Abstract: Disclosed herein are systems, methods and apparatus, for detection and identification of analytes in a volatilized or volatilizable sample, using the mobility-based signature that is produced when the volatilized sample is passed through an ion mobility based analyzer.
Type:
Grant
Filed:
May 29, 2007
Date of Patent:
April 8, 2008
Assignees:
Sionex Corporation, The Charles Stark Draper Laboratory, Inc.
Inventors:
Raanan A. Miller, Erkinjon G. Nazarov, Angela Zapata, Cristina E. Davis, Gary A. Eiceman, Anthony D. Bashall
Abstract: A sample analyzer including a MALDI ionization source, an ion mobility based filter for receiving ions from the MALDI ionization source and for providing a time-varying electric field through which select ions are passed, and a mass spectrometer for measuring the ion intensity of ions received from the ion mobility based filter.
Type:
Application
Filed:
January 25, 2007
Publication date:
November 29, 2007
Applicant:
SIONEX CORPORATION
Inventors:
Raanan Miller, Erkinjon Nazarov, Anthony Bashall
Abstract: The invention relates generally to devices and methods for displaying ion mobility based analysis information using a processor that processes data from an ion mobility based analyzer and a display that displays the processed data in a three-dimensional representation.
Type:
Application
Filed:
March 16, 2007
Publication date:
November 1, 2007
Applicant:
SIONEX CORPORATION
Inventors:
Raanan Miller, Erkinjon Nazarov, Lawrence Kaufman, Douglas Cameron
Abstract: An RF-driven plasma source, including a pair of spaced-apart plasma electrodes, wherein the electrodes act as plates of a capacitor, the gas electrically discharges and creates a plasma of both positive and negative ions, in a clean process that enables efficient sample analysis, with preferred isolated sample photo-ionization, reduced-power operation and also including signal detection with modulated drive electronics.
Type:
Grant
Filed:
June 21, 2006
Date of Patent:
October 9, 2007
Assignee:
Sionex Corporation
Inventors:
Raanan A. Miller, Erkinjon G. Nazarov, Evgeny Krylov, Gary A. Eiceman, John A. Wright, Stephen D. Kendig, C. James Morris, Douglas B. Cameron
Abstract: Disclosed herein are systems, methods and apparatus, for detection and identification of analytes in a volatilized or volatilizable sample, using the mobility-based signature that is produced when the volatilized sample is passed through an ion mobility based analyzer.
Type:
Application
Filed:
May 29, 2007
Publication date:
October 4, 2007
Applicants:
SIONEX CORPORATION, The Charles Stark Draper Laboratory, Inc.
Inventors:
Raanan Miller, Erkinjon Nazarov, Angela Zapata, Cristina Davis, Gary Eiceman, Anthony Bashall
Abstract: In a system for chemical analysis, an RF-driven plasma ionization device including a pair of spaced-apart and plasma-isolated electrodes, the electrodes are connected to a power source wherein the electrodes act as plates of a capacitor of a resonant circuit, the gas electrically discharges and creates a plasma of both positive and negative ions, and the voltage is applied as a continuous alternating waveform or as a series of pulses, such as a packet waveform.
Type:
Grant
Filed:
August 7, 2002
Date of Patent:
September 25, 2007
Assignee:
Sionex Corporation
Inventors:
Raanan A. Miller, Erkinjon G. Nazarov, Evgeny Krylov, Gary A. Eiceman, Lawrence A. Kaufman
Abstract: The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, in some embodiments to compact GC-DMS systems, methods, and devices employing enhanced GC column temperature control and configurations to identify various sample constituents.
Type:
Grant
Filed:
June 20, 2006
Date of Patent:
August 28, 2007
Assignee:
Sionex Corporation
Inventors:
Raanan A. Miller, Erkinjon G. Nazarov, David B. Wheeler, Quan Shi, John A. Wright, Gary A. Eiceman
Abstract: A system for analyzing one or more ion species of a sample including a first ion mobility filter associated with a first flow path for passing first ions of the sample, a second ion mobility filter associated with a second flow path for passing second ions of the sample, a first outlet from the first flow path for passing a portion of the first ions from the first flow path to the second flow path, and a first outlet from the second flow path for removing neutral particles from the second flow path where the first outlet from the second flow path is upstream of the second ion mobility filter in relation to the ion flow in the second flow path.
Type:
Application
Filed:
November 7, 2006
Publication date:
August 2, 2007
Applicant:
SIONEX CORPORATION
Inventors:
Raanan Miller, Evgeny Krylov, Erkinjon Nazarov, Gary Eiceman, John Wright
Abstract: System for control of ion species behavior in a time-varying filter field of an ion mobility-based spectrometer to improve species identification, based on control of electrical and environmental aspects of sample analysis.
Type:
Grant
Filed:
December 13, 2004
Date of Patent:
June 12, 2007
Assignee:
Sionex Corporation
Inventors:
Raanan A. Miller, Erkinjon G. Nazarov, Evgeny Krylov, Gary A. Eiceman
Abstract: Method and apparatus for identification of chemical compounds in a sample based on differences in ion mobility, wherein the filter and detector electrodes are formed radially spaced on facing substrates.
Abstract: The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, in some embodiments to compact GC-DMS systems, methods, and devices employing enhanced GC column temperature control and configurations to identify various sample constituents.
Type:
Application
Filed:
May 1, 2006
Publication date:
February 8, 2007
Applicant:
SIONEX CORPORATION
Inventors:
Raanan Miller, Erkinjon Nazarov, David Wheeler, Kenneth Markoski
Abstract: An apparatus for identification of chemical species by measurement of mobility as a function of high electric field and for generating unique compound-dependent signatures based on ion mobility at a plurality of peak RF voltages for a given compensation. The resulting detection data is compared against a library of data in order to identify a detected chemical species.
Type:
Grant
Filed:
July 26, 2005
Date of Patent:
January 2, 2007
Assignee:
Sionex Corporation
Inventors:
Lawrence A. Kaufman, Raanan A. Miller, Erkinjon G. Nazarov, Gary A. Eiceman, Evgeny Krylov
Abstract: Method and apparatus for field ion mobility spectrometry for identification of chemical compounds in a sample by trajectory of sample ions in a transverse electric field.
Type:
Grant
Filed:
May 7, 2004
Date of Patent:
December 12, 2006
Assignee:
Sionex Corporation
Inventors:
Raanan A. Miller, Erkinjon G. Nazarov, Lawrence A. Kaufman
Abstract: System for control of ion species behavior in a time-varying filter field of an ion mobility-based spectrometer to improve species identification for explosives detection.
Type:
Grant
Filed:
April 8, 2004
Date of Patent:
October 31, 2006
Assignee:
Sionex Corporation
Inventors:
Raanan A. Miller, Erkinjon G. Nazarov, David B. Wheeler, Quan Shi, John A. Wright, Gary A. Eiceman
Abstract: The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, in some embodiments to compact GC-DMS systems, methods, and devices employing enhanced GC column temperature control and configurations to identify various sample constituents.
Type:
Application
Filed:
June 20, 2006
Publication date:
October 26, 2006
Applicant:
SIONEX CORPORATION
Inventors:
Raanan Miller, Erkinjon Nazarov, David Wheeler, Quan Shi, John Wright, Gary Eiceman