Patents Assigned to Siemens Healthcare Diagnostics Inc.
  • SYSTEM WITH IMPROVED SEAL BETWEEN A LIQUID CONTAINER AND A MANIFOLD
    Publication number: 20220354744
    Abstract: The invention relates to a system with a seal between a manifold and a liquid container in which a sealing without an elastomer material is used, wherein the sealing properties of the seal are independent of the rotational position of the manifold in relation to the container
    Type: Application
    Filed: November 10, 2020
    Publication date: November 10, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Heiko Kalbfell, Joachim Bernhard
  • ACOUSTOPHORETIC LYSIS DEVICES AND METHODS
    Publication number: 20220355294
    Abstract: Lysis devices, methods, and systems are disclosed including a lysis device comprising a sample vessel having an outer surface, a microchannel within the confines of the outer surface, a first port extending through the outer surface to the microchannel, and a second port extending through the outer surface to the microchannel; and an acoustic transducer bonded to the outer surface of the sample vessel to form a monolithic structure, the acoustic transducer configured to emit ultrasonic acoustic waves into and/or to induce shear forces into a blood sample within the microchannel, thereby rupturing the blood cells.
    Type: Application
    Filed: July 25, 2022
    Publication date: November 10, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Peter Paulicka, Jeffrey Jasperse
  • Performance visualization methods and diagnostic laboratory systems including same
    Patent number: 11495349
    Abstract: Methods of visualizing performance of a diagnostic laboratory system are provided. The methods include displaying on a display, an image representing a layout of a plurality of laboratory analyzers included within the diagnostic laboratory system, and overlaying the image with a dynamically-changeable color overlay that indicates a performance for the plurality of laboratory analyzers over a period of time via using changeable colors. Systems including color-changeable overlays are provided as are other aspects.
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: November 8, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Gregory Cockerham, Michael Heydlauf
  • DEVICES AND METHODS FOR MINIMIZING HOOK EFFECT INTEFERENCE IN IMMUNOASSAYS
    Publication number: 20220349877
    Abstract: Methods of minimizing hook effect interference in an immunoassay are disclosed. Also disclosed are reagents, kits, and immunoassay devices that may be utilized in accordance with the method.
    Type: Application
    Filed: July 18, 2022
    Publication date: November 3, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Chris Zimmerle, Gary Rheinheimer
  • POSITIVE TEMPERATURE COEFFICIENT HEATING OF LABORATORY DIAGNOSTIC INSTRUMENTS
    Publication number: 20220353957
    Abstract: A diagnostic device has a sample probe for receiving sample material from one or more containers, a sample line for delivering the sample material to one or more reaction containers, a reagent supply and reagent supply line for supplying reagent to the one or more reaction containers, an incubation ring for receiving the reaction containers and incubating a mixture of the sample material and the reagent for a period of time, and a heating system for heating one or more areas or components of the device. The heating system has one or more positive temperature coefficient heaters.
    Type: Application
    Filed: September 26, 2019
    Publication date: November 3, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Christopher P. Ebeling
  • REAGENTS AND METHODS FOR DETECTING AAV SHEDDING
    Publication number: 20220349017
    Abstract: The present disclosure provides, among other things, primers and probes for detecting shedding of an AAV construct or fragment thereof in a subject. In some embodiments the primers are selected to generate an amplicon that comprises (i) a first strand comprising (1) a nucleotide sequence corresponding to the forward primer, and (2) a nucleotide sequence corresponding to a portion of the AAV construct or fragment thereof, (ii) a second strand comprising (1) a nucleotide sequence of the reverse primer, and (2) a nucleotide sequence that is complementary to the portion of the AAV construct or fragment thereof, or (iii) a combination thereof, where the portion of the AAV construct or fragment thereof comprises a nucleotide sequence that spans a junction between a regulatory element and the therapeutic gene of interest.
    Type: Application
    Filed: August 29, 2020
    Publication date: November 3, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Arejas J. Uzgiris, Isabelle Philipp, Xiaolei Qiu, Sara Weitz, Zuguang Wang
  • Probe tip eject devices and methods thereof for automated diagnostic analysis apparatus
    Patent number: 11486889
    Abstract: Automated diagnostic analysis apparatus for analyzing patient specimens may include a probe to aspirate and dispense a bio-liquid. A probe tip on the probe may require replacement after contact with each bio-liquid. The automated diagnostic analysis apparatus may include a probe tip eject device and a waste chute for controlled removal and disposal of the probe tip to mitigate splattering or splashing of any residual bio-liquid in the probe tip as it is removed from the probe. A sloped ramp in the probe tip eject device may engage and remove the probe tip as it rotates through the probe tip eject device. The waste chute may include guides to transfer a removed probe tip directly into a waste bin without any surface contact by the probe tip. Methods of removing and disposing of a probe tip in an automated diagnostic analysis apparatus are described, as are other aspects.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: November 1, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Toby Ballen, Frank Bakonyi, Steffen Pharai, Domenick Ansalone
  • Method and device comprising an optical fiber located inside a channel for determining the concentration of analyte in whole blood based on change of reflected light wavelength
    Patent number: 11480558
    Abstract: A method and a device for determining the concentration of an analyte in whole blood is disclosed. In one embodiment, the method includes generating a plasma layer in the whole blood sample. Furthermore, the method includes exposing the plasma layer to light. The method also includes capturing light reflected from the plasma layer. Additionally, the method includes analyzing the reflected light to determine the concentration of the analyte.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: October 25, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Satish Kumar Dubey, Ashish Kumar Lal, Vishal Manjanath Prabhu, David Ledden
  • ANTI-HOG TCN1 MONOCLONAL ANTIBODIES AND METHODS OF PRODUCTION AND USE THEREOF
    Publication number: 20220332803
    Abstract: Anti-hog TCN1 monoclonal antibodies are disclosed, along with epitopes recognized by same. Also disclosed are kits containing the monoclonal antibodies and methods of producing the antibodies. Further disclosed are methods of using the monoclonal antibodies, such as (but not limited to) in methods of estimating and/or removing TCN1 from hog intrinsic factor preparations.
    Type: Application
    Filed: August 7, 2020
    Publication date: October 20, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Manoj Sharma, Tatiana Mareeva, Yuriy Smirnov, Pratap Singh, William Bedzyk
  • IMPROVED ROTOR MIXER FOR AGITATION OF FLUIDS DURING SAMPLE PREPARATION
    Publication number: 20220333058
    Abstract: An apparatus, multi-well plate and method for automated cell lysis and nucleic acid purification and processing. The plate includes a lysis well, at least one wash well, and an elution well. The apparatus includes a vertically aligned rotor mixer comprising a magnetic tip and actuators for moving the rotor mixer in a vertical and horizontal directions, to transfer magnetic beads from well to well. The rotor mixer is used to vortex lysis mixtures, wherein the vortexing speed is sufficient to overcome the magnetic attraction between the beads and mixer tip and disperse the beads in solution, to collect nucleic acids such as DNA.
    Type: Application
    Filed: August 18, 2020
    Publication date: October 20, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Alex Hofai Lee, Daniel Chu
  • SAMPLE PREPARATION APPARATUS AND MULTI-WELL PLATE WITH PCR CHIP
    Publication number: 20220325272
    Abstract: An apparatus, multi-well plate and method for automated cell lysis and nucleic acid purification and amplification. The plate includes a lysis well, at least one wash well, an elution well, and a PCR chip. The apparatus includes a vertically aligned rotor mixer comprising a magnetic tip and actuators for moving the rotor mixer in a vertical and horizontal directions, to transfer magnetic beads from well to well. The rotor mixer is used to vortex lysis mixtures, wherein the vortexing speed is sufficient to overcome the magnetic attraction between the beads and mixer tip and disperse the beads in solution, to collect nucleic acids such as DNA in an elution solution that is transferred to the PCR chip for amplification of target sequences.
    Type: Application
    Filed: August 18, 2020
    Publication date: October 13, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Daniel Chu, Alex Hofai Lee
  • Dye-based liquid reagent volume indicator for use in analyte detection assays
    Patent number: 11460476
    Abstract: Devices, kits, and methods are disclosed for use in detecting a concentration of an analyte of interest in a patient's liquid test sample. The devices, kits, and methods employ the use of one or more solid reagent zones that includes at least one analytical reagent for detection of an analyte of interest. The solid reagent zone(s) also includes at least one dye for determining whether results obtained from the diagnostic assay for the at least one analyte of interest are biased or inaccurate due to a loss of volume of a liquid reagent during the dispensing of the liquid reagent.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: October 4, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Aaron Kauffmann, David Ledden, Chris Zimmerle, Jon Stradinger
  • Composition of a bilirubin stock and a method of preparation thereof
    Patent number: 11460475
    Abstract: A composition of a bilimbin stock and a method of preparation are provided. In one aspect of the invention, the composition includes a base solution. The composition further includes a carbonate salt. Additionally, the composition includes bilimbin. Furthermore, the composition includes human serum albumin.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: October 4, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Sudipa Galgalkar, Ishita Chakraborty, Ragavendar Ms, David Ledden
  • AUTOMATED CLINICAL ANALYZER SYSTEM AND METHOD
    Publication number: 20220308078
    Abstract: An analyzer system for in vitro diagnostics includes a sample handler module having a robot arm that delivers samples from drawers into carriers on a linear synchronous motor automation track. Samples are delivered via the automation track to individual track sections associated with individual analyzer modules. Analyzer modules aspirate sample portions directly from the sample carriers and perform analysis thereon.
    Type: Application
    Filed: June 15, 2022
    Publication date: September 29, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: David Stein, Roy Barr, Mark Edwards, Colin Mellars, Thomas J. Bao, Charles V. Cammarata, Benjamin S. Pollack, Baris Yagci, Beri Cohen
  • Rotary platform for cell lysing and purification and method of use
    Patent number: 11446652
    Abstract: Magnetic beads having cell components of interest are translated between a sequence of processing wells in a tray without need for pipetting. The circular tray contains one or more sequences of wells each interconnected by a respective channel. The tray is rotated about a central axis and a magnet, an agitator, and a heater provided external to the tray enable magnetic bead translation, mixing, and incubation, respectively. The magnet proximate a well forms a cluster of beads. Manipulation of the tray in rotation and elevation results in translation of the cluster from one well, through a channel, and into an adjacent well. The well containing a cluster may be rotationally positioned in front of the agitator, the agitator extended into contact with the well, followed by mechanical agitation. The heater, disposed beneath the tray, may accept a well lowered thereto for selective heating.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: September 20, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Jason Bryant, Eric Yeaton, Dan Harris, Josiah Hackendorf, Steven Allen, Mark Talmer
  • WALK-AWAY TIME VISUALIZATION METHODS AND SYSTEMS
    Publication number: 20220291247
    Abstract: A status visualization method of a diagnostic laboratory system. The status visualization method includes receiving, at a system controller, computer-readable data comprising analyzers included within the diagnostic laboratory system, and test demand for types of tests and number of the tests to be performed on samples by the analyzers, wherein the analyzers each include consumable items and maintenance items. The method further includes determining, via a walk-away time estimation module executing on the system controller, an estimated walk-away time for the analyzers based upon the test demand and status of the consumable items and maintenance items. Diagnostic laboratory systems with walk-away time estimation are disclosed, as are other aspects.
    Type: Application
    Filed: August 3, 2020
    Publication date: September 15, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Heinrich Helmut Degen, Sara Kendrick, Scott Salmon
  • REAGENT PACK LOAD PLAN OPTIMIZATION METHODS AND SYSTEMS
    Publication number: 20220293226
    Abstract: An optimization method of a diagnostic laboratory system. The method includes receiving, at a system controller, computer-readable data comprising an inventory of a plurality of analyzers included within the diagnostic laboratory system, and types of tests and numbers of the tests to be performed on samples by the diagnostic laboratory system over a planning period; and determining, via a reagent pack optimization module executing on the system controller, a reagent pack loading plan over the planning period. Diagnostic laboratory systems are disclosed, as are other aspects.
    Type: Application
    Filed: June 10, 2020
    Publication date: September 15, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Ahmet Tuysuzoglu, Yue Zhang, Michael Heydlauf, Luxi Zheng
  • IMPROVED SOLID-STATE MAGNESIUM ION SELECTIVE MICROELECTRODE AND METHODS OF PRODUCTION AND USE THEREOF
    Publication number: 20220291164
    Abstract: A magnesium sensing membrane is disclosed for use in a potentiometric ion selective microelectrode that exhibits an increased lower detection limit. Potentiometric ion selective microelectrodes containing said magnesium sensing membranes are also disclosed. Kits containing the microelectrodes are also disclosed, along with methods of production and use of the magnesium sensing membranes and/or potentiometric ion selective microelectrodes.
    Type: Application
    Filed: August 17, 2020
    Publication date: September 15, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Wei Zhang
  • TUBE FRAME APPARATUS, TUBE FRAME ASSEMBLIES, AND METHODS OF HOLDING TUBES
    Publication number: 20220288596
    Abstract: A tube frame apparatus is disclosed. In one aspect, the tube frame apparatus has a body having a top surface and a plurality of apertures formed in rows therein, the apertures configured to receive strips of tubes, and locking tabs projecting from the top surface that are configured to engage with the strips of tubes. Flanges of the tubes, or optionally connector strips between the tubes, can be engaged by the locking tabs. Tube frame assemblies and methods of holding strips of tubes in tube frame apparatus are provided, as are other aspects.
    Type: Application
    Filed: November 11, 2020
    Publication date: September 15, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: James Grayson, Raymond Mei, Philip Chia, Don Collado
  • PERFORMANCE VISUALIZATION METHODS AND DIAGNOSTIC LABORATORY SYSTEMS INCLUDING SAME
    Publication number: 20220293255
    Abstract: Methods of visualizing performance of a diagnostic laboratory system are provided. The methods include displaying on a display, an image representing a layout of a plurality of laboratory analyzers included within the diagnostic laboratory system, and overlaying the image with a dynamically-changeable color overlay that indicates a performance for the plurality of laboratory analyzers over a period of time via using changeable colors. Systems including color-changeable overlays are provided as are other aspects.
    Type: Application
    Filed: January 15, 2021
    Publication date: September 15, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Gregory Cockerham, Michael Heydlauf