Patents Assigned to SmithKline Beecham Corporation
  • Compounds and methods
    Patent number: 7365085
    Abstract: Disclosed is a compound having the formula: pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agonists.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: April 29, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Ajita Bhat, John Jeffrey McAtee, Scott K. Thompson, James S. Frazee, Lara S. Kallander, Chun Ma, Joseph Marino, Michael J. Neeb, Robert A. Stavenger
  • FARNESOID X RECEPTOR AGONISTS
    Publication number: 20080096921
    Abstract: The present invention provides novel substituted isoxazole compounds, pharmaceutical compositions, therapeutic uses and processes for preparing the same.
    Type: Application
    Filed: October 23, 2007
    Publication date: April 24, 2008
    Applicant: SmithKline Beecham Corporation
    Inventors: Frank NAVAS, Paul Spearing
  • Chemical Compounds
    Publication number: 20080096861
    Abstract: The present invention provides compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind to chemokine receptor, and which affect the binding of the natural ligand or chemokine to a receptor such as CXCR4 of a target cell.
    Type: Application
    Filed: July 29, 2005
    Publication date: April 24, 2008
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Kristjan Gudmundsson, John Franklin Miller, Elizabeth Madalena Turner
  • Orphan Nuclear Receptor
    Publication number: 20080096239
    Abstract: The present invention relates to a novel human orphan nuclear receptor that binds to a cytochrome P-450 monoxygenase (CYP) promoter and that is activated by compounds that induce CYP gene expression. The invention further relates to nucleic acid sequences encoding such a receptor, to methods of making the receptor and to methods of using the receptor and nucleic acid sequences encoding same. The invention also relates to non-human animals transformed to express the human receptor and to methods of using such animals to screen compounds for drug interactions and toxicities.
    Type: Application
    Filed: June 22, 2007
    Publication date: April 24, 2008
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Steven Kliewer, Stacey Jones, Timothy Willson
  • S8 rRNA-binding protein from the small ribosomal subunit of
    Patent number: 7361734
    Abstract: A Staphylococcus aureus S8 native crystalline structure and a Staphylococcus aureus S8 mode of binding with rRNA were identified.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: April 22, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Nestor O. Concha, Richard R. Gontarek, Cheryl A. Janson
  • Tetrahydrocarbazole derivatives and their pharmaceutical use
    Patent number: 7351733
    Abstract: The present invention relates to novel compounds that are useful in the treatment of human papillomaviruses, and also to the methods for the making and use of such compounds.
    Type: Grant
    Filed: June 7, 2004
    Date of Patent: April 1, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Sharon Davis Boggs, Kristjan S Gudmundsson, Leah D'Aurora Richardson, Paul Richard Sebahar
  • Valve for aerosol container
    Patent number: 7350676
    Abstract: Valve for an aerosol container for dispensing a suspension of a substance in a liquid propellant contained therein. The valve comprises a valve body (1) having at least one orifice (16) to allow a quantity of the suspension to pass from the container into the valve. The valve further comprises a ring (18) disposed around the valve body (1), the ring being positioned below the at least one orifice to reduce the volume of suspension that can be accommodated within the container below the at least one orifice when the container is orientated with the valve at the bottom, the ring having at least one portion of reduced axial thickness to provide a trough (19) around the valve body below the at least one orifice.
    Type: Grant
    Filed: April 15, 2005
    Date of Patent: April 1, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Patrick Di Giovanni, Cheryl Vanessa Rogerson
  • Method to improve translation of polypeptides by using untranslated regions from heat-shock proteins
    Patent number: 7351818
    Abstract: Untranslated regions associated with the heat shock response can be used to obtain increased efficiency of translation of polypeptides that are not necessarily normally associated with the heat shock response. This allows the development of greatly improved expression systems. The invention is also useful, for example, in the treatment of a patient suffering from a deficiency in the expression of a polypeptide and in the provision of vaccines.
    Type: Grant
    Filed: June 27, 2005
    Date of Patent: April 1, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Herve Jean-Clement Coste, Jonathan Henry Ellis
  • Medicament dispenser
    Patent number: 7347200
    Abstract: A medicament dispenser comprising: (i) a housing having an outlet; (ii) a medicament container locatable within said housing; (iii) an electronic dose counter associated with said outlet, wherein said dose counter comprises a first sensor for directly detecting a medicament release dispensible from said medicament container through said outlet is disclosed.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: March 25, 2008
    Assignee: Smithkline Beecham Corporation
    Inventors: Anthony Patrick Jones, Andrew Paul Horton, Richard William Hartley
  • Chemical compounds
    Patent number: 7345041
    Abstract: The invention relates to methods for the treatment of a sleep disorder comprising administering a compound of formula (I): wherein all variables are as defined herein.
    Type: Grant
    Filed: January 18, 2006
    Date of Patent: March 18, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Giuseppe Alvaro, Romano Di Fabio, Riccardo Giovannini, Giuseppe Guercio, Yves St-Denis, Antonella Ursini
  • Substituted oxindole derivatives as tyrosine kinase inhibitors
    Patent number: 7338966
    Abstract: The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.
    Type: Grant
    Filed: June 9, 2005
    Date of Patent: March 4, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Karen Elizabeth Lackey, Edgar Raymond Wood, III
  • Phenylalkanoic acid and phenyloxyalkanoic acid derivatives as hPPAR activators
    Patent number: 7338960
    Abstract: A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, wherein:
    Type: Grant
    Filed: June 18, 2003
    Date of Patent: March 4, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Richard Bell, Paul John Beswick, Romain Luc Marie Gosmini, Richard Martin Grimes, Christopher Charles Frederick Hamlett, Nigel Paul King, Vipulkumar Kantibhai Patel
  • Diamino-pyrimidines and their use as angiogenesis inhibitors
    Patent number: 7338959
    Abstract: Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: March 4, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Stanley Dawes Chamberlain, Mui Cheung, Holly Kathleen Emerson, Neil W. Johnson, Kristen Elizabeth Nailor, Douglas McCord Sammond, Marcus Semones
  • Novel Compounds
    Publication number: 20080051416
    Abstract: The present invention is directed to novel compounds of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
    Type: Application
    Filed: October 5, 2005
    Publication date: February 28, 2008
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Jeffrey Boehm, James Callahan, Zehong Wan, Hongxing Yan
  • Thrombopoietin mimetics
    Patent number: 7335649
    Abstract: Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: February 26, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Kevin J. Duffy, Connie Erickson-Miller, Julian Jenkins, Juan I. Luengo, Sophie Visonneau
  • Modulation of KSP kinesin activity with heterocyclic-fused pyrimidinone derivatives
    Patent number: 7332498
    Abstract: A method of modulating KSP kinesin activity in vitro comprising contacting KSP kinesin with at least one chemical entity chosen from compounds represented by Formula I: and pharmaceutically acceptable salts thereof, where the variables are as defined further herein.
    Type: Grant
    Filed: November 23, 2005
    Date of Patent: February 19, 2008
    Assignees: Cytokinetics, Inc., SmithKline Beecham Corporation
    Inventors: Pu-Ping Lu, David J. Morgans, Jr., Bing Yao, Dashyant Dhanak, Steven David Knight
  • Thrombopoietin mimetics
    Patent number: 7332481
    Abstract: Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: February 19, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Kevin J. Duffy, Connie Erickson-Miller, Julian Jenkins, Juan Luengo, Alan T. Price, Antony N. Shaw, Sophie Visonneau, Kenneth Wiggall
  • Child resistant blister packages utilizing walled structures enclosing medicament therein
    Patent number: 7328802
    Abstract: A child resistant blister package includes a film having a surface wherein a plurality of cavities are formed therein containing at least one medicament; a cover sheet which overlies the cavities and is bonded to the film; and a wall structure raised above the surface of the film which extends throughout the film forming an interior region enclosing the plurality of cavities therein.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: February 12, 2008
    Assignee: SmithKline Beecham Corporation
    Inventor: Fred Mieras Killinger
  • Container
    Patent number: D562151
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: February 19, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael J. Larocca, Stephen J. Costa
  • Antibody purification
    Patent number: RE40070
    Abstract: This invention relates to the application of hydrophobic interaction chromatography combination chromatography to the purification of antibody molecule proteins.The questions raised in reexamination request, 09/006,966 filed Mar. 12, 2004 have been considered and the results thereof are reflected in this reissue patent which constitutes the reexamination certificate required by 35 U.S.C. 307 as provided in 37 CFR 1.570(e), for ex parte reexaminations, or the reexamination certificate required by 35 U.S.C. 316 as provided in 37 CFR 1.997(e) for inter partes reexaminations.
    Type: Grant
    Filed: May 27, 2005
    Date of Patent: February 19, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Paula Shadle, John C. Erickson, Robert G. Scott, Thomas M. Smith