Abstract: This invention provides a method to enhance an immune response of nucleic acid vaccination by simultaneous administration of a polynucleotide and a polypeptide of interest.
Type:
Grant
Filed:
June 12, 2000
Date of Patent:
December 31, 2002
Assignee:
SmithKline Beecham Biologicals, S.A.
Inventors:
Wilfried Dalemans, Marcelle Van Mechelen, Claudine Bruck, Martin Friede
Abstract: A novel vaccine formulation is provided, comprising a hepatitis B component, particularly hepatitis B surface antigen, in combination with aluminum phosphate and 3 de-O-acylated monophosphoryl lipid A.
Type:
Application
Filed:
December 6, 2000
Publication date:
December 19, 2002
Applicant:
SmithKline Beecham Biologicals, s.a.
Inventors:
Pierre Hauser, Nathalie Marie-Josephe Claude Garcon, Pierre Desmons
Abstract: A novel vaccine formulation is provided, comprising a hepatitis B component, particularly hepatitis B surface antigen, in combination with aluminum phosphate and 3 de-O-acylated monophosphoryl lipid A.
Type:
Grant
Filed:
December 6, 2000
Date of Patent:
December 3, 2002
Assignee:
SmithKline Beecham Biologicals S.A.
Inventors:
Pierre Hauser, Nathalie Marie-Josephe Claude Garcon, Pierre Desmons
Abstract: This invention relates to a vaccine composition useful in the prevention or treatment of malaria comprises a plurality of malaria-derived antigens in combination with an adjuvant which is a preferential stimulator of TH1 cell response.
Abstract: Novel combined vaccine compositions preferentially for administration to adolescents are provided, comprising a hepatitis B viral antigen and a herpes simplex viral antigen and optionally in addition one or more of the following: an EBV antigen, a hepatitis A antigen or inactivated attenuated virus, an HPV antigen, a VZV antigen, an HCMV antigen, a Toxoplasma gondii antigen. The vaccine compositions are formulated with an adjuvant which is a preferential stimulator of TH1 cell response such as 3D-MPL and QS21.
Type:
Grant
Filed:
October 27, 2000
Date of Patent:
September 17, 2002
Assignee:
SmithKline Beecham Biologicals S.A.
Inventors:
Jean Stephenne, Martine Anne Cecile Wettendorff
Abstract: The present invention pertains to improved adjuvant compositions comprising a mixture of a saponin adjuvant such as QS21 with monophosphoryl lipid A or derivative thereof such as 3D-MPL and interleukin 12. These compositions are useful in a range of prophylactic and therapeutic applications, particularly in vaccines, including cancer vaccines.
Abstract: The present invention relates to oil in water emulsion compositions, their use in medicine, in particular to their use in augmenting immune responses to a wide range of antigens, and to methods of their manufacture; the compositions having oil phase and an aqueous phase, a sterol and a saponin; the sterol being present in the oil phase and the saponin being present in the aqueous phase.
Type:
Grant
Filed:
April 24, 2000
Date of Patent:
April 16, 2002
Assignee:
SmithKline Beecham Biologicals, s.a.
Inventors:
Nathalie Garcon, Patricia Marie Christine Aline Francoise Momin
Abstract: The present invention relates to fusions proteins, comprising a protein or part of a protein that provides T helper epitopes and an antigen from a human-papilloma virus. In particular the invention relates to fusion proteins comprising an E6 or E7 protein from HPV strain 16 or 18 linked to protein D from Haemophilus influenza B. The invention also provides vaccine compositions that are useful in the treatment or prophylaxis of human papilloma induced tumours.
Type:
Grant
Filed:
February 18, 2000
Date of Patent:
January 29, 2002
Assignee:
SmithKline Beecham Biologicals, S.A.
Inventors:
Claudine Bruck, Teresa Cabezon Silva, Anne-Marie Eva Fernande Delisse, Catherine Marie Ghislaine Gerard, Angela Lombardo-Bencheikh
Abstract: The present invention relates to compositions for the treatment or prevention of Zoster of individuals infected with Varicella Zoster virus (VZV), and to the prevention and treatment of Varicella infections. The compositions of the invention comprise the protein encoded by VZV gene 63 or an immunologically active derivative thereof. The invention further relates to compositions containing DNA or RNA corresponding to VZV gene 63.
Abstract: This invention relates to a diphtheria, tetanus and pertussis vaccine comprising a low dose of each of diphtheria toxoid (D), tetanus toxoid (T), pertussis toxin (PT), filamentous haemagglutinin (FHA) and pertactin (69K). The vaccine maintains an ability to prevent pertussis while showing exceptionally low reactogenicity. Combination vaccines comprising additional antigens are also provided.
Type:
Application
Filed:
April 6, 2001
Publication date:
August 16, 2001
Applicant:
SmithKline Beecham Biologicals s.a.
Inventors:
Patrick Florent, Jean Stephenne, Christian Vandecasserie
Abstract: A luer connector which facilitates connection of a hypodermic syringe to the vial, comprising a luer connectable to a syringe and which extends to a sharpened end capable of being driven through a puncturable vial closure to thereby puncture the closure; a luer support, mountable on a vial, and which initially supports the luer in a first position in which the sharpened end of the conduit is pointed toward the closure; a luer driver such that movement of the driver relative to the support causes the luer to be driven so that the sharpened end punctures the closure and enters the vial.
Abstract: Isolated DNA sequences encoding a novel hybrid protein are provided which comprise a portion of the CS protein of P. falciparum and the surface antigen of Hepatitis B virus. Vectors and host cells containing the isolated DNA sequences are also disclosed.
Abstract: The present invention provides vaccine compositions comprising an oil-in-water emulsion optionally with 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccines compositions are potent inducers of a range of immune responses.
Type:
Grant
Filed:
July 2, 1996
Date of Patent:
November 14, 2000
Assignee:
SmithKline Beecham Biologicals s.a.
Inventors:
Patricia Marie Momin, Nathalie Marie-Josephe Garcon
Abstract: The invention relates to novel Borrelia, and OspA antigens derived therefrom. These antigens show little homology with known OspA's and are therefore useful as vaccine and diagnostic reagents. Multicomponent vaccines based on OspA's from different Borrelia groups are also disclosed.
Type:
Grant
Filed:
July 5, 1994
Date of Patent:
September 5, 2000
Assignee:
Smithkline Beecham Biologicals (S.A.)
Inventors:
Yves Lobet, Markus Simon, Ulrich Schaible, Reinhard Wallich, Michael Kramer
Abstract: A new mumps vaccine is presented, comprising a homogeneous pure isolate derived from the Jeryl-Lynn strain of mumps virus. In a preferred embodiment of the invention the vaccine produces higher seroconversion and antibody titres than known commercial vaccines.
Type:
Grant
Filed:
May 13, 1996
Date of Patent:
February 15, 2000
Assignee:
Smithkline Beecham Biologicals (S.A.)
Inventors:
Nigel Maurice Harford, Brigitte Desiree Alberte Colau, Jean Didelez
Abstract: For storage of syringes, a support rack comprising a plurality of elongate fingers (2) connected together at one end by a spine member (1) is used. The fingers (2) define parallel support channels (5) open at one end, and the syringes are stored in the channels (5) with their lips or wings (4) resting on the elongate fingers (2). Also disclosed are support cradles, storage boxes, and lifting devices for handling the loaded racks. The support rack is better adapted than existing systems for cooperation with automated machinery since it can receive syringes into the channels by a horizontal translation movement, readily provided by a simple pushing device.
Abstract: A novel vaccine formulation is provided, comprising a hepatitis B component, particularly hepatitis B surface antigen, in combination with aluminum phosphate and 3-O-acylated monophosphoryl lipid A.
Type:
Grant
Filed:
October 27, 1997
Date of Patent:
October 26, 1999
Assignee:
SmithKline Beecham Biologicals S.A.
Inventors:
Pierre Hauser, Nathalie Marie-Josephe Claude Garcon, Pierre Desmons