Abstract: The present invention discloses an acoustic emission sensor, including an acoustic emission probe, a probe installation mechanism, and a transmission mechanism transmitting a combination of the acoustic emission probe and the probe installation mechanism to a setting position in a borehole of a monitored rock mass; the probe installation mechanism includes a shell, a probe sleeve, a spring sleeve, a spring, and a fixed pulley component; the probe sleeve is installed in the guide cylinder of the shell, the spring sleeve is fixed on two sides of the probe sleeve, the spring is installed inside the spring sleeve; one end of the first rope in the fixed pulley component is fixedly connected to the end cap in the upper end surface of the probe sleeve through the fixed pulley mounted on the top of the inner wall of the shell.

Abstract: The present invention discloses an acoustic emission monitoring and transmission system for engineering rock mass including an acoustic emission sensor and a ground workstation. The acoustic emission sensor is installed in a borehole of the monitored rock mass and transmits a received monitoring signal to the ground workstation through a cable. The acoustic emission sensor includes an acoustic emission probe, a probe installation mechanism and a transmission mechanism which transmits the probe installation mechanism with the acoustic emission probe to a setting position inside the borehole. The probe installation mechanism includes a shell connecting to the transmission mechanism and a probe sleeve for accommodating the acoustic emission probe.

Abstract: A series of hepatitis C virus (HCV) inhibitors and compositions and applications thereof in the preparation of drugs for treating chronic HCV infection. Especially, a series of compounds that are used as NS5A inhibitors, and compositions and uses thereof in the preparations of drugs.

Abstract: A test system for a microseismic test of rock mass fractures provided by the present invention includes at least one microseismic sensor, a push rod provided at two ends of the microseismic sensor through a connecting mechanism for feeding the microseismic sensor into a monitoring hole , an introducing mechanism mounted on the push rod for introducing the microseismic sensor into the monitoring hole, a hydraulic system providing support hydraulic oil for the microseismic sensor, a microseismic monitoring computer connected with the signal of microseismic sensor through; the microseismic sensor includes a microseismic probe, a holding component holding the microseismic probe, a support plate and a hydraulic support mechanism; the connecting mechanism can make the push rod swing relative to the microseismic sensor, and the introducing mechanism is three-rollers introducing mechanism.

Abstract: The present invention discloses a microseismic monitoring system, which includes at least a microseismic sensor, a push rod set at both ends of the microseismic sensor through the first connecting mechanism for sending the microseismic sensor into a monitoring hole, a guide mechanism installed on the push rod for guiding the microseismic sensor into the monitoring hole, and a microseismic monitoring computer connecting with the microseismic sensor signal. The microseismic sensor is reusable. The first connecting mechanism can make the push rod swing relative to the microseismic sensor. The guide mechanism is a three-roller guide mechanism. The present invention can satisfy the need of monitoring different locations in monitoring holes with large depths for multiple microseismic sensors, and solve problems of effective contact coupling between the microseismic sensors and monitoring holes, which improves the accuracy of microseismic monitoring and reduces the cost of a microseismic monitoring system.

Abstract: This invention discloses a method for preparing TDNs-AS1411-nucleic acid drug nanocomposite based drug delivery system, which includes the following steps: binding AS1411 and nucleic acid drug to a tetrahedral DNA nanostructure respectively; selecting four DNA single strands that respectively carry AS1411 and nucleic acid drug; mixing the four DNA single strands; mixing the DNA single strands and the TM buffer uniformly; putting the mixture into a PCR apparatus; raising the temperature to 95° C. quickly and maintaining for 10 min; and next cooling down to 4° C. and maintaining for 20 min to obtain the TDNs-AS1411-nucleic acid drug nanocomposite based drug delivery system. This drug delivery system can directly act on cell nucleus and will not be degraded by lysosomal. The targeting specificity is good. The drug can take a good efficacy and the pertinency is high.

Abstract: A DR radiography lung contour extraction method based on fully convolutional network, which includes the steps: Establish the fully convolutional network structure of lung contour segmentation; Conduct off-line training on the weighting parameters of the fully convolutional network; Read DR image and weighting parameters of the fully convolutional network; Input DR image into fully convolutional network and output segmentation results of image through network terminal with network layer-by-layer feedforward. Establish lung contour in accordance with segmentation results.

Abstract: The present invention discloses a rock mechanics experiment system for simulating deep-underground environment, including a triaxial chamber consisting of a chamber cavity and a test pedestal, a stress field building module, a high pressure seepage field building module, a high temperature field building and a seepage medium permeating control measurement module arranged in the triaxial chamber, a lifting module used for installing and disassembling of the chamber cavity, and computer module used for controlling the operation of system and calculating and outputting the test data. The lifting module includes a door-shaped support frame, a cylinder piston device vertically mounted on the door-shaped support frame beam, a coupling device and a safety suspension device. The coupling device includes an oil hydraulic rod with the upper end fixedly coupled with the piston, a safety disk fixedly coupled with the lower end of the hydraulic rod, and two symmetrically disposed coupling assemblies.

Abstract: Provided is a nRGD polypeptide formed by connecting alanine-alanine-asparagine (AAN) and a polypeptide containing arginine-glycine-aspartic acid (RGD), wherein the nRGD polypeptide can target tumour vessels, tumour cells and tumour-associated macrophages, and mediate the targeted delivery of tumours.

Abstract: Provided is a benzofuran analog having a structure represented by formula (I) and used as an NS4B inhibitor, or a pharmaceutically acceptable salt of the benzofuran analog. The benzofuran analog has anti-hepatitis C virus activity.

Abstract: A rock specimen, including a rock body having the shape of a cylinder or a regular square prism. The rock body includes: an upper end face, a first circular groove, a first cylinder, a first circular body, a lower end face, a second circular groove, a second cylinder, and a second circular body. The first circular groove is disposed on the upper end face of the rock body and has a circle center coinciding with the center of the upper end face of the rock body. The second circular groove is disposed on the lower end face of the rock body and has a circle center coinciding with the center of the lower end face of the rock body. The outer diameter of the first circular groove is smaller than the inner diameter of the second circular groove, and the first circular groove and the second circular groove are staggered.

Abstract: A rock specimen, including a rock body. The rock body includes: an upper part, an upper end face, a first circular groove, a first cylinder, a first circular body, a lower part, a lower end face, a second circular groove, a second cylinder, and a second circular body. The first circular groove is disposed on the upper end face of the rock body and has a circle center coinciding with a center of the upper end face. A method for testing pure shear of the rock specimen, includes: 1) disposing the rock specimen on a test bench of a rock mechanics testing system, allowing the end face of the second circular body to contact the test bench; and 2) operating the rock mechanics testing system, loading a pressure on the rock specimen via the end face of the first cylinder and the end face of the second circular body.

Abstract: A fixing device for acoustic emission test sensors for rock damage testing, the device including: a fixing frame, installation bases operating to accommodate the acoustic emission test sensors, respectively, fixing assemblies operating to fix the acoustic emission test sensors in the installation bases, and installation mechanisms operating to install the installation bases on the fixing frame. The fixing frame is an integrated loop-shaped frame. Each of the installation bases is a cylinder structure which includes: a cavity corresponding to an outer edge of each of the acoustic emission test sensors, and a wall including a gap for leading out wires of each sensor. The installation mechanisms are adapted to automatically and axially adjust positions of the installation bases. The installation mechanisms are four in number. The four installation mechanisms are disposed on a same section plane of the fixing frame and every two installation mechanisms are oppositely disposed.

Abstract: A fixing device for acoustic emission test sensors for rock damage testing, the device including: a fixing frame; installation bases operating to accommodate the acoustic emission test sensors, respectively; fixing assemblies operating to fix the acoustic emission test sensors in the installation bases; and installation mechanisms operating to arrange the installation bases on the fixing frame. The fixing frame is an assembled loop-shaped frame and includes between two and four frame members and corresponding fixing structures; and the frame members are assembled into an integrated loop-shaped frame by the fixing structures. Each of the installation bases is a cylinder structure. The cylinder structure includes: a cavity corresponding to an outer edge of each of the acoustic emission test sensors, and a wall including a gap for leading out wires of each sensor.

Abstract: The present invention relates to long-chain dimethylaniline derivative compounds, their preparation methods, self-assembled texture, and uses thereof. Said compounds show ultralong acting anaesthetic effect, and belong to N-diethylaminoacetyl-2,6-dimethylaniline compounds, having a structure according to formula (I). Said compounds may self-assemble into micelle or gel in an aqueous solvent, and exert an in vivo elongated local anesthetic actions. Local anesthesia and/or analgesic activity can last more than 72 hours. The biomaterials can self-assemble into micelles or gels in water and have local anesthetic effect, as well as can further be used as the coating of medicinal bioactive molecules for treatment of pain, itching and the like and/or the drug carriers, together with as pharmaceutical adjuvants for delivery system. Thus, said materials have a favorable perspective.

Abstract: An adjustable fixing device for acoustic emission test sensors for rock damage testing, the device including: a fixing frame; installation bases operating to accommodate the acoustic emission test sensors, respectively; fixing assemblies operating to fix the acoustic emission test sensors in the installation bases; and installation mechanisms operating to install the installation bases on the fixing frame. The fixing frame is a rectangular frame, and at least a pair of opposite frame walls of four frame walls is provided with installation slots adapted to install the installation mechanisms. The installation slots positioned at different frame walls are in a same cross section of the rectangular frame. Each of the installation bases is a cylinder structure. The cylinder structure includes: a cavity corresponding to an outer edge of each of the acoustic emission test sensors, and a wall including a gap for leading out wires of each sensor.

Abstract: The present invention provides a low pressure anion exchange chromatography—turbidimetric method for simultaneous online analysis of trace S2? and Cl? in water samples using an apparatus comprising a low pressure pump, a sample valve, a sample loop, a low pressure anion chromatographic column, a reactor, an optical flow cell, an optical detector, a computer system, a mixer, a sample flow path, a propelling solution flow path, and a color developer solution flow path, the method comprising: (a) mapping a baseline; (b) mapping spectrogram of S2? and Cl? in test samples; (c) mapping standard working curves; and (d) calculating the concentrations of S2? and Cl? in the test samples based on the peak heights of S2? and Cl? in the spectrogram and the regression equations of standard working curves.

Abstract: This invention comes up with a kind of Android malicious code detection method on the base of community structure analysis. During the reverse analysis process of target program, firstly, it obtains critical static feature information automatically, such as permission, function, class, system API, etc,; secondly, it uses the call relation between functions to create function call graph, and undertakes pretreatment on function call graph; make cycle division and analysis for the weighted function call graph so as to get the correction division of community structure; finally, it extract features from community structures for machine learning and get the final maliciousness determination result. This invention method is able to undertake program internal structure analysis and malicious code detection rapidly when facing a large number of Android application program samples generated by “repackaging” technology.

Abstract: The present invention relates to an N-substituted imidazole carboxylic ester chiral compound containing an ether side chain and to its preparation and application. The structure of this compound is represented by Formula (I). This compound can induce a rapid and reversible general anesthesia effect. Animal experiments show that this compound has rapid and short-acting pharmacological characteristics, so that it can be used as a rapid and short-acting general anesthesia medicine. Compared with etomidate, this compound can reduce the inhibition on the synthesis of adrenal cortical hormone, with an advantage of rapid and full recovery of the post-operative patient. The only chiral carbon in the compound structure belongs to the R form.

Abstract: A DR radiography lung contour extraction method based on fully convolutional network, which includes the steps: Establish the fully convolutional network structure of lung contour segmentation; Conduct off-line training on the weighting parameters of the fully convolutional network; Read DR image and weighting parameters of the fully convolutional network; Input DR image into fully convolutional network and output segmentation results of image through network terminal with network layer-by-layer feedforward. Establish lung contour in accordance with segmentation results.