Patents Assigned to Sigma-Aldrich Co.
  • GENOMIC EDITING OF GENES INVOLVED WITH PARKINSON'S DISEASE
    Publication number: 20110023141
    Abstract: The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins associated with Parkinson's disease. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of using the genetically modified animals or cells disclosed herein to study PD development and screen agents for assessing their effect on progression or symptoms of PD.
    Type: Application
    Filed: July 23, 2010
    Publication date: January 27, 2011
    Applicant: SIGMA-ALDRICH CO.
    Inventors: Edward Weinstein, Xiaoxia Cui, Phil Simmons
  • EQUINE GENOME EDITING WITH ZINC FINGER NUCLEASES
    Publication number: 20110023157
    Abstract: The present invention provides a genetically modified equine or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the equine genome.
    Type: Application
    Filed: July 23, 2010
    Publication date: January 27, 2011
    Applicant: Sigma-Aldrich Co.
    Inventors: Joseph Bedell, Brian Buntaine, Xiaoxia Cui
  • GENOMIC EDITING OF PRION DISORDER-RELATED GENES IN ANIMALS
    Publication number: 20110023147
    Abstract: The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with cognitive disorders. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of using the genetically modified animals or cells disclosed herein to screen agents for toxicity and other effects.
    Type: Application
    Filed: July 23, 2010
    Publication date: January 27, 2011
    Applicant: SIGMA-ALDRICH CO.
    Inventors: Edward Weinstein, Phil Simmons, Xiaoxia Cui
  • RABBIT GENOME EDITING WITH ZINC FINGER NUCLEASES
    Publication number: 20110023140
    Abstract: The present invention provides a genetically modified rabbit or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the rabbit genome.
    Type: Application
    Filed: July 23, 2010
    Publication date: January 27, 2011
    Applicant: SIGMA-ALDRICH CO.
    Inventors: Joseph Bedell, Brian Buntaine, Xiaoxia Cui
  • GENOMIC EDITING OF GENES INVOLVED IN TUMOR SUPPRESSION IN ANIMALS
    Publication number: 20110023149
    Abstract: The present invention provides genetically modified animals and cells comprising edited chromosomal sequences involved in tumor suppression. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. The invention also provides zinc finger nucleases that target chromosomal sequence involved in tumor suppression and the nucleic acids encoding the zinc finger nucleases. Also provided are methods of assessing the effects of agents in genetically modified animals and cells comprising edited chromosomal sequences involved in tumor suppression.
    Type: Application
    Filed: July 23, 2010
    Publication date: January 27, 2011
    Applicant: SIGMA-ALDRICH CO.
    Inventors: Edward Weinstein, Xiaoxia Cui, Phil Simmons
  • GENOME EDITING OF COGNITION RELATED GENES IN ANIMALS
    Publication number: 20110023152
    Abstract: The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with cognitive disorders. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of assessing the effects of agents in genetically modified animals and cells comprising edited chromosomal sequences associated with cognitive disorders.
    Type: Application
    Filed: July 23, 2010
    Publication date: January 27, 2011
    Applicant: SIGMA-ALDRICH CO.
    Inventors: Edward Weinstein, Xiaoxia Cui, Phil Simmons
  • GENOMIC EDITING OF GENES INVOLVED IN AUTISM SPECTRUM DISORDERS
    Publication number: 20110023145
    Abstract: The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins associated with ASD. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of using the genetically modified animals or cells disclosed herein to study ASD development and screen agents for assessing their effect on progression or symptoms of an ASD.
    Type: Application
    Filed: July 23, 2010
    Publication date: January 27, 2011
    Applicant: SIGMA-ALDRICH CO.
    Inventors: Edward Weinstein, Xiaoxia Cui, Phil Simmons
  • FELINE GENOME EDITING WITH ZINC FINGER NUCLEASES
    Publication number: 20110023156
    Abstract: The present invention provides a genetically modified feline or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the feline genome.
    Type: Application
    Filed: July 23, 2010
    Publication date: January 27, 2011
    Applicant: SIGMA-ALDRICH CO.
    Inventors: Joseph Bedell, Gregory Davis, Shondra Miller, Brian Buntaine, Xiaoxia Cui
  • SILKWORM GENOME EDITING WITH ZINC FINGER NUCLEASES
    Publication number: 20110023154
    Abstract: The present invention provides a genetically modified silkworm or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the silkworm genome.
    Type: Application
    Filed: July 23, 2010
    Publication date: January 27, 2011
    Applicant: SIGMA-ALDRICH CO.
    Inventors: Joseph Bedell, Brian Buntaine, Xiaoxia Cui
  • GENOMIC EDITING OF GENES INVOLVED IN ALZHEIMER'S DISEASE
    Publication number: 20110023153
    Abstract: The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins associated with AD. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of using the genetically modified animals or cells disclosed herein to study AD development and methods of assessing the effects of agents in genetically modified animals and cells comprising edited chromosomal sequences encoding proteins associated with AD.
    Type: Application
    Filed: July 23, 2010
    Publication date: January 27, 2011
    Applicant: SIGMA-ALDRICH CO.
    Inventors: Edward Weinstein, Xiaoxia Cui, Phil Simmons
  • OVINE GENOME EDITING WITH ZINC FINGER NUCLEASES
    Publication number: 20110023159
    Abstract: The present invention provides a genetically modified ovine or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the ovine genome.
    Type: Application
    Filed: July 23, 2010
    Publication date: January 27, 2011
    Applicant: SIGMA-ALDRICH CO.
    Inventors: Joseph Bedell, Brian Buntaine, Xiaoxia Cui
  • GENOMIC EDITING OF GENES INVOLVED IN CARDIOVASCULAR DISEASE
    Publication number: 20110023139
    Abstract: The present invention provides genetically modified animals and cells comprising edited chromosomal involved in cardiovascular disease. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. The invention also provides zinc finger nucleases that target chromosomal sequences involved in cardiovascular disease and the nucleic acids encoding said zinc finger nucleases. Also provided are methods of using the genetically modified animals or cells disclosed herein to screen agents for toxicity and other effects.
    Type: Application
    Filed: July 23, 2010
    Publication date: January 27, 2011
    Applicant: SIGMA-ALDRICH CO.
    Inventors: Edward Weinstein, Xiaoxia Cui, Phil Simmons
  • GENOME EDITING OF ADDICTION-RELATED GENES IN ANIMALS
    Publication number: 20110023148
    Abstract: The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins associated with addiction disorders. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. The invention also provides zinc finger nucleases that target chromosomal sequence encoding addiction-related proteins and the nucleic acids encoding said zinc finger nucleases. Also provided are methods of using the genetically modified animals or cells disclosed herein to screen agents for addiction and withdrawal side effects and other effects.
    Type: Application
    Filed: July 23, 2010
    Publication date: January 27, 2011
    Applicant: SIGMA-ALDRICH CO.
    Inventors: Edward Weinstein, Xiaoxia Cui, Phil Simmons
  • GENOMIC EDITING OF NEURODEVELOPMENTAL GENES IN ANIMALS
    Publication number: 20110023143
    Abstract: The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with neurodevelopmental disorders. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of using the genetically modified animals or cells disclosed herein to screen agents for toxicity and other effects.
    Type: Application
    Filed: July 23, 2010
    Publication date: January 27, 2011
    Applicant: SIGMA-ALDRICH CO.
    Inventors: Edward Weinstein, Xiaoxia Cui, Phil Simmons
  • DICATIONIC LIQUID SALTS AND METHODS OF USE THEREOF
    Publication number: 20110017908
    Abstract: Dicationic liquid salts and methods of using such dicationic liquid salts in techniques such as ESI-MS are provided.
    Type: Application
    Filed: February 17, 2009
    Publication date: January 27, 2011
    Applicant: SIGMA-ALDRICH CO.
    Inventor: Armstrong W. Daniel
  • GENOME EDITING OF GENES ASSOCIATED WITH SCHIZOPHRENIA IN ANIMALS
    Publication number: 20110023150
    Abstract: The present invention provides genetically modified animals and cells comprising edited chromosomal sequences associated with schizophrenia. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. The invention also provides zinc finger nucleases that target chromosomal sequence associated with schizophrenia and the nucleic acids encoding said zinc finger nucleases. Also provided are methods of assessing the effects of agents in genetically modified animals and cells comprising edited chromosomal sequences associated with schizophrenia.
    Type: Application
    Filed: July 23, 2010
    Publication date: January 27, 2011
    Applicant: SIGMA-ALDRICH CO.
    Inventors: Edward Weinstein, Xiaoxia Cui, Phil Simmons
  • Polysilazane thermosetting polymers for use in chromatographic systems and applications
    Patent number: 7875738
    Abstract: This invention relates to an amorphous non-glassy ceramic composition that may be prepared by curing, calcining and/or pyrolyzing a precursor material comprising silicon, a Group III metal, a Group IVA metal, and/or a Group IVB metal.
    Type: Grant
    Filed: September 29, 2008
    Date of Patent: January 25, 2011
    Assignee: Sigma-Aldrich Co.
    Inventors: William R. Betz, Christopher M. Linton
  • GENOMIC EDITING OF GENES INVOLVED IN INFLAMMATION
    Publication number: 20110016543
    Abstract: The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding inflammation-related proteins. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of assessing the effects of agents in genetically modified animals and cells comprising edited chromosomal sequences encoding inflammation-related proteins.
    Type: Application
    Filed: July 23, 2010
    Publication date: January 20, 2011
    Applicant: SIGMA-ALDRICH CO.
    Inventors: Edward Weinstein, Xiaoxia Cui, Phil Simmons
  • CANINE GENOME EDITING WITH ZINC FINGER NUCLEASES
    Publication number: 20110016542
    Abstract: The present invention provides a genetically modified canine or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the canine genome.
    Type: Application
    Filed: July 23, 2010
    Publication date: January 20, 2011
    Applicant: SIGMA-ALDRICH CO.
    Inventors: Joseph Bedell, Brian Buntaine, Xiaoxia Cui
  • GENOME EDITING OF NEUROTRANSMISSION-RELATED GENES IN ANIMALS
    Publication number: 20110016539
    Abstract: The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with neurotransmission disorders. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of using the genetically modified animals or cells disclosed herein to screen agents for toxicity and other effects.
    Type: Application
    Filed: July 23, 2010
    Publication date: January 20, 2011
    Applicant: SIGMA-ALDRICH CO.
    Inventors: Edward Weinstein, Xiaoxia Cui, Phil Simmons