Abstract: For dose calibration (39) in functional imaging, different precision sources (22, 25) for a same long-lived isotope are used to calibrate, avoiding having to ship one source from one location to another location. A ratio of sensitivities of a gas ion chamber-based dose calibrator (20) at a reference laboratory to the precision source (22) of the long-lived isotope to a source (23) with an isotope to be used for imaging is found. At the clinical site (e.g., radio-pharmacy or functional imaging facility), a measure (34) of the sensitivity of a local gas ion chamber-based dose calibrator (24) to the other source (25) with the long-lived isotope and the ratio from the remote gas ion chamber-based dose calibrator (20) are used to determine sensitivity of the local gas ion chamber-based dose calibrator (24) to the isotope of the radiopharmaceutical (26).

Abstract: Disclosed herein is a material, comprising a first metal halide that is operative to function as a scintillator; where the first metal halide excludes cesium iodide, strontium iodide, and cesium bromide; and a surface layer comprising a second metal halide that is disposed on a surface of the first metal halide; where the second metal halide has a lower water solubility than the first metal halide.

Abstract: A method for determining an abnormality score map for Single-photon Emission Computed Tomography (SPECT) gamma camera flood analysis includes extracting a plurality of image patches from an input flood image and generating a feature vector for each image patch. A per-patch abnormality score is generated for each feature vector by comparing the feature vector against a normal flood feature dictionary comprising one or more normal flood feature vectors generated using a plurality of normal flood images. Then, an abnormality score map may be generated to depict the per-patch abnormality scores for the input flood image.

Abstract: A system and method include acquisition of a set of tomographic images of a patient volume associated with each of a plurality of timepoints of a first radiopharmaceutical therapy cycle, determination, for each of the plurality of timepoints, of a systematic uncertainty for each of a plurality of regions within the patient volume based on the set of tomographic images associated with the timepoint, determination, for each of the plurality of timepoints, of a quantitative statistical uncertainty based on the set of tomographic images associated with the timepoint, determination of a dose and a dose uncertainty for each of the plurality of regions based on the set of tomographic images, the systematic uncertainty and the quantitative statistical uncertainty for each of the plurality of timepoints, and display of a cumulative dose and cumulative dose uncertainty for each of the plurality of regions based on the dose and the dose uncertainty determined for each of the plurality of regions.

Abstract: Systems and methods of image reconstruction are disclosed. First image scan data corresponding to a first imaging modality is obtained. One or more deep learning processes are applied to the first image scan data, where the one or more deep learning processes are trained based on first image scan data corresponding to a second imaging modality, to generate second image scan data corresponding to the first imaging modality. An image is then reconstructed based on the first image scan data and the second image scan data corresponding to the first imaging modality.

Abstract: A method and system for determining system-based tumor burden is disclosed. In one aspect, the method includes obtaining the medical image from a source, through an interface. Additionally, the method includes identifying a first region of interest in the medical image. The method also includes selecting from the first region of interest a second region of interest whose tumor burden is to be determined. Furthermore, the method includes defining a segmentation criterion for the second region of interest. The method also includes determining the tumor burden for the second region of interest.

Abstract: For phase inversion-based ultrasound imaging with a transmit and receive circuit at an array, a unipolar transmitter is used to reduce the number of high voltage wires. Rather than adding a T/R switch or increasing connections by connecting the receive amplifier to a different electrode than the transmitter, two different receive paths from the element to the receive amplifier are provided. One path is used where the unipolar transmitter ends in one state (e.g., 0V), and the other path is used where the unipolar transmitter ends in another state (e.g., Vtx).

Abstract: During calibration of a SPECT system, system-specific sensitivities and cross-calibration factors for multiple isotopes for correcting for dose are determined for various combinations of options, including the option of which specific well counter with which to measure the dose. The options may include selected energy windows for isotopes with multiple energy windows. This arrangement allows for custom-specified isotopes not included in standard listings. For use with a particular patient, the cross-calibration factor for the well counter used to measure the dosage for the patient is accessed and used for dose correction. More accurate quantitative functional information may result from the corrected dose. The cross-calibration may be more easily implemented despite the options using the sensitivities and cross-calibrations provided for various combinations.

Abstract: Shear wave propagation is used to estimate the speed of sound in a patient. An ultrasound scanner detects a time of occurrence of a shear wave at each of multiple locations. The difference in time of occurrence, given tissue stiffness or shear velocity, is used to estimate the speed of sound for the specific tissue of the patient.

Abstract: For region of interest (ROI) placement in quantitative ultrasound imaging with an ultrasound scanner, the ROI is automatically placed using anatomy detection specific to the quantification, signal processing for clutter, attenuation, or noise, and/or identification of regions of fluid. For quantification, multiple ROIs may be positioned automatically. The automatic placement may improve consistency of measures over time and between sonographers and may provide for better image quality with less influence from undesired signals. As a result, diagnosis and/or treatment may be improved.

Abstract: A computer-implemented method for decoding brain imaging data of individual subjects by using additional imaging data from other subjects includes receiving a plurality of functional Magnetic Resonance Imaging (fMRI) datasets corresponding to a plurality of subjects. Each fMRI dataset corresponds to a distinct subject and comprises brain activation patterns resulting from presentation of a plurality of stimuli to the distinct subject. A group dimensionality reduction (GDR) technique is applied to the example fMRI datasets to yield a low-dimensional space of response variables shared by the plurality of subjects. A model is trained to predict a set of target variables based on the low-dimensional space of response variables shared by all subjects, wherein the set of target variables comprise one or more characteristics of the plurality of stimuli.

Abstract: Systems and methods to determine random coincidence rates include determination of a detector rate for each of a plurality of detectors of a positron emission tomography scanner based on a frame of positron emission tomography data, determination of a sensitivity for each detector crystal of the plurality of detectors, based on the detector rate of the detector including the detector crystal, determination of a singles rate for each detector crystal based on the detector rate of the detector including the detector crystal and the determined sensitivity of the detector crystal, estimation of a mean random coincidence rate for each of a plurality of pairs of the detector crystals based on the singles rate of each detector crystal of each of the plurality of pairs of the detector crystals, correction of the acquired frame of positron emission tomography data based on the estimated mean random coincidence rates, and reconstruction of a positron emission tomography image based on the corrected frame of positron em

Abstract: Disclosed is a PET detector assembly in a combined PET/CT scanner system having a backplane structure for supporting two or more PET detector rings that provides substantially balanced load on the gantry backplane while accommodating the varying number of PET detector rings between short axial PET FOV system as well as long axial PET FOV system.

Abstract: A system and method of image reconstruction is disclosed. First image scan data corresponding to a spiral CT modality received during a first time period is received. The first image scan data includes at least partially overlapping axial positions. A change in position over time for each of the at least partially overlapping axial positions is determined and a first respiratory waveform is estimated from the change in position over time for each of the at least partially overlapping axial positions.

Abstract: Methods and systems are provided for registration of preoperative images to ultrasound images. The preoperative images are segmented using a shape model. An ultrasound procedure is performed to acquire the ultrasound images. The path of an ultrasound transducer used in the ultrasound procedure is tracked. The path is used to deform the segmented preoperative images, providing an alignment. The ultrasound images are registered to the preoperative images using the alignment.

Abstract: Disclosed herein is a method including manufacturing a powder having a composition of formula (1), M1aM2bM3cM4dO12??(1) where O represents oxygen, M1, M2, M3, and M4 represents a first, second, third, and fourth metal that are different from each other, where the sum of a+b+c+d is about 8, where “a” has a value of about 2 to about 3.5, “b” has a value of 0 to about 5, “c” has a value of 0 to about 5 “d” has a value of 0 to about 1, where “b” and “c”, “b” and “d”, or “c” and “d” cannot both be equal to zero simultaneously, where M1 is a rare earth element comprising gadolinium, yttrium, lutetium, scandium, or a combination of thereof, M2 is aluminum or boron, M3 is gallium, and M4 is a dopant; and heating the powder to a temperature of 500 to 1700° C. in an oxygen containing atmosphere to manufacture a crystalline scintillator.

Abstract: A system and method includes acquisition of a plurality of images depicting a respective scintillator crystal, determination of a plurality of categories based on the plurality of images, determination of a crystal quality value associated with each of the plurality of categories, training of a network to receive an input image and output an indication of one of the plurality of categories based on the input image, the training based on the plurality of images and the at least one category associated with each pf the plurality of images, operation of the trained network to receive a first image of a first scintillator crystal and output a first one of the plurality of categories based on the first image, and determination of a quality of the first scintillator crystal based on the first one of the plurality of categories and a first crystal quality value associated with the first one of the plurality of categories.

Abstract: Flash suppression is provided in motion imaging. Separate regions of motion in a same frame or image are tested for flash independently. The size, shape, spatial variance, and/or location of a given region are used to categorize a level or likelihood of flash artifact for that region. Based on the level or likelihood, the motion information is altered to reduce flash.

Abstract: Image enhancement is provided for medical diagnostic ultrasound. Knowledge-based detection of anatomy or artifact identifies locations to be enhanced. The knowledge-based detection of the locations may avoid identification of other anatomy or artifacts. The image enhancement is applied to the identified locations and not others.