 2010
Assignees:
North Carolina State University, Sicel Technologies, Inc.
Inventors:
Charles W. Scarantino, H. Troy Nagle, Lester C. Hall, Jeffrey Mueller, Bahram G. Kermani
Abstract: Biocompatible sensors configured for implantation include a first body in communication with a plurality of remote sensor bodies to detect physiological parameters in vivo.
Type:
Grant
Filed:
June 9, 2005
Date of Patent:
July 13, 2010
Assignees:
North Carolina State University, Sicel Technologies, Inc.
Inventors:
Charles W. Scarantino, H. Troy Nagle, Lester C. Hall, Jeffrey Mueller, Bahram Ghaffarzadeh Kermani
Abstract: Methods, systems, devices, and computer program products include positioning disposable single-use radiation sensor patches that have adhesive means onto the skin of a patient to evaluate the radiation dose delivered during a treatment session. The sensor patches are configured to be minimally obtrusive and operate without the use of externally extending power chords or lead wires.
Type:
Grant
Filed:
November 25, 2002
Date of Patent:
July 7, 2009
Assignee:
Sicel Technologies, Inc.
Inventors:
Robert D. Black, Gregory Glenwood Mann, Steven R. Widener, Phillip M. Lehman
Abstract: Methods, systems, devices, and computer program products include positioning single-use radiation internal dosimeters with MOSFETs into a patient to evaluate the radiation dose delivered during a medical procedure or treatment session. The MOSFETs can be unpowered during irradiation.
Type:
Application
Filed:
January 15, 2009
Publication date:
May 14, 2009
Applicant:
Sicel Technologies, Inc.
Inventors:
Robert D. Black, Steven R. Widener, John Carroll, Gregory Glenwood Mann, Phillip M. Lehman
Abstract: Methods, systems, devices and computer program product include: (i) administering a fluorescent analyte to a subject; (ii) repetitively emitting excitation light from an implanted sensor over a desired monitoring period; (iii) detecting fluorescence intensity in response to the excitation light using the implanted sensor that outputs the excitation light; and (iv) using data associated with the detected fluorescence intensity to perform at least one of: (a) calculate the concentration or dose of the analyte received proximate to the implanted sensor site; (b) evaluate the pharmacodynamic or pharmacokinetic activity of the fluorescent analyte; (c) confirm Ab attachment to a tumor site; (d) monitor a non-target site to confirm it is not unduly affected by a therapy; (e) monitor for changes in cellular properties; (f) use the calculated dose or concentration data to adjust or customize a therapeutic amount of the analyte administered to the subject; (g) confirm micelle concentration at a target site and then sti
Abstract: Methods, systems, devices, and computer program products include positioning disposable single-use radiation sensor patches that have adhesive means onto the skin of a patient to evaluate the radiation dose delivered during a treatment session. The sensor patches are configured to be minimally obtrusive and operate without the use of externally extending power chords or lead wires.
Abstract: Methods, systems, devices, and computer program products include positioning single-use radiation internal dosimeters with MOSFETs into a patient to evaluate the radiation dose delivered during a medical procedure or treatment session. The MOSFETs can be unpowered during irradiation.
Type:
Grant
Filed:
June 10, 2004
Date of Patent:
February 17, 2009
Assignee:
Sicel Technologies, Inc.
Inventors:
Robert D. Black, Steven R. Widener, John Carroll, Gregory Glenwood Mann, Phillip M. Lehman
Abstract: A method for obtaining data using an implantable sensor unit in a body of a patient includes: implanting the sensor unit in the body; conducting an imaging procedure on the body such that the sensor unit in the body serves as a fiducial marker; detecting a parameter using the sensor unit in the body; and transmitting data associated with the detected parameter from the sensor unit to a remote receiver unit.
Abstract: Methods are disclosed wherein labeled antibodies can be provided in vivo to tissue having antigens that specifically bind the labeled antibody. A first optical radiation is emitted into the tissue in vivo to excite the labeled antibody bound to the antigen in vivo. A second optical radiation that is emitted by the excited labeled antibody, in response to the excitation thereof, can be detected in vivo. Related telemetric circuits and compositions of matter are also disclosed.
Abstract: Systems for locating implanted in vivo sensors systems adapted for use with an external beam radiation therapy delivery source include: (a) an external solenoid member; (b) an articulated arm opertively associated with the external solenoid member, wherein, in operation, the articulated arm is configured to translate the solenoid; (c) a controller configured to direct the movement of the articulated arm, the controller being in communication with the power source configured to power the external solenoid; (d) at least one implantable sensors unit, wherein the at least one implantable sensor unit is configured to sense at least one predetermined parameter of interest in vivo, and wherein the at least one implantable sensor unit comprises a solenoid, and wherein, in operation, the sensor unit solenoid corporates with the external solenoid to generate a magnetic coupling signal having a signal strength that varies based on the possession of the external solenoid member relative to the implanted sensors unit; (e)
Type:
Application
Filed:
March 29, 2004
Publication date:
July 12, 2007
Applicant:
SICEL TECHNOLOGIES, INC.
Inventors:
Robert Black, Gregory Mann, Steven Widener
Abstract: Calibration of in vivo oxygen and pH sensor systems can be performed by generating a constituent element of an environment proximate to an in vivo sensor electrode via an in vivo generating electrode and determining a level of the constituent element in the tissue via the in vivo sensor electrode. Accordingly, accurate monitoring of tissue can be achieved while reducing the need to calibrate the in vivo sensor systems using invasive procedures. Related electrode assemblies are also discussed.
Type:
Grant
Filed:
March 29, 2000
Date of Patent:
January 30, 2007
Assignees:
Sicel Technologies, Inc., North Carolina State University
Inventors:
Charles W. Scarantino, H. Troy Nagle, Chang-Soo Kim, Stefan Ufer, Jason Fiering, Bahram Ghaffarzadeh Kermani