Abstract: The present disclosure relates to the field of scientific drilling technologies, and provides a deep rock in-situ active thermal-insulation coring device and thermal-insulation coring method thereof. The coring device comprises an in-situ coring system and an in-situ truth-preserving moving system, the in-situ coring system comprises a driving module, a coring module and a thermal insulation module, and the in-situ truth-preserving moving system comprises a truth-preserving chamber storage module and a mechanical arm; the thermal insulation module comprises a coring truth-preserving chamber and a temperature regulation control system, the truth-preserving chamber storage module comprises a storage truth-preserving chamber and a temperature balance control system, the mechanical arm is mounted in the storage truth-preserving chamber, and the coring truth-preserving chamber and the storage truth-preserving chamber are mutually butted.

Abstract: A system for monitoring rock damage in deep engineering environment includes an acoustic emission sensor assembly and an acoustic emission amplifier assembly. The assemblies are mounted on a rock mechanics test system. The acoustic emission sensor clamp includes a coupling screw, as well as a clamp cover, a clamp cylinder, and a coupling panel threadedly connected in sequence. The acoustic emission amplifier assembly includes an acoustic emission amplifier, an upright column having a guide rail, a lifting support plate, and a support plate lifting oil cylinder. Additionally, an evaluation method based on acoustic emission tempo-spatial evolution laws is presented. According to the properties of acoustic emission, fractal characteristics of damage evolution processes of rock test pieces are analyzed and the relationship between stress, energy and fractal dimension in the whole process of tensile deformation damage of the rock test pieces is obtained.

Abstract: A tempo-spatial evolution test system for rock breaking in deep and complex environment includes an acoustic emission sensor assembly and an acoustic emission amplifier assembly that are arranged on a rock mechanics test system. A triaxial cavity coupling bracket is arranged on an outer wall of the triaxial cavity and between two sets of acoustic emission sensor assemblies. The triaxial cavity coupling bracket includes a plate-shaped bracket, two sickle-shaped brackets, and at least three bracket bolts, which can be tightly wrapped on the outer wall of the triaxial cavity. A lateral side of the plate-shaped bracket vertically fixes two guide columns. The acoustic emission amplifier assembly is arranged between the two guide columns and is located above the plate-shaped bracket, and the acoustic emission amplifier assembly is connected to the acoustic emission sensor assembly through a signal line.

Abstract: The invention belongs to the field of rock mechanics test of engineering rock masses and is intended to address the safety and alignment challenges of a rock mechanics test response system for existing simulated complex deep earth environment. A rock mechanics test response system for a simulated complex deep earth environment includes a bearing system for rock mechanics tests in simulated deep earth environment and an MTS triaxial sensor aligning and mounting device arranged on the bearing system for rock mechanics tests in simulated deep earth environment. The invention improves installation and dismounting efficiency of an MTS triaxial force sensor, enhances reliability of lifting and solves the problem of aligning holes during installation of the force sensor, thus improving the installation efficiency.

Abstract: A three-dimensional porous polyurethane scaffold for repairing central nerve injuries and a preparation method are disclosed. The scaffold includes three-dimensional porous polyurethane, wherein the compression modulus of the three-dimensional porous polyurethane is 0.001-10.0 MPa and the pore diameter is 10-200 ?m. The three-dimensional porous polyurethane scaffold has an efficient central nerve repair function without additionally inoculating functional cells or factors and can partially restore the original nerve function of tested animals, the preparation method is simple and it has a great prospect of application.

Abstract: The present invention discloses pyrazolo[3,4-d]pyrimidine derivatives of formula (I). Compounds provided in the present invention have significant inhibitory effects on tumor cells, can be used for the prevention and/or treatment of tumor-related diseases, especially lung cancer, and have wide application prospects.

Abstract: An in situ phase change gel sustained-release preparation for a small molecule drug and a preparation method thereof. The in situ phase change gel sustained-release preparation comprises a small molecule drug comprising an active pharmaceutical ingredient, a phospholipid, Span, and an ethanol solution. The in situ phase change gel sustained-release preparation has a high concentration of phospholipids combined with Span, and is thus able to reduce the immediate-release of the small molecule drug and extend the release time, and is suitable for various administration routes, such as subcutaneous injection and external administration.

Abstract: An electronic integrated multi-electrode detection system of a potential determination includes a multi-electrode array, a circuit unit and a total signal output and acquisition unit. The circuit unit includes a multi-electrode array signal input end, a high input impedance voltage follower, a phase shifting filter circuit, an extension module input end, a summing circuit and a total output signal end. The detection system promotes the detection sensitivity and increase the accuracy and precision of detection results. The detection system can be used for monitoring the change in trace ion concentration in a sample, analyzing a constant conventional sample and analyzing a sample with higher error requirement. The detection system can be widely applied to various analysis detection fields, including life sciences, environmental sciences, medicine clinics, and the like.

Abstract: This invention discloses a nucleic acid aptamer AS1411 modified DNA tetrahedron. The preparation method includes the steps of (1) binding an AS1411 sequence to the 5? terminal of any DNA single-strand in a DNA tetrahedron, synthesizing the DNA, dissolving obtained DNA powder with ddH2O; (2) measuring an absorbance of the DNA and then calculating a total volume of the four single strands; (3) pipetting the DNA obtained in step (1) according to the calculation results in step (2), mixing the DNA with a TM buffer, mixing the mixture uniformly with vortex vibration, and performing a PCR progress. The preparation method is simple. The produced product can effectively solve the problem that the unmodified DNA tetrahedron cannot enter the nucleus and the problem that the AS1411 cannot carry drugs directly.

Abstract: A method of detecting malware in Linux platform through the following steps: use objdump-D command to disassemble ELF format benign software and malware samples to generate assembly files; traverse the generated assembly files one by one, read the ELF files' code segment and meanwhile identify whether the code segment contains main( ) function; analyze the code segment read. Divide assembly code into different basic blocks. Each basic block is marked by its lowest address. Add control flow graph's vertex to the adjacency linked list; establish the relation between basic blocks, add control flow graph's edges to the adjacency linked list and generate a basic control flow graph; extract control flow graph's features and write them into ARFF files; take ARFF files as the data set of a machine learning tool named weka to carry out data mining and construct classifier; classify the ELF samples to be tested by using the classifier.

Abstract: The present disclosure relates to the technical field of comparative proteomics, in particular to a detection and quantitation method for proteomics of post-translational modifications. With this method, the protein samples to be studied and internal standards are labeled with isobaric tandem mass tags, and tandem mass spectrometry analysis is carried out for the labeled peptide mixture, wherein the internal standard is a peptide mixture rich in post-translational modifications to be detected. Through this method, the signal of peptides containing the post-translational modifications to be detected can be amplified under the situation that mass spectrometer sensitivity is unchanged, and enrichment of the post-translational modification peptides is not needed. The probability of detecting the peptides containing the post-translational modifications to be detected by mass spectrometer and being selected for subsequent MS/MS analysis is increased.

Abstract: Disclosed are a method and device for using CO2 mineralization to produce sodium bicarbonate or sodium carbonate and output electric energy. The device comprises an anode area, an intermediate area, and a cathode area. The anode area and the intermediate area are spaced by a negative ion exchange membrane (2). The intermediate area and the cathode area are spaced by a positive ion exchange membrane (3). The anode area, the intermediate area, and the cathode area can accommodate corresponding electrolytes. An anode electrode (1) is disposed in the anode area, a cathode electrode (4) is disposed in the cathode area, and the cathode electrode and the anode electrode are connected through a circuit. A raw material hydrogen gas inlet is disposed in the anode area, and a CO2 inlet and a product hydrogen gas outlet are disposed in the cathode area.

Abstract: This invention discloses a method for preparing TDNs-AS1411-nucleic acid drug nanocomposite based drug delivery system, which includes the following steps: binding AS1411 and nucleic acid drug to a tetrahedral DNA nanostructure respectively; selecting four DNA single strands that respectively carry AS1411 and nucleic acid drug; mixing the four DNA single strands; mixing the DNA single strands and the TM buffer uniformly; putting the mixture into a PCR apparatus; raising the temperature to 95° C. quickly and maintaining for 10 min; and next cooling down to 4° C. and maintaining for 20 min to obtain the TDNs-AS1411-nucleic acid drug nanocomposite based drug delivery system. This drug delivery system can directly act on cell nucleus and will not be degraded by lysosomal. The targeting specificity is good. The drug can take a good efficacy and the pertinency is high.

Abstract: A mouse for magnetic resonance, comprising an upper shell (1), a lower shell (2), a trackball (3), a circuit board (4) and a cable (5), wherein the inner surfaces of the upper shell (1) and the lower shell (2) are coated with a silver and copper conductive paint layer, the concentration of a silver and copper conductive paint being 13% to 17%; and a manufacturing method for the mouse for magnetic resonance, and a signal transmission apparatus are further comprised. The clinical usage of functional magnetic resonance can be satisfied, a signal interference is avoided, and it is ensured that a remote computer accurately receives a response of a subject.

Abstract: The present invention relates to a technical field of microwave heating, and more particularly to a microwave frequency-selective heating device and a method thereof. The microwave frequency-selective heating device includes: a heating chamber with a microwave feed-in device, and a frequency controller; wherein the frequency controller is connected to the microwave feed-in device. According to the microwave frequency-selective heating device and the method of the present invention, the heating frequency is adjusted by setting the microwave adjusting device, which improves a material heating uniformity while greatly increases a material microwave absorption rate, so as to solve a heating efficiency problem of the conventional technologies. According to the present invention, the frequency for the heated material is intelligently selected by the micro-processor of the microwave adjusting device, and then fed in after being adjusted by the frequency control circuit, which is effective and convenient.

Abstract: The invention belongs to the field of rock mechanics test of engineering rock masses and is intended to address the safety and alignment challenges of a rock mechanics test response system for existing simulated complex deep earth environment. A rock mechanics test response system for a simulated complex deep earth environment includes a bearing system for rock mechanics tests in simulated deep earth environment and an MTS triaxial sensor aligning and mounting device arranged on the bearing system for rock mechanics tests in simulated deep earth environment. The invention improves installation and dismounting efficiency of an MTS triaxial force sensor, enhances reliability of lifting and solves the problem of aligning holes during installation of the force sensor, thus improving the installation efficiency.

Abstract: A bearing system for rock mechanics test under high temperature and high pressure multi-field coupling includes a force sensor lifting seat and a jack. The force sensor lifting seat includes a connecting disk connected with the jack, a support disk, and an operation channel. A groove dented downwards is arranged on the connecting disk, the support disk is disposed in the groove and freely propped upon the connecting disk; through holes of the connecting disk and the support disk form a control operation channel; and a limiting device is arranged for preventing an MTS triaxial force sensor from disengaging from the support disk. A bolt hole of the force sensor can be aligned with a mounting hole on a solid steel column by rotating the connecting disk for convenient and accurate bolting.

Abstract: A rock damage mechanics test system for high temperature and high pressure deep earth environment includes an MTS triaxial test machine and a control system connected therewith. The MTS triaxial test machine is composed of a rigid frame, a high temperature and high pressure triaxial chamber, and a triaxial chamber base. The control system includes a workstation for data processing and a manual controller for controlling the workstation and a master controller. The system improves mounting and dismounting efficiency of an MTS triaxial force sensor, enhances reliability of lifting and solves the problem of aligning holes during the force sensor mounting process, thus improving the mounting efficiency.

Abstract: A loading platform for a rock mechanics test system (MTS) to realize simple and reliable connection between a high temperature and high pressure force sensor in a triaxial chamber cavity and an upper solid rigid column. The loading platform for rock mechanics test includes a master rod, a secondary rod and a stop sleeve sleeved on the master rod; the stop sleeve is provided with two corbel structures; the secondary rod is composed of a secondary rod head body and a secondary rod body; a circular magnetic block is fixed on the secondary rod to adsorb a hole alignment sleeve sleeved on the secondary rod; and the hole alignment sleeve marked with a first scale line and a second scale line.

Abstract: A triaxial high temperature and high pressure rock mechanics load test platform includes a base, a lifting seat, and an intermediate connecting seat arranged between the base and the lifting seat. A hydraulic assembly is arranged between the base and the intermediate connecting seat; the intermediate connecting seat is connected with the lifting seat by means of a group of connecting rods; the lifting seat is enclosed by a side wall and a base plate to form a receiving groove with an upward opening; and a limiting device is arranged on the side wall of the lifting seat for preventing an MTS triaxial force sensor from disengaging from a support disk.