Abstract: Methods, systems, devices and computer program products monitor in vivo detected radiation in a target localized site within a subject, over a selected time period, to do one or more of: (a) quantify a radiation dose received at a local site; (b) assess bioreceptiveness to a particular treatment time or type; (c) evaluate the pharmacokinetics of a radiolabeled analyte corresponding to a non-radiolabeled analyte; (d) monitor or evaluate metabolic activity; or (e) evaluate a tumor prior to or after a therapeutic treatment.
Type:
Grant
Filed:
April 22, 2002
Date of Patent:
March 14, 2006
Assignee:
Sicel Technologies, Inc.
Inventors:
Steven Suddarth, Charles W. Scarantino, Robert D. Black
Abstract: Methods of monitoring and evaluating the status of a tumor undergoing treatment includes monitoring in vivo at least one physiological parameter associated with a tumor in a subject undergoing treatment, transmitting data from an in situ located sensor to a receiver external of the subject, analyzing the transmitted data, repeating the monitoring and transmitting steps at sequential points in time and evaluating a treatment strategy. The method provides dynamic tracking of the monitored parameters over time. The method can also include identifying in a substantially real time manner when conditions are favorable for treatment and when conditions are unfavorable for treatment and can verify or quantify how much of a known drug dose or radiation dose was actually received at the tumor. The method can include remote transmission from a non-clinical site to allow oversight of the tumor's condition even during non-active treatment periods (in between active treatments).
Type:
Grant
Filed:
February 18, 2002
Date of Patent:
March 7, 2006
Assignees:
North Carolina State University, Sicel Technologies, Inc
Inventors:
Charles W. Scarantino, H. Troy Nagle, Lester C. Hall, Jeffrey Mueller, Bahram Ghaffarzadeh Kermani
Abstract: Methods and systems for evaluating external beam radiation therapy delivered to a subject include: (a) placing at least one wireless implantable sensor in a first subject at a target location; (b) administering a first dose of radiation therapy into the first subject; (c) obtaining radiation data from the at least one wireless implantable sensor; and (d) calculating a radiation dose amount received by the first subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to the first administered dose of radiation to determine and/or verify a dose amount of radiation delivered to the target location.
Type:
Grant
Filed:
September 4, 2003
Date of Patent:
November 8, 2005
Assignees:
North Carolina State University, Sicel Technologies, Inc.
Inventors:
Charles W. Scarantino, H. Troy Nagle, Lester C. Hall, Jeffrey Mueller
Abstract: Methods for quantifying the irradiation dose received by an item or items, such as food items and medical items, undergoing irradiation-based sterilization, includes the steps of monitoring a selected electronic parameter associated with an economic single use sensor positioned adjacent the item or items and telemetrically relaying data associated with the monitored electronic parameter to a computer. The computer includes a computer program which is configured to determine the radiation dose received by the item or items by correlating the value of the monitored electronic parameter to a corresponding amount of radiation associated with the value. Related sensors and systems are also described.
Type:
Grant
Filed:
July 31, 2001
Date of Patent:
April 6, 2004
Assignee:
Sicel Technologies, Inc.
Inventors:
Robert D. Black, Gregory Glenwood Mann, Steven R. Widener
Abstract: Methods of monitoring and evaluating the status of a tumor undergoing treatment includes monitoring in vivo at least one physiological parameter associated with a tumor in a subject undergoing treatment, transmitting data from an in situ located sensor to a receiver external of the subject, analyzing the transmitted data, repeating the monitoring and transmitting steps at sequential points in time and evaluating a treatment strategy. The method provides dynamic tracking of the monitored parameters over time. The method can also include identifying in a substantially real time manner when conditions are favorable for treatment and when conditions are unfavorable for treatment and can verify or quantify how much of a known drug dose or radiation dose was actually received at the tumor. The method can include remote transmission from a non-clinical site to allow oversight of the tumor's condition even during non-active treatment periods (in between active treatments).
Type:
Grant
Filed:
September 29, 1999
Date of Patent:
June 11, 2002
Assignees:
Sicel Technologies, Inc., North Carolina State University
Inventors:
Charles W. Scarantino, H. Troy Nagle, Leslie C. Hall, Jeffrey Mueller, Chang-Soo Kim