Patents Assigned to Sichuan University
  • Patent number: 10947334
    Abstract: A method for preparing an anionic thermoviscosifying water-soluble polymer includes the following steps: performing an inverse emulsion polymerization by using acrylamide, acrylic acid and Pluronic triblock polymer. The high reactivity of acrylamide and the inverse emulsion polymerization can increase the molecular weight of the thermoviscosifying polymer, and exhibit an obvious thermoviscosifying effect even at a low polymer concentration, which can reduce the application cost. The dissolution rate of the obtained polymer emulsion is significantly higher than the dissolution rate of the dry powder of the polymer. The obtained emulsion-diluted solution has a relatively strong thermoviscosifying behavior after further adding a small amount of reverse demulsifier, and the emulsion-diluted solution exhibits different thermoviscosifying behaviors as the amount of the reverse demulsifier is increased.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: March 16, 2021
    Assignee: SICHUAN UNIVERSITY
    Inventors: Yujun Feng, Mengmeng Wang
  • Publication number: 20210071263
    Abstract: Disclosed are a tumor biomarker and application thereof, and a tumor detection kit. Patients suffering from non-small cell lung cancer, containing an EML4-ALK or SLC34A2-ROS1 fusion gene, have a specific circular RNA in blood. The base sequences of the circular RNA are represented by SEQ ID NOS. 1-6. The circular RNA is associated with non-small cell lung cancer, stably and constantly exists in plasma samples, and has high specificity and effectiveness, and thus can be used as a biomarker for tumor detection. Reagents such as primers and probes for detecting the circular RNA can be used for preparing the tumor detection kit.
    Type: Application
    Filed: September 8, 2020
    Publication date: March 11, 2021
    Applicant: Sichuan University
    Inventors: YONG PENG, Yuquan WEI, Shuangyan TAN, Ke WU
  • Publication number: 20210052714
    Abstract: The present invention relates to the field of tuberculosis vaccines, and specifically relates to a tuberculosis vaccine, a preparation method thereof, and a use thereof. To address the problem of existing vaccines being unsuitable for patients having weak immunity, the present invention provides a preparation method for a tuberculosis vaccine: first obtaining mycobacterium single cell bacteria, and using low dosage radiation to irradiate cyclically the mycobacterium single cell bacteria, so as to obtain the tuberculosis vaccine. The present invention completely retains all of the antigen characteristics of the bacteria, and can more rapidly stimulate stronger specific immune responses, thereby achieving effective and long-lasting immunity. The vaccine prepared using the present invention has low toxicity, is rapid-acting and safer, and can be used for the prevention and treatment of tuberculosis for people having immunodeficiency.
    Type: Application
    Filed: July 1, 2019
    Publication date: February 25, 2021
    Applicant: SICHUAN UNIVERSITY
    Inventors: Zhenling WANG, Yuquan WEI
  • Publication number: 20210002224
    Abstract: An organic amine ester derivative drug of 2-(?-hydroxypentyl)benzoic acid and a preparation method thereof and an use thereof are disclosed. The present disclosure particularly relates to a compound having the general formula I or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable formulation prepared from the compound or the pharmaceutically acceptable salt thereof. The compound having the general formula I or the pharmaceutically acceptable salt thereof has in vitro a good solubility and a low hygroscopicity, and has in vivo a bioavailability and a brain aggregation concentration that are significantly greater than those of the original medicine butyphthalide and/or an improving drug efficacy. The use of the compound in the preparation of a drug for preventing and/or treating heart and cerebral ischemic diseases, a drug for preventing and/or treating heart and cerebral artery occlusion diseases, an anti-parkinsonian drug and an anti-senile-dementia drug is also disclosed.
    Type: Application
    Filed: April 28, 2019
    Publication date: January 7, 2021
    Applicant: SICHUAN UNIVERSITY
    Inventors: Ling ZHANG, Zhirong ZHANG, Jianabo LI
  • Patent number: 10869922
    Abstract: The invention belongs to the field of biological medicine, in particular refers to an alhydrogel-sodium chloride compound immunologic adjuvant, preparation method and use thereof. The technical problem to be solved by the invention is to provide a well-behaved and novel immunologic adjuvant. The technical solution for solving the technical problem of the invention is to provide the use of sodium chloride in preparing immunologic adjuvant and the alhydrogel-sodium chloride compound immunologic adjuvant obtained on the basis thereof. The compound immunologic adjuvant mainly includes alhydrogel and sodium chloride. The alhydrogel-sodium chloride compound immunologic adjuvant of the invention is an excellent compound immunologic adjuvant, which can be used for various antigens, and provides a new and effective choice for the development and application of vaccines due to the advantages of simple and convenient use, low cost, strong immune activity, high clinical safety and the like.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: December 22, 2020
    Assignee: SICHUAN UNIVERSITY
    Inventors: Xiawei Wei, Min Luo, Yuquan Wei
  • Publication number: 20200394348
    Abstract: A method for assessing fatigue damage and a fatigue life based on a crystal plastic welding process model. According to the new method, consideration is given to the effects of the crystal slip system and the polycrystal plastic strain on the welding process performance of the material. A welding process damage and fatigue life assessment model is established on the mesoscopic scale. The effect of microscopic characterizations of materials on the welding process performance, as well as on the fatigue damage and life of welded joints, can be studied from the mesoscopic point of view. The relationship between the welding process and the evolution of the material performance can be determined by the macro-mesoscopic coupling calculation model to further determine the effect and degree of welding processes on the fatigue damage and life of materials.
    Type: Application
    Filed: May 15, 2020
    Publication date: December 17, 2020
    Applicant: Sichuan University
    Inventors: Qingyuan WANG, Hong ZHANG, Yongjie LIU, Chong WANG, Lang LI, Chao HE
  • Publication number: 20200394347
    Abstract: A method for assessing fatigue damage and fatigue life based on Abaqus is provided. The micro-macroscopic scale coupled model is based on the macroscopic representative area and the microstructure characterization of the material, and the microscopic sub-model is established by the Voronoi algorithm. The algorithm has good cross-platform compatibility and portability, fundamentally solves the technical problem of micro-macroscopic multi-scale coupling and establishes and applies the multi-scale coupled model to the fatigue damage and life assessment. The micro-macroscopic multi-scale coupled fatigue damage and life assessment model and algorithm of the material is capable of both considering the fatigue damage evolution on a microscopic scale and assessing the fatigue life, as well as calculating and assessing the two physical parameters on a macroscopic scale, so as to predict the fatigue damage and life of the whole workpiece.
    Type: Application
    Filed: May 14, 2020
    Publication date: December 17, 2020
    Applicant: Sichuan University
    Inventors: Qingyuan WANG, Hong ZHANG, Yongjie LIU, Chong WANG, Lang LI, Chao HE
  • Patent number: 10865109
    Abstract: A method for preparing a magic-sized nano-crystalline substance, wherein a component containing at least one metal element of groups IIB, IIIA and IVA in the periodic table, and a component containing at least one non-metal element of groups VIA and VA are used as raw materials. In a reaction system for preparing a conventional nano-crystalline substance and in an inert gas atmosphere, after heating the reaction, reactants are cooled to a temperature 50% lower than the actual heating temperature of the reaction thereof, and after standing, the target product of the magic-sized nano-crystalline substance is obtained. The required pure target product can be obtained by the preparation method.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: December 15, 2020
    Assignee: SICHUAN UNIVERSITY
    Inventors: Mingyang Liu, Kui Yu, Qiyu Yu, Jing Zhang, Tingting Zhu, Min Fu, Li Zhang
  • Publication number: 20200369818
    Abstract: A method for preparing an anionic thermoviscosifying water-soluble polymer includes the following steps: performing an inverse emulsion polymerization by using acrylamide, acrylic acid and Pluronic triblock polymer. The high reactivity of acrylamide and the inverse emulsion polymerization can increase the molecular weight of the thermoviscosifying polymer, and exhibit an obvious thermoviscosifying effect even at a low polymer concentration, which can reduce the application cost. The dissolution rate of the obtained polymer emulsion is significantly higher than the dissolution rate of the dry powder of the polymer. The obtained emulsion-diluted solution has a relatively strong thermoviscosifying behavior after further adding a small amount of reverse demulsifier, and the emulsion-diluted solution exhibits different thermoviscosifying behaviors as the amount of the reverse demulsifier is increased.
    Type: Application
    Filed: June 5, 2019
    Publication date: November 26, 2020
    Applicant: SICHUAN UNIVERSITY
    Inventors: Yujun FENG, Mengmeng WANG
  • Patent number: 10834368
    Abstract: This invention discloses a kind of reliable data transmission method based on hidden Markov model that specific to video transmission quality enhancement over lossy satellite links. It uses HMM model to forecast retransmission rate and adopts the network packet loss rate to reflect the network performance. The underlying network packet loss rate is used as the hidden state of HMM model and the retransmission rate is used as the observation state. By analyzing the historically transmitted data sessions, APRT establishes the relationship between the hidden state transition probability and the emission probability. Then, a robust and efficient retransmission rate prediction is obtained. This invention takes into full consideration of high BER in satellite network channels and adjusts the reliable level according to the satellite network channel characteristics so as to make tradeoff between instantaneity and quality. Consequently, it guarantee the QoS and QoE of video stream.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: November 10, 2020
    Assignee: SICHUAN UNIVERSITY
    Inventors: Junfeng Wang, Qin Luo, Ying Liu, Hao Niu, Xiaohui Li
  • Publication number: 20200348534
    Abstract: Provided are a desktop 3D display system and a display method thereof. The desktop 3D display system comprises a 2D image display module (1), a viewing angle directing module (2), a light modulating module (3) and a rotating module (5), wherein the 2D image display module is used for receiving and displaying an integral imaging source; the viewing angle guide module is arranged on the 2D image display module, and is used for guiding light emitted from the integral imaging source of the 2D image display module; the light modulation module is arranged above the viewing angle guide module for modulating the light guided by the viewing angle guide module and reconstructing a 3D image; and the rotation module is configured to enable synchronous rotation of the 2D image display module, the view angle guide module and the light modulation module, wherein, the rotation angle speed of the synchronous rotation is associated with the switching speed of the integral imaging source of the 2D image display module.
    Type: Application
    Filed: February 15, 2019
    Publication date: November 5, 2020
    Applicants: BEIHANG UNIVERSITY, SICHUAN UNIVERSITY
    Inventors: Qionghua WANG, Ling LUO, Huan DENG, Hui REN, Min ZHAO, Sai LI
  • Patent number: 10823652
    Abstract: A triaxial high temperature and high pressure rock mechanics load test platform includes a base, a lifting seat, and an intermediate connecting seat arranged between the base and the lifting seat. A hydraulic assembly is arranged between the base and the intermediate connecting seat; the intermediate connecting seat is connected with the lifting seat by means of a group of connecting rods; the lifting seat is enclosed by a side wall and a base plate to form a receiving groove with an upward opening; and a limiting device is arranged on the side wall of the lifting seat for preventing an MTS triaxial force sensor from disengaging from a support disk.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: November 3, 2020
    Assignee: SICHUAN UNIVERSITY
    Inventors: Jianfeng Liu, Xiaozhang Lei, Wenxi Fu, Feng Dai, Yufeng Wei, Chunping Wang, Huining Xu, Jianliang Pei, Fei Wu, Gang Chen, Jinbing Wei
  • Patent number: 10823706
    Abstract: The present invention discloses an acoustic emission monitoring and transmission system for engineering rock mass including an acoustic emission sensor and a ground workstation. The acoustic emission sensor is installed in a borehole of the monitored rock mass and transmits a received monitoring signal to the ground workstation through a cable. The acoustic emission sensor includes an acoustic emission probe, a probe installation mechanism and a transmission mechanism which transmits the probe installation mechanism with the acoustic emission probe to a setting position inside the borehole. The probe installation mechanism includes a shell connecting to the transmission mechanism and a probe sleeve for accommodating the acoustic emission probe.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: November 3, 2020
    Assignee: SICHUAN UNIVERSITY
    Inventors: Jianfeng Liu, Lu Wang, Chunping Wang, Jianliang Pei, Huining Xu, Jun Zheng
  • Patent number: 10823653
    Abstract: A rock damage mechanics test system for high temperature and high pressure deep earth environment includes an MTS triaxial test machine and a control system connected therewith. The MTS triaxial test machine is composed of a rigid frame, a high temperature and high pressure triaxial chamber, and a triaxial chamber base. The control system includes a workstation for data processing and a manual controller for controlling the workstation and a master controller. The system improves mounting and dismounting efficiency of an MTS triaxial force sensor, enhances reliability of lifting and solves the problem of aligning holes during the force sensor mounting process, thus improving the mounting efficiency.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: November 3, 2020
    Assignee: SICHUAN UNIVERSITY
    Inventors: Jianfeng Liu, Heping Xie, Jianliang Pei, Wenxi Fu, Jianhui Deng, Zhide Wu, Huining Xu, Lu Wang, Fei Wu
  • Patent number: 10815231
    Abstract: The present invention discloses [1,2,4]triazolo[1,5-a]pyridine derivatives, as well as the crystalline form thereof. Compounds provided in the present invention have significant inhibitory effects on tumor cells, can be used for the prevention and/or treatment of tumor-related diseases, especially lung cancer, and have wide application prospects.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: October 27, 2020
    Assignee: WEST CHINA HOSPITAL, SICHUAN UNIVERSITY
    Inventors: Weimin Li, Yang He, Li Zhang, Bojiang Chen, Zhixin Qiu
  • Patent number: 10801934
    Abstract: The present invention discloses a rock mechanics experiment system for simulating deep-underground environment, including a triaxial chamber consisting of a chamber cavity and a test pedestal, a stress field building module, a high pressure seepage field building module, a high temperature field building and a seepage medium permeating control measurement module arranged in the triaxial chamber, a lifting module used for installing and disassembling of the chamber cavity, and computer module used for controlling the operation of system and calculating and outputting the test data. The lifting module includes a door-shaped support frame, a cylinder piston device vertically mounted on the door-shaped support frame beam, a coupling device and a safety suspension device. The coupling device includes an oil hydraulic rod with the upper end fixedly coupled with the piston, a safety disk fixedly coupled with the lower end of the hydraulic rod, and two symmetrically disposed coupling assemblies.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: October 13, 2020
    Assignees: SICHUAN UNIVERSITY, RESEARCH INSTITUTE OF PETROLEUM EXPLORATION & DEVELOPMENT, PETROCHINA COMPANY LIMITED
    Inventors: Jianfeng Liu, Guosheng Ding, Zhide Wu, Qiqi Wanyan, Lina Ran, Jianliang Pei, Lu Wang, Huining Xu, Chunping Wang, Yilin Liao, Qiangxing Zhang, Xiaozhang Lei, Wenxi Fu, Min Zhang
  • Patent number: 10794869
    Abstract: The present invention discloses an acoustic emission sensor, including an acoustic emission probe, a probe installation mechanism, and a transmission mechanism transmitting a combination of the acoustic emission probe and the probe installation mechanism to a setting position in a borehole of a monitored rock mass; the probe installation mechanism includes a shell, a probe sleeve, a spring sleeve, a spring, and a fixed pulley component; the probe sleeve is installed in the guide cylinder of the shell, the spring sleeve is fixed on two sides of the probe sleeve, the spring is installed inside the spring sleeve; one end of the first rope in the fixed pulley component is fixedly connected to the end cap in the upper end surface of the probe sleeve through the fixed pulley mounted on the top of the inner wall of the shell.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: October 6, 2020
    Assignees: SICHUAN UNIVERSITY, RESEARCH INSTITUTE OF PETROLEUM EXPLORATION & DEVELOPMENT, PETROCHINA COMPANY LIMITED
    Inventors: Jianfeng Liu, Huining Xu, Jianliang Pei, Lu Wang, Chunping Wang, Xiaozhang Lei, Wenxi Fu, Jianhui Deng
  • Patent number: 10790610
    Abstract: Disclosed is a connector for high data transfer rate, including a female element, a male element. The female element includes a housing, a plurality of sheets and a first shielding plate. The male element includes a base, a differential signal contact and a second shielding plate. At least two sheets are provided on the housing, and the first shielding plate is provided between adjacent sheets. The second shielding plate corresponding to the sheets is provided on the base. A signal pin is provided at a bottom of the sheets. The differential signal contact is provided in the base. The housing is matched with the base, and the signal pin is configured to contact the differential signal contact. The connector of the present invention improves space utilization rate in the longitudinal direction, assembly efficiency and fault tolerance rate thereof.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: September 29, 2020
    Assignee: Sichuan University
    Inventors: Wenqiang Li, Sitong Ling, Yan Li, Wu Zhao, Zhe Li, Mengkui Li
  • Publication number: 20200266722
    Abstract: A dynamic stability analysis and control method for a voltage sourced converter based high voltage direct current (VSC-HVDC) transmission system. The method includes the following steps: unlocking a converter station of the VSC-HVDC transmission system to make the VSC-HVDC transmission system run in a non-island control mode; extracting corresponding parameters of the VSC-HVDC transmission system, wherein the parameters include an effective voltage value Ut0 of an AC system, an outgoing reactive power Qvsc0 of the VSC-HVDC transmission system, a gain kp of a phase-locked loop (PLL), and a proportional integral time constant ki of the PLL; calculating a short-circuit ratio (SCR), an unit value of Ut0 and an unit value of Qvsc0; calculating a key stable component; checking the sign of the key stable component to determine the stability of the VSC-HVDC transmission system.
    Type: Application
    Filed: February 14, 2020
    Publication date: August 20, 2020
    Applicant: Sichuan University
    Inventors: Baohong LI, Tianqi LIU, Yan TAO, Shunliang WANG
  • Patent number: 10744528
    Abstract: Disclosed is an adjustable ultrasonic micro-jet nozzle array with minimal quantity lubrication, relating to cooling of machining. The array-type nozzle includes an inlet conduit, a recycle conduit and a cooling body having a microjet ejection assembly and a recycling assembly. The cooling body includes a microjet ejection chamber which is closed. The inlet conduit is provided at a top of the cooling body and communicates with the microjet ejection chamber. The recycle conduit is located in the microjet ejection chamber, and connects the recycling assembly and an external vacuum machine. The adjustable ultrasonic micro jet nozzle array of the present invention has the advantages of simple structure and being convenient to use. A flow rate of trace cooling fluid is increased to improve the cooling and lubricating effect. A cooling fluid mist is recycled by the vacuum suction to reduce the consumption of the lubricating fluid while ensuring the cooling effect.
    Type: Grant
    Filed: November 17, 2019
    Date of Patent: August 18, 2020
    Assignee: Sichuan University
    Inventors: Ling Chen, Wu Zhao, Wei Jiang, Hao Wan, Qianmiao Zhou, Xin Guo, Miao Yu, Kai Zhang, Lin Du, Zeyuan Yu, Nianhan Wu