Abstract: A pre-filter assembly including a differential mobility spectrometer (DMS) that is configured to be in-line with a mass spectrometer (MS) such that the MS continuously receives carrier flow from the DMS when the DMS filtering fields are removed.
Abstract: The invention relates generally to systems, methods and devices for analyzing samples and, more particularly, to systems using tandem differential mobility spectrometers in combination with a mass analyzer to enhance the analysis process of constituents of a sample.
Type:
Grant
Filed:
June 28, 2007
Date of Patent:
October 12, 2010
Assignees:
Sionex Corporation, Northeastern University
Inventors:
Raanan A. Miller, Erkinjon G. Nazarov, Paul Vouros
Abstract: The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, to sample detection using multiple detection and analytical techniques in combination.
Type:
Grant
Filed:
January 13, 2005
Date of Patent:
May 11, 2010
Assignee:
Sionex Corporation
Inventors:
Raanan A. Miller, Erkinjon G. Nazarov, Lawrence A. Kaufman, Evgeny Krylov, Gary A. Eiceman
Abstract: A compact integrated ion mobility based analysis system includes at least one gas chromatograph (GC) column that receives a sample and elutes constituents of the sample where each of the eluted constituents are temporally separated from each other The system also includes at least one ion mobility based sample analyzer that analyzes the eluted constituents based on their ion mobility characteristics. The system further includes a controller that selectively adjusts the temperature within at least one GC column over a period of time and selectively adjusts the temperature within at least one ion mobility based sample analyzer over a period of time.
Type:
Grant
Filed:
May 1, 2006
Date of Patent:
October 27, 2009
Assignee:
Sionex Corporation
Inventors:
Raanan A. Miller, Erkinjon G. Nazarov, David B. Wheeler, Kenneth A. Markoski
Abstract: The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, in some embodiments to compact GC-DMS systems, methods, and devices employing enhanced GC column temperature control and configurations to identify various sample constituents.
Type:
Grant
Filed:
July 17, 2007
Date of Patent:
October 20, 2009
Assignee:
Sionex Corporation
Inventors:
Raanan A. Miller, Erkinjon G. Nazarov, David B. Wheeler, Quan Shi, John A. Wright, Gary A. Eiceman
Abstract: An ultra compact ion mobility based analyzer in a multilayered chip assembly employing various features such as a ion flow generator to propel ions through an ion mobility based filter and, thereby, reduce analyzer size, cost, and power requirements.
Type:
Grant
Filed:
July 26, 2006
Date of Patent:
August 25, 2009
Assignee:
Sionex Corporation
Inventors:
Raanan A. Miller, Stephen Coy, Stephen D. Kendig, C. James Morris, John A. Wright, Erkinjon G. Nazarov
Abstract: Disclosed herein are systems, methods and apparatus, for detection and identification of chemical warfare agents (CWAs) using a differential mobility spectrometer.
Type:
Grant
Filed:
February 1, 2008
Date of Patent:
August 18, 2009
Assignees:
Sionex Corporation, The Charles Stark Draper Laboratory, Inc.
Inventors:
Raanan A. Miller, Erkinjon G. Nazarov, Angela Zapata, Cristina E. Davis, Gary A. Eiceman, Anthony D. Bashall
Abstract: An ultra compact ion mobility based analyzer in a multilayered chip assembly employing various features such as a ion flow generator to propel ions through an ion mobility based filter and, thereby, reduce analyzer size, cost, and power requirements.
Type:
Application
Filed:
July 26, 2006
Publication date:
July 30, 2009
Applicant:
SIONEX CORPORATION
Inventors:
Raanan A. Miller, Stephen Coy, Stephen D. Kendig, C. James Morris, John A. Wright, Erkinjon G. Nazarov
Abstract: The invention, in various embodiments, is directed to a method for analyzing a sample using a solid-state flow generator that provides a flow of effluent including the sample through an ion mobility based filter.
Abstract: The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, in some embodiments to compact GC-DMS systems and methods, and techniques for correcting nonlinear characteristics in an ion mobility based analyzer.
Type:
Grant
Filed:
February 2, 2005
Date of Patent:
November 25, 2008
Assignee:
Sionex Corporation
Inventors:
Douglas B. Cameron, David B. Wheeler, Quan Shi, Raanan A. Miller, Erkinjon G. Nazarov, John A. Wright
Abstract: The invention, in various embodiments, is directed to an analyzer using a solid-state flow generator to provide effluent flow along a flow path and deliver a sample to an ion mobility based filter and detector for analysis.
Abstract: A micromechanical field asymmetric ion mobility filter for a detection system includes a pair of spaced substrates defining between them a flow path between a sample inlet and an outlet; an ion filter disposed in the path and including a pair of spaced filter electrodes, one electrode associated with each substrate; and an electrical controller for applying a bias voltage and an asymmetric periodic voltage across the ion filter electrodes for controlling the paths of ions through the filter.
Abstract: A ion mobility-based analyzer system including a first ion mobility-based filter for passing selected ions through a time-varying field where the time-varying field being compensated by an adjustable compensation setting. The analyzer also includes a second ion mobility-based filter for receiving a first portion of ions from the first ion mobility-based filter. The second ion mobility-based filter includes a voltage gradient for separating ions of the first portion of ions where the ions have associated retention times based on their times of flight through the voltage gradient. The second ion mobility-based filter includes a detector for detecting the ions at their retention times. The analyzer system further includes a display that displays the detected ions in a plot relating the retention times of the ions in the second ion mobility-based filter with compensation settings of the first ion mobility-based filter.
Type:
Application
Filed:
April 1, 2008
Publication date:
August 7, 2008
Applicant:
SIONEX CORPORATION
Inventors:
Raanan A. Miller, Evgeny Krylov, Erkinjon G. Nazarov, Gary A. Eiceman, John A. Wright
Abstract: A system for analyzing one or more ion species of a sample including a first ion mobility filter associated with a first flow path for passing first ions of the sample, a second ion mobility filter associated with a second flow path for passing second ions of the sample, a first outlet from the first flow path for passing a portion of the first ions from the first flow path to the second flow path, and a first outlet from the second flow path for removing neutral particles from the second flow path where the first outlet from the second flow path is upstream of the second ion mobility filter in relation to the ion flow in the second flow path.
Type:
Grant
Filed:
November 7, 2006
Date of Patent:
July 15, 2008
Assignee:
Sionex Corporation
Inventors:
Raanan A. Miller, Evgeny Krylov, Erkinjon G. Nazarov, Gary A. Eiceman, John A. Wright
Abstract: The invention provides, in various embodiments, systems and methods relating to enhancing the filtering and detection capability of ion mobility based systems by various techniques to counteract a charge buildup in the ion mobility based system.
Type:
Grant
Filed:
December 2, 2005
Date of Patent:
July 15, 2008
Assignee:
Sionex Corporation
Inventors:
Raanan A. Miller, Erkinjon G. Nazarov, C. James Morris, Stephen Coy, Edward Bullister
Abstract: An RF-driven plasma source, including a pair of spaced-apart plasma electrodes, wherein the electrodes act as plates of a capacitor, the gas electrically discharges and creates a plasma of both positive and negative ions, in a clean process that enables efficient sample analysis, with preferred isolated sample photo-ionization, reduced-power operation and also including signal detection with modulated drive electronics.
Type:
Application
Filed:
August 20, 2007
Publication date:
July 3, 2008
Applicant:
SIONEX CORPORATION
Inventors:
Raanan A. Miller, Erkinjon G. Nazarov, Evgeny Krylov, Gary A. Eiceman, John A. Wright, Stephen D. Kendig, C. James Morris, Douglas B. Cameron
Abstract: The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, in some embodiments to compact GC-DMS systems, methods, and devices employing enhanced GC column temperature control and configurations to identify various sample constituents.
Type:
Application
Filed:
July 17, 2007
Publication date:
June 12, 2008
Applicant:
SIONEX CORPORATION
Inventors:
Raanan A. Miller, Erkinjon G. Nazarov, David B. Wheeler, Quan Shi, John A. Wright, Gary A. Eiceman
Abstract: Disclosed herein are systems, methods and apparatus, for detection and identification of chemical warfare agents (CWAs) using a differential mobility spectrometer.
Type:
Application
Filed:
February 1, 2008
Publication date:
June 5, 2008
Applicants:
SIONEX CORPORATION, The Charles Stark Draper Laboratory, Inc.
Inventors:
Raanan A. Miller, Erkinjon G. Nazarov, Angela Zapata, Cristina E. Davis, Gary A. Eiceman, Anthony D. Bashall
Abstract: The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, to sample detection using enhanced condition control and data interpretation.
Type:
Grant
Filed:
April 28, 2005
Date of Patent:
June 3, 2008
Assignee:
Sionex Corporation
Inventors:
Douglas B. Cameron, David B. Wheeler, Quan Shi, Raanan A. Miller, Erkinjon G. Nazarov, Evgeny Krylov, Stephen Coy, Gary A. Eiceman